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Basic
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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC26A2


Basic description
Gene Name SLC26A2
Protein Name Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)
Family SLC26
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 7 3 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730 
MSSESKEQHN VSPRDSAEGN DSYPSGIHLE LQRESSTDFK QFETNDQCRP YHRILIERQE KSDTNFKEFV IKKLQKNCQC SPAKAKNMIL GFLPVLQWLP KYDLKKNILG DVMSGLIVGI LLVPQSIAYS LLAGQEPVYG LYTSFFASII YFLLGTSRHI SVGIFGVLCL MIGETVDREL QKAGYDNAHS APSLGMVSNG STLLNHTSDR ICDKSCYAIM VGSTVTFIAG VYQVAMGFFQ VGFVSVYLSD ALLSGFVTGA SFTILTSQAK YLLGLNLPRT NGVGSLITTW IHVFRNIHKT NLCDLITSLL CLLVLLPTKE LNEHFKSKLK APIPIELVVV VAATLASHFG KLHENYNSSI AGHIPTGFMP PKVPEWNLIP SVAVDAIAIS IIGFAITVSL SEMFAKKHGY TVKANQEMYA IGFCNIIPSF FHCFTTSAAL AKTLVKESTG CHTQLSGVVT ALVLLLVLLV IAPLFYSLQK SVLGVITIVN LRGALRKFRD LPKMWSISRM DTVIWFVTML SSALLSTEIG LLVGVCFSIF CVILRTQKPK SSLLGLVEES EVFESVSAYK NLQIKPGIKI FRFVAPLYYI NKECFKSALY KQTVNPILIK VAWKKAAKRK IKEKVVTLGG IQDEMSVQLS HDPLELHTIV IDCSAIQFLD TAGIHTLKEV RRDYEAIGIQ VLLAQCNPTV RDSLTNGEYC KKEEENLLFY SVYEAMAFAE VSKNQKGVCV PNGLSLSSD 
CCHHHHHCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHHHHHCCC CHHHHHHHHH HHCCHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHHHCCCCC CHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH CHHHHHHCCH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCHHHHHHH HHHHHCCCCC CHHHHHHHHH HHHHHHHHHH HCHHHHHCCC CCHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCHHHHH HHHHHHHHHH CCCCCHHCHH HHHHHHHHCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCHHH HHHHHCCCHH HHHHHHHHHH HHHHHCCHHH HHHHHHHHHH HHHHHHHCCC EEECEECCCC CCEECHHHHC CCCCCCCEEE EEECCCCCCH HHHHHHHHHH HHHCCCHHHH HHHHHHHHHH HHHHHCCCCC CCHHHHHHCC CCCCCCCEEE EECEECCCCC HHHHHHHHHH HHHHHHCCCE EEEECCCHHH HHHHHCCCCC CCCCCCCEEC CHHHHHHHHH HHHHCCCCCC CCCCCCCCC
[Overview] SLC26A1 SLC26A10 SLC26A11 SLC26A2 SLC26A3 SLC26A4 SLC26A5 SLC26A6 SLC26A7 SLC26A8 SLC26A9 
SLC26A1   --------MDESPEPLQQGRGPVP--------------------------------VRRQRPAPRGLRE------------------MLKARLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAG--LQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLC-LMVGQVV------------DRELQLAGFDPSQDGLQPG--ANSSTL--------NGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTS---TVCLAVLLAA---KELSDRYRHRLRVPLPT---------------ELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVA------------LALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLD-----AGCMAARRKEGGSE----------------------------------------------------------------------------------TGVGEGGPAQGEDLG----------------PVSTRAALVPAAA-----------GFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGA----LGISLLLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARARHR---ELE------------------ATDAHL-----------------------------------------------------------------------------------------------------------------------------------------------
SLC26A10  -----------------------------------MRLDL-------------ASLMSAPKSLGSAFKS-WRLDKAPSPQHT-----------------------------FPSTS-IP-------------------------GMAFALLAS--VPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAILS-LMTG----SAVERLVPE-----------------PLVG-----------------NLSGIEKEQLDAQRVGVAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVVKALTSGAALHVLLSQLPSLLGLSLPRQIGCFSLFKTLASLLTALPRSSPAELTIS---ALSLALLVPV---KELNVRFRDRLPTPIPG---------------EVVLVLLASVLCFTSSVDTRYQVQIVGLLPGGFPQPLLPNLAELPRILADSLP------------IALVSFAVSASLASIHADKYSYTIDSNQEFLAHGASNLISSLFSCFPNSATLATTNLLVDAGGKTQLAGLFSCTVVLSVLLWLGPFFYYLPKAVLACINISSMRQVFCQMQELPQLWHISRVDFLL-----------------------------------------------------------QVPGLCILSYPTPLYFGTRGQFRCNLEWHLGLGE---------------GEK----------------------------------------------------------------------------------ETSKPDG------------------------PMVAVAE-----------------PVRVVVLDFSGVTFADAAGAREVVQVRERLASRCRDARIRLLLAQCNALVQGTLTRVGLL-----DRVTPDQLFVSVQDAAAYALGSLLRGSSTRS--GSQEALGCGK----------------------------------------------------------------------------------------------------------------------------------------------------------
