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Detail Data SLC28A1


Basic description
Gene Name SLC28A1
Protein Name Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1)
Family SLC28
Category Transport of vitamins, nucleosides, and related molecules
Reaction name Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
Reaction 1 ligands of SLC28A1 [extracellular region] + 1 Na+ [extracellular region] --> 1 ligands of SLC28A1 [cytosol] + 1 Na+ [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640 
MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS WSEAAPKPFS RWRNLQPALR ARSFCREHMQ LFRWIGTGLL CTGLSAFLLV ACLLDFQRAL ALFVLTCVVL TFLGHRLLKR LLGPKLRRFL KPQGHPRLLL WFKRGLALAA FLGLVLWLSL DTSQRPEQLV SFAGICVFVA LLFACSKHHC AVSWRAVSWG LGLQFVLGLL VIRTEPGFIA FEWLGEQIRI FLSYTKAGSS FVFGEALVKD VFAFQVLPII VFFSCVISVL YHVGLMQWVI LKIAWLMQVT MGTTATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA GSLLGAYISF GIDATSLIAA SVMAAPCALA LSKLVYPEVE ESKFRREEGV KLTYGDAQNL IEAASTGAAI SVKVVANIAA NLIAFLAVLD FINAALSWLG DMVDIQGLSF QLICSYILRP VAFLMGVAWE DCPVVAELLG IKLFLNEFVA YQDLSKYKQR RLAGAEEWVG DRKQWISVRA EVLTTFALCG FANFSSIGIM LGGLTSMVPQ RKSDFSQIVL RALFTGACVS LVNACMAGIL YMPRGAEVDC MSLLNTTLSS SSFEIYQCCR EAFQSVNPEF SPEALDNCCR FYNHTICAQ 
CCCCCCCCCC CCCCCHHHHC CCCCCHHHHH HHCCCCCCCC CCCHHHHCCC CCCCCCCCCC HHHHCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHHCCCCC CCCHHHHHHH HHHHHHHHHH HHCCCCCHHH HHHHHHHHHH HHHHHHCCCH HCCCCCCCCC CCCCCCCCHH HHHHHHHHHH HHCCHHHHHH HHHHHHHHHH HCCCHHHHHC CCCHHHCCCC CHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHHHHH HHHHHCCCCH HCCCCCCCCC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCCH HHHHHHHHHH HHHHHCCCHH HCCHHHHHHH HHHHHCCHHH HHHHHHHHHH CCCCCCHHCC CCCCCCCHHH HHHHHHHHHC HHCHHHHHHH HHHHHHHCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHCCCCCC CHHHHHCCCC CCCCCCCCC
[Overview] SLC28A1 SLC28A2 SLC28A3 
SLC28A1   MENDPSRRRESISLTPVAKGLENMGADFLE-SLEEGQLP-RSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRAR------------------------SFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLL----LWFKRGLALAAFLGLVLWLSLDTSQ-RPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGIL-YMPRGAEVDCMSLL----NTTLSSSSFEIYQCCREAFQS--------VNP----------EFSPEALDNCCRFYNHTI--CAQ-----
SLC28A2   MEK--ASGRQSIALSTVETGTVNPGLELMEKEVEPEGSK-RTDAQGHSLGDGLGPSTYQRRSRW----PFSKAR------------------------SFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLR----LWTKWVFAGVSLVGLILWLALDTAQ-RPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGIL-YVPRGAEADCVSFP----NTSFTNRTYETYMCCRGLFQSTSLNG---TNPPSFSGPWEDKEFSAMALTNCCGFYNNTV--CA------
SLC28A3   MEL-----RSTAA--PRAEGYSNVGFQNEENFLENENTSGNNSIRSRAVQSREHTNTKQDEEQVTVEQDSPRNREHMEDDDEEMQQKGCLERRYDTVCGFCRKHKTTLRHIIWGILLAGYLVMVISACVLNFHRALPLFVITVAAIFFVVWDHLMAKYEHRIDEMLSP--GRRLLNSHWFWLKWVIWSSLVLAVIFWLAFDTAKLGQQQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYKDHFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKSELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHLRKEGGPKFVNGVQQYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAGILSSTP--VDINCHHVLENAFNSTFPGNTTKVIACCQSLLSSTVAKGPGEVIP---GG-----NHSLYSLKGCCTLLNPSTFNCNGISNTF

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC28A1 4 D/G 0.000107364 rs773468869
-- SLC28A1 13 S/C 0.000290284 rs17215968
-- SLC28A1 26 A/D 0.000111344 rs148747980
-- SLC28A1 43 S/N 0.0012238 rs17222295
-- SLC28A1 44 P/T 0.00027726 rs141245994
-- SLC28A1 69 L/R 0.000109447 rs535804371
-- SLC28A1 85 I/T 0.000201507 rs143995891
-- SLC28A1 126 R/C 0.000119299 rs759745634
-- SLC28A1 147 R/H 0.00540232 rs116707209
-- SLC28A1 157 R/G 0.000208916 rs151297638
-- SLC28A1 164 P/L 0.00109303 rs200109727
-- SLC28A1 189 V/I 0.40331 rs2290272
-- SLC28A1 190 A/G 0.000139209 rs202068367
-- SLC28A1 190 A/S 0.00970596 rs45523532
-- SLC28A1 192 L/V 0.00011138 rs763163087
-- SLC28A1 230 A/V 0.00108572 rs17215934
-- SLC28A1 237 Q/K 0.280882 rs8187758
-- SLC28A1 256 A/S 0.00031432 rs113748249
-- SLC28A1 279 V/I 0.00106587 rs17215975
-- SLC28A1 290 I/T 0.00027049 rs185043976
-- SLC28A1 304 T/I 0.000127253 rs191099985
-- SLC28A1 338 V/A 0.000723762 rs139484056
-- SLC28A1 356 A/V 0.000266815 rs200518039
-- SLC28A1 478 A/V 0.000103397 rs116070802
-- SLC28A1 510 R/C 0.0582952 rs2242047
-- SLC28A1 520 G/S 0.000115565 rs147369428
-- SLC28A1 521 D/N 0.37411 rs2242046
-- SLC28A1 546 S/P 0.000862892 rs45584739
-- SLC28A1 575 T/M 0.000139235 rs116482204
-- SLC28A1 620 R/H 0.000413864 rs147924097
-- SLC28A1 627 N/S 0.000377794 rs72547519

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC28A1 SLC28A1 [plasma membrane] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data