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Detail Data SLC29A1


Basic description
Gene Name SLC29A1
Protein Name Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)
Family SLC29
Category Transport of vitamins, nucleosides, and related molecules
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450 
MTTSHQPQDR YKAVWLIFFM LGLGTLLPWN FFMTATQYFT NRLDMSQNVS LVTAELSKDA QASAAPAAPL PERNSLSAIF NNVMTLCAML PLLLFTYLNS FLHQRIPQSV RILGSLVAIL LVFLITAILV KVQLDALPFF VITMIKIVLI NSFGAILQGS LFGLAGLLPA SYTAPIMSGQ GLAGFFASVA MICAIASGSE LSESAFGYFI TACAVIILTI ICYLGLPRLE FYRYYQQLKL EGPGEQETKL DLISKGEEPR AGKEESGVSV SNSQPTNESH SIKAILKNIS VLAFSVCFIF TITIGMFPAV TVEVKSSIAG SSTWERYFIP VSCFLTFNIF DWLGRSLTAV FMWPGKDSRW LPSLVLARLV FVPLLLLCNI KPRRYLTVVF EHDAWFIFFM AAFAFSNGYL ASLCMCFGPK KVKPAEAETA GAIMAFFLCL GLALGAVFSF LFRAIV 
CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCHH HHHHHHHHHH HHHHHHHHCC HHHHHHHCCH HHHCHHHHCC HHHHHHHHHH HHHHHHCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCEE EEEECCCCCC CCCHHHCCCC HHHHHHHHHH HHHHHHHHHH HHCCCCCCCH HHHHHHHHHH HHHHHHHHCC CCCCCCCCEE CCHHHHHHHH HHHHHCCCHH HHHHHHHCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHC
[Overview] SLC29A1 SLC29A2 SLC29A3 SLC29A4 
SLC29A1   MT--------------------------TSHQ-----------------------------------PQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGS-LVAILLVFLITAILVKVQLDALP--FFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYY-----QQLKLEG-PG-----EQETKLDLISKG----EEPRAGKEESGVSVS------------NSQPTNE-------------------------SHSIKAIL-------KNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSST-W-ERYFIPVSCFLTFNIFDWLGRSLTAV-FMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYL-TVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV---------------------
SLC29A2   MA--------------------------RGDA-----------------------------------PRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGN---STARI-----LSTNHTGPEDAFN-----FNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGS-LLAILLLFALTAALVKVDMSPGP--FFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQ---------ELETKAELLQ------------SDENGIPSSPQKVALTLDLDLEKEPESEP--------------DEPQ---KPGKPSVFTVF-------QKIWLTALCLVLVFTVTLSVFPAITAMVTSSTS-PGK-W-SQFFNPICCFLLFNIMDWLGRSLTSY-FLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRL-PILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL---------------------
SLC29A3   MAVVSEDDFQHSSNSTYR----TTSSSLRADQE------------------ALLEKLLDRPPPGLQRPEDRFCGTYIIFFSLGIGSLLPWNFFITAKEYWMFKL---RN-------------SSSPATGEDPEGSDILNYFESYLAVASTVPSMLCLVANFLLVNRVAVHIRVLAS-LTVILAIFMVITALVKVDTSSWTRGFFAVTIVCMVILSGASTVFSSSIYGMTGSFPMRNSQALISGGAMGGTVSAVASLVDLAASSDVRNSALAFFLTATVFLVLCMGLYLLLSRLEYARYYMR---PVLAAHVFSG-----EEELPQDSLS--------------------APSVASRFIDSH---------------------------------TPPLRPIL-------KKTASLGFCVTYVFFITSLIYPAICTNIESLNKGSGSLWTTKFFIPLTTFLLYNFADLCGRQLTAW-IQVPGPNSKALPGFVLLRTCLIPLFVLCNYQPRVHLKTVVFQSDVYPALLSSLLGLSNGYLSTLALLYGPKIVPRELAEATGVVMSFYVCLGLTLGSACSTLLVHLI---------------------
SLC29A4   MGSVGSQRLEEPSVAGTPDPGVVMSFTFDSHQLEEAAEAAQGQGLRARGVPAFTDTTLDEPV-----PDDRYHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSIV------------------------------FD--MSLTYILVALAAVLLNNVLVERLTLHTRITAGYLLALGPLLFISICDVWLQLFSRDQ-AYAINLAAVGTVAFGCTVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTLIFFLVSVALELLCFLLHLLVRRSRFVLFYTTR--PRDSHRGRPGLGRGYGYRVHHDVVA-GDVHFEHP-----------APALAP-------NESPKDSPAHEVTGSGGAYMRFDVPRPRVQRSWPTFRALLLHRYVVARVIWADMLSIAVTYFITLCLFPGLESEIRHCILGE---W-----LPILIMAVFNLSDFVGKILAALPVDWRGTH---LLACSCLRVVFIPLFILCVYPSGMPA----LRHPAWPCIFSLLMGISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHGSCLHASTANGSILAGL

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC29A1 62 A/P 0.000814079 rs145684411
-- SLC29A1 67 G/R 0.000148005 rs375683637
SLC29A1 81 N/S 0.00107041 rs72555353
SLC29A1 216 I/T 0.0181571 rs45573936
SLC29A1 225 G/S 0.000222742 rs766358063
SLC29A1 301 T/N 0.000170986 rs372644592
SLC29A1 359 R/H 0.00031352 rs766758816
SLC29A1 391 E/K 0.00097838 rs45458701
SLC29A1 430 A/T 0.00143979 rs74750454

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC29A1 SLC29A1 [plasma membrane] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data