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Basic
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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC27A4


Basic description
Gene Name SLC27A4
Protein Name Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4)
Family SLC27
Category Transport of vitamins, nucleosides, and related molecules
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640 
MLLGASLVGV LLFSKLVLKL PWTQVGFSLL FLYLGSGGWR FIRVFIKTIR RDIFGGLVLL KVKAKVRQCL QERRTVPILF ASTVRRHPDK TALIFEGTDT HWTFRQLDEY SSSVANFLQA RGLASGDVAA IFMENRNEFV GLWLGMAKLG VEAALINTNL RRDALLHCLT TSRARALVFG SEMASAICEV HASLDPSLSL FCSGSWEPGA VPPSTEHLDP LLKDAPKHLP SCPDKGFTDK LFYIYTSGTT GLPKAAIVVH SRYYRMAALV YYGFRMRPND IVYDCLPLYH SAGNIVGIGQ CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE NQHQVRMALG NGLRQSIWTN FSSRFHIPQV AEFYGATECN CSLGNFDSQV GACGFNSRIL SFVYPIRLVR VNEDTMELIR GPDGVCIPCQ PGEPGQLVGR IIQKDPLRRF DGYLNQGANN KKIAKDVFKK GDQAYLTGDV LVMDELGYLY FRDRTGDTFR WKGENVSTTE VEGTLSRLLD MADVAVYGVE VPGTEGRAGM AAVASPTGNC DLERFAQVLE KELPLYARPI FLRLLPELHK TGTYKFQKTE LRKEGFDPAI VKDPLFYLDA QKGRYVPLDQ EAYSRIQAGE EKL 
CHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHCCCHH HHHHHHHHCC HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHCCCC EEEEEECCCE EEEHHHHHHH HHHHHHHHHH CCCCCCCEEE EECCCCHHHH HHHHHHHHCC CEEECCCCCC CHHHHHHHHH HCCCCEEEEC HHHHHHHHHH HHHCCCCEEE EEECCCCCCC CCCCCCCHHH HHHCCCCCCC CCCCCCCCCE EEEEEECCCC CCCEEEEEEH HHHHHHHHHH HHHCCCCCCC EEEECCCCCC HHHHHHHHHH HHHCCCEEEE CCCCCHHHHH HHHHHHCCCE EEEHHHHHHH HHCCCCCCHH HCCCEEEEEE CCCCHHHHHH HHHHHCCCEE EEEECCCCCC EEEEECCCCC CCCCCCCCCC CCCCCCEEEE ECCCCCCCCC CCCCCEEECC CCCCCCEEEE EEECCCCCCC CCCCCCCCHH HHHHCCCCCC CCEEEEECCE EEECCCCCEE EEECCCCEEE ECCEEECHHH HHHHHHCCCC EEEEEEEEEE CCCCCCEEEE EEEECCCCCC CHHHHHHHHH HCCCHHHCCE EEEEHHHHHC CCCCCCCHHH HHHCCCCHHH CCCCEEEEEC CCCEEEECCH HHHHHHHCCC CCC
[Overview] SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6 
SLC27A1   ------------------------------MRAPG---------AGAASVVSLALLWLL-----------------------------GL---------PWT----WSAAAALGV------------YVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH--QRAGHTIPR------------IFQAVVQRQPERLALVDAGTGE-CWTFAQLDAYSNAVANLFR----------------------------------------------------QLGFAPGDVVAIFL--EGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHL-GKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKG--MDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVS-ESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVA-DPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
SLC27A2   --------------------------------------------------MLSAIYTVL--------------------------------------------------AGLLFLPLLVNLCCP---YFFQDIGYFLKVAA---------------VGRRVRSYGKRRPARTILR------------AFLEKARQTPHKPFLLFRDE---TLTYAQVDRRSNQVARALH---------------------------------------------------DHLGLRQGDCVALLM--GNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIYYVS---RTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGL-TFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTP---FNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAISAKTLKL
SLC27A3   MGVCQRTRAPWKEKSQLERAALGFRKGGSGMFASGWNQTVPIEEAGSMAALLLLPLLLL-----------------------------------------------------LPLLLLKLHLWPQLRWLPADLAFAVRALC---------------CKRALRA---RALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSR---RFSYSEAERESNRAARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLL--PAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWAAG---PGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGF-YQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSP---FLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLRI
SLC27A4   -------------------------------MLLG---------ASLVGVLLFSKL-VL-----------------------------KL---------PWT----QVGFSLLFL------------YLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQC--LQERRTVPI------------LFASTVRRHPDKTALIFEGTDT-HWTFRQLDEYSSSVANFLQ----------------------------------------------------ARGLASGDVAAIFM--ENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASL-DPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKH-LPSCPDKG--FTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLN-QGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVA-SPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL
SLC27A5   MGVRQ----------QL--------------------------------ALLLLLLLLLWGLGQPVWPVAVALTLRWLLGDPTCCVLLGLAMLARPWLGPWVPHGLSLAAAALALTLLPARLPPGLRWLPADVIFLAKILH---------------LGLKIRGCLSRQPPDTFVD------------AFERRARAQPGRALLVWTGPGAGSVTFGELDARACQAAWALKAEL-----------------------------------------------GDPASLCAGEPTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVLSSGARVLVVDPDLRESLEEILPKLQAENIRCFYLS---HTSPTPGVGALGAALDAAPSHPVPADLRAGITWRSPALFIYTSGTTGLPKPAILTHERVLQMSKM-LSLSGATADDVVYTVLPLYHVMGLVVGILGCLDLGATCVLAPKFSTSCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVGRCGALGKMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQP---FVGYRGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAWLPAYATPHFIRIQDAMEVTSTFKLMKTRLVREGFNVGIVVDPLFVLDNRAQSFRPLTAEMYQAVCEGTWRL
SLC27A6   --------------------------------------------------MLLSWLTVL-------------------------------------------------GAGMVVLHFLQKLLFP---YFWDDFWFVLKVVL---------------IIIRLKKYEKRGELVTVLD------------KFLSHAKRQPRKPFIIYEGD---IYTYQDVDKRSSRVAHVFL---------------------------------------------------NHSSLKKGDTVALLM--SNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSL-SENISVWGM----KDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAV-LWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNP---FFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC27A4 2 P/L 0.0224867 rs113785080
-- SLC27A4 14 I/L 0.00013442 rs1330608328
-- SLC27A4 56 G/V 0.00155385 rs140481562
-- SLC27A4 105 R/H 0.000872378 rs142664086
-- SLC27A4 121 R/Q 0.0183686 rs56224008
-- SLC27A4 136 R/H 0.000318972 rs148684713
-- SLC27A4 150 G/S 0.000291918 rs148013164
-- SLC27A4 174 A/T 0.000107531 rs139712194
-- SLC27A4 188 C/G 0.000251437 rs112690666
-- SLC27A4 209 G/S 0.0752796 rs2240953
-- SLC27A4 233 P/L 0.000274749 rs192211964
-- SLC27A4 318 R/W 0.000115371 rs374003386
-- SLC27A4 351 N/S 0.0219762 rs111417655
-- SLC27A4 376 H/R 0.000167072 rs187433964
-- SLC27A4 420 R/H 0.000139185 rs546174669
-- SLC27A4 435 V/I 0.000191252 rs148488076
-- SLC27A4 470 N/K 0.000131608 rs150834858
-- SLC27A4 564 R/C 0.000111597 rs200769384
-- SLC27A4 578 R/C 0.000147281 rs201409856

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC27A4 SLC27A4 [plasma membrane] Transport of fatty acids

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC27A4 SLC27A4 A92T [plasma membrane] Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
SLC27A4 SLC27A4 R583H [plasma membrane] Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
SLC27A4 SLC27A4 S247P [plasma membrane] Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
SLC27A4 SLC27A4 C168* [plasma membrane] Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
SLC27A4 SLC27A4 Q300R [plasma membrane] Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)