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Basic
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Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC27A2


Basic description
Gene Name SLC27A2
Protein Name Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)
Family SLC27
Category -
Reaction name DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)
THCA is conjugated with Coenzyme A (SLC27A2 VLCS)
TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)
3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)
pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate
Reaction 1 ATP [cytosol] + 1 CoA-SH [cytosol] + 1 DHCA [cytosol] --> 1 PPi [cytosol] + 1 25(R) DHCA-CoA [cytosol] + 1 AMP [cytosol]
1 THCA [cytosol] + 1 ATP [cytosol] + 1 CoA-SH [cytosol] --> 1 PPi [cytosol] + 1 25(R) THCA-CoA [cytosol] + 1 AMP [cytosol]
1 ATP [cytosol] + 1 CoA-SH [cytosol] + 1 TetraHCA [cytosol] --> 1 PPi [cytosol] + 1 25(R) TetraHCA-CoA [cytosol] + 1 H2O [cytosol] + 1 AMP [cytosol]
1 ATP [cytosol] + 1 CoA-SH [cytosol] + 1 3,7,24THCA [cytosol] --> 1 PPi [cytosol] + 1 H2O [cytosol] + 1 3,7,24THCA-CoA [cytosol] + 1 AMP [cytosol]
1 pristanate [peroxisomal matrix] + 1 CoA-SH [peroxisomal matrix] + 1 ATP [peroxisomal matrix] --> 1 PPi [peroxisomal matrix] + 1 (2R) Pristanoyl-CoA [peroxisomal matrix] + 1 AMP [peroxisomal matrix]
1 Phytanate [peroxisomal matrix] + 1 CoA-SH [peroxisomal matrix] + 1 ATP [peroxisomal matrix] --> 1 PPi [peroxisomal matrix] + 1 Phytanoyl-CoA [peroxisomal matrix] + 1 AMP [peroxisomal matrix]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620 
MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGKRR PARTILRAFL EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG LRQGDCVALL MGNEPAYVWL WLGLVKLGCA MACLNYNIRA KSLLHCFQCC GAKVLLVSPE LQAAVEEILP SLKKDDVSIY YVSRTSNTDG IDSFLDKVDE VSTEPIPESW RSEVTFSTPA LYIYTSGTTG LPKAAMITHQ RIWYGTGLTF VSGLKADDVI YITLPFYHSA ALLIGIHGCI VAGATLALRT KFSASQFWDD CRKYNVTVIQ YIGELLRYLC NSPQKPNDRD HKVRLALGNG LRGDVWRQFV KRFGDICIYE FYAATEGNIG FMNYARKVGA VGRVNYLQKK IITYDLIKYD VEKDEPVRDE NGYCVRVPKG EVGLLVCKIT QLTPFNGYAG AKAQTEKKKL RDVFKKGDLY FNSGDLLMVD HENFIYFHDR VGDTFRWKGE NVATTEVADT VGLVDFVQEV NVYGVHVPDH EGRIGMASIK MKENHEFDGK KLFQHIADYL PSYARPRFLR IQDTIEITGT FKHRKMTLVE EGFNPAVIKD ALYFLDDTAK MYVPMTEDIY NAISAKTLKL  
CHHHHHHHHH HHHHHHHHHH HHCCHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCHHHHHH HHHHHCCCCC EEEEECCCCC HHHHHHHHHH HHHHHHHHHC CCCCCEEEEE CCCCHHHHHH HHHHHHCCCE EECCCCCCCH HHHHHHHHHC CCCEEEECHH HHHHHHHHHH HCCCCCCEEE EEECCCCCCC CCCHHHHHHH HCCCCCCHHH CCCCCCCCCE EEEECCCCCC CCEEEEEEHH HHHHHHHHHH HHCCCCCCEE EECCCCCCHH HHHHHHHHHH HHCCEEEECC CCCHHHHHHH HHHHCCCEEE CCHHHHHHHH CCCCCCCCCC CCEEEEEECC CCHHHHHHHH HHHCCCEEEE CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCEEEEC CCCCCCCCCC CCCEEECCCC CEEEEEEEEC CCCCCCCCCC CHHHHHHHHH HCCEEECCEE EECCEEEEEC CCCCEEEEEC CCCEEEECCC CCCHHHHHHH HHCCCCEEEE EEEEEECCCC CCEEEEEEEE ECCCCCCCHH HHHHHHHHHC CHHCCCCEEE EECCCCCCCC CCCCHHHHHH CCCCHHHCCC CEEEEECCCC EEEECCHHHH HHHHCCCCCC
[Overview] SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6 
SLC27A1   ------------------------------MRAPG---------AGAASVVSLALLWLL-----------------------------GL---------PWT----WSAAAALGV------------YVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH--QRAGHTIPR------------IFQAVVQRQPERLALVDAGTGE-CWTFAQLDAYSNAVANLFR----------------------------------------------------QLGFAPGDVVAIFL--EGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHL-GKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKG--MDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVS-ESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVA-DPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
