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Detail Data SLC28A3


Basic description
Gene Name SLC28A3
Protein Name Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (hCNT3)
Family SLC28
Category Transport of vitamins, nucleosides, and related molecules
Reaction name Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
Reaction 1 ligands of SLC28A3 & 29A1 [extracellular region] + 2 Na+ [extracellular region] --> 1 ligands of SLC28A3 & 29A1 [cytosol] + 2 Na+ [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690 
MELRSTAAPR AEGYSNVGFQ NEENFLENEN TSGNNSIRSR AVQSREHTNT KQDEEQVTVE QDSPRNREHM EDDDEEMQQK GCLERRYDTV CGFCRKHKTT LRHIIWGILL AGYLVMVISA CVLNFHRALP LFVITVAAIF FVVWDHLMAK YEHRIDEMLS PGRRLLNSHW FWLKWVIWSS LVLAVIFWLA FDTAKLGQQQ LVSFGGLIMY IVLLFLFSKY PTRVYWRPVL WGIGLQFLLG LLILRTDPGF IAFDWLGRQV QTFLEYTDAG ASFVFGEKYK DHFFAFKVLP IVVFFSTVMS MLYYLGLMQW IIRKVGWIML VTTGSSPIES VVASGNIFVG QTESPLLVRP YLPYITKSEL HAIMTAGFST IAGSVLGAYI SFGVPSSHLL TASVMSAPAS LAAAKLFWPE TEKPKITLKN AMKMESGDSG NLLEAATQGA SSSISLVANI AVNLIAFLAL LSFMNSALSW FGNMFDYPQL SFELICSYIF MPFSFMMGVE WQDSFMVARL IGYKTFFNEF VAYEHLSKWI HLRKEGGPKF VNGVQQYISI RSEIIATYAL CGFANIGSLG IVIGGLTSMA PSRKRDIASG AVRALIAGTV ACFMTACIAG ILSSTPVDIN CHHVLENAFN STFPGNTTKV IACCQSLLSS TVAKGPGEVI PGGNHSLYSL KGCCTLLNPS TFNCNGISNT F 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHCCC CCCCCHHHHH HHHHHHHHHH HHHHCCCCCH HHHHHHHHHH HHHHHHHHHC CCCCCCCCHH HCHHCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCHH HHCCCCCCCC CCCCHHCCHH HHCCCCHHHH HHHHHHCCCH HHHHHHHHHH HHCCCCCHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCCCCH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC HHHHHCCCCC CCCCCCCHHH HHHHHHHHHC CCCCCCCCCC CCCCCCHHHH CCCCCCCCCC CCCCCCCCCC C
[Overview] SLC28A1 SLC28A2 SLC28A3 
SLC28A1   MENDPSRRRESISLTPVAKGLENMGADFLE-SLEEGQLP-RSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRAR------------------------SFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLL----LWFKRGLALAAFLGLVLWLSLDTSQ-RPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGIL-YMPRGAEVDCMSLL----NTTLSSSSFEIYQCCREAFQS--------VNP----------EFSPEALDNCCRFYNHTI--CAQ-----
SLC28A2   MEK--ASGRQSIALSTVETGTVNPGLELMEKEVEPEGSK-RTDAQGHSLGDGLGPSTYQRRSRW----PFSKAR------------------------SFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLR----LWTKWVFAGVSLVGLILWLALDTAQ-RPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGIL-YVPRGAEADCVSFP----NTSFTNRTYETYMCCRGLFQSTSLNG---TNPPSFSGPWEDKEFSAMALTNCCGFYNNTV--CA------
SLC28A3   MEL-----RSTAA--PRAEGYSNVGFQNEENFLENENTSGNNSIRSRAVQSREHTNTKQDEEQVTVEQDSPRNREHMEDDDEEMQQKGCLERRYDTVCGFCRKHKTTLRHIIWGILLAGYLVMVISACVLNFHRALPLFVITVAAIFFVVWDHLMAKYEHRIDEMLSP--GRRLLNSHWFWLKWVIWSSLVLAVIFWLAFDTAKLGQQQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYKDHFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKSELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHLRKEGGPKFVNGVQQYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAGILSSTP--VDINCHHVLENAFNSTFPGNTTKVIACCQSLLSSTVAKGPGEVIP---GG-----NHSLYSLKGCCTLLNPSTFNCNGISNTF

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC28A3 4 R/K 0.000218726 rs11568401
-- SLC28A3 5 S/N 0.00544032 rs11568403
-- SLC28A3 17 V/M 0.000131232 rs372845211
-- SLC28A3 54 E/K 0.00010371 rs758597815
-- SLC28A3 62 D/H 0.000179097 rs45621433
-- SLC28A3 67 R/K 0.000191013 rs11568411
-- SLC28A3 72 D/E 0.000234828 rs146479215
SLC28A3 113 Y/C 0.0838623 rs10868138
SLC28A3 119 S/L 0.00103963 rs75061381
SLC28A3 221 P/Q 0.000526303 rs11140503
SLC28A3 328 I/V 0.00352679 rs11568418
SLC28A3 336 N/S 0.000556083 rs140340331
SLC28A3 405 K/Q 0.000274509 rs147279405
SLC28A3 418 L/I 0.000377926 rs11568405
SLC28A3 424 M/I 0.000182997 rs148078245
SLC28A3 510 L/V 0.000306465 rs142065092
SLC28A3 513 Y/F 0.0723531 rs56350726
SLC28A3 585 R/H 0.000354995 rs11568398
-- SLC28A3 626 E/D 0.00111546 rs141990386
-- SLC28A3 632 T/A 0.000390308 rs138805274

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC28A3 SLC28A3 [plasma membrane] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data