SLC26A11  ----------------------MPSS---------------------------VTALGQARSSGPGMAP-------------------------SACCCSPA----ALQRRLPILAWLPSYSL-QWLKMDFVAGLSVGLTAIPQALAYAEVAG--LPPQYGLYSAFMGCFVYFFLGTSRDVTLGPTAIMS-LLVSFYT-----------------------FHE---------------PAY---------------------AVLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQ----NIPRPFFLQVYHTFLRIAETRVGDAVLG---LVCMLLLLVL---KLMRDHVPPVHPEMPPGVRLSRGLVWAATTARNALVVSFAALVAYSFEVTGYQPFILTGETAEGLPPVRIPPFSVTTANGTISFTEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLF-DTKIFRTLWRVKRLDLLPLCVTFLLC-FWEVQYGILAGALVSLLMLLHSAARPETKV--------------------SEGPVLVLQPASGLSFPAMEALREEILSRA-------------------------------------------------------------------------------------------------------------------------------------------------------LEVSPP----RCLVLECTHVCSIDYTVVLGLGELLQDFQK----QGVALAFVGLQVPVLRVLLSA--------D-LKGFQYFSTLEEAEKHLRQEPG---------------------TQPYNIREDSILDQKVALLKA-----------------------------------------------------------------------------------------------------------------------------------
SLC26A2   MSSESKEQHNVSPRDSAEGNDSYPSGIHLELQRESS-TDFKQFETNDQCRPYHRILIERQEKSDTNFKE------------------FVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAG--QEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLC-LMIGETV------------DRELQKAGYDNAHSAPSLGMVSNGSTL--------LNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITS---LLCLLVLLPT---KELNEHFKSKLKAPIPI---------------ELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIA------------ISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAKRKI--KE----------------------------------------------------------------------------------KVVTLGG-IQDE--------------------MSVQLSHDPLE-------------LHTIVIDCSAIQFLDTAGIHTLKEVRRDYEA----IGIQVLLAQCNPTVRDSLTNGEYCKK-----EEENLLFYSVYEAMAFAEVSKN---QKGVCVPN---------GLSLSSD--------------------------------------------------------------------------------------------------------------------------------------------------
SLC26A3   ---------------MIEPFGN-------------------------------QYIVARPVYSTNAFEE--NHKKTGRHH------KTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVD--IPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILS-MMVGLAVSGAVSKAVP---DR--------------------NATTLGLPN--NSNNSSLLD---DERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTA---LIVLLVVSIV---KEINQRFKDKLPVPIPI---------------EFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFG------------IAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKI--RK-----------------------------LQK-------QGLLQ---VTPKGFI---CTVDTI--KDSDEELDNN-------QIEVLDQPINTTDLPFHIDWNDDL-------PL---------------NIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIR----IKVDVYIVGTDDDFIEKLNRYEFF-DGE---VKSSIFFLTIHDAVLHILMKKDYSTSKFN--PSQEKDGKIDFTINTNGGLRNRVYEVPVE----------------------TKF--------------------------------------------------------------------------------------------------------------
SLC26A4   ---------------MAAPGGRSEP---PQLPEYSC-----------------SYMVSRPVYSELAFQQ--QHERRLQER------KTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAA--VPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVS-LMVG----SVVLSMAP---DEHFLVSS-------------SNGTVL---------NTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAG---LLTIVVCMAV---KELNDRFRHKIPVPIPI---------------EVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFS------------IAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKI--QK-----------------------------LIK-------SGQLR---ATKNGIISDAVSTNNA--FEPDEDIED---------LEELDIP--TKEIEIQVDWNSEL-------PV---------------KVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQR----IDVNVYFASLQDYVIEKLEQCGFF-DDN---IRKDTFFLTVHDAILYLQNQVK----------SQEGQGSILETITLIQDCKDTL-EL-IE----------------------TELTEE-----------ELDVQDEAM-----------RTLAS-----------------------------------------------------------------------
SLC26A5   -------------MDHAEEN---------EILAATQ-----------------RYYVERPIFSHPVLQE--------RLHTKDKVPDSIADKLKQAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAA--VPPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIG----GVAVRLVP---DDIVIPGG-------------VNATNG---------------TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSL------GVGLMVFGLLLGGKEFNERFKEKLPAPIPL---------------EFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIA------------IAIVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKY--AK-----------------------------------------------------------------EVGNANMANA-------TVVKADAEVDGEDATKPEEEDGEVK----YPPIVIKST-FPEEM---QRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGD----VGIYVYLAGCSAQVVNDLTRNRFF-ENP---ALWELLFHSIHDAVLGSQLREALAEQEASAPPSQE------------DLEPNATPATPEA---------------------------------------------------------------------------------------------------------------------------------------
