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Detail Data SLC22A3


Basic description
Gene Name SLC22A3
Protein Name Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3)
Family SLC22
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name OCT3 mediates renal uptake of organic cations
OCT3 mediates renal clearance of organic cations
Reaction 1 OCT3 substrates [extracellular region] --> 1 OCT3 substrates [cytosol]
1 OCT3 substrates [cytosol] --> 1 OCT3 substrates [extracellular region]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550 
MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW CRGPSAAALA ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND SASATSALSC ADPLAAFPNR SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN AWMLDLTQAI LNLGFLTGAF TLGYAADRYG RIVIYLLSCL GVGVTGVVVA FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR IVGIVIQMFF TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC TLILMFAWFT SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT IERLGRRLPF AASNIVAGVA CLVTAFLPEG IAWLRTTVAT LGRLGITMAF EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG GIIAPFLLFR LAAVWLELPL IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS CKCGRNKKTP VSRSHL 
CCCHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCHHHHH HHCCCCHHHH HHCCCCCCCC CCCCCCCCCC EEEEEECCCC CCCCCCCCCC CCCCCCCCCC CCCEEECCCC EEECCCCCCE EECHHHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHCC HHHHHHHHHH HHHHCCCHHH HCCCCCHHHE EEEEECCCCC CCCCCCEEEE EEECCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHCHHHHH HHHHHHHHHH HHHHHCCCCC CHHHHHHCCC HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCCHH HHHCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCHH HHHHHHHHHH HHHHHHCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHCHHH CCCCCCCCHH HHHHHCCCCC CCCCCCCCCC CCCCCC
[Overview] SLC22A1 SLC22A10 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A2 SLC22A20 SLC22A23 SLC22A25 SLC22A3 SLC22A32 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC22A9 SLC22B1 SLC22B2 SLC22B3 SLC22B4 SLC22B5 
SLC22A1   --------------------------------MP--------------------------------------------------------------------------------------------------------------------------------------------------------------------TVDDILEQV---GESGWFQKQAFLILC-LLSAAFAPICVGIVFLGFTPDHH-CQSPGV-AELSQ---------RCGW-----------------SPAEELNYTVPGL-GPAGEA--------------FLGQCRRYEVDWNQ------SALSCVDPLASLATNRS-------------HLPLGP-------------C-QDGW------------VYD-TP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSL----------GVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYM---SMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIM-YQMAFTVGLVALTGLAYAL----------------PHWRWLQLAVSLPTFLFLLYYW--CVPESP------RWLLSQKRNTEAIKIMDHIAQKNGKL-------PPA---D--LKML-SLEEDV------TEKLSPSFADLF----------------------------RTPRLRKRTFILMYLWFTDSVLYQGLILHMGATS----------------------------------------------------------------------------------------------------------------------GN----------LYLDFLYSALVEIPGAFIALITIDR--VGRIYPMA---MSNLLAGAACLVMIFISP---------------------------DLHWLNII----IMCVGRMGITIAIQMICLVNAELYPTF-----------VRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTL-LL---P-ETKGVA---LPETMKDAEN-LGRK--------------A-----KPK----ENTIYLKVQTSE---------------PSGT--------
SLC22A10  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FEELLSQV---GGLGRFQMLHLVFIL-PSLMLLIPHILLENFAAAIPGHR-C-----------------------WVHMLDNNTGSGNETGILSEDALLRISIPLD--------------SNL----RPEKCRRFV----------HPQWQLLHLNGTIH-STS-------------EADTEP-------------C-VDGW------------VYD-QSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGI----------IGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFP---VYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVIL-SSGALSIGQIILGGLAYVF----------------RDWQTLHVVASVPFFVFFLLSR--WLVESA------RWLIITNKLDEGLKALRKVARTNGIK-------NAEETLN--IEVVRSTMQEE-LDAAQTKT---TVCDLF----------------------------RNPSMRKRICILVFLRFANTIPFYGTMVNLQHVG----------------------------------------------------------------------------------------------------------------------SN----------IFLLQVLYGAVALIVRCLALLTLNH--MGRRISQI---LFMFLVGLSILANTFVPK---------------------------EMQTLRVA----LACLGIGCSAATFSSVAVHFIELIPTV-----------LRARASGIDLTASRIGAALAPLLMT-LTVFFTTLPWIIYGIFPIIGGLIVF-LL---P-ETKNLP---LPDTIKDVEN-------------------Q-----K-K----NLKEKA---------------------------------
