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Basic
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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC27A1


Basic description
Gene Name SLC27A1
Protein Name Long-chain fatty acid transport protein 1 (FATP-1) (Fatty acid transport protein 1) (EC 6.2.1.-) (Solute carrier family 27 member 1)
Family SLC27
Category Transport of vitamins, nucleosides, and related molecules
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640 
MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT ARRDLFGLSV LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT GECWTFAQLD AYSNAVANLF RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK AGMEAALLNV NLRREPLAFC LGTSGAKALI FGGEMVAAVA EVSGHLGKSL IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM DDRLFYIYTS GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR EAERRHRVRL AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD GKVGSCGFNS RILPHVYPIR LVKVNEDTME LLRDAQGLCI PCQAGEPGLL VGQINQQDPL RRFDGYVSES ATSKKIAHSV FSKGDSAYLS GDVLVMDELG YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY GVAVPGVEGK AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL 
CCHHHHHHHH HHHHHHHHHH CCHHHHHHHH HHHHHHHHCH HHHHHHHHHC HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHCC CCEEEEECCC CCEEEHHHHH HHHHHHHHHH HHCCCCCCCE EEEECCCCHH HHHHHHHHHH CCCEEECCCC CCCHHHHHHH HHHCCCCEEE EEHHHHHHHH HHHHHHCCCE EEEEECCCCC CCCCCCCCCH HHHHHHCCCC CCCCCCCCCC CCCEEEEEEC CCCCCCCEEE EEHHHHHHHH HHHHHHCCCC CCCEEEECCC CCCHHHHHHH HHHHHHCCCE EEECCCCCHH HHHHHHHHHC CCEEEEHHHH HHHHHCCCCC HHHHCCCEEE EEECCCCHHH HHHHHHHHCC CEEEEEECCC CCCEEEEECC CCCCCCCCCC CCCCCCCCEE EEEECCCCCE EEECCCCCEE ECCCCCCCEE EEEEECCCCC CCCCCCCCCC HHHHHHHCCC CCCCCEEEEE CCEEEECCCC CEEEEECCCC CEEECCCCCC HHHHHHHHHH CCCEEEEEEE EEECCCCCCE EEEEEEECCC CCCCHHHHHH HHHHCCHHHC CCEEEEECCH HCCCCCCCCC HHHHHHCCCC HHHCCCCEEE EECCCCCEEE CCHHHHHHHH CCCCCC
[Overview] SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6 
SLC27A1   ------------------------------MRAPG---------AGAASVVSLALLWLL-----------------------------GL---------PWT----WSAAAALGV------------YVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRH--QRAGHTIPR------------IFQAVVQRQPERLALVDAGTGE-CWTFAQLDAYSNAVANLFR----------------------------------------------------QLGFAPGDVVAIFL--EGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHL-GKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKG--MDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVS-ESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVA-DPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
SLC27A2   --------------------------------------------------MLSAIYTVL--------------------------------------------------AGLLFLPLLVNLCCP---YFFQDIGYFLKVAA---------------VGRRVRSYGKRRPARTILR------------AFLEKARQTPHKPFLLFRDE---TLTYAQVDRRSNQVARALH---------------------------------------------------DHLGLRQGDCVALLM--GNEPAYVWLWLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIYYVS---RTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQRIWYGTGL-TFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDDCRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYEFYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKGEVGLLVCKITQLTP---FNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDRVGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGKKLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAKMYVPMTEDIYNAISAKTLKL
