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Detail Data SLC27A3
Basic description
| Gene Name | SLC27A3 |
|---|---|
| Protein Name | Solute carrier family 27 member 3 (EC 6.2.1.-) (Long-chain fatty acid transport protein 3) (FATP-3) (Fatty acid transport protein 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3) |
| Family | SLC27 |
| Category | - |
| Reaction name |
SLC27A3 ligates CoA-SH to VLCFA |
| Reaction |
1 VLCFA [mitochondrial matrix] + 1 CoA-SH [mitochondrial matrix] + 1 ATP [mitochondrial matrix] --> 1 adenosine 5'-monophosphate [mitochondrial matrix] + 1 PPi [mitochondrial matrix] + 1 VLCFA-CoA [mitochondrial matrix] |
[Overview]
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 MGVCQRTRAP WKEKSQLERA ALGFRKGGSG MFASGWNQTV PIEEAGSMAA LLLLPLLLLL PLLLLKLHLW PQLRWLPADL AFAVRALCCK RALRARALAA AAADPEGPEG GCSLAWRLAE LAQQRAAHTF LIHGSRRFSY SEAERESNRA ARAFLRALGW DWGPDGGDSG EGSAGEGERA APGAGDAAAG SGAEFAGGDG AARGGGAAAP LSPGATVALL LPAGPEFLWL WFGLAKAGLR TAFVPTALRR GPLLHCLRSC GARALVLAPE FLESLEPDLP ALRAMGLHLW AAGPGTHPAG ISDLLAEVSA EVDGPVPGYL SSPQSITDTC LYIFTSGTTG LPKAARISHL KILQCQGFYQ LCGVHQEDVI YLALPLYHMS GSLLGIVGCM GIGATVVLKS KFSAGQFWED CQQHRVTVFQ YIGELCRYLV NQPPSKAERG HKVRLAVGSG LRPDTWERFV RRFGPLQVLE TYGLTEGNVA TINYTGQRGA VGRASWLYKH IFPFSLIRYD VTTGEPIRDP QGHCMATSPG EPGLLVAPVS QQSPFLGYAG GPELAQGKLL KDVFRPGDVF FNTGDLLVCD DQGFLRFHDR TGDTFRWKGE NVATTEVAEV FEALDFLQEV NVYGVTVPGH EGRAGMAALV LRPPHALDLM QLYTHVSENL PPYARPRFLR LQESLATTET FKQQKVRMAN EGFDPSTLSD PLYVLDQAVG AYLPLTTARY SALLAGNLRI CCCCCCCCCC HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHC HHCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCHHHHHHH HHHHCCCCEE EEECCEEECH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCH HHHHCCCCCC CCEECCCCCC CHHHHHHHHH HHHHHHHHCC CCCCCEEEEE CCCCHHHHHH HHHHHHCCCE EECCCHHCCC HHHHHHHHHC CCCEEEECHH HHHHHHHHHH HHHHCCEEEE EECCCCCCCC HHHHHHHHHH CCCCCCCCCC CCCCCCCCEE EEEECCCCCC CCCEEEEHHH HHHHHHHHHH HHCCCCCCEE EECCCCCCHH HHHHHHHHHH HCCCEEEECC CCCHHHHHHH HHHHCCCEEE ECHHHHHHHH CCCCCCCCCC CCEEEEEECC CCHHHHHHHH HHHCCCEEEE EECCCCCCCE EEECCCCCCC CCCCCCCCCC CCCEEEEEEE CCCCCCCCCC CCCEEECCCC CCEEEEEECC CCCCCCCCCC CHHHHHHHHH CCCCCCCCEE EECCCEEEEC CCCCEEEEEC CCCEEEECCC CCCHHHHHHH HHCCCCEEEE EECCCCCCCC CCCCEEEEEE ECCCCCCCHH HHHHHHHHHC CHHCCCCCEE EEECCCCCCC CCHHHHHHHH CCCCHHHCCC CEEEEECCCC CEEECCHHHH HHHHCCCCCC
[Overview]
SLC27A1 ------------------------------MRAPG---------AGAASVVSLALLWLL-----------------------------GL---------PWT----WSAAAALGV------------YVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH--QRAGHTIPR------------IFQAVVQRQPERLALVDAGTGE-CWTFAQLDAYSNAVANLFR----------------------------------------------------QLGFAPGDVVAIFL--EGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHL-GKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKG--MDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVS-ESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVA-DPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL SLC27A2 --------------------------------------------------MLSAIYTVL--------------------------------------------------AGLLFLPLLVNLCCP---YFFQDIGYFLKVAA---------------VGRRVRSYGKRRPARTILR------------AFLEKARQTPHKPFLLFRDE---TLTYAQVDRRSNQVARALH---------------------------------------------------DHLGLRQGDCVALLM--GNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIYYVS---RTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGL-TFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTP---FNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAISAKTLKL