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Basic
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Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC26A3


Basic description
Gene Name SLC26A3
Protein Name Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3)
Family SLC26
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 7 3 0 7 4 0 7 5 0 7 6 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730        740        750        760 
MIEPFGNQYI VARPVYSTNA FEENHKKTGR HHKTFLDHLK VCCSCSPQKA KRIVLSLFPI ASWLPAYRLK EWLLSDIVSG ISTGIVAVLQ GLAFALLVDI PPVYGLYASF FPAIIYLFFG TSRHISVGPF PILSMMVGLA VSGAVSKAVP DRNATTLGLP NNSNNSSLLD DERVRVAAAA SVTVLSGIIQ LAFGILRIGF VVIYLSESLI SGFTTAAAVH VLVSQLKFIF QLTVPSHTDP VSIFKVLYSV FSQIEKTNIA DLVTALIVLL VVSIVKEINQ RFKDKLPVPI PIEFIMTVIA AGVSYGCDFK NRFKVAVVGD MNPGFQPPIT PDVETFQNTV GDCFGIAMVA FAVAFSVASV YSLKYDYPLD GNQELIALGL GNIVCGVFRG FAGSTALSRS AVQESTGGKT QIAGLIGAII VLIVVLAIGF LLAPLQKSVL AALALGNLKG MLMQFAEIGR LWRKDKYDCL IWIMTFIFTI VLGLGLGLAA SVAFQLLTIV FRTQFPKCST LANIGRTNIY KNKKDYYDMY EPEGVKIFRC PSPIYFANIG FFRRKLIDAV GFSPLRILRK RNKALRKIRK LQKQGLLQVT PKGFICTVDT IKDSDEELDN NQIEVLDQPI NTTDLPFHID WNDDLPLNIE VPKISLHSLI LDFSAVSFLD VSSVRGLKSI LQEFIRIKVD VYIVGTDDDF IEKLNRYEFF DGEVKSSIFF LTIHDAVLHI LMKKDYSTSK FNPSQEKDGK IDFTINTNGG LRNRVYEVPV ETKF 
CCCCCCCCEE EECCCCCHHH HHHHCCCCCC CCCCHHHHHH HHCCCCHHHH HHHHHHHCCH HHHHCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CHHHHHHHHH HHHHHHHHHC CCHHHCCCCH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHCCH HHHHCCHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCH HHHHHHHHHH HHCCCCCCHH HHHHHHHHHH HHHHHHHHCH HCCCCCCCCH HHHHHHHHHH HHHHHHCCCC CCCCEEECCC CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCHHHHHHHH HHHHHHHHHC CCCCCCCHHH HHHHHCCCCH HHHHHHHHHH HHHHHHHHCH HHHHHHHHHH HHHHHHHHHH HHCCHHHHHH HHHHCHHHHH HHHHHHHHHH HHCHHHHHHH HHHHHHHHHH HHHHCCCCCC CEECCCCCCE EEHHHHCCCC CCCCEEEEEC CCCCCCCCHH HHHHHHHHHH CCCHHHHHHH CCHHHHHHHH HHHHCCCCCC CCCEEEECCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCEEEE EECCCCCCCC HHHHHHHHHH HHHHHHCCCE EEEECCCHHH HHHHHHCCCC CCCCCCCEEE CCHHHHHHHH HHHCCCCCCC CCCCCCCCCC CCCEECCCCC CCCCCCCCCC CCCC
[Overview] SLC26A1 SLC26A10 SLC26A11 SLC26A2 SLC26A3 SLC26A4 SLC26A5 SLC26A6 SLC26A7 SLC26A8 SLC26A9 
SLC26A1   --------MDESPEPLQQGRGPVP--------------------------------VRRQRPAPRGLRE------------------MLKARLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAG--LQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLC-LMVGQVV------------DRELQLAGFDPSQDGLQPG--ANSSTL--------NGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTS---TVCLAVLLAA---KELSDRYRHRLRVPLPT---------------ELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVA------------LALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLD-----AGCMAARRKEGGSE----------------------------------------------------------------------------------TGVGEGGPAQGEDLG----------------PVSTRAALVPAAA-----------GFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGA----LGISLLLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARARHR---ELE------------------ATDAHL-----------------------------------------------------------------------------------------------------------------------------------------------
SLC26A10  -----------------------------------MRLDL-------------ASLMSAPKSLGSAFKS-WRLDKAPSPQHT-----------------------------FPSTS-IP-------------------------GMAFALLAS--VPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAILS-LMTG----SAVERLVPE-----------------PLVG-----------------NLSGIEKEQLDAQRVGVAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVVKALTSGAALHVLLSQLPSLLGLSLPRQIGCFSLFKTLASLLTALPRSSPAELTIS---ALSLALLVPV---KELNVRFRDRLPTPIPG---------------EVVLVLLASVLCFTSSVDTRYQVQIVGLLPGGFPQPLLPNLAELPRILADSLP------------IALVSFAVSASLASIHADKYSYTIDSNQEFLAHGASNLISSLFSCFPNSATLATTNLLVDAGGKTQLAGLFSCTVVLSVLLWLGPFFYYLPKAVLACINISSMRQVFCQMQELPQLWHISRVDFLL-----------------------------------------------------------QVPGLCILSYPTPLYFGTRGQFRCNLEWHLGLGE---------------GEK----------------------------------------------------------------------------------ETSKPDG------------------------PMVAVAE-----------------PVRVVVLDFSGVTFADAAGAREVVQVRERLASRCRDARIRLLLAQCNALVQGTLTRVGLL-----DRVTPDQLFVSVQDAAAYALGSLLRGSSTRS--GSQEALGCGK----------------------------------------------------------------------------------------------------------------------------------------------------------
