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Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC27A5


Basic description
Gene Name SLC27A5
Protein Name Bile acyl-CoA synthetase (BACS) (EC 6.2.1.7) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Fatty acid transport protein 5) (FATP-5) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)
Family SLC27
Category -
Reaction name Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)
THCA is conjugated with Coenzyme A (SLC27A5 BACS)
DHCA is conjugated with Coenzyme A (SLC27A5 BACS)
3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)
TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)
Reaction 1 ATP [cytosol] + 1 CoA-SH [cytosol] + 1 cholate; chenodeoxycholate [cytosol] --> 1 PPi [cytosol] + 1 H2O [cytosol] + 1 choloyl-CoA; chenodeoxycholoyl-CoA [cytosol] + 1 AMP [cytosol]
1 THCA [cytosol] + 1 ATP [cytosol] + 1 CoA-SH [cytosol] --> 1 PPi [cytosol] + 1 25(R) THCA-CoA [cytosol] + 1 AMP [cytosol]
1 ATP [cytosol] + 1 DHCA [cytosol] + 1 CoA-SH [cytosol] --> 1 PPi [cytosol] + 1 25(R) DHCA-CoA [cytosol] + 1 AMP [cytosol]
1 ATP [cytosol] + 1 CoA-SH [cytosol] + 1 3,7,24THCA [cytosol] --> 1 PPi [cytosol] + 1 H2O [cytosol] + 1 3,7,24THCA-CoA [cytosol] + 1 AMP [cytosol]
1 ATP [cytosol] + 1 CoA-SH [cytosol] + 1 TetraHCA [cytosol] --> 1 PPi [cytosol] + 1 25(R) TetraHCA-CoA [cytosol] + 1 H2O [cytosol] + 1 AMP [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690 
MGVRQQLALL LLLLLLLWGL GQPVWPVAVA LTLRWLLGDP TCCVLLGLAM LARPWLGPWV PHGLSLAAAA LALTLLPARL PPGLRWLPAD VIFLAKILHL GLKIRGCLSR QPPDTFVDAF ERRARAQPGR ALLVWTGPGA GSVTFGELDA RACQAAWALK AELGDPASLC AGEPTALLVL ASQAVPALCM WLGLAKLGCP TAWINPHGRG MPLAHSVLSS GARVLVVDPD LRESLEEILP KLQAENIRCF YLSHTSPTPG VGALGAALDA APSHPVPADL RAGITWRSPA LFIYTSGTTG LPKPAILTHE RVLQMSKMLS LSGATADDVV YTVLPLYHVM GLVVGILGCL DLGATCVLAP KFSTSCFWDD CRQHGVTVIL YVGELLRYLC NIPQQPEDRT HTVRLAMGNG LRADVWETFQ QRFGPIRIWE VYGSTEGNMG LVNYVGRCGA LGKMSCLLRM LSPFELVQFD MEAAEPVRDN QGFCIPVGLG EPGLLLTKVV SQQPFVGYRG PRELSERKLV RNVRQSGDVY YNTGDVLAMD REGFLYFRDR LGDTFRWKGE NVSTHEVEGV LSQVDFLQQV NVYGVCVPGC EGKVGMAAVQ LAPGQTFDGE KLYQHVRAWL PAYATPHFIR IQDAMEVTST FKLMKTRLVR EGFNVGIVVD PLFVLDNRAQ SFRPLTAEMY QAVCEGTWRL  
CCHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHCCHH HHHHHHHHHH HHHHHHCCHH HHHHHHHHHH HHHHHHHHHC CHHHCCHHHH HHHHHHHHHH HHHHHHHHHC CCCCCHHHHH HHHHHHCCCC EEEEECCCCC CCCCHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCEEEEEC CCCCHHHHHH HHHHHHHCCC EECCCCCCCC HHHHHHHHHC CCCEEEECHH HHHHHHHHHH HCCCCCEEEE EECCCCCCCC CCHHHHHHHH CCCCCCCHHH CCCCCCCCCE EEEEECCCCC CCCEEEEEHH HHHHHHHHHH HCCCCCCCEE EEECCCCCHH HHHHHHHHHH CCCCEEEECC CCCHHHHHHH HHHHCCCEEE ECHHHHHHHH CCCCCCCCCC CCEEEEEECC CCHHHHHHHH HHHCCCEEEE EECCCCCCEE EEECCCCCCC CCCCCCCHHC CCCCEEEEEC CCCCCCCCCC CCCEEECCCC CCEEEEEEEC CCCCCCCCCC CHHHHHCCCC CCEEEECCEE EECCCEEEEC CCCCEEEEEC CCCCEEECCC CCCHHHHHHH HHCCCCEEEE EEEEEECCCC CCEEEEEEEE ECCCCCCCHH HHHHHHHHHC CHHCCCEEEE ECCCCCCCCC CCCCHHHHHH CCCCCCCCCC CEEEEECCCC EEEECCHHHH HHHHCCCCCC
[Overview] SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6 
SLC27A1   ------------------------------MRAPG---------AGAASVVSLALLWLL-----------------------------GL---------PWT----WSAAAALGV------------YVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH--QRAGHTIPR------------IFQAVVQRQPERLALVDAGTGE-CWTFAQLDAYSNAVANLFR----------------------------------------------------QLGFAPGDVVAIFL--EGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHL-GKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKG--MDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVS-ESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVA-DPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
SLC27A2   --------------------------------------------------MLSAIYTVL--------------------------------------------------AGLLFLPLLVNLCCP---YFFQDIGYFLKVAA---------------VGRRVRSYGKRRPARTILR------------AFLEKARQTPHKPFLLFRDE---TLTYAQVDRRSNQVARALH---------------------------------------------------DHLGLRQGDCVALLM--GNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIYYVS---RTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGL-TFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTP---FNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAISAKTLKL
SLC27A3   MGVCQRTRAPWKEKSQLERAALGFRKGGSGMFASGWNQTVPIEEAGSMAALLLLPLLLL-----------------------------------------------------LPLLLLKLHLWPQLRWLPADLAFAVRALC---------------CKRALRA---RALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSR---RFSYSEAERESNRAARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLL--PAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWAAG---PGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGF-YQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSP---FLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLRI
SLC27A4   -------------------------------MLLG---------ASLVGVLLFSKL-VL-----------------------------KL---------PWT----QVGFSLLFL------------YLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQC--LQERRTVPI------------LFASTVRRHPDKTALIFEGTDT-HWTFRQLDEYSSSVANFLQ----------------------------------------------------ARGLASGDVAAIFM--ENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASL-DPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKH-LPSCPDKG--FTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLN-QGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVA-SPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL
SLC27A5   MGVRQ----------QL--------------------------------ALLLLLLLLLWGLGQPVWPVAVALTLRWLLGDPTCCVLLGLAMLARPWLGPWVPHGLSLAAAALALTLLPARLPPGLRWLPADVIFLAKILH---------------LGLKIRGCLSRQPPDTFVD------------AFERRARAQPGRALLVWTGPGAGSVTFGELDARACQAAWALKAEL-----------------------------------------------GDPASLCAGEPTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVLSSGARVLVVDPDLRESLEEILPKLQAENIRCFYLS---HTSPTPGVGALGAALDAAPSHPVPADLRAGITWRSPALFIYTSGTTGLPKPAILTHERVLQMSKM-LSLSGATADDVVYTVLPLYHVMGLVVGILGCLDLGATCVLAPKFSTSCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVGRCGALGKMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQP---FVGYRGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAWLPAYATPHFIRIQDAMEVTSTFKLMKTRLVREGFNVGIVVDPLFVLDNRAQSFRPLTAEMYQAVCEGTWRL
SLC27A6   --------------------------------------------------MLLSWLTVL-------------------------------------------------GAGMVVLHFLQKLLFP---YFWDDFWFVLKVVL---------------IIIRLKKYEKRGELVTVLD------------KFLSHAKRQPRKPFIIYEGD---IYTYQDVDKRSSRVAHVFL---------------------------------------------------NHSSLKKGDTVALLM--SNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSL-SENISVWGM----KDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAV-LWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNP---FFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC27A5 37 L/R 0.00116788 rs146147877
-- SLC27A5 50 M/T 0.16755 rs35350976
-- SLC27A5 53 R/W 0.167853 rs34415062
-- SLC27A5 88 P/L 0.000350678 rs137880349
-- SLC27A5 150 A/T 0.00010605 rs775453374
-- SLC27A5 167 A/V 0.000749147 rs149541658
-- SLC27A5 175 T/I 0.00050473 rs150780205
-- SLC27A5 185 V/I 0.000127062 rs757127359
-- SLC27A5 209 R/Q 0.00023332 rs148336155
-- SLC27A5 214 A/V 0.00404491 rs113904799
-- SLC27A5 232 R/Q 0.000100996 rs143789846
-- SLC27A5 248 R/H 0.00110627 rs138318343
-- SLC27A5 271 A/V 0.000280694 rs528258407
-- SLC27A5 294 Y/C 0.000121273 rs759023377
-- SLC27A5 312 V/I 0.000199164 rs146682651
-- SLC27A5 344 V/I 0.000156156 rs199844677
-- SLC27A5 372 R/W 0.000191106 rs546045040
-- SLC27A5 387 R/Q 0.00268004 rs142672241
-- SLC27A5 399 R/Q 0.000398254 rs148488764
-- SLC27A5 404 R/C 0.000206883 rs144545445
-- SLC27A5 410 G/E 0.00170234 rs149709084
-- SLC27A5 539 M/T 0.00432821 rs147464959
-- SLC27A5 647 R/L 0.00106907 rs564295346
-- SLC27A5 654 N/S 0.000411033 rs138433306
-- SLC27A5 669 A/G 0.00787625 rs145618122

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
SLC27A5 SLC27A5 [endoplasmic reticulum membrane] Recycling of bile acids and salts
SLC27A5 SLC27A5 [endoplasmic reticulum membrane] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
SLC27A5 SLC27A5 [endoplasmic reticulum membrane] Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data