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Disease

Detail Data SLC22A12


Basic description
Gene Name SLC22A12
Protein Name Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1)
Family SLC22
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name SLC22A12 exchanges extracellular urate for cytosolic LACT
Reaction 1 LACT [cytosol] + 1 urate [extracellular region] --> 1 LACT [extracellular region] + 1 urate [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550 
MAFSELLDLV GGLGRFQVLQ TMALMVSIMW LCTQSMLENF SAAVPSHRCW APLLDNSTAQ ASILGSLSPE ALLAISIPPG PNQRPHQCRR FRQPQWQLLD PNATATSWSE ADTEPCVDGW VYDRSIFTST IVAKWNLVCD SHALKPMAQS IYLAGILVGA AACGPASDRF GRRLVLTWSY LQMAVMGTAA AFAPAFPVYC LFRFLLAFAV AGVMMNTGTL LMEWTAARAR PLVMTLNSLG FSFGHGLTAA VAYGVRDWTL LQLVVSVPFF LCFLYSWWLA ESARWLLTTG RLDWGLQELW RVAAINGKGA VQDTLTPEVL LSAMREELSM GQPPASLGTL LRMPGLRFRT CISTLCWFAF GFTFFGLALD LQALGSNIFL LQMFIGVVDI PAKMGALLLL SHLGRRPTLA ASLLLAGLCI LANTLVPHEM GALRSALAVL GLGGVGAAFT CITIYSSELF PTVLRMTAVG LGQMAARGGA ILGPLVRLLG VHGPWLPLLV YGTVPVLSGL AALLLPETQS LPLPDTIQDV QNQAVKKATH GTLGNSVLKS TQF 
CCHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCHH HHHHCCCCCC CCCCCCCCCE ECCCCHHHCC CCCCCCCCCC CCCCCCCCCE EEECCCCEEE CCHHHHHCCC CCHHHHHHHH HHHHHHCCCC EECCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHCC CCHHHHHHHH HHHHHHHCHH HHHHHHHCHH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHCCCCC CCCCCCHHHH HHHHHHHHHC CCCCCCHHHH HCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHCHHHH HHHHHHHHHH CCCCCCCHHH HHHHHHHHHH HHHHCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCHHHHHHH HCCCCEEEEH HHHHHHHHHC CCCCCHHHHH HHHHHHHHHH HHHHCHHHCC CCCCCHHHHH HHHHCCCCCC CCCCCCCCCC CCC
[Overview] SLC22A1 SLC22A10 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A2 SLC22A20 SLC22A23 SLC22A25 SLC22A3 SLC22A32 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC22A9 SLC22B1 SLC22B2 SLC22B3 SLC22B4 SLC22B5 
SLC22A1   --------------------------------MP--------------------------------------------------------------------------------------------------------------------------------------------------------------------TVDDILEQV---GESGWFQKQAFLILC-LLSAAFAPICVGIVFLGFTPDHH-CQSPGV-AELSQ---------RCGW-----------------SPAEELNYTVPGL-GPAGEA--------------FLGQCRRYEVDWNQ------SALSCVDPLASLATNRS-------------HLPLGP-------------C-QDGW------------VYD-TP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSL----------GVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYM---SMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIM-YQMAFTVGLVALTGLAYAL----------------PHWRWLQLAVSLPTFLFLLYYW--CVPESP------RWLLSQKRNTEAIKIMDHIAQKNGKL-------PPA---D--LKML-SLEEDV------TEKLSPSFADLF----------------------------RTPRLRKRTFILMYLWFTDSVLYQGLILHMGATS----------------------------------------------------------------------------------------------------------------------GN----------LYLDFLYSALVEIPGAFIALITIDR--VGRIYPMA---MSNLLAGAACLVMIFISP---------------------------DLHWLNII----IMCVGRMGITIAIQMICLVNAELYPTF-----------VRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTL-LL---P-ETKGVA---LPETMKDAEN-LGRK--------------A-----KPK----ENTIYLKVQTSE---------------PSGT--------
SLC22A10  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FEELLSQV---GGLGRFQMLHLVFIL-PSLMLLIPHILLENFAAAIPGHR-C-----------------------WVHMLDNNTGSGNETGILSEDALLRISIPLD--------------SNL----RPEKCRRFV----------HPQWQLLHLNGTIH-STS-------------EADTEP-------------C-VDGW------------VYD-QSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGI----------IGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFP---VYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVIL-SSGALSIGQIILGGLAYVF----------------RDWQTLHVVASVPFFVFFLLSR--WLVESA------RWLIITNKLDEGLKALRKVARTNGIK-------NAEETLN--IEVVRSTMQEE-LDAAQTKT---TVCDLF----------------------------RNPSMRKRICILVFLRFANTIPFYGTMVNLQHVG----------------------------------------------------------------------------------------------------------------------SN----------IFLLQVLYGAVALIVRCLALLTLNH--MGRRISQI---LFMFLVGLSILANTFVPK---------------------------EMQTLRVA----LACLGIGCSAATFSSVAVHFIELIPTV-----------LRARASGIDLTASRIGAALAPLLMT-LTVFFTTLPWIIYGIFPIIGGLIVF-LL---P-ETKNLP---LPDTIKDVEN-------------------Q-----K-K----NLKEKA---------------------------------
SLC22A11  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSKLLEQA---GGVGLFQTLQVLTFI-LPCLMIPSQMLLENFSAAIPGHR-C-----------------------WTHMLDNGSAVST---NMTPKALLTISIPPG--------------PNQ----GPHQCRRFR----------QPQWQLLDPNATAT-SWS-------------EADTEP-------------C-VDGW------------VYD-RSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSF----------IWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFV---IYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTV-VGCAFSAGQAALGGLAFAL----------------RDWRTLQLAASVPFFAISLISW--WLPESA------RWLIIKGKPDQALQELRKVARINGHK-------EAKN-LT--IEVLMSSVKEE-VASAKEPR---SVLDLF----------------------------CVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLG----------------------------------------------------------------------------------------------------------------------RD----------IFLLQALFGAVDFLGRATTALLLSF--LGRRTIQA---GSQAMAGLAILANMLVPQ---------------------------DLQTLRVV----FAVLGKGCFGISLTCLTIYKAELFPTP-----------VRMTADGILHTVGRLGAMMGPLILM-SRQALPLLPPLLYGVISIASSLVVLFFL---P-ETQGLP---LPDTIQDLES-------------------Q-----K-S----TAAQGNRQEAVTV-----ESTSL----------------