SLC26A11  ----------------------MPSS---------------------------VTALGQARSSGPGMAP-------------------------SACCCSPA----ALQRRLPILAWLPSYSL-QWLKMDFVAGLSVGLTAIPQALAYAEVAG--LPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMS-LLVSFYT-----------------------FHE---------------PAY---------------------AVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQ----NIPRPFFLQVYHTFLRIAETRVGDAVLG---LVCMLLLLVL---KLMRDHVPPVHPEMPPGVRLSRGLVWAATTARNALVVSFAALVAYSFEVTGYQPFILTGETAEGLPPVRIPPFSVTTANGTISFTEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLF-DTKIFRTLWRVKRLDLLPLCVTFLLC-FWEVQYGILAGALVSLLMLLHSAARPETKV--------------------SEGPVLVLQPASGLSFPAMEALREEILSRA-------------------------------------------------------------------------------------------------------------------------------------------------------LEVSPP----RCLVLECTHVCSIDYTVVLGLGELLQDFQK----QGVALAFVGLQVPVLRVLLSA--------D-LKGFQYFSTLEEAEKHLRQEPG---------------------TQPYNIREDSILDQKVALLKA-----------------------------------------------------------------------------------------------------------------------------------
SLC26A2   MSSESKEQHNVSPRDSAEGNDSYPSGIHLELQRESS-TDFKQFETNDQCRPYHRILIERQEKSDTNFKE------------------FVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAG--QEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLC-LMIGETV------------DRELQKAGYDNAHSAPSLGMVSNGSTL--------LNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITS---LLCLLVLLPT---KELNEHFKSKLKAPIPI---------------ELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIA------------ISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAKRKI--KE----------------------------------------------------------------------------------KVVTLGG-IQDE--------------------MSVQLSHDPLE-------------LHTIVIDCSAIQFLDTAGIHTLKEVRRDYEA----IGIQVLLAQCNPTVRDSLTNGEYCKK-----EEENLLFYSVYEAMAFAEVSKN---QKGVCVPN---------GLSLSSD--------------------------------------------------------------------------------------------------------------------------------------------------
SLC26A3   ---------------MIEPFGN-------------------------------QYIVARPVYSTNAFEE--NHKKTGRHH------KTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVD--IPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILS-MMVGLAVSGAVSKAVP---DR--------------------NATTLGLPN--NSNNSSLLD---DERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTA---LIVLLVVSIV---KEINQRFKDKLPVPIPI---------------EFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFG------------IAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKI--RK-----------------------------LQK-------QGLLQ---VTPKGFI---CTVDTI--KDSDEELDNN-------QIEVLDQPINTTDLPFHIDWNDDL-------PL---------------NIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIR----IKVDVYIVGTDDDFIEKLNRYEFF-DGE---VKSSIFFLTIHDAVLHILMKKDYSTSKFN--PSQEKDGKIDFTINTNGGLRNRVYEVPVE----------------------TKF--------------------------------------------------------------------------------------------------------------
SLC26A4   ---------------MAAPGGRSEP---PQLPEYSC-----------------SYMVSRPVYSELAFQQ--QHERRLQER------KTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAA--VPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVS-LMVG----SVVLSMAP---DEHFLVSS-------------SNGTVL---------NTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAG---LLTIVVCMAV---KELNDRFRHKIPVPIPI---------------EVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFS------------IAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKI--QK-----------------------------LIK-------SGQLR---ATKNGIISDAVSTNNA--FEPDEDIED---------LEELDIP--TKEIEIQVDWNSEL-------PV---------------KVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQR----IDVNVYFASLQDYVIEKLEQCGFF-DDN---IRKDTFFLTVHDAILYLQNQVK----------SQEGQGSILETITLIQDCKDTL-EL-IE----------------------TELTEE-----------ELDVQDEAM-----------RTLAS-----------------------------------------------------------------------
SLC26A5   -------------MDHAEEN---------EILAATQ-----------------RYYVERPIFSHPVLQE--------RLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAA--VPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIG----GVAVRLVP---DDIVIPGG-------------VNATNG---------------TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSL------GVGLMVFGLLLGGKEFNERFKEKLPAPIPL---------------EFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIA------------IAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKY--AK-----------------------------------------------------------------EVGNANMANA-------TVVKADAEVDGEDATKPEEEDGEVK----YPPIVIKST-FPEEM---QRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGD----VGIYVYLAGCSAQVVNDLTRNRFF-ENP---ALWELLFHSIHDAVLGSQLREALAEQEASAPPSQE------------DLEPNATPATPEA---------------------------------------------------------------------------------------------------------------------------------------