SLC22A11  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSKLLEQA---GGVGLFQTLQVLTFI-LPCLMIPSQMLLENFSAAIPGHR-C-----------------------WTHMLDNGSAVST---NMTPKALLTISIPPG--------------PNQ----GPHQCRRFR----------QPQWQLLDPNATAT-SWS-------------EADTEP-------------C-VDGW------------VYD-RSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSF----------IWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFV---IYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTV-VGCAFSAGQAALGGLAFAL----------------RDWRTLQLAASVPFFAISLISW--WLPESA------RWLIIKGKPDQALQELRKVARINGHK-------EAKN-LT--IEVLMSSVKEE-VASAKEPR---SVLDLF----------------------------CVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLG----------------------------------------------------------------------------------------------------------------------RD----------IFLLQALFGAVDFLGRATTALLLSF--LGRRTIQA---GSQAMAGLAILANMLVPQ---------------------------DLQTLRVV----FAVLGKGCFGISLTCLTIYKAELFPTP-----------VRMTADGILHTVGRLGAMMGPLILM-SRQALPLLPPLLYGVISIASSLVVLFFL---P-ETQGLP---LPDTIQDLES-------------------Q-----K-S----TAAQGNRQEAVTV-----ESTSL----------------
SLC22A12  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSELLDLV---GGLGRFQVLQTMALM-VSIMWLCTQSMLENFSAAVPSHR-C-----------------------WAPLLDNSTAQASILGSLSPEALLAISIPPG--------------PNQ----RPHQCRRFR----------QPQWQLLDPNATAT-SWS-------------EADTEP-------------C-VDGW------------VYD-RSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAA----------ACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFP---VYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTL-NSLGFSFGHGLTAAVAYGV----------------RDWTLLQLVVSVPFFLCFLYSW--WLAESA------RWLLTTGRLDWGLQELWRVAAINGKG-------AVQDTLT--PEVLLSAMREE-LSMGQPPA---SLGTLL----------------------------RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALG----------------------------------------------------------------------------------------------------------------------SN----------IFLLQMFIGVVDIPAKMGALLLLSH--LGRRPTLA---ASLLLAGLCILANTLVPH---------------------------EMGALRSA----LAVLGLGGVGAAFTCITIYSSELFPTV-----------LRMTAVGLGQMAARGGAILGPLVRL-LGVHGPWLPLLVYGTVPVLSGLAAL-LL---P-ETQSLP---LPDTIQDVQN-------------------Q-----AVK----KATHGTLGNSV-L-----KSTQF----------------
SLC22A13  --------------------------------MA--------------------------------------------------------------------------------------------------------------------------------------------------------------------QFVQVLAEI---GDFGRFQIQLLILLC-VLNFLSPFYFFAHVFMVLDEPHH-CA--------------------VAWV---------KNHTFNLSAAEQLVLSVPLD--------------TAG----HPEPCLMFR----------PPP-----ANASLQ-DIL--SHR--------FNETQP-------------C-DMGW------------EYP-ENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTL----------MFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFE---LYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVL-AQCNFSLGQMVLAGLAYGF----------------RNWRLLQITGTAPGLLLFFYFW--ALPESA------RWLLTRGRMDEAIQLIQKAASVNRRK------------LS--PELMNQLVPEK-TGPSG------NALDLF----------------------------RHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFG----------------------------------------------------------------------------------------------------------------------LD----------VYLTQLIFGAVEVPARCSSIFMMQR--FGRKWSQL---GTLVLGGLMCIIIIFIPA---------------------------DLPVVVTM----LAVVGKMATAAAFTISYVYSAELFPTI-----------LRQTGMGLVGIFSRIGGILTPLVIL-LGEYHAALPMLIYGSLPIVAGLLCT-LL---P-ETHGQG---LKDTLQDLEL---------------GPHPR-----SPK----SVPSEKETEAKGR-----TSSPG-------VAFVSSTYF
SLC22A14  --------------------------------MAGE----------------ENFKEEL--------------------------------------------------RSQDAS----------RNLNQ--------HEVAGHPHSWSL-------------------EMLLRRL-------------RAVHTKQDDKFANLLDAV---GEFGTFQQRLVALTF-IPSIMSAFFMFADHFVFTAQKPY-CN--------------------TSWILAVGP---------HLSKAEQLNLTIPQA--------------PNG----SFLTCFMYL----------PVPWNL----DSII-QFG-------------LNDTDT-------------C-QDGW------------IYP-DAK-KRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSL----------IFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFH---LYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIIL-GHCFFAVGAVLLTGIAYSL----------------PHWQLLFLVGGILVIPFISYIW--ILPESP------RWLMMKGKVKEAKQVLCYAASVNKKT-------------------IPSNLLDE-LQLPRKKVTRASVLDFC----------------------------KNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELG----------------------------------------------------------------------------------------------------------------------VS----------VHFRHVVPSIMEVPARLCCIFLLQQ--IGRKWSLA---VTLLQAIIWCLLLLFLPEGEDGLRLKWPRCP------------ATELKSMTIL----VLMLREFSLAATVTVFFLYTAELLPTV-----------LRATGLGLVSLASVAGAILS--LTI-ISQTPSLLPIFLCCVLAIVAFSLSS-LL---P-ETRDQP---LSESLNHSSQ-IR----------------N-----KVK----DMKTKETSSDDV---------------------------
