Detail Data SLC23A3

Basic description

Gene Name	SLC23A3
Protein Name	Solute carrier family 23 member 3 (HPC E2-binding protein 3) (Na(+)/L-ascorbic acid transporter 3) (Sodium-dependent vitamin C transporter 3)
Family	SLC23
Category	-
Reaction name	-
Reaction	-

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490 
MSRSPLNPSQ LRSVGSQDAL APLPPPAPQN PSTHSWDPLC GSLPWGLSCL LALQHVLVMA SLLCVSHLLL LCSLSPGGLS YSPSQLLASS FFSCGMSTIL QTWMGSRLPL VQAPSLEFLI PALVLTSQKL PRAIQTPGNS SLMLHLCRGP SCHGLGHWNT SLQEVSGAVV VSGLLQGMMG LLGSPGHVFP HCGPLVLAPS LVVAGLSAHR EVAQFCFTHW GLALLTWAPA SFMCAPGGEL QRHQLTLLSL SSGSFRNCLP PPRHHGFGCL TQAGSQQVAH LVGLLCVGLG LSPRLAQLLT TIPLPVVGGV LGVTQAVVLS AGFSSFYLAD IDSGRNIFIV GFSIFMALLL PRWFREAPVL FSTGWSPLDV LLHSLLTQPI FLAGLSGFLL ENTIPGTQLE RGLGQGLPSP FTAQEARMPQ KPREKAAQVY RLPFPIQNLC PCIPQPLHCL CPLPEDPGDE EGGSSEPEEM ADLLPGSGEP CPESSREGFR SQK 
CCCCCCCHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CHHHHHHHHH HHHCCHHHHH HHHHCCCCCC CCCCCCCCCC CHHHHHHCCC CCCCCCCCCC CEEEECCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCEEEHHH HHHCCCCCCH HHHHHHHHHH HHHHHCCCCH HHHCCCCCHH HHHHHHHCCC CCCCCCCCCC CCCCCCEEEE HHCCCCCEEE EEHHHHHHCC CCHHHHHHHC CCCCCCCCCH HHHHHHHHHH CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHCCHH HHCCCCHHHH HHHHHCCHHH HHHHHHHHHH HHCCCCCHHH CCCCCCCCCC CCHHHCCCCC CCCHHHHHCC CCCCCHHHCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCH HCCCCCCCCC CCCCCCCCCC CCC

Family alignment

[Overview]

SLC23A1   ------------MRAQEDLEGRTQHETTRDPSTPLPT---------------------------------------------EP-KFDMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLP-LN---------TSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVW----LLCYVLTLTDVLPTDPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQ-------WKAGAHANSDMSSSLKSYDFPIGMG-----IVKRITFLKYIPICPVFKGFSSSSKDQIA-----IPEDTPENTETASVCTKV
SLC23A2   MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTAELLH---------TEHIWYPRIREIQGAIIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSW----LLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQFIDLNSSRNLFVLGFSIFFGLVLPSYLRQNP--LVTGITGIDQVLNVLLTTAMFVGGCVAFILDNTIPGTPEERGIRK-------WKKGVGKGNKSLDGMESYNLPFGMN-----IIKKYRCFSYLPISPTFVGYTWKGLRK---------SDNSRSSDEDSQATG-
SLC23A3   ------------MSRSPLNPSQLRSVGSQDALAPLPP----------------------------------PAPQNPSTHSWDP--------LCGSLPWGLSCLLALQHVLVMASLLCVSHLLLLCSLSPGGLSYSPSQLLASSFFSCGMSTILQTWMGSRLPLVQAPSLEFLIPA---LVLTSQKLPRAIQTPGNSSLM-LHLCRGPSCHGLGH-WNTSLQEVSGAVVVSGLLQGMMGLLGSPGHVFPHCGPLVLAPSLVVAGLSAHREVAQFCFTHWGLALLT-----------------------------------------------WAPASFMC-------------------------------AP-----------------GGELQRHQLTLLSL--SSGSFRNCL------PPPRH--------HGFGC-----------------------LTQAGSQQVAHLVGLLCVGLGLSPRLAQLLTTIPLPVVGGVLGVTQAVVLSAGFSSFYLADIDSGRNIFIVGFSIFMALLLPRWFREAPVLFSTGWSPLDVLLHSLLTQPIFLAGLSGFLLENTIPGTQLERGLGQGLPSPFTAQEARMPQKPREKAAQVYRLPFPIQNLCPCIPQPLHCLCPLPEDPGDEEGGSSEPEEMADLLPGSGEPCPESSREGFRSQK-

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC23A3	104	M/I	0.00520725	rs79578215
--	SLC23A3	125	C/Y	0.000156769	rs182843694
--	SLC23A3	142	C/S	0.0106538	rs372823671
--	SLC23A3	233	M/I	0.000156769	rs182843694
--	SLC23A3	244	V/M	0.000156769	rs182843694
--	SLC23A3	261	V/L	0.0106538	rs372823671
--	SLC23A3	287	V/M	0.000100867	rs750903971
--	SLC23A3	336	N/K	0.00215977	rs192756070
--	SLC23A3	346	P/S	0.000186795	rs761497245
--	SLC23A3	379	F/V	0.000147686	rs539482589
--	SLC23A3	386	S/P	0.00015631	rs764056603
--	SLC23A3	461	E/Q	0.000140535	rs368867994

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
No data

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data