SLC27A3   MGVCQRTRAPWKEKSQLERAALGFRKGGSGMFASGWNQTVPIEEAGSMAALLLLPLLLL-----------------------------------------------------LPLLLLKLHLWPQLRWLPADLAFAVRALC---------------CKRALRA---RALAAAAADPEGPEGGCSLAWRLAELAQQRAAHTFLIHGSR---RFSYSEAERESNRAARAFLRALGWDWGPDGGDSGEGSAGEGERAAPGAGDAAAGSGAEFAGGDGAARGGGAAAPLSPGATVALLL--PAGPEFLWLWFGLAKAGLRTAFVPTALRRGPLLHCLRSCGARALVLAPEFLESLEPDLPALRAMGLHLWAAG---PGTHPAGISDLLAEVSAEVDGPVPGYLSSPQSITDTCLYIFTSGTTGLPKAARISHLKILQCQGF-YQLCGVHQEDVIYLALPLYHMSGSLLGIVGCMGIGATVVLKSKFSAGQFWEDCQQHRVTVFQYIGELCRYLVNQPPSKAERGHKVRLAVGSGLRPDTWERFVRRFGPLQVLETYGLTEGNVATINYTGQRGAVGRASWLYKHIFPFSLIRYDVTTGEPIRDPQGHCMATSPGEPGLLVAPVSQQSP---FLGYAGGPELAQGKLLKDVFRPGDVFFNTGDLLVCDDQGFLRFHDRTGDTFRWKGENVATTEVAEVFEALDFLQEVNVYGVTVPGHEGRAGMAALVLRPPHALDLMQLYTHVSENLPPYARPRFLRLQESLATTETFKQQKVRMANEGFDPSTLSDPLYVLDQAVGAYLPLTTARYSALLAGNLRI
SLC27A4   -------------------------------MLLG---------ASLVGVLLFSKL-VL-----------------------------KL---------PWT----QVGFSLLFL------------YLGSGGWRFIRVFIKTIRRDIFGGLVLLKVKAKVRQC--LQERRTVPI------------LFASTVRRHPDKTALIFEGTDT-HWTFRQLDEYSSSVANFLQ----------------------------------------------------ARGLASGDVAAIFM--ENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSEMASAICEVHASL-DPSLSLFCSGSWEPGAVPPSTEHLDPLLKDAPKH-LPSCPDKG--FTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQHQVRMALGNGLRQSIWTNFSSRFHIPQVAEFYGATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGEPGQLVGRIIQKDPLRRFDGYLN-QGANNKKIAKDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVA-SPTGNCDLERFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRKEGFDPAIVKDPLFYLDAQKGRYVPLDQEAYSRIQAGEEKL
SLC27A5   MGVRQ----------QL--------------------------------ALLLLLLLLLWGLGQPVWPVAVALTLRWLLGDPTCCVLLGLAMLARPWLGPWVPHGLSLAAAALALTLLPARLPPGLRWLPADVIFLAKILH---------------LGLKIRGCLSRQPPDTFVD------------AFERRARAQPGRALLVWTGPGAGSVTFGELDARACQAAWALKAEL-----------------------------------------------GDPASLCAGEPTALLVLASQAVPALCMWLGLAKLGCPTAWINPHGRGMPLAHSVLSSGARVLVVDPDLRESLEEILPKLQAENIRCFYLS---HTSPTPGVGALGAALDAAPSHPVPADLRAGITWRSPALFIYTSGTTGLPKPAILTHERVLQMSKM-LSLSGATADDVVYTVLPLYHVMGLVVGILGCLDLGATCVLAPKFSTSCFWDDCRQHGVTVILYVGELLRYLCNIPQQPEDRTHTVRLAMGNGLRADVWETFQQRFGPIRIWEVYGSTEGNMGLVNYVGRCGALGKMSCLLRMLSPFELVQFDMEAAEPVRDNQGFCIPVGLGEPGLLLTKVVSQQP---FVGYRGPRELSERKLVRNVRQSGDVYYNTGDVLAMDREGFLYFRDRLGDTFRWKGENVSTHEVEGVLSQVDFLQQVNVYGVCVPGCEGKVGMAAVQLAPGQTFDGEKLYQHVRAWLPAYATPHFIRIQDAMEVTSTFKLMKTRLVREGFNVGIVVDPLFVLDNRAQSFRPLTAEMYQAVCEGTWRL
SLC27A6   --------------------------------------------------MLLSWLTVL-------------------------------------------------GAGMVVLHFLQKLLFP---YFWDDFWFVLKVVL---------------IIIRLKKYEKRGELVTVLD------------KFLSHAKRQPRKPFIIYEGD---IYTYQDVDKRSSRVAHVFL---------------------------------------------------NHSSLKKGDTVALLM--SNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSL-SENISVWGM----KDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAV-LWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNP---FFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC27A1 79 P/S 0.00041052 rs200393696
-- SLC27A1 153 M/L 0.0114303 rs61743602
-- SLC27A1 421 L/P 0.000135292 rs200569053
-- SLC27A1 484 G/S 0.000343931 rs578091570
-- SLC27A1 505 R/Q 0.000147479 rs149049260
-- SLC27A1 530 R/H 0.000199513 rs200816692
-- SLC27A1 530 R/C 0.000641723 rs555948105
-- SLC27A1 602 T/M 0.000135262 rs373170683
-- SLC27A1 612 R/C 0.000198881 rs149575978
-- SLC27A1 645 A/V 0.00128289 rs138685840

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC27A1 SLC27A1 [plasma membrane] Transport of fatty acids
SLC27A1 SLC27A1 [plasma membrane] PPARA activates gene expression

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data