SLC22A15  --------------------------------ME---------------------------------------------------------------------------------------------------------------------------------------------------------------------VEEAFQAV---GEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH-------------------------W---------------------DLAELLPNQ--------------SHG--------------------------------------NQSAGEDQ---------------------------A-FGDWLLTANGSEIHKHVHF-SSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVI----------SFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYE---FFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSI-GGLFFAVGIAQYALLGYFI----------------RSWRTLAILVNLQGTVVFLLSL--FIPESP------RWLYSQGRLSEAEEALYLIAKRNRKL-------KCTFSLT--HPANRSCRETG------------SFLDLF----------------------------RYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLG----------------------------------------------------------------------------------------------------------------------GS----------IYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLS---AFLCLGGLACLIVMFLPEKK-------------------------DTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTV-----------IRNVGLGTCSMFSRVGGIIAPFIPS-LKYVQWSLPFIVFGATGLTSGLLSL-LL---P-ETLNSP---LLETFSDLQV-YSYRRLGEEALSLQALDPQQC---VDK----ESSLGSESEEEEEFYDADEETQMIK--------------
SLC22A16  ------------------------------MGSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------HFEGIYDHV---GHFGRFQRVLYFICA-FQNISCGIHYLASVFMGVTPHHV-CRPPG---NVSQVVFH----NHSNW-----------------S----LEDTGAL--LSSGQKDYVTVQLQNGE-IWELSRCSRNKRE-----------------------NTS-------------SLGYEY-----TGSKKEFPC-VDGY------------IYD-QNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSV----------TFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYY---TFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH-LHSFFAVGTLLVALTGYLV----------------RTWWLYQMILSTVTVPFILCCW--VLPETP------FWLLSEGRYEEAQKIVDIMAKWN-----------RASSCK--LSELLSLDLQGPVSNSPTEVQKHNLSYLF----------------------------YNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLG----------------------------------------------------------------------------------------------------------------------GN----------EYLNLFLLGVVEIPAYTFVCIAMDK--VGRRTVLA---YSLFCSALACGVVMVIPQ---------------------------KHYILGVV----TAMVGKFAIGAAFGLIYLYTAELYPTI-----------VRSLAVGSGSMVCRLASILAPFSVD-LSSIWIFIPQLFVGTMALLSGVLTL-KL---P-ETLGKR---LATTWEEAAK-LESE--------------N-----ESK----SSKLLLTTNNSGL-----EKTEA--ITPRDSGLGE----
SLC22A17  --------------------------------MASD----------------PIFTLA-------------------------------------------------------------------PPLH---------CHYGAFP-----------------------------------------------------------PNA---SG-------------W-----------------EQP-----------PNASGVSV----------------------------------ASAALA-ASAASRVATS---TD-------PSCSGFA----------PPD-------------FN-----------H--------------------C-LKDW------------DYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYL----------FLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSST---GVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALA-GELVGVGGHFLFLGLALVS----------------KDWRFLQRMITAPCILFLFYGWPGLFLESA------RWLIVKRQIEEAQSVLRILAERNR---------PHGQMLG---EEAQEALQDLENTCPLPATSSFSFASLL----------------------------NYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGS-------------------------------------------------------------------------------------------------------------------P--SD----------FYLCSLLASGTAALACVFLGVTVDR--FGRRGILL---LSMTLTGIASLVLLGLWD---------CEHPIFPTVWAQQGNPNRDLNEAAIT---TFSVLGLFSSQAAAILSTLLAAEVIPTT-----------VRGRGLGLIMALGALGGLSGPAQRL-HMGHGAFLQHVVLAACALLCILSIM-LL---P-ETKRKL---LPEVLRDGEL-CRRPSLLR------QPPPT-----RCD----HVPLLAT--------------------PNPAL-------
