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Detail Data SLC29A2


Basic description
Gene Name SLC29A2
Protein Name Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)
Family SLC29
Category Transport of vitamins, nucleosides, and related molecules
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450 
MARGDAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ ARLAGAGNST ARILSTNHTG PEDAFNFNNW VTLLSQLPLL LFTLLNSFLY QCVPETVRIL GSLLAILLLF ALTAALVKVD MSPGPFFSIT MASVCFINSF SAVLQGSLFG QLGTMPSTYS TLFLSGQGLA GIFAALAMLL SMASGVDAET SALGYFITPC VGILMSIVCY LSLPHLKFAR YYLANKSSQA QAQELETKAE LLQSDENGIP SSPQKVALTL DLDLEKEPES EPDEPQKPGK PSVFTVFQKI WLTALCLVLV FTVTLSVFPA ITAMVTSSTS PGKWSQFFNP ICCFLLFNIM DWLGRSLTSY FLWPDEDSRL LPLLVCLRFL FVPLFMLCHV PQRSRLPILF PQDAYFITFM LLFAVSNGYL VSLTMCLAPR QVLPHEREVA GALMTFFLAL GLSCGASLSF LFKALL 
CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCEEEE EHHHHCCCHH HHHHHHHHHH HHHHCCHHHH HHHHCCCCHH HHHHHHHHHH HHHCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHCCCCC CHHCCCCCCC CCCHHHCCCC CHHHHHHHHH HHHHHHHHHH HCCCCHHHCH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCHHHHHHH HHHHHHCCCH HHHHHHHCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHC
[Overview] SLC29A1 SLC29A2 SLC29A3 SLC29A4 
SLC29A1   MT--------------------------TSHQ-----------------------------------PQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGS-LVAILLVFLITAILVKVQLDALP--FFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYY-----QQLKLEG-PG-----EQETKLDLISKG----EEPRAGKEESGVSVS------------NSQPTNE-------------------------SHSIKAIL-------KNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSST-W-ERYFIPVSCFLTFNIFDWLGRSLTAV-FMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYL-TVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV---------------------
SLC29A2   MA--------------------------RGDA-----------------------------------PRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGN---STARI-----LSTNHTGPEDAFN-----FNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGS-LLAILLLFALTAALVKVDMSPGP--FFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQ---------ELETKAELLQ------------SDENGIPSSPQKVALTLDLDLEKEPESEP--------------DEPQ---KPGKPSVFTVF-------QKIWLTALCLVLVFTVTLSVFPAITAMVTSSTS-PGK-W-SQFFNPICCFLLFNIMDWLGRSLTSY-FLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRL-PILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL---------------------
SLC29A3   MAVVSEDDFQHSSNSTYR----TTSSSLRADQE------------------ALLEKLLDRPPPGLQRPEDRFCGTYIIFFSLGIGSLLPWNFFITAKEYWMFKL---RN-------------SSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLVANFLLVNRVAVHIRVLAS-LTVILAIFMVITALVKVDTSSWTRGFFAVTIVCMVILSGASTVFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATVFLVLCMGLYLLLSRLEYARYYMR---PVLAAHVFSG-----EEELPQDSLS--------------------APSVASRFIDSH---------------------------------TPPLRPIL-------KKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADLCGRQLTAW-IQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSSLLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI---------------------
SLC29A4   MGSVGSQRLEEPSVAGTPDPGVVMSFTFDSHQLEEAAEAAQGQGLRARGVPAFTDTTLDEPV-----PDDRYHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSIV------------------------------FD--MSLTYILVALAAVLLNNVLVERLTLHTRITAGYLLALGPLLFISICDVWLQLFSRDQ-AYAINLAAVGTVAFGCTVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTLIFFLVSVALELLCFLLHLLVRRSRFVLFYTTR--PRDSHRGRPGLGRGYGYRVHHDVVA-GDVHFEHP-----------APALAP-------NESPKDSPAHEVTGSGGAYMRFDVPRPRVQRSWPTFRALLLHRYVVARVIWADMLSIAVTYFITLCLFPGLESEIRHCILGE---W-----LPILIMAVFNLSDFVGKILAALPVDWRGTH---LLACSCLRVVFIPLFILCVYPSGMPA----LRHPAWPCIFSLLMGISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHGSCLHASTANGSILAGL

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC29A2 35 A/T 0.000127753 rs547711857
-- SLC29A2 52 R/G 0.00431549 rs146937376
-- SLC29A2 59 T/M 0.00017511 rs200637398
-- SLC29A2 68 N/K 0.000342139 rs8187644
-- SLC29A2 94 P/L 0.000691964 rs8187648
-- SLC29A2 123 P/S 0.00015364 rs748640576
-- SLC29A2 159 Y/H 0.00078629 rs182128727
-- SLC29A2 160 S/T 0.00023663 rs764592046
-- SLC29A2 208 V/L 0.000183092 rs150459418
-- SLC29A2 248 G/R 0.000135295 rs542568717
-- SLC29A2 250 A/T 0.000131317 rs747624207
-- SLC29A2 265 R/C 0.00508681 rs8187661
-- SLC29A2 268 P/L 0.000194893 rs146921129
-- SLC29A2 332 A/T 0.00198907 rs149121404
-- SLC29A2 376 M/I 0.00198907 rs149121404
-- SLC29A2 454 A/V 0.00030359 rs140572979

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC29A2 SLC29A2 [plasma membrane] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data