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Disease |
Detail Data SLC22A9
Basic description
Gene Name | SLC22A9 |
---|---|
Protein Name | Solute carrier family 22 member 9 (Organic anion transporter 7) |
Family | SLC22 |
Category | - |
Reaction name | - |
Reaction | - |
[Overview]
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 MAFQDLLGHA GDLWRFQILQ TVFLSIFAVA TYLHFMLENF TAFIPGHRCW VHILDNDTVS DNDTGALSQD ALLRISIPLD SNMRPEKCRR FVHPQWQLLH LNGTFPNTSD ADMEPCVDGW VYDRISFSST IVTEWDLVCD SQSLTSVAKF VFMAGMMVGG ILGGHLSDRF GRRFVLRWCY LQVAIVGTCA ALAPTFLIYC SLRFLSGIAA MSLITNTIML IAEWATHRFQ AMGITLGMCP SGIAFMTLAG LAFAIRDWHI LQLVVSVPYF VIFLTSSWLL ESARWLIINN KPEEGLKELR KAAHRSGMKN ARDTLTLEIL KSTMKKELEA AQKKKPSLCE MLHMPNICKR ISLLSFTRFA NFMAYFGLNL HVQHLGNNVF LLQTLFGAVI LLANCVAPWA LKYMNRRASQ MLLMFLLAIC LLAIIFVPQE MQTLREVLAT LGLGASALAN TLAFAHGNEV IPTIIRARAM GINATFANIA GALAPLMMIL SVYSPPLPWI IYGVFPFISG FAFLLLPETR NKPLFDTIQD EKNERKDPRE PKQEDPRVEV TQF CCHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCEE EEECCCCCCC CCCCCCCCHH HHHEEECCCC CCCCCHHHCC CCCCCCCCEE CCCCCCCCCC CCCCCCCCCC CCCCCCCEEE EHHHHHHHCC HHHHHHHHHH HHHHHHHHHH HHCCCHHHCC CHHHHHHHHH HHHHHHHHHH CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CHHHHHHHHH HHHHHCCCCC CHHHHHHHHH HHHHHHHHHH HHHCCCHHHH HHCCHHHHHH HHHHHHHHHH HHHHHHHHHH CHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCHH HCHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCH HHCHHHHHHH HHHHHCHHHC CCCCCCCHHH HHHCCCCCCC CCCCCCCCCC CCC
[Overview]
SLC22A1 --------------------------------MP--------------------------------------------------------------------------------------------------------------------------------------------------------------------TVDDILEQV---GESGWFQKQAFLILC-LLSAAFAPICVGIVFLGFTPDHH-CQSPGV-AELSQ---------RCGW-----------------SPAEELNYTVPGL-GPAGEA--------------FLGQCRRYEVDWNQ------SALSCVDPLASLATNRS-------------HLPLGP-------------C-QDGW------------VYD-TP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSL----------GVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYM---SMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIM-YQMAFTVGLVALTGLAYAL----------------PHWRWLQLAVSLPTFLFLLYYW--CVPESP------RWLLSQKRNTEAIKIMDHIAQKNGKL-------PPA---D--LKML-SLEEDV------TEKLSPSFADLF----------------------------RTPRLRKRTFILMYLWFTDSVLYQGLILHMGATS----------------------------------------------------------------------------------------------------------------------GN----------LYLDFLYSALVEIPGAFIALITIDR--VGRIYPMA---MSNLLAGAACLVMIFISP---------------------------DLHWLNII----IMCVGRMGITIAIQMICLVNAELYPTF-----------VRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTL-LL---P-ETKGVA---LPETMKDAEN-LGRK--------------A-----KPK----ENTIYLKVQTSE---------------PSGT-------- SLC22A10 --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FEELLSQV---GGLGRFQMLHLVFIL-PSLMLLIPHILLENFAAAIPGHR-C-----------------------WVHMLDNNTGSGNETGILSEDALLRISIPLD--------------SNL----RPEKCRRFV----------HPQWQLLHLNGTIH-STS-------------EADTEP-------------C-VDGW------------VYD-QSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGI----------IGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFP---VYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVIL-SSGALSIGQIILGGLAYVF----------------RDWQTLHVVASVPFFVFFLLSR--WLVESA------RWLIITNKLDEGLKALRKVARTNGIK-------NAEETLN--IEVVRSTMQEE-LDAAQTKT---TVCDLF----------------------------RNPSMRKRICILVFLRFANTIPFYGTMVNLQHVG----------------------------------------------------------------------------------------------------------------------SN----------IFLLQVLYGAVALIVRCLALLTLNH--MGRRISQI---LFMFLVGLSILANTFVPK---------------------------EMQTLRVA----LACLGIGCSAATFSSVAVHFIELIPTV-----------LRARASGIDLTASRIGAALAPLLMT-LTVFFTTLPWIIYGIFPIIGGLIVF-LL---P-ETKNLP---LPDTIKDVEN-------------------Q-----K-K----NLKEKA--------------------------------- SLC22A11 --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSKLLEQA---GGVGLFQTLQVLTFI-LPCLMIPSQMLLENFSAAIPGHR-C-----------------------WTHMLDNGSAVST---NMTPKALLTISIPPG--------------PNQ----GPHQCRRFR----------QPQWQLLDPNATAT-SWS-------------EADTEP-------------C-VDGW------------VYD-RSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSF----------IWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFV---IYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTV-VGCAFSAGQAALGGLAFAL----------------RDWRTLQLAASVPFFAISLISW--WLPESA------RWLIIKGKPDQALQELRKVARINGHK-------EAKN-LT--IEVLMSSVKEE-VASAKEPR---SVLDLF----------------------------CVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLG----------------------------------------------------------------------------------------------------------------------RD----------IFLLQALFGAVDFLGRATTALLLSF--LGRRTIQA---GSQAMAGLAILANMLVPQ---------------------------DLQTLRVV----FAVLGKGCFGISLTCLTIYKAELFPTP-----------VRMTADGILHTVGRLGAMMGPLILM-SRQALPLLPPLLYGVISIASSLVVLFFL---P-ETQGLP---LPDTIQDLES-------------------Q-----K-S----TAAQGNRQEAVTV-----ESTSL---------------- SLC22A12 --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSELLDLV---GGLGRFQVLQTMALM-VSIMWLCTQSMLENFSAAVPSHR-C-----------------------WAPLLDNSTAQASILGSLSPEALLAISIPPG--------------PNQ----RPHQCRRFR----------QPQWQLLDPNATAT-SWS-------------EADTEP-------------C-VDGW------------VYD-RSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAA----------ACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFP---VYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTL-NSLGFSFGHGLTAAVAYGV----------------RDWTLLQLVVSVPFFLCFLYSW--WLAESA------RWLLTTGRLDWGLQELWRVAAINGKG-------AVQDTLT--PEVLLSAMREE-LSMGQPPA---SLGTLL----------------------------RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALG----------------------------------------------------------------------------------------------------------------------SN----------IFLLQMFIGVVDIPAKMGALLLLSH--LGRRPTLA---ASLLLAGLCILANTLVPH---------------------------EMGALRSA----LAVLGLGGVGAAFTCITIYSSELFPTV-----------LRMTAVGLGQMAARGGAILGPLVRL-LGVHGPWLPLLVYGTVPVLSGLAAL-LL---P-ETQSLP---LPDTIQDVQN-------------------Q-----AVK----KATHGTLGNSV-L-----KSTQF---------------- SLC22A13 --------------------------------MA--------------------------------------------------------------------------------------------------------------------------------------------------------------------QFVQVLAEI---GDFGRFQIQLLILLC-VLNFLSPFYFFAHVFMVLDEPHH-CA--------------------VAWV---------KNHTFNLSAAEQLVLSVPLD--------------TAG----HPEPCLMFR----------PPP-----ANASLQ-DIL--SHR--------FNETQP-------------C-DMGW------------EYP-ENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTL----------MFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFE---LYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVL-AQCNFSLGQMVLAGLAYGF----------------RNWRLLQITGTAPGLLLFFYFW--ALPESA------RWLLTRGRMDEAIQLIQKAASVNRRK------------LS--PELMNQLVPEK-TGPSG------NALDLF----------------------------RHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFG----------------------------------------------------------------------------------------------------------------------LD----------VYLTQLIFGAVEVPARCSSIFMMQR--FGRKWSQL---GTLVLGGLMCIIIIFIPA---------------------------DLPVVVTM----LAVVGKMATAAAFTISYVYSAELFPTI-----------LRQTGMGLVGIFSRIGGILTPLVIL-LGEYHAALPMLIYGSLPIVAGLLCT-LL---P-ETHGQG---LKDTLQDLEL---------------GPHPR-----SPK----SVPSEKETEAKGR-----TSSPG-------VAFVSSTYF SLC22A14 --------------------------------MAGE----------------ENFKEEL--------------------------------------------------RSQDAS----------RNLNQ--------HEVAGHPHSWSL-------------------EMLLRRL-------------RAVHTKQDDKFANLLDAV---GEFGTFQQRLVALTF-IPSIMSAFFMFADHFVFTAQKPY-CN--------------------TSWILAVGP---------HLSKAEQLNLTIPQA--------------PNG----SFLTCFMYL----------PVPWNL----DSII-QFG-------------LNDTDT-------------C-QDGW------------IYP-DAK-KRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSL----------IFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFH---LYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIIL-GHCFFAVGAVLLTGIAYSL----------------PHWQLLFLVGGILVIPFISYIW--ILPESP------RWLMMKGKVKEAKQVLCYAASVNKKT-------------------IPSNLLDE-LQLPRKKVTRASVLDFC----------------------------KNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELG----------------------------------------------------------------------------------------------------------------------VS----------VHFRHVVPSIMEVPARLCCIFLLQQ--IGRKWSLA---VTLLQAIIWCLLLLFLPEGEDGLRLKWPRCP------------ATELKSMTIL----VLMLREFSLAATVTVFFLYTAELLPTV-----------LRATGLGLVSLASVAGAILS--LTI-ISQTPSLLPIFLCCVLAIVAFSLSS-LL---P-ETRDQP---LSESLNHSSQ-IR----------------N-----KVK----DMKTKETSSDDV--------------------------- SLC22A15 --------------------------------ME---------------------------------------------------------------------------------------------------------------------------------------------------------------------VEEAFQAV---GEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH-------------------------W---------------------DLAELLPNQ--------------SHG--------------------------------------NQSAGEDQ---------------------------A-FGDWLLTANGSEIHKHVHF-SSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVI----------SFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYE---FFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSI-GGLFFAVGIAQYALLGYFI----------------RSWRTLAILVNLQGTVVFLLSL--FIPESP------RWLYSQGRLSEAEEALYLIAKRNRKL-------KCTFSLT--HPANRSCRETG------------SFLDLF----------------------------RYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLG----------------------------------------------------------------------------------------------------------------------GS----------IYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLS---AFLCLGGLACLIVMFLPEKK-------------------------DTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTV-----------IRNVGLGTCSMFSRVGGIIAPFIPS-LKYVQWSLPFIVFGATGLTSGLLSL-LL---P-ETLNSP---LLETFSDLQV-YSYRRLGEEALSLQALDPQQC---VDK----ESSLGSESEEEEEFYDADEETQMIK-------------- SLC22A16 ------------------------------MGSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------HFEGIYDHV---GHFGRFQRVLYFICA-FQNISCGIHYLASVFMGVTPHHV-CRPPG---NVSQVVFH----NHSNW-----------------S----LEDTGAL--LSSGQKDYVTVQLQNGE-IWELSRCSRNKRE-----------------------NTS-------------SLGYEY-----TGSKKEFPC-VDGY------------IYD-QNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSV----------TFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYY---TFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH-LHSFFAVGTLLVALTGYLV----------------RTWWLYQMILSTVTVPFILCCW--VLPETP------FWLLSEGRYEEAQKIVDIMAKWN-----------RASSCK--LSELLSLDLQGPVSNSPTEVQKHNLSYLF----------------------------YNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLG----------------------------------------------------------------------------------------------------------------------GN----------EYLNLFLLGVVEIPAYTFVCIAMDK--VGRRTVLA---YSLFCSALACGVVMVIPQ---------------------------KHYILGVV----TAMVGKFAIGAAFGLIYLYTAELYPTI-----------VRSLAVGSGSMVCRLASILAPFSVD-LSSIWIFIPQLFVGTMALLSGVLTL-KL---P-ETLGKR---LATTWEEAAK-LESE--------------N-----ESK----SSKLLLTTNNSGL-----EKTEA--ITPRDSGLGE---- SLC22A17 --------------------------------MASD----------------PIFTLA-------------------------------------------------------------------PPLH---------CHYGAFP-----------------------------------------------------------PNA---SG-------------W-----------------EQP-----------PNASGVSV----------------------------------ASAALA-ASAASRVATS---TD-------PSCSGFA----------PPD-------------FN-----------H--------------------C-LKDW------------DYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYL----------FLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSST---GVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALA-GELVGVGGHFLFLGLALVS----------------KDWRFLQRMITAPCILFLFYGWPGLFLESA------RWLIVKRQIEEAQSVLRILAERNR---------PHGQMLG---EEAQEALQDLENTCPLPATSSFSFASLL----------------------------NYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGS-------------------------------------------------------------------------------------------------------------------P--SD----------FYLCSLLASGTAALACVFLGVTVDR--FGRRGILL---LSMTLTGIASLVLLGLWD---------CEHPIFPTVWAQQGNPNRDLNEAAIT---TFSVLGLFSSQAAAILSTLLAAEVIPTT-----------VRGRGLGLIMALGALGGLSGPAQRL-HMGHGAFLQHVVLAACALLCILSIM-LL---P-ETKRKL---LPEVLRDGEL-CRRPSLLR------QPPPT-----RCD----HVPLLAT--------------------PNPAL------- SLC22A18 --------------------------------MQGA---------------------------------------RA-------------------------------------------------------------------PRDQGRSP----------------------------------------------------------GRMSALGRSSVILLT-------------------------------------------------YV----------------------------------------------------------------------------------------------------LAATELT------------C-----------------LFM-QFSIVPYLSRKLGL------------DSIAFGYLQTTF-GVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGR-LGLCFGVGVILGSLLGGTLVSAYGIQCP-------------AILAALATLLGAVLSF-TCIPAST-----------------------KGAKTDAQAPLPG--GPRASVFD--LKAIASLLRLP------------DVPRIF----------LVKVASNCP-----------------TGLFMVMFSIISMDFFQLEAAQAGYL----------------------------------------------------------------------------------------------------------------------MS--------FFGLLQMVTQGLV----------------IGQLSSHF---SEEVLLRASVLVFIVVGL---------------------------AMAWMSSV--FHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTS--------DTGTMLGLCASVQPLLRTLGPTVGG-LLYRSFGVP--VFGHVQVAINTLVLLVLWRKP----------MPQ--------------------------R-----KDKV---R-------------------------------------- SLC22A2 --------------------------------MP-------------------------------------------------------------------------------------------------------------------------------------------------------------------TTVDDVLEHG---GEFHFFQKQMFFLLA-LLSATFAPIYVGIVFLGFTPDHR-CRSPGV-AELSL---------RCGW-----------------SPAEELNYTVPGP-GPAGEA--------------SPRQCRRYEVDWNQ------STFDCVDPLASLDTNRS-------------RLPLGP-------------C-RDGW------------VYE-TP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSM----------SIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYT---WMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF-YQVAYTVGLLVLAGVAYAL----------------PHWRWLQFTVSLPNFFFLLYYW--CIPESP------RWLISQNKNAEAMRIIKHIAKKNGKS-------LPA---S--LQRL-RLEEET------GKKLNPSFLDLV----------------------------RTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAG----------------------------------------------------------------------------------------------------------------------DN----------IYLDFFYSALVEFPAAFMIILTIDR--IGRRYPWA---ASNMVAGAACLASVFIPG---------------------------DLQWLKII----ISCLGRMGITMAYEIVCLVNAELYPTF-----------IRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVL-LL---P-ETKGKA---LPETIEEAEN-MQRP--------------R-----KNK----EKMIYLQVQKLD--------------IPLN--------- SLC22A20 ------------------------------MAMA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FTDLLDAL---GSMGRFQLNHTALLL-LPCGLLACHNFLQNFTAAVPPHH-CRGPANHTEASTNDS-------GAW----------------------LRATIPLD--------------QLG----APEPCRRFT----------KPQWALLSPNSSIP-----------------GAATEG-------------C-KDGW------------VYN-RSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAA----------VFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFS---AYCVFRFLMGMTFSGIILNSVSLVASRV--------------------------IPLAP----------------PAW---QVPVSC--------------TESAEGGCNEREEGGRGKADQGGDELLHPKRV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CK----------CLHLQLNLGPLPNPGHPQGHM-LSH--GDLRGRQ----------------------------------------------------------------------------------------------------RSSGSG------EQGGSCEP------ESRNGRLPA----------------VA---P-AGLGLPFVHLPLSAREKQI-LS----------------S-----KFQ----S-------------------------------------- SLC22A23 MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASA----------------PLGGRAG--------------------------------------------------PGGGAEIQ------PLPPLHPGGGPHPSCCSAAAAPS------------------------LLLL-----------------------DYDGSVLPFL---GGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFW-CRGAGKGTELAGVTTTGRGGDMGNWT----------------SLPTTPFATAPWE-AAGNRSNSSG---ADGGDTPPLPS---------------PPDKGD---------NAS-----------N--------------------CDCRAW------------DYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYL----------ITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVT---MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMV-ASFVAMAGQFLMPGLAALC----------------RDWQVLQALIICPFLLMLLY-W-SIFPESL------RWLMATQQFESAKRLILHFTQKNRMN-------PEGDIKGVIPELEKELSRRPKKVC---------IVKVV----------------------------GTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVK----------------------------------------------------------------------------------------------------------------VPLLEN----------FYADYYTTASIALVSCLAMCVVVRF--LGRRGGLL---LFMILTALASLLQLGLLN----LIGKYSQHP-------DSGMSDSVKDKFSI----AFSIVGMFASHAVGSLSVFFCAEITPTV-----------IRCGGLGLVLASAGFGMLTAPIIEL-HNQKGYFLHHIIFACCTLICIICIL-LL---P-ESRDQN---LPENISNGEH-YTRQPLL----------PH-----KKG----EQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM SLC22A25 --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FQDLLDQV---GGLGRFQILQMVFLI-MFNVIVYHQTQLENFAAFILDHR-C-----------------------WVHILDNDTIPDNDPGTLSQDALLRISIPFD--------------SNL----RPEKCRRFV----------HPQWKLIHLNGTFP-NTS-------------EPDTEP-------------C-VDGW------------VYD-QSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGN----------LYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTIL---VYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTL-TLCAASIGHITLGSLAFVI----------------RDQCILQLVMSAPCFVFFLFSR--WLAESA------RWLIINNKPEEGLKELRKAAHRNGMK-------NAEDILT--MEVLKSTMKQE-LEAAQKKH---SLCELL----------------------------RIPNICKRICFLSFVRFASTIPFWGLTLHLQHLG----------------------------------------------------------------------------------------------------------------------NN----------VFLLQTLFGAVTLLANCVAPWALNH--MSRRLSQM---LLMFLLATCLLAIIFVPQ---------------------------EMQTLRVV----LATLGVGAASLGITCSTAQENELIPSI-----------IRGRATGITGNFANIGGALASLMMI-LSIYSRPLPWIIYGVFAILSGLVVL-LL---P-ETRNQP---LLDSIQDVEN-------------------E-----G-V----NSLAAPQ---R-S-----SVL------------------ SLC22A3 --------------------------------MP--------------------------------------------------------------------------------------------------------------------------------------------------------------------SFDEALQRV---GEFGRFQRRVFLLLC-LTGVTFAFLFVGVVFLGTQPDHYWCRGPSA-AALAE---------RCGW-----------------SPEEEWNRTAPASRGPEPPE--------------RRGRCQRYLLEAANDSASATSALSCADPLAAFP-NRS--------------APLVP-------------C-RGGW------------RYA-QA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAF----------TLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFP---VFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIV-IQMFFTLGIIILPGIAYFI----------------PNWQGIQLAITLPSFLFLLYYW--VVPESP------RWLITRKKGDKALQILRRIAKCNGKY-------LSS---N--YSEI-TVTDE--------EVSNPSFLDLV----------------------------RTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIG----------------------------------------------------------------------------------------------------------------------GN----------LYIDFFISGVVELPGALLILLTIER--LGRRLPFA---ASNIVAGVACLVTAFLPE---------------------------GIAWLRTT----VATLGRLGITMAFEIVYLVNSELYPTT-----------LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVM-LL---P-ETKGIA---LPETVDDVEK-LGSP--------------HSCKCGRNK----KT-------------------------PVSRSHL----- SLC22A32 --------------------------------MG--------------------------------------WG-----------------------------------GGGGCTPR--------PPIHQ----QP--------PER---------------------------------------------------------------------RVVTVVFLG-LLLDLLAFTLLLPLLPGLLESHGRAHDP----------------LYGSW--------------------------------------------QGG-------------------------------------------------------------------------V---DWF---------------ATAIGMPVEKRYNSV--------------LFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFA---AFLASRLIGGISKGNVSLST-AIVADLGSPLARSQGMAV-IGVAFSLGFTLGPMLGASL------PLEM------APWFALLFAASDLLFIF------CFLPETL--PLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLS-------------------------SLRRLG-----------------------------------------LVYFLYLFLFSGLEYTLSFLT---------------------------------HQRFQF-------------------------------------------------------------------------------SS----LQQGKMFFLIGLTMATIQGA-------------YARRIHPGGE-----VAAVKRALLLLVPA--FLLIG-----------W-----------------GRSLPVLGLGLLLYSFAAAVVV-----PCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASV--------YWLAGAQACFTTWSGLFLL---P--------FFLLQKLSYPAQ-------------------------TLKA---E-------------------------------------- SLC22A4 --------------------------------MR--------------------------------------------------------------------------------------------------------------------------------------------------------------------DYDEVIAFL---GEWGPFQRLIFFLLS-ASIIPNGFNGMSVVFLAGTPEHR-CRVPDA-ANLS-----------SAW-----------------R-----NNSVPLR-LRDGRE--------------VPHSCSRYR-------------------LATIA-NFS-------------ALGLEPGRDVDLGQLEQESC-LDGW------------EFS-QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSF----------VSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWE---MFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFI----------------RDWRMLLLALTVPGVLCVPLWW--FIPESP------RWLISQRRFREAEDIIQKAAKMNNIA-------VPAVIFD--SVE--ELNPL--------KQQKAFILDLF----------------------------RTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLH----------------------------------------------------------------------------------------------------------------------GD----------AYLNCFLSALIEIPAYITAWLLLRT--LPRRYIIA---AVLFWGGGVLLFIQLVPV---------------------------DYYFLSIG----LVMLGKFGITSAFSMLYVFTAELYPTL-----------VRNMAVGVTSTASRVGSIIAPYFVY-LGAYNRMLPYIVMGSLTVLIGILTL-FF---P-ESLGMT---LPETLEQMQK-VKWF--------------R-----SGK----KTRDSMETEEN----------------PKVL-ITAF--- SLC22A5 --------------------------------MR--------------------------------------------------------------------------------------------------------------------------------------------------------------------DYDEVTAFL---GEWGPFQRLIFFLLS-ASIIPNGFTGLSSVFLIATPEHR-CRVPDA-ANLS-----------SAW-----------------R-----NHTVPLR-LRDGRE--------------VPHSCRRYR-------------------LATIA-NFS-------------ALGLEPGRDVDLGQLEQESC-LDGW------------EFS-QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSF----------ISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFE---MFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFI----------------RDWRMLLVALTMPGVLCVALWW--FIPESP------RWLISQGRFEEAEVIIRKAAKANGIV-------VPSTIFD--PSELQDLSSK--------KQQSHNILDLL----------------------------RTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLH----------------------------------------------------------------------------------------------------------------------GD----------IFVNCFLSAMVEVPAYVLAWLLLQY--LPRRYSMA---TALFLGGSVLLFMQLVPP---------------------------DLYYLATV----LVMVGKFGVTAAFSMVYVYTAELYPTV-----------VRNMGVGVSSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTL-FL---P-ESFGTP---LPDTIDQMLR-VKGM--------------K-----HRKT-PSHTRMLKDGQER----------------PTILKSTAF--- SLC22A6 --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FNDLLQQV---GGVGRFQQIQVTLVV-LPLLLMASHNTLQNFTAAIPTHH-CR-PPADANLSKNGG------LEVW--------------------------LPRD--------------RQG----QPESCLRFT----------SPQWGLPFLNGTEA-NGT--------------GATEP-------------C-TDGW------------IYD-NSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAM----------VFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFP---IYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSLGQFLLAGVAYAV----------------PHWRHLQLLVSAPFFAFFIYSW--FFIESA------RWHSSSGRLDLTLRALQRVARINGKR-------EEGAKLS--MEVLRASLQKE-LTMGKGQA---SAMELL----------------------------RCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFG----------------------------------------------------------------------------------------------------------------------VS----------IYLIQVIFGAVDLPAKLVGFLVINS--LGRRPAQM---AALLLAGICILLNGVIPQ---------------------------DQSIVRTS----LAVLGKGCLAASFNCIFLYTGELYPTM-----------IRQTGMGMGSTMARVGSIVSPLVSM-TAELYPSMPLFIYGAVPVAASAVTV-LL---P-ETLGQP---LPDTVQDLESRWAPTQ------KEAGIYPR-----KGK----QTRQQQEHQK--------YMVPLQASAQEKNGL------ SLC22A7 --------------------------------MG---------------------------------------------------------------------------------------------------------------------------------------------------------------------FEELLEQV---GGFGPFQLRNVALLA-LPRVLLPLHFLLPIFLAAVPAHR-CALPGAPANFSHQ---------DVW----------------------LEAHLPRE--------------PDG----TLSSCLRFA----------YPQ--------ALP-NTTLGEERQSRGELEDEPATVP-------------C-SQGW------------EYD-HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAV----------AFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYV---MFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVL-SSTFWTGGVMLLALVGYLI----------------RDWRWLLLAVTLPCAPGILSLW--WVPESA------RWLLTQGHVKEAHRYLLHCARLNGRP-------VCEDSFS--QEAVSKVAAGE-RVVRRP-----SYLDLF----------------------------RTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLG----------------------------------------------------------------------------------------------------------------------LN----------VYQTQLLFGAVELPSKLLVYLSVRY--AGRRLTQA---GTLLGTALAFGTRLLVSS---------------------------DMKSWSTV----LAVMGKAFSEAAFTTAYLFTSELYPTV-----------LRQTGMGLTALVGRLGGSLAPLAAL-LDGVWLSLPKLTYGGIALLAAGTAL-LL---P-ETRQAQ---LPETIQDVER---------------------------K----SAPTSLQEEEMPM-----KQVQN---------------- SLC22A8 --------------------------------MT---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSEILDRV---GSMGHFQFLHVAILG-LPILNMANHNLLQIFTAATPVHH-CR-PPHNASTGP------------WV-------------------------LPMG--------------PNG----KPERCLRFV----------HPP------NASLP-NDT-------------QRAMEP-------------C-LDGW------------VY--NST-KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGL----------VLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP---IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA-LGYCYTFGQFILPGLAYAI----------------PQWRWLQLTVSIPFFVFFLSSW--WTPESI------RWLVLSGKSSKALKILRRVAVFNGKK-------EEGERLS--LEELKLNLQKE-ISLAKAKY---TASDLF----------------------------RIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFG----------------------------------------------------------------------------------------------------------------------VN----------LYILQIIFGGVDVPAKFITILSLSY--LGRHTTQA---AALLLAGGAILALTFVPL---------------------------DLQTVRTV----LAVFGKGCLSSSFSCLFLYTSELYPTV-----------IRQTGMGVSNLWTRVGSMVSPLVKI-TGEVQPFIPNIIYGITALLGGSAAL-FL---P-ETLNQP---LPETIEDLEN-WS----------------L-----RAK----KPKQEPEVEKA-S-----QRIPLQPHGP---GLGSS--- SLC22A9 --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FQDLLGHA---GDLWRFQILQTVFLS-IFAVATYLHFMLENFTAFIPGHR-C-----------------------WVHILDNDTVSDNDTGALSQDALLRISIPLD--------------SNM----RPEKCRRFV----------HPQWQLLHLNGTFP-NTS-------------DADMEP-------------C-VDGW------------VYD-RISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGI----------LGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFL---IYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITL-GMCPSGIAFMTLAGLAFAI----------------RDWHILQLVVSVPYFVIFLTSS--WLLESA------RWLIINNKPEEGLKELRKAAHRSGMK-------NARDTLT--LEILKSTMKKE-LEAAQKKK--PSLCEML----------------------------HMPNICKRISLLSFTRFANFMAYFGLNLHVQHLG----------------------------------------------------------------------------------------------------------------------NN----------VFLLQTLFGAVILLANCVAPWALKY--MNRRASQM---LLMFLLAICLLAIIFVPQ---------------------------EMQTLREV----LATLGLGASALANTLAFAHGNEVIPTI-----------IRARAMGINATFANIAGALAPLMMI-LSVYSPPLPWIIYGVFPFISGFAFL-LL---P-ETRNKP---LFDTIQDEKN-------------------E-----R-K----DPREPKQEDPR-V-----EVTQF---------------- SLC22B1 --------------------------------MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPSDGYYRGEGTQDEEE---GGASSDATEGHDEDDEIYE--------GEYQGIPRAESGG---------KGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLG-LALMADGVEVFVVGFV--LPSAE-KD----------------------M------------------------------------------------------------------------------------------------------------------------C-LSDS----------------NKGMLGLIV--------------------YLGMMVGAF----------LWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYG---TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSW-LCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALT--TQPESP------RFFLENGKHDEAWMVLKQVHDTNMRAK-----GHPERVFS--VTHIKTIHQED------------ELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPL------DVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDK--IGRLRMLA---GSSVMSCVSCFFLSFGNS-ESAMIA--------------------------------LLCLFGGVSIASWNALDVLTVELYPSD-----------KRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL-KL---P-ETRGQV---LQ------------------------------------------------------------------------------- SLC22B2 --------------------------------MDDY-------------------------------KYQDNYG--------------GY-APSDGYYRGNESNPEED-----AQSDVTEGHDEEDEIYE--------GEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDL------------------MAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLG-LALMADGVEVFVVSFA--LPSAE-KD----------------------M------------------------------------------------------------------------------------------------------------------------C-LSSS----------------KKGMLGMIV--------------------YLGMMAGAF----------ILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG---AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSW-LGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALK--FMPESP------RFLLEMGKHDEAWMILKQVHDTNMRAK-----GTPEKVFT--VSNIKTPKQMD------------EFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLE--QDND------FLIYLVSFLGSLSVLPGNIISALLMDR--IGRLKMIG---GSMLISAVCCFFLFFGNS-ESAMIG--------------------------------WQCLFCGTSIAAWNALDVITVELYPTN-----------QRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIAL-RL---P-ETREQV---LM------------------------------------------------------------------------------- SLC22B3 --------------------------------MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDY-YPAGETYNGEANDDE-------GSSEATEGHDEDDEIYE--------GEYQGIPSMNQAKDSIVSVGQPKGDEYKDRREL------------------ESERRADEEELAQQYELIIQECGHGRFQWALFFVLG-MALMADGVEVFVVGFV--LPSAE-TD----------------------L------------------------------------------------------------------------------------------------------------------------C-IPNS----------------GSGWLGSIV--------------------YLGMMVGAF----------FWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYG---FFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSW-LCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALT--FMPESP------RFLLEVGKHDEAWMILKLIHDTNMRAR-----GQPEKVFT--VNKIKTPKQID------------ELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFD--DDYS-----AYWIYFVNFLGTLAVLPGNIVSALLMDR--IGRLTMLG---GSMVLSGISCFFLWFGTS-ESMMIG--------------------------------MLCLYNGLTISAWNSLDVVTVELYPTD-----------RRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGL-CL---P-DTRTQV---LM------------------------------------------------------------------------------- SLC22B4 --------------------------------MEED------LF--------QLRQLPVVKFRRT----------------------------------GESARSEDDTASGEHEVQIEGVHVGLEAVEL--------DDGAAVPKE------------------------------------------FANPTDDTFMVEDAVEAI----GFGKFQWKLSVLTG-LAWMADAMEMMILSIL--APQLH-CE----------------------W------------------------------------------------------------------------------------------------------------------------R-LPSW----------------QVALLTSVV--------------------FVGMMSSST----------LWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYS---WILVLRGLVGFGIGG-VPQSVTLYAEFLPMKARAKCILL-IEVFWAIGTVFEVVLAVFVMPSLG-------------WRWLLILSAVPLLLFAVLCF--WLPESA------RYDVLSGNQEKAIATLKRIATENGAP-------MPLGKLI--ISRQEDRGKMR------------DL--------------------------------FTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAV----------------------------------------------------------EAKCSLA------------------------------CEYLSE--ED-----------YMDLLWTTLSEFPGVLVTLWIIDR--LGRKKTMAL---CFVIFSFCSLLLFICVG-RNVLTL--------------------------------LLFIARAFISGGFQAAYVYTPEVYPTA-----------TRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASC-FL---PIETKGRG---LQESSHREWG-------------------QEM-VGRGMHGAGVTRSNSGSQE----------------------------- SLC22B5 --------------------------------MATKPTEPVTIL--------SLRKLSL----------------------------------------------------GTAEPQVKE------------------------PK--------------------------------------------------TFTVEDAVETI----GFGRFHIALFLIMG-STGVVEAMEIMLIAVV--SPVIR-CE----------------------W------------------------------------------------------------------------------------------------------------------------Q-LENW----------------QVALVTTMV--------------------FFGYMVFSI----------LFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYI---WFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGYMLPL-SQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFK--FIPESA------RFNVSTGNTRAALATLERVAKMNRSV-------MPEGKLV--EPVLEKRGRFA------------DL--------------------------------LDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVV---------------------------------------------------VTGGDSGESQSPCY------------------------------CHMFAP--SD-----------YRTMIISTIGEIALNPLNILGINF--LGRRLSLSITMGCTALF---FLLLNICTS-SAGLIG--------------------------------FLFMLRALVAANFNTVYIYTAEVYPTT-----------MRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAF-TL---PIETKGRA---LQQIK----------------------------------------------------------------------------
Variant
check | gene name | residue number | Reference Amino Acid / Variant Amino Acid | minor allele frequency | rs number |
---|---|---|---|---|---|
-- | SLC22A9 | 80 | D/G | 0.000274808 | rs139996395 |
-- | SLC22A9 | 81 | S/P | 0.000641184 | rs112075331 |
-- | SLC22A9 | 132 | V/M | 0.000130894 | rs140912333 |
-- | SLC22A9 | 164 | G/S | 0.000119661 | rs138297035 |
-- | SLC22A9 | 174 | F/L | 0.000418445 | rs202164269 |
-- | SLC22A9 | 184 | I/T | 0.00101714 | rs80034352 |
-- | SLC22A9 | 195 | D/V | 0.000478904 | rs79899382 |
-- | SLC22A9 | 203 | R/H | 0.00101989 | rs372527720 |
-- | SLC22A9 | 238 | Q/K | 0.000103641 | rs200498139 |
-- | SLC22A9 | 244 | A/V | 0.000151612 | rs139591412 |
-- | SLC22A9 | 247 | T/S | 0.000478904 | rs79899382 |
-- | SLC22A9 | 256 | R/Q | 0.000451231 | rs3737458 |
-- | SLC22A9 | 289 | N/K | 0.000103641 | rs200498139 |
-- | SLC22A9 | 322 | S/F | 0.00103732 | rs373670819 |
-- | SLC22A9 | 332 | Q/K | 0.000223002 | rs201804022 |
-- | SLC22A9 | 363 | M/V | 0.000605558 | rs182247457 |
-- | SLC22A9 | 403 | Y/H | 0.000995675 | rs78019460 |
-- | SLC22A9 | 411 | M/T | 0.000159415 | rs532350906 |
-- | SLC22A9 | 433 | T/M | 0.0225432 | rs61742518 |
-- | SLC22A9 | 435 | R/H | 0.00134975 | rs144303933 |
-- | SLC22A9 | 435 | R/C | 0.000135789 | rs569298081 |
-- | SLC22A9 | 445 | A/V | 0.00010773 | rs138350283 |
-- | SLC22A9 | 462 | P/T | 0.000778611 | rs147323107 |
-- | SLC22A9 | 479 | I/M | 0.00577079 | rs146027075 |
-- | SLC22A9 | 481 | G/E | 0.000382293 | rs373675567 |
-- | SLC22A9 | 489 | I/T | 0.00035836 | rs371194548 |
-- | SLC22A9 | 512 | A/S | 0.000111481 | rs555730358 |
-- | SLC22A9 | 551 | T/M | 0.000167337 | rs142543443 |
Phylogenetic tree
Pathway
Priority | Gene Name | Reactome (Gene) | Reactome (Pathway) |
---|---|---|---|
No data |
Disease
Gene Name | Reactome (Gene) | Reactome (Pathway) |
---|---|---|
No data |