SLC22A18  --------------------------------MQGA---------------------------------------RA-------------------------------------------------------------------PRDQGRSP----------------------------------------------------------GRMSALGRSSVILLT-------------------------------------------------YV----------------------------------------------------------------------------------------------------LAATELT------------C-----------------LFM-QFSIVPYLSRKLGL------------DSIAFGYLQTTF-GVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGR-LGLCFGVGVILGSLLGGTLVSAYGIQCP-------------AILAALATLLGAVLSF-TCIPAST-----------------------KGAKTDAQAPLPG--GPRASVFD--LKAIASLLRLP------------DVPRIF----------LVKVASNCP-----------------TGLFMVMFSIISMDFFQLEAAQAGYL----------------------------------------------------------------------------------------------------------------------MS--------FFGLLQMVTQGLV----------------IGQLSSHF---SEEVLLRASVLVFIVVGL---------------------------AMAWMSSV--FHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTS--------DTGTMLGLCASVQPLLRTLGPTVGG-LLYRSFGVP--VFGHVQVAINTLVLLVLWRKP----------MPQ--------------------------R-----KDKV---R--------------------------------------
SLC22A2   --------------------------------MP-------------------------------------------------------------------------------------------------------------------------------------------------------------------TTVDDVLEHG---GEFHFFQKQMFFLLA-LLSATFAPIYVGIVFLGFTPDHR-CRSPGV-AELSL---------RCGW-----------------SPAEELNYTVPGP-GPAGEA--------------SPRQCRRYEVDWNQ------STFDCVDPLASLDTNRS-------------RLPLGP-------------C-RDGW------------VYE-TP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSM----------SIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYT---WMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF-YQVAYTVGLLVLAGVAYAL----------------PHWRWLQFTVSLPNFFFLLYYW--CIPESP------RWLISQNKNAEAMRIIKHIAKKNGKS-------LPA---S--LQRL-RLEEET------GKKLNPSFLDLV----------------------------RTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAG----------------------------------------------------------------------------------------------------------------------DN----------IYLDFFYSALVEFPAAFMIILTIDR--IGRRYPWA---ASNMVAGAACLASVFIPG---------------------------DLQWLKII----ISCLGRMGITMAYEIVCLVNAELYPTF-----------IRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVL-LL---P-ETKGKA---LPETIEEAEN-MQRP--------------R-----KNK----EKMIYLQVQKLD--------------IPLN---------
SLC22A20  ------------------------------MAMA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FTDLLDAL---GSMGRFQLNHTALLL-LPCGLLACHNFLQNFTAAVPPHH-CRGPANHTEASTNDS-------GAW----------------------LRATIPLD--------------QLG----APEPCRRFT----------KPQWALLSPNSSIP-----------------GAATEG-------------C-KDGW------------VYN-RSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAA----------VFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFS---AYCVFRFLMGMTFSGIILNSVSLVASRV--------------------------IPLAP----------------PAW---QVPVSC--------------TESAEGGCNEREEGGRGKADQGGDELLHPKRV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CK----------CLHLQLNLGPLPNPGHPQGHM-LSH--GDLRGRQ----------------------------------------------------------------------------------------------------RSSGSG------EQGGSCEP------ESRNGRLPA----------------VA---P-AGLGLPFVHLPLSAREKQI-LS----------------S-----KFQ----S--------------------------------------
SLC22A23  MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASA----------------PLGGRAG--------------------------------------------------PGGGAEIQ------PLPPLHPGGGPHPSCCSAAAAPS------------------------LLLL-----------------------DYDGSVLPFL---GGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFW-CRGAGKGTELAGVTTTGRGGDMGNWT----------------SLPTTPFATAPWE-AAGNRSNSSG---ADGGDTPPLPS---------------PPDKGD---------NAS-----------N--------------------CDCRAW------------DYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYL----------ITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVT---MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMV-ASFVAMAGQFLMPGLAALC----------------RDWQVLQALIICPFLLMLLY-W-SIFPESL------RWLMATQQFESAKRLILHFTQKNRMN-------PEGDIKGVIPELEKELSRRPKKVC---------IVKVV----------------------------GTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVK----------------------------------------------------------------------------------------------------------------VPLLEN----------FYADYYTTASIALVSCLAMCVVVRF--LGRRGGLL---LFMILTALASLLQLGLLN----LIGKYSQHP-------DSGMSDSVKDKFSI----AFSIVGMFASHAVGSLSVFFCAEITPTV-----------IRCGGLGLVLASAGFGMLTAPIIEL-HNQKGYFLHHIIFACCTLICIICIL-LL---P-ESRDQN---LPENISNGEH-YTRQPLL----------PH-----KKG----EQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM
SLC22A25  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FQDLLDQV---GGLGRFQILQMVFLI-MFNVIVYHQTQLENFAAFILDHR-C-----------------------WVHILDNDTIPDNDPGTLSQDALLRISIPFD--------------SNL----RPEKCRRFV----------HPQWKLIHLNGTFP-NTS-------------EPDTEP-------------C-VDGW------------VYD-QSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGN----------LYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTIL---VYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTL-TLCAASIGHITLGSLAFVI----------------RDQCILQLVMSAPCFVFFLFSR--WLAESA------RWLIINNKPEEGLKELRKAAHRNGMK-------NAEDILT--MEVLKSTMKQE-LEAAQKKH---SLCELL----------------------------RIPNICKRICFLSFVRFASTIPFWGLTLHLQHLG----------------------------------------------------------------------------------------------------------------------NN----------VFLLQTLFGAVTLLANCVAPWALNH--MSRRLSQM---LLMFLLATCLLAIIFVPQ---------------------------EMQTLRVV----LATLGVGAASLGITCSTAQENELIPSI-----------IRGRATGITGNFANIGGALASLMMI-LSIYSRPLPWIIYGVFAILSGLVVL-LL---P-ETRNQP---LLDSIQDVEN-------------------E-----G-V----NSLAAPQ---R-S-----SVL------------------
SLC22A3   --------------------------------MP--------------------------------------------------------------------------------------------------------------------------------------------------------------------SFDEALQRV---GEFGRFQRRVFLLLC-LTGVTFAFLFVGVVFLGTQPDHYWCRGPSA-AALAE---------RCGW-----------------SPEEEWNRTAPASRGPEPPE--------------RRGRCQRYLLEAANDSASATSALSCADPLAAFP-NRS--------------APLVP-------------C-RGGW------------RYA-QA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAF----------TLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFP---VFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIV-IQMFFTLGIIILPGIAYFI----------------PNWQGIQLAITLPSFLFLLYYW--VVPESP------RWLITRKKGDKALQILRRIAKCNGKY-------LSS---N--YSEI-TVTDE--------EVSNPSFLDLV----------------------------RTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIG----------------------------------------------------------------------------------------------------------------------GN----------LYIDFFISGVVELPGALLILLTIER--LGRRLPFA---ASNIVAGVACLVTAFLPE---------------------------GIAWLRTT----VATLGRLGITMAFEIVYLVNSELYPTT-----------LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVM-LL---P-ETKGIA---LPETVDDVEK-LGSP--------------HSCKCGRNK----KT-------------------------PVSRSHL-----
SLC22A32  --------------------------------MG--------------------------------------WG-----------------------------------GGGGCTPR--------PPIHQ----QP--------PER---------------------------------------------------------------------RVVTVVFLG-LLLDLLAFTLLLPLLPGLLESHGRAHDP----------------LYGSW--------------------------------------------QGG-------------------------------------------------------------------------V---DWF---------------ATAIGMPVEKRYNSV--------------LFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFA---AFLASRLIGGISKGNVSLST-AIVADLGSPLARSQGMAV-IGVAFSLGFTLGPMLGASL------PLEM------APWFALLFAASDLLFIF------CFLPETL--PLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLS-------------------------SLRRLG-----------------------------------------LVYFLYLFLFSGLEYTLSFLT---------------------------------HQRFQF-------------------------------------------------------------------------------SS----LQQGKMFFLIGLTMATIQGA-------------YARRIHPGGE-----VAAVKRALLLLVPA--FLLIG-----------W-----------------GRSLPVLGLGLLLYSFAAAVVV-----PCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASV--------YWLAGAQACFTTWSGLFLL---P--------FFLLQKLSYPAQ-------------------------TLKA---E--------------------------------------