SLC26A6   -------------MGLADASGPRDT---QALLSATQAMDL----------RRRDYHMERPLLNQEHLEELGRWGSAPRTH-----------QWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMS-VMVG----SVTESLAPQALNDSMI-----------------NET-------------------ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLL------NDKLQQQLPMPIPG---------------ELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFT------------IAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQ--EQL------------------------KLKQLQK-------EEKLRKQAASPKGASVS-INVNTSLEDMRSNNVEDC-------KMMQVSSGDKMEDATANGQEDS-------------KAP-DGSTL---KALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFRE----IEVEVYMAACHSPVVSQLEAGHFF-DAS---ITKKHLFASVHDAV-------TFALQ-----------------------HPRPVPDSPVSV---------------------TRL--------------------------------------------------------------------------------------------------------------
SLC26A7   -------------------------------------------------------MTGAKRKKKSMLWS--------KMH------TPQCEDIIQWCR-----------RRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSS--VHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTS-LISA----NAVERIVPQN---------------------MQNLTTQ--------SNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLS---LLSIVVLVLV---KELNEQFKRKIKVVLPV---------------DLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFG------------VALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMI--------------------QK----------------------------------------------------------------ENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCPNEKCY-----------------------------------LILDCSGFTFFDYSGVSMLVEVYMDCKG----RSVDVLLAHCTASLIKAMTYYGNL-----D-SEKPIFFESVSAAISHIHSNKN---------------------LSKLSDHSEV----------------------------------------------------------------------------------------------------------------------------------------------
SLC26A8   ---------------MAQLERSAISG----FSSKSRRNSF-------------AYDVKREVYNEETFQQ--EHKRKASSSGNMNI-NITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLIN------VLKVSPFN-NGQLVMGSF-----------VKNEFSA--PSYLMGYNKS-----------LSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSI------LVFLTVVVALRINKCIRISF-NQYPIEFPM---------------ELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFS------------LSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDM---------VKVPLKE--EEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTV-----SSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLP--SVHTIILDFSMVHYVDSRGLVVLRQICNAFQN----ANILILIAGCHSSIVRAFERNDFF-DAG---ITKTQLFLSVHDAVLFALSRKVIGSSELSIDESET---VIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
SLC26A9   ---------------MSQP--------------------------------RPRYVVDRAAYSLTLFDD--EFEKKDRTY-------PVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLAN--LPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVIS-ILVG----NICLQLAP---ESKFQVFN--------------NAT-----------NESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLV------KELNARYMHKIRFPIPT---------------EMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFS------------LAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQ--EKR------------------------RMRPTQQ-------RRSLF-------------MKTKTVSLQELQQDFENAPPTDP-NNNQTPANGTSVSYITFSPDSSSPAQS---EPPASAEAPGEPSDM---LASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGK----IGVKVFLVNIHAQVYNDISHGGVFEDGS---LECKHVFPSIHDAVLFAQANAR------DVTPGHNFQGAP-------GDAELSLYDSEEDI---------------------RSY---------------WDLEQEMFGSM-----FHAETLTAL----------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC26A3 68 R/Q 0.0029908 rs10280704
-- SLC26A3 81 I/V 0.00337271 rs116793431
-- SLC26A3 119 F/L 0.00866926 rs73419912
-- SLC26A3 155 T/I 0.000107407 rs532228172
-- SLC26A3 177 A/V 0.000127305 rs147974764
-- SLC26A3 197 R/Q 0.000455898 rs201844799
-- SLC26A3 237 H/Q 0.000238819 rs145962719
-- SLC26A3 283 K/N 0.00011539 rs755764036
-- SLC26A3 307 C/W 0.0413629 rs34407351
-- SLC26A3 425 V/I 0.000505493 rs146161125
-- SLC26A3 510 T/M 0.00182914 rs60147601
-- SLC26A3 554 R/Q 0.00243652 rs2301635
-- SLC26A3 596 C/G 0.000199392 rs201220816
-- SLC26A3 601 I/T 0.00173325 rs35776303
-- SLC26A3 698 E/Q 0.0008517 rs138002384
-- SLC26A3 723 K/N 0.000821424 rs142908255
-- SLC26A3 753 N/S 0.00199338 rs35342296

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC26A3 SLC26A3 [plasma membrane] Multifunctional anion exchangers

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC26A3 SLC26A3 W462* [plasma membrane] Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
SLC26A3 SLC26A3 G187* [plasma membrane] Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
SLC26A3 SLC26A3 I676ins [plasma membrane] Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)
SLC26A3 SLC26A3 V317del [plasma membrane] Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)