SLC27A3 MGVCQRTRAPWKEKSQLERAALGFRKGGSGMFASGWNQTVPIEEAGSMAALLLLPLLLL-----------------------------------------------------LPLLLLKLHLWPQLRWLPADLAFAVRALC---------------CKRALRA---RALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSR---RFSYSEAERESNRAARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLL--PAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWAAG---PGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGF-YQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSP---FLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLRI SLC27A4 -------------------------------MLLG---------ASLVGVLLFSKL-VL-----------------------------KL---------PWT----QVGFSLLFL------------YLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQC--LQERRTVPI------------LFASTVRRHPDKTALIFEGTDT-HWTFRQLDEYSSSVANFLQ----------------------------------------------------ARGLASGDVAAIFM--ENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASL-DPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKH-LPSCPDKG--FTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLN-QGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVA-SPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL SLC27A5 MGVRQ----------QL--------------------------------ALLLLLLLLLWGLGQPVWPVAVALTLRWLLGDPTCCVLLGLAMLARPWLGPWVPHGLSLAAAALALTLLPARLPPGLRWLPADVIFLAKILH---------------LGLKIRGCLSRQPPDTFVD------------AFERRARAQPGRALLVWTGPGAGSVTFGELDARACQAAWALKAEL-----------------------------------------------GDPASLCAGEPTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVLSSGARVLVVDPDLRESLEEILPKLQAENIRCFYLS---HTSPTPGVGALGAALDAAPSHPVPADLRAGITWRSPALFIYTSGTTGLPKPAILTHERVLQMSKM-LSLSGATADDVVYTVLPLYHVMGLVVGILGCLDLGATCVLAPKFSTSCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVGRCGALGKMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQP---FVGYRGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAWLPAYATPHFIRIQDAMEVTSTFKLMKTRLVREGFNVGIVVDPLFVLDNRAQSFRPLTAEMYQAVCEGTWRL SLC27A6 --------------------------------------------------MLLSWLTVL-------------------------------------------------GAGMVVLHFLQKLLFP---YFWDDFWFVLKVVL---------------IIIRLKKYEKRGELVTVLD------------KFLSHAKRQPRKPFIIYEGD---IYTYQDVDKRSSRVAHVFL---------------------------------------------------NHSSLKKGDTVALLM--SNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSL-SENISVWGM----KDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAV-LWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNP---FFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL
Variant
| check | gene name | residue number | Reference Amino Acid / Variant Amino Acid | minor allele frequency | rs number |
|---|---|---|---|---|---|
| -- | SLC27A3 | 3 | G/R | 0.000497224 | rs142414300 |
| -- | SLC27A3 | 10 | W/C | 0.000107406 | rs778449064 |
| -- | SLC27A3 | 18 | G/R | 0.000160404 | rs571550476 |
| -- | SLC27A3 | 34 | A/S | 0.000106098 | rs778518509 |
| -- | SLC27A3 | 38 | P/R | 0.000160195 | rs760167280 |
| -- | SLC27A3 | 50 | W/S | 0.000103548 | rs369246509 |
| -- | SLC27A3 | 50 | W/C | 0.000142558 | rs540566011 |
| -- | SLC27A3 | 51 | G/W | 0.000413447 | rs565610766 |
| -- | SLC27A3 | 128 | S/P | 0.000216395 | rs756882168 |
| -- | SLC27A3 | 131 | A/V | 0.00161308 | rs145619769 |
| -- | SLC27A3 | 172 | R/G | 0.000387232 | rs138225868 |
| -- | SLC27A3 | 191 | G/R | 0.000176525 | rs143813756 |
| -- | SLC27A3 | 191 | G/A | 0.0232957 | rs34527123 |
| -- | SLC27A3 | 209 | H/Q | 0.000140685 | rs199514238 |
| -- | SLC27A3 | 217 | R/Q | 0.000270829 | rs200975179 |
| -- | SLC27A3 | 218 | R/H | 0.00116016 | rs139923577 |
| -- | SLC27A3 | 312 | W/S | 0.000317454 | rs757980775 |
| -- | SLC27A3 | 336 | H/P | 0.000444108 | rs550497581 |
| -- | SLC27A3 | 374 | G/R | 0.000417724 | rs35212289 |
| -- | SLC27A3 | 404 | P/L | 0.000361895 | rs539968144 |
| -- | SLC27A3 | 427 | R/W | 0.000194882 | rs150357360 |
| -- | SLC27A3 | 484 | S/L | 0.000186919 | rs199984591 |
| -- | SLC27A3 | 503 | I/V | 0.00013525 | rs374690026 |
| -- | SLC27A3 | 503 | I/T | 0.00026254 | rs146814975 |
| -- | SLC27A3 | 508 | R/Q | 0.00017511 | rs77673307 |
| -- | SLC27A3 | 520 | R/C | 0.000130431 | rs535256255 |
| -- | SLC27A3 | 520 | R/H | 0.00478668 | rs35102232 |
| -- | SLC27A3 | 525 | R/W | 0.000537009 | rs147176615 |
| -- | SLC27A3 | 525 | R/Q | 0.000572655 | rs141932545 |
| -- | SLC27A3 | 531 | G/R | 0.00148248 | rs146128753 |
| -- | SLC27A3 | 533 | R/H | 0.000884432 | rs142650546 |
| -- | SLC27A3 | 539 | R/C | 0.000311325 | rs375994470 |
| -- | SLC27A3 | 539 | R/H | 0.000331176 | rs201939587 |
| -- | SLC27A3 | 542 | R/W | 0.000167572 | rs182081931 |
| -- | SLC27A3 | 542 | R/Q | 0.000111658 | rs201437608 |
| -- | SLC27A3 | 543 | R/C | 0.000159454 | rs772039356 |
| -- | SLC27A3 | 543 | R/H | 0.000183353 | rs143908472 |
| -- | SLC27A3 | 545 | G/R | 0.000306775 | rs372623621 |
| -- | SLC27A3 | 560 | V/M | 0.00016716 | rs139458875 |
| -- | SLC27A3 | 574 | R/H | 0.000239143 | rs199869514 |
| -- | SLC27A3 | 589 | R/G | 0.000143179 | rs143621188 |
| -- | SLC27A3 | 589 | R/C | 0.000123293 | rs143621188 |
| -- | SLC27A3 | 589 | R/P | 0.00238624 | rs189944468 |
| -- | SLC27A3 | 599 | R/W | 0.00036593 | rs137908170 |
| -- | SLC27A3 | 599 | R/Q | 0.000497224 | rs142414300 |
| -- | SLC27A3 | 607 | A/P | 0.000107406 | rs778449064 |
| -- | SLC27A3 | 639 | K/R | 0.000875287 | rs147963978 |
| -- | SLC27A3 | 646 | R/W | 0.000222751 | rs138614386 |
| -- | SLC27A3 | 660 | C/W | 0.00057266 | rs145965895 |
| -- | SLC27A3 | 661 | D/N | 0.000178958 | rs141752584 |
| -- | SLC27A3 | 667 | R/C | 0.000119307 | rs140437865 |
| -- | SLC27A3 | 671 | R/C | 0.000111353 | rs374567006 |
| -- | SLC27A3 | 680 | G/W | 0.000111357 | rs200472466 |
| -- | SLC27A3 | 703 | V/I | 0.000226691 | rs775281896 |
| -- | SLC27A3 | 714 | R/K | 0.000318471 | rs202142419 |
| -- | SLC27A3 | 727 | A/S | 0.00165488 | rs111292643 |
| -- | SLC27A3 | 746 | R/Q | 0.00051385 | rs200824960 |
| -- | SLC27A3 | 748 | R/Q | 0.000139546 | rs373742297 |
| -- | SLC27A3 | 761 | T/S | 0.0021522 | rs199542091 |
| -- | SLC27A3 | 764 | Q/K | 0.000139427 | rs559054034 |
| -- | SLC27A3 | 768 | R/Q | 0.000147295 | rs191183550 |
| -- | SLC27A3 | 800 | R/Q | 0.000503086 | rs140906306 |
| -- | SLC27A3 | 803 | A/T | 0.00109313 | rs35517522 |
Phylogenetic tree
Pathway
| Priority | Gene Name | Reactome (Gene) | Reactome (Pathway) |
|---|---|---|---|
| SLC27A3 | SLC27A3 [mitochondrial matrix] | Synthesis of very long-chain fatty acyl-CoAs |
Disease
| Gene Name | Reactome (Gene) | Reactome (Pathway) |
|---|---|---|
| No data | ||