SLC22A4   --------------------------------MR--------------------------------------------------------------------------------------------------------------------------------------------------------------------DYDEVIAFL---GEWGPFQRLIFFLLS-ASIIPNGFNGMSVVFLAGTPEHR-CRVPDA-ANLS-----------SAW-----------------R-----NNSVPLR-LRDGRE--------------VPHSCSRYR-------------------LATIA-NFS-------------ALGLEPGRDVDLGQLEQESC-LDGW------------EFS-QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSF----------VSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWE---MFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFI----------------RDWRMLLLALTVPGVLCVPLWW--FIPESP------RWLISQRRFREAEDIIQKAAKMNNIA-------VPAVIFD--SVE--ELNPL--------KQQKAFILDLF----------------------------RTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLH----------------------------------------------------------------------------------------------------------------------GD----------AYLNCFLSALIEIPAYITAWLLLRT--LPRRYIIA---AVLFWGGGVLLFIQLVPV---------------------------DYYFLSIG----LVMLGKFGITSAFSMLYVFTAELYPTL-----------VRNMAVGVTSTASRVGSIIAPYFVY-LGAYNRMLPYIVMGSLTVLIGILTL-FF---P-ESLGMT---LPETLEQMQK-VKWF--------------R-----SGK----KTRDSMETEEN----------------PKVL-ITAF---
SLC22A5   --------------------------------MR--------------------------------------------------------------------------------------------------------------------------------------------------------------------DYDEVTAFL---GEWGPFQRLIFFLLS-ASIIPNGFTGLSSVFLIATPEHR-CRVPDA-ANLS-----------SAW-----------------R-----NHTVPLR-LRDGRE--------------VPHSCRRYR-------------------LATIA-NFS-------------ALGLEPGRDVDLGQLEQESC-LDGW------------EFS-QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSF----------ISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFE---MFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFI----------------RDWRMLLVALTMPGVLCVALWW--FIPESP------RWLISQGRFEEAEVIIRKAAKANGIV-------VPSTIFD--PSELQDLSSK--------KQQSHNILDLL----------------------------RTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLH----------------------------------------------------------------------------------------------------------------------GD----------IFVNCFLSAMVEVPAYVLAWLLLQY--LPRRYSMA---TALFLGGSVLLFMQLVPP---------------------------DLYYLATV----LVMVGKFGVTAAFSMVYVYTAELYPTV-----------VRNMGVGVSSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTL-FL---P-ESFGTP---LPDTIDQMLR-VKGM--------------K-----HRKT-PSHTRMLKDGQER----------------PTILKSTAF---
SLC22A6   --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FNDLLQQV---GGVGRFQQIQVTLVV-LPLLLMASHNTLQNFTAAIPTHH-CR-PPADANLSKNGG------LEVW--------------------------LPRD--------------RQG----QPESCLRFT----------SPQWGLPFLNGTEA-NGT--------------GATEP-------------C-TDGW------------IYD-NSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAM----------VFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFP---IYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSLGQFLLAGVAYAV----------------PHWRHLQLLVSAPFFAFFIYSW--FFIESA------RWHSSSGRLDLTLRALQRVARINGKR-------EEGAKLS--MEVLRASLQKE-LTMGKGQA---SAMELL----------------------------RCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFG----------------------------------------------------------------------------------------------------------------------VS----------IYLIQVIFGAVDLPAKLVGFLVINS--LGRRPAQM---AALLLAGICILLNGVIPQ---------------------------DQSIVRTS----LAVLGKGCLAASFNCIFLYTGELYPTM-----------IRQTGMGMGSTMARVGSIVSPLVSM-TAELYPSMPLFIYGAVPVAASAVTV-LL---P-ETLGQP---LPDTVQDLESRWAPTQ------KEAGIYPR-----KGK----QTRQQQEHQK--------YMVPLQASAQEKNGL------
SLC22A7   --------------------------------MG---------------------------------------------------------------------------------------------------------------------------------------------------------------------FEELLEQV---GGFGPFQLRNVALLA-LPRVLLPLHFLLPIFLAAVPAHR-CALPGAPANFSHQ---------DVW----------------------LEAHLPRE--------------PDG----TLSSCLRFA----------YPQ--------ALP-NTTLGEERQSRGELEDEPATVP-------------C-SQGW------------EYD-HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAV----------AFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYV---MFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVL-SSTFWTGGVMLLALVGYLI----------------RDWRWLLLAVTLPCAPGILSLW--WVPESA------RWLLTQGHVKEAHRYLLHCARLNGRP-------VCEDSFS--QEAVSKVAAGE-RVVRRP-----SYLDLF----------------------------RTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLG----------------------------------------------------------------------------------------------------------------------LN----------VYQTQLLFGAVELPSKLLVYLSVRY--AGRRLTQA---GTLLGTALAFGTRLLVSS---------------------------DMKSWSTV----LAVMGKAFSEAAFTTAYLFTSELYPTV-----------LRQTGMGLTALVGRLGGSLAPLAAL-LDGVWLSLPKLTYGGIALLAAGTAL-LL---P-ETRQAQ---LPETIQDVER---------------------------K----SAPTSLQEEEMPM-----KQVQN----------------