SLC27A2   --------------------------------------------------MLSAIYTVL--------------------------------------------------AGLLFLPLLVNLCCP---YFFQDIGYFLKVAA---------------VGRRVRSYGKRRPARTILR------------AFLEKARQTPHKPFLLFRDE---TLTYAQVDRRSNQVARALH---------------------------------------------------DHLGLRQGDCVALLM--GNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIYYVS---RTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGL-TFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTP---FNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAISAKTLKL
SLC27A3   MGVCQRTRAPWKEKSQLERAALGFRKGGSGMFASGWNQTVPIEEAGSMAALLLLPLLLL-----------------------------------------------------LPLLLLKLHLWPQLRWLPADLAFAVRALC---------------CKRALRA---RALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSR---RFSYSEAERESNRAARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLL--PAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWAAG---PGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGF-YQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSP---FLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLRI
SLC27A4   -------------------------------MLLG---------ASLVGVLLFSKL-VL-----------------------------KL---------PWT----QVGFSLLFL------------YLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQC--LQERRTVPI------------LFASTVRRHPDKTALIFEGTDT-HWTFRQLDEYSSSVANFLQ----------------------------------------------------ARGLASGDVAAIFM--ENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASL-DPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKH-LPSCPDKG--FTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLN-QGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVA-SPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL
SLC27A5   MGVRQ----------QL--------------------------------ALLLLLLLLLWGLGQPVWPVAVALTLRWLLGDPTCCVLLGLAMLARPWLGPWVPHGLSLAAAALALTLLPARLPPGLRWLPADVIFLAKILH---------------LGLKIRGCLSRQPPDTFVD------------AFERRARAQPGRALLVWTGPGAGSVTFGELDARACQAAWALKAEL-----------------------------------------------GDPASLCAGEPTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVLSSGARVLVVDPDLRESLEEILPKLQAENIRCFYLS---HTSPTPGVGALGAALDAAPSHPVPADLRAGITWRSPALFIYTSGTTGLPKPAILTHERVLQMSKM-LSLSGATADDVVYTVLPLYHVMGLVVGILGCLDLGATCVLAPKFSTSCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVGRCGALGKMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQP---FVGYRGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAWLPAYATPHFIRIQDAMEVTSTFKLMKTRLVREGFNVGIVVDPLFVLDNRAQSFRPLTAEMYQAVCEGTWRL
SLC27A6   --------------------------------------------------MLLSWLTVL-------------------------------------------------GAGMVVLHFLQKLLFP---YFWDDFWFVLKVVL---------------IIIRLKKYEKRGELVTVLD------------KFLSHAKRQPRKPFIIYEGD---IYTYQDVDKRSSRVAHVFL---------------------------------------------------NHSSLKKGDTVALLM--SNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSL-SENISVWGM----KDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAV-LWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNP---FFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC27A2 48 K/Q 0.68252 rs1648348
-- SLC27A2 70 P/L 0.00127236 rs62623668
-- SLC27A2 144 L/Q 0.000152603 rs540863847
-- SLC27A2 175 D/H 0.000262511 rs144348855
-- SLC27A2 262 I/V 0.00128461 rs144192537
-- SLC27A2 377 K/R 0.00014345 rs201510127
-- SLC27A2 428 K/R 0.000167447 rs200071436
-- SLC27A2 483 D/G 0.000111757 rs777568517
-- SLC27A2 538 D/E 0.000127347 rs200561074
-- SLC27A2 610 Y/C 0.000203697 rs147177240

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
SLC27A2 SLC27A2 [endoplasmic reticulum membrane] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
SLC27A2 SLC27A2 [endoplasmic reticulum membrane] Synthesis of bile acids and bile salts via 24-hydroxycholesterol
SLC27A2 SLC27A2 [peroxisomal membrane] Alpha-oxidation of phytanate
SLC27A2 SLC27A2 [specific granule membrane] Neutrophil degranulation
SLC27A2 SLC27A2 [plasma membrane] Neutrophil degranulation
SLC27A2 SLC27A2 [peroxisomal membrane] Peroxisomal protein import
SLC27A2 SLC27A2 [cytosol] Peroxisomal protein import
SLC27A2 SLC27A2 [cytosol] Peroxisomal protein import

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data