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Variant
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Detail Data SLC28A2


Basic description
Gene Name SLC28A2
Protein Name Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside co-transporter) (SPNT) (Solute carrier family 28 member 2)
Family SLC28
Category Transport of vitamins, nucleosides, and related molecules
Reaction name Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
Reaction 1 ligands of SLC28A2 [extracellular region] + 1 Na+ [extracellular region] --> 1 ligands of SLC28A2 [cytosol] + 1 Na+ [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650 
MEKASGRQSI ALSTVETGTV NPGLELMEKE VEPEGSKRTD AQGHSLGDGL GPSTYQRRSR WPFSKARSFC KTHASLFKKI LLGLLCLAYA AYLLAACILN FQRALALFVI TCLVIFVLVH SFLKKLLGKK LTRCLKPFEN SRLRLWTKWV FAGVSLVGLI LWLALDTAQR PEQLIPFAGI CMFILILFAC SKHHSAVSWR TVFSGLGLQF VFGILVIRTD LGYTVFQWLG EQVQIFLNYT VAGSSFVFGD TLVKDVFAFQ ALPIIIFFGC VVSILYYLGL VQWVVQKVAW FLQITMGTTA TETLAVAGNI FVGMTEAPLL IRPYLGDMTL SEIHAVMTGG FATISGTVLG AFIAFGVDAS SLISASVMAA PCALASSKLA YPEVEESKFK SEEGVKLPRG KERNVLEAAS NGAVDAIGLA TNVAANLIAF LAVLAFINAA LSWLGELVDI QGLTFQVICS YLLRPMVFMM GVEWTDCPMV AEMVGIKFFI NEFVAYQQLS QYKNKRLSGM EEWIEGEKQW ISVRAEIITT FSLCGFANLS SIGITLGGLT SIVPHRKSDL SKVVVRALFT GACVSLISAC MAGILYVPRG AEADCVSFPN TSFTNRTYET YMCCRGLFQS TSLNGTNPPS FSGPWEDKEF SAMALTNCCG FYNNTVCA 
CCCCCCCCCC CCCCCCCCCC CCCHHHHHCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHCHH HHHHHHCHHC HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHH CCCCCCCCHH HHHHHHHHHH HHHHHHHCCH HHHHHHHHHH HHHHHHHHHH HHCCCEECCC CCCCCCHHHH HHHHHHHHHH HHHHHHHCCH HHHHHHHHHH HHHHHHCCCH HHHHHCCCCH HHCCCCHHHH CCHHHCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHCCHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCHHHHH CCCCHHHHHH CCCCCHHHCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHH HHCHHCHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCCCH HCCHHHHHHC CCCCCCCCCC CCCCCCCCCC HHHHHHCCCC CCCCCCCC
[Overview] SLC28A1 SLC28A2 SLC28A3 
SLC28A1   MENDPSRRRESISLTPVAKGLENMGADFLE-SLEEGQLP-RSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRAR------------------------SFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLL----LWFKRGLALAAFLGLVLWLSLDTSQ-RPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGIL-YMPRGAEVDCMSLL----NTTLSSSSFEIYQCCREAFQS--------VNP----------EFSPEALDNCCRFYNHTI--CAQ-----
SLC28A2   MEK--ASGRQSIALSTVETGTVNPGLELMEKEVEPEGSK-RTDAQGHSLGDGLGPSTYQRRSRW----PFSKAR------------------------SFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLR----LWTKWVFAGVSLVGLILWLALDTAQ-RPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGIL-YVPRGAEADCVSFP----NTSFTNRTYETYMCCRGLFQSTSLNG---TNPPSFSGPWEDKEFSAMALTNCCGFYNNTV--CA------
SLC28A3   MEL-----RSTAA--PRAEGYSNVGFQNEENFLENENTSGNNSIRSRAVQSREHTNTKQDEEQVTVEQDSPRNREHMEDDDEEMQQKGCLERRYDTVCGFCRKHKTTLRHIIWGILLAGYLVMVISACVLNFHRALPLFVITVAAIFFVVWDHLMAKYEHRIDEMLSP--GRRLLNSHWFWLKWVIWSSLVLAVIFWLAFDTAKLGQQQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYKDHFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKSELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHLRKEGGPKFVNGVQQYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAGILSSTP--VDINCHHVLENAFNSTFPGNTTKVIACCQSLLSSTVAKGPGEVIP---GG-----NHSLYSLKGCCTLLNPSTFNCNGISNTF

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC28A2 12 L/P 0.00015927 rs567096708
-- SLC28A2 22 P/L 0.474119 rs11854484
-- SLC28A2 23 G/W 0.000494126 rs147419508
-- SLC28A2 60 R/Q 0.000198957 rs115889945
-- SLC28A2 75 S/R 0.500518 rs1060896
-- SLC28A2 142 R/H 0.00057452 rs115740452
-- SLC28A2 163 L/W 0.0237402 rs2271437
-- SLC28A2 172 E/D 0.00273679 rs113624548
-- SLC28A2 193 H/Q 0.000220157 rs199611859
-- SLC28A2 245 S/T 0.0155821 rs10519020
-- SLC28A2 296 M/T 0.000218817 rs142684006
-- SLC28A2 355 F/S 0.00191711 rs17215633
-- SLC28A2 462 L/F 0.00535 rs17222057
-- SLC28A2 479 M/T 0.000190878 rs140528116
-- SLC28A2 515 E/Q 0.00294356 rs116547844
-- SLC28A2 540 S/T 0.000330125 rs186144558
-- SLC28A2 612 M/I 0.000159081 rs200120748
-- SLC28A2 612 M/T 0.000445406 rs373539209

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC28A2 SLC28A2 [plasma membrane] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data