SLC22A8   --------------------------------MT---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSEILDRV---GSMGHFQFLHVAILG-LPILNMANHNLLQIFTAATPVHH-CR-PPHNASTGP------------WV-------------------------LPMG--------------PNG----KPERCLRFV----------HPP------NASLP-NDT-------------QRAMEP-------------C-LDGW------------VY--NST-KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGL----------VLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP---IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA-LGYCYTFGQFILPGLAYAI----------------PQWRWLQLTVSIPFFVFFLSSW--WTPESI------RWLVLSGKSSKALKILRRVAVFNGKK-------EEGERLS--LEELKLNLQKE-ISLAKAKY---TASDLF----------------------------RIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFG----------------------------------------------------------------------------------------------------------------------VN----------LYILQIIFGGVDVPAKFITILSLSY--LGRHTTQA---AALLLAGGAILALTFVPL---------------------------DLQTVRTV----LAVFGKGCLSSSFSCLFLYTSELYPTV-----------IRQTGMGVSNLWTRVGSMVSPLVKI-TGEVQPFIPNIIYGITALLGGSAAL-FL---P-ETLNQP---LPETIEDLEN-WS----------------L-----RAK----KPKQEPEVEKA-S-----QRIPLQPHGP---GLGSS---
SLC22A9   --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FQDLLGHA---GDLWRFQILQTVFLS-IFAVATYLHFMLENFTAFIPGHR-C-----------------------WVHILDNDTVSDNDTGALSQDALLRISIPLD--------------SNM----RPEKCRRFV----------HPQWQLLHLNGTFP-NTS-------------DADMEP-------------C-VDGW------------VYD-RISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGI----------LGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFL---IYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITL-GMCPSGIAFMTLAGLAFAI----------------RDWHILQLVVSVPYFVIFLTSS--WLLESA------RWLIINNKPEEGLKELRKAAHRSGMK-------NARDTLT--LEILKSTMKKE-LEAAQKKK--PSLCEML----------------------------HMPNICKRISLLSFTRFANFMAYFGLNLHVQHLG----------------------------------------------------------------------------------------------------------------------NN----------VFLLQTLFGAVILLANCVAPWALKY--MNRRASQM---LLMFLLAICLLAIIFVPQ---------------------------EMQTLREV----LATLGLGASALANTLAFAHGNEVIPTI-----------IRARAMGINATFANIAGALAPLMMI-LSVYSPPLPWIIYGVFPFISGFAFL-LL---P-ETRNKP---LFDTIQDEKN-------------------E-----R-K----DPREPKQEDPR-V-----EVTQF----------------
SLC22B1   --------------------------------MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPSDGYYRGEGTQDEEE---GGASSDATEGHDEDDEIYE--------GEYQGIPRAESGG---------KGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLG-LALMADGVEVFVVGFV--LPSAE-KD----------------------M------------------------------------------------------------------------------------------------------------------------C-LSDS----------------NKGMLGLIV--------------------YLGMMVGAF----------LWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYG---TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSW-LCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALT--TQPESP------RFFLENGKHDEAWMVLKQVHDTNMRAK-----GHPERVFS--VTHIKTIHQED------------ELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPL------DVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDK--IGRLRMLA---GSSVMSCVSCFFLSFGNS-ESAMIA--------------------------------LLCLFGGVSIASWNALDVLTVELYPSD-----------KRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL-KL---P-ETRGQV---LQ-------------------------------------------------------------------------------
SLC22B2   --------------------------------MDDY-------------------------------KYQDNYG--------------GY-APSDGYYRGNESNPEED-----AQSDVTEGHDEEDEIYE--------GEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDL------------------MAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLG-LALMADGVEVFVVSFA--LPSAE-KD----------------------M------------------------------------------------------------------------------------------------------------------------C-LSSS----------------KKGMLGMIV--------------------YLGMMAGAF----------ILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG---AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSW-LGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALK--FMPESP------RFLLEMGKHDEAWMILKQVHDTNMRAK-----GTPEKVFT--VSNIKTPKQMD------------EFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLE--QDND------FLIYLVSFLGSLSVLPGNIISALLMDR--IGRLKMIG---GSMLISAVCCFFLFFGNS-ESAMIG--------------------------------WQCLFCGTSIAAWNALDVITVELYPTN-----------QRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIAL-RL---P-ETREQV---LM-------------------------------------------------------------------------------