SLC26A6   -------------MGLADASGPRDT---QALLSATQAMDL----------RRRDYHMERPLLNQEHLEELGRWGSAPRTH-----------QWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMS-VMVG----SVTESLAPQALNDSMI-----------------NET-------------------ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLL------NDKLQQQLPMPIPG---------------ELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFT------------IAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQ--EQL------------------------KLKQLQK-------EEKLRKQAASPKGASVS-INVNTSLEDMRSNNVEDC-------KMMQVSSGDKMEDATANGQEDS-------------KAP-DGSTL---KALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFRE----IEVEVYMAACHSPVVSQLEAGHFF-DAS---ITKKHLFASVHDAV-------TFALQ-----------------------HPRPVPDSPVSV---------------------TRL--------------------------------------------------------------------------------------------------------------
SLC26A7   -------------------------------------------------------MTGAKRKKKSMLWS--------KMH------TPQCEDIIQWCR-----------RRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSS--VHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTS-LISA----NAVERIVPQN---------------------MQNLTTQ--------SNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLS---LLSIVVLVLV---KELNEQFKRKIKVVLPV---------------DLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFG------------VALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMI--------------------QK----------------------------------------------------------------ENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCPNEKCY-----------------------------------LILDCSGFTFFDYSGVSMLVEVYMDCKG----RSVDVLLAHCTASLIKAMTYYGNL-----D-SEKPIFFESVSAAISHIHSNKN---------------------LSKLSDHSEV----------------------------------------------------------------------------------------------------------------------------------------------
SLC26A8   ---------------MAQLERSAISG----FSSKSRRNSF-------------AYDVKREVYNEETFQQ--EHKRKASSSGNMNI-NITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLIN------VLKVSPFN-NGQLVMGSF-----------VKNEFSA--PSYLMGYNKS-----------LSVVATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSI------LVFLTVVVALRINKCIRISF-NQYPIEFPM---------------ELFLIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFS------------LSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDM---------VKVPLKE--EEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTV-----SSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLP--SVHTIILDFSMVHYVDSRGLVVLRQICNAFQN----ANILILIAGCHSSIVRAFERNDFF-DAG---ITKTQLFLSVHDAVLFALSRKVIGSSELSIDESET---VIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
SLC26A9   ---------------MSQP--------------------------------RPRYVVDRAAYSLTLFDD--EFEKKDRTY-------PVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLAN--LPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVIS-ILVG----NICLQLAP---ESKFQVFN--------------NAT-----------NESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLV------KELNARYMHKIRFPIPT---------------EMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFS------------LAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQ--EKR------------------------RMRPTQQ-------RRSLF-------------MKTKTVSLQELQQDFENAPPTDP-NNNQTPANGTSVSYITFSPDSSSPAQS---EPPASAEAPGEPSDM---LASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGK----IGVKVFLVNIHAQVYNDISHGGVFEDGS---LECKHVFPSIHDAVLFAQANAR------DVTPGHNFQGAP-------GDAELSLYDSEEDI---------------------RSY---------------WDLEQEMFGSM-----FHAETLTAL----------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC26A2 58 R/H 0.000159271 rs199893058
-- SLC26A2 65 N/D 0.000115444 rs755049614
-- SLC26A2 66 F/L 0.000103512 rs200981220
-- SLC26A2 77 N/H 0.00458756 rs76784312
-- SLC26A2 147 A/S 0.000103974 rs201012489
-- SLC26A2 217 Y/C 0.000171371 rs377095681
-- SLC26A2 219 I/V 0.00190928 rs35919114
-- SLC26A2 232 Y/F 0.00010463 rs75097996
-- SLC26A2 261 S/C 0.000747925 rs114260147
-- SLC26A2 279 R/W 0.000975163 rs104893915
-- SLC26A2 279 R/Q 0.000191065 rs114569184
-- SLC26A2 292 H/R 0.000115444 rs761259326
-- SLC26A2 298 H/R 0.000123416 rs115111282
-- SLC26A2 349 F/Y 0.000541651 rs114212275
-- SLC26A2 361 A/T 0.00023897 rs139051143
-- SLC26A2 412 V/I 0.000286709 rs201714602
-- SLC26A2 492 R/W 0.0167205 rs78676079
-- SLC26A2 504 M/I 0.000282643 rs76668544
-- SLC26A2 574 I/T 0.99308 rs30832
-- SLC26A2 653 C/S 0.00011143 rs104893924
-- SLC26A2 689 T/S 0.17227 rs3776070
-- SLC26A2 696 N/S 0.000552031 rs34351171

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC26A2 SLC26A2 [plasma membrane] Multifunctional anion exchangers
SLC26A2 SLC26A2 [plasma membrane] Transport and synthesis of PAPS

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC26A2 SLC26A2 G255E [plasma membrane] Defective SLC26A2 causes chondrodysplasias
SLC26A2 SLC26A2 L483P [plasma membrane] Defective SLC26A2 causes chondrodysplasias
SLC26A2 SLC26A2 N425D [plasma membrane] Defective SLC26A2 causes chondrodysplasias
SLC26A2 SLC26A2 R178* [plasma membrane] Defective SLC26A2 causes chondrodysplasias