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Detail Data SLC29A4


Basic description
Gene Name SLC29A4
Protein Name Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (Solute carrier family 29 member 4)
Family SLC29
Category Transport of vitamins, nucleosides, and related molecules
Reaction name Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4
Reaction 1 ligands of SLC29A4 [extracellular region] --> 1 ligands of SLC29A4 [cytosol]
1 ligands of SLC29A4 [cytosol] --> 1 ligands of SLC29A4 [extracellular region]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530 
MGSVGSQRLE EPSVAGTPDP GVVMSFTFDS HQLEEAAEAA QGQGLRARGV PAFTDTTLDE PVPDDRYHAI YFAMLLAGVG FLLPYNSFIT DVDYLHHKYP GTSIVFDMSL TYILVALAAV LLNNVLVERL TLHTRITAGY LLALGPLLFI SICDVWLQLF SRDQAYAINL AAVGTVAFGC TVQQSSFYGY TGMLPKRYTQ GVMTGESTAG VMISLSRILT KLLLPDERAS TLIFFLVSVA LELLCFLLHL LVRRSRFVLF YTTRPRDSHR GRPGLGRGYG YRVHHDVVAG DVHFEHPAPA LAPNESPKDS PAHEVTGSGG AYMRFDVPRP RVQRSWPTFR ALLLHRYVVA RVIWADMLSI AVTYFITLCL FPGLESEIRH CILGEWLPIL IMAVFNLSDF VGKILAALPV DWRGTHLLAC SCLRVVFIPL FILCVYPSGM PALRHPAWPC IFSLLMGISN GYFGSVPMIL AAGKVSPKQR ELAGNTMTVS YMSGLTLGSA VAYCTYSLTR DAHGSCLHAS TANGSILAGL  
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCHHHHHHH CCCCCHHCCC CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCHHHHH HHHHHHHHHH HHHHHHHCHH HHCCCCCCCC CHHHCCCHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHCCHHHHH HHCCCCCCCC CCCCCCCCCC CCEECCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCCCCHHEE EHHHHCCHHH CCHHHHCCCC CCCHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCHHHH HHHHHHHHHC HHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCHH HHCCCCCCCC
[Overview] SLC29A1 SLC29A2 SLC29A3 SLC29A4 
SLC29A1   MT--------------------------TSHQ-----------------------------------PQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGS-LVAILLVFLITAILVKVQLDALP--FFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYY-----QQLKLEG-PG-----EQETKLDLISKG----EEPRAGKEESGVSVS------------NSQPTNE-------------------------SHSIKAIL-------KNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSST-W-ERYFIPVSCFLTFNIFDWLGRSLTAV-FMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYL-TVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV---------------------
SLC29A2   MA--------------------------RGDA-----------------------------------PRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGN---STARI-----LSTNHTGPEDAFN-----FNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGS-LLAILLLFALTAALVKVDMSPGP--FFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQ---------ELETKAELLQ------------SDENGIPSSPQKVALTLDLDLEKEPESEP--------------DEPQ---KPGKPSVFTVF-------QKIWLTALCLVLVFTVTLSVFPAITAMVTSSTS-PGK-W-SQFFNPICCFLLFNIMDWLGRSLTSY-FLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRL-PILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL---------------------
SLC29A3   MAVVSEDDFQHSSNSTYR----TTSSSLRADQE------------------ALLEKLLDRPPPGLQRPEDRFCGTYIIFFSLGIGSLLPWNFFITAKEYWMFKL---RN-------------SSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLVANFLLVNRVAVHIRVLAS-LTVILAIFMVITALVKVDTSSWTRGFFAVTIVCMVILSGASTVFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATVFLVLCMGLYLLLSRLEYARYYMR---PVLAAHVFSG-----EEELPQDSLS--------------------APSVASRFIDSH---------------------------------TPPLRPIL-------KKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADLCGRQLTAW-IQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSSLLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI---------------------
SLC29A4   MGSVGSQRLEEPSVAGTPDPGVVMSFTFDSHQLEEAAEAAQGQGLRARGVPAFTDTTLDEPV-----PDDRYHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSIV------------------------------FD--MSLTYILVALAAVLLNNVLVERLTLHTRITAGYLLALGPLLFISICDVWLQLFSRDQ-AYAINLAAVGTVAFGCTVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTLIFFLVSVALELLCFLLHLLVRRSRFVLFYTTR--PRDSHRGRPGLGRGYGYRVHHDVVA-GDVHFEHP-----------APALAP-------NESPKDSPAHEVTGSGGAYMRFDVPRPRVQRSWPTFRALLLHRYVVARVIWADMLSIAVTYFITLCLFPGLESEIRHCILGE---W-----LPILIMAVFNLSDFVGKILAALPVDWRGTH---LLACSCLRVVFIPLFILCVYPSGMPA----LRHPAWPCIFSLLMGISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHGSCLHASTANGSILAGL

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC29A4 24 M/L 0.00446221 rs73332823
-- SLC29A4 29 D/G 0.00244614 rs145276221
-- SLC29A4 50 V/I 0.00018432 rs143263478
-- SLC29A4 64 D/N 0.000111967 rs140231673
-- SLC29A4 105 V/M 0.000127327 rs761330090
-- SLC29A4 138 A/T 0.00113861 rs148426706
-- SLC29A4 147 S/C 0.000693614 rs143586404
-- SLC29A4 199 T/M 0.000170267 rs764692318
-- SLC29A4 256 R/C 0.00388489 rs144364439
-- SLC29A4 259 L/V 0.000154028 rs762994450
-- SLC29A4 271 G/S 0.000359954 rs552193674
-- SLC29A4 279 Y/C 0.000183147 rs768646689
-- SLC29A4 291 D/G 0.000742374 rs376762145
-- SLC29A4 301 L/V 0.000102611 rs140320575
-- SLC29A4 303 P/L 0.000114777 rs141514048
-- SLC29A4 317 G/S 0.00123788 rs117803237
-- SLC29A4 319 G/S 0.000621916 rs138638344
-- SLC29A4 334 R/C 0.00312881 rs150889269
-- SLC29A4 334 R/H 0.000134569 rs544632146
-- SLC29A4 344 L/M 0.000212992 rs138477882
-- SLC29A4 439 G/A 0.000123533 rs147773173
-- SLC29A4 519 A/T 0.000554754 rs144064645
-- SLC29A4 519 A/V 0.00211785 rs148653061
-- SLC29A4 521 T/I 0.0002227 rs767103185
-- SLC29A4 524 G/A 0.000142598 rs142220610
-- SLC29A4 528 A/E 0.000183072 rs750541052

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC29A4 SLC29A4 [plasma membrane] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data