SLC22B3   --------------------------------MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDY-YPAGETYNGEANDDE-------GSSEATEGHDEDDEIYE--------GEYQGIPSMNQAKDSIVSVGQPKGDEYKDRREL------------------ESERRADEEELAQQYELIIQECGHGRFQWALFFVLG-MALMADGVEVFVVGFV--LPSAE-TD----------------------L------------------------------------------------------------------------------------------------------------------------C-IPNS----------------GSGWLGSIV--------------------YLGMMVGAF----------FWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYG---FFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSW-LCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALT--FMPESP------RFLLEVGKHDEAWMILKLIHDTNMRAR-----GQPEKVFT--VNKIKTPKQID------------ELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFD--DDYS-----AYWIYFVNFLGTLAVLPGNIVSALLMDR--IGRLTMLG---GSMVLSGISCFFLWFGTS-ESMMIG--------------------------------MLCLYNGLTISAWNSLDVVTVELYPTD-----------RRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGL-CL---P-DTRTQV---LM-------------------------------------------------------------------------------
SLC22B4   --------------------------------MEED------LF--------QLRQLPVVKFRRT----------------------------------GESARSEDDTASGEHEVQIEGVHVGLEAVEL--------DDGAAVPKE------------------------------------------FANPTDDTFMVEDAVEAI----GFGKFQWKLSVLTG-LAWMADAMEMMILSIL--APQLH-CE----------------------W------------------------------------------------------------------------------------------------------------------------R-LPSW----------------QVALLTSVV--------------------FVGMMSSST----------LWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYS---WILVLRGLVGFGIGG-VPQSVTLYAEFLPMKARAKCILL-IEVFWAIGTVFEVVLAVFVMPSLG-------------WRWLLILSAVPLLLFAVLCF--WLPESA------RYDVLSGNQEKAIATLKRIATENGAP-------MPLGKLI--ISRQEDRGKMR------------DL--------------------------------FTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAV----------------------------------------------------------EAKCSLA------------------------------CEYLSE--ED-----------YMDLLWTTLSEFPGVLVTLWIIDR--LGRKKTMAL---CFVIFSFCSLLLFICVG-RNVLTL--------------------------------LLFIARAFISGGFQAAYVYTPEVYPTA-----------TRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASC-FL---PIETKGRG---LQESSHREWG-------------------QEM-VGRGMHGAGVTRSNSGSQE-----------------------------
SLC22B5   --------------------------------MATKPTEPVTIL--------SLRKLSL----------------------------------------------------GTAEPQVKE------------------------PK--------------------------------------------------TFTVEDAVETI----GFGRFHIALFLIMG-STGVVEAMEIMLIAVV--SPVIR-CE----------------------W------------------------------------------------------------------------------------------------------------------------Q-LENW----------------QVALVTTMV--------------------FFGYMVFSI----------LFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYI---WFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGYMLPL-SQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFK--FIPESA------RFNVSTGNTRAALATLERVAKMNRSV-------MPEGKLV--EPVLEKRGRFA------------DL--------------------------------LDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVV---------------------------------------------------VTGGDSGESQSPCY------------------------------CHMFAP--SD-----------YRTMIISTIGEIALNPLNILGINF--LGRRLSLSITMGCTALF---FLLLNICTS-SAGLIG--------------------------------FLFMLRALVAANFNTVYIYTAEVYPTT-----------MRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAF-TL---PIETKGRA---LQQIK----------------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC22A3 102 A/D 0.000138455 rs750208423
-- SLC22A3 116 A/S 0.00085548 rs8187717
-- SLC22A3 124 L/P 0.000110408 rs748951424
-- SLC22A3 126 P/L 0.000118531 rs113898574
-- SLC22A3 126 P/R 0.00135233 rs113898574
-- SLC22A3 172 L/S 0.000103448 rs368914737
-- SLC22A3 263 F/L 0.000107511 rs575539551
-- SLC22A3 298 R/Q 0.000497802 rs151135411
-- SLC22A3 375 I/R 0.00016323 rs200861075
-- SLC22A3 388 V/M 0.00013135 rs189883656
-- SLC22A3 407 R/H 0.000811895 rs145082363
-- SLC22A3 494 V/L 0.000219199 rs565948998

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC22A3 SLC22A3 [plasma membrane] Organic cation transport
SLC22A3 SLC22A3 [plasma membrane] Abacavir transmembrane transport

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data