SLC22A12  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSELLDLV---GGLGRFQVLQTMALM-VSIMWLCTQSMLENFSAAVPSHR-C-----------------------WAPLLDNSTAQASILGSLSPEALLAISIPPG--------------PNQ----RPHQCRRFR----------QPQWQLLDPNATAT-SWS-------------EADTEP-------------C-VDGW------------VYD-RSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAA----------ACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFP---VYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTL-NSLGFSFGHGLTAAVAYGV----------------RDWTLLQLVVSVPFFLCFLYSW--WLAESA------RWLLTTGRLDWGLQELWRVAAINGKG-------AVQDTLT--PEVLLSAMREE-LSMGQPPA---SLGTLL----------------------------RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALG----------------------------------------------------------------------------------------------------------------------SN----------IFLLQMFIGVVDIPAKMGALLLLSH--LGRRPTLA---ASLLLAGLCILANTLVPH---------------------------EMGALRSA----LAVLGLGGVGAAFTCITIYSSELFPTV-----------LRMTAVGLGQMAARGGAILGPLVRL-LGVHGPWLPLLVYGTVPVLSGLAAL-LL---P-ETQSLP---LPDTIQDVQN-------------------Q-----AVK----KATHGTLGNSV-L-----KSTQF----------------
SLC22A13  --------------------------------MA--------------------------------------------------------------------------------------------------------------------------------------------------------------------QFVQVLAEI---GDFGRFQIQLLILLC-VLNFLSPFYFFAHVFMVLDEPHH-CA--------------------VAWV---------KNHTFNLSAAEQLVLSVPLD--------------TAG----HPEPCLMFR----------PPP-----ANASLQ-DIL--SHR--------FNETQP-------------C-DMGW------------EYP-ENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTL----------MFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFE---LYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVL-AQCNFSLGQMVLAGLAYGF----------------RNWRLLQITGTAPGLLLFFYFW--ALPESA------RWLLTRGRMDEAIQLIQKAASVNRRK------------LS--PELMNQLVPEK-TGPSG------NALDLF----------------------------RHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFG----------------------------------------------------------------------------------------------------------------------LD----------VYLTQLIFGAVEVPARCSSIFMMQR--FGRKWSQL---GTLVLGGLMCIIIIFIPA---------------------------DLPVVVTM----LAVVGKMATAAAFTISYVYSAELFPTI-----------LRQTGMGLVGIFSRIGGILTPLVIL-LGEYHAALPMLIYGSLPIVAGLLCT-LL---P-ETHGQG---LKDTLQDLEL---------------GPHPR-----SPK----SVPSEKETEAKGR-----TSSPG-------VAFVSSTYF
SLC22A14  --------------------------------MAGE----------------ENFKEEL--------------------------------------------------RSQDAS----------RNLNQ--------HEVAGHPHSWSL-------------------EMLLRRL-------------RAVHTKQDDKFANLLDAV---GEFGTFQQRLVALTF-IPSIMSAFFMFADHFVFTAQKPY-CN--------------------TSWILAVGP---------HLSKAEQLNLTIPQA--------------PNG----SFLTCFMYL----------PVPWNL----DSII-QFG-------------LNDTDT-------------C-QDGW------------IYP-DAK-KRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSL----------IFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFH---LYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIIL-GHCFFAVGAVLLTGIAYSL----------------PHWQLLFLVGGILVIPFISYIW--ILPESP------RWLMMKGKVKEAKQVLCYAASVNKKT-------------------IPSNLLDE-LQLPRKKVTRASVLDFC----------------------------KNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELG----------------------------------------------------------------------------------------------------------------------VS----------VHFRHVVPSIMEVPARLCCIFLLQQ--IGRKWSLA---VTLLQAIIWCLLLLFLPEGEDGLRLKWPRCP------------ATELKSMTIL----VLMLREFSLAATVTVFFLYTAELLPTV-----------LRATGLGLVSLASVAGAILS--LTI-ISQTPSLLPIFLCCVLAIVAFSLSS-LL---P-ETRDQP---LSESLNHSSQ-IR----------------N-----KVK----DMKTKETSSDDV---------------------------
SLC22A15  --------------------------------ME---------------------------------------------------------------------------------------------------------------------------------------------------------------------VEEAFQAV---GEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH-------------------------W---------------------DLAELLPNQ--------------SHG--------------------------------------NQSAGEDQ---------------------------A-FGDWLLTANGSEIHKHVHF-SSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVI----------SFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYE---FFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSI-GGLFFAVGIAQYALLGYFI----------------RSWRTLAILVNLQGTVVFLLSL--FIPESP------RWLYSQGRLSEAEEALYLIAKRNRKL-------KCTFSLT--HPANRSCRETG------------SFLDLF----------------------------RYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLG----------------------------------------------------------------------------------------------------------------------GS----------IYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLS---AFLCLGGLACLIVMFLPEKK-------------------------DTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTV-----------IRNVGLGTCSMFSRVGGIIAPFIPS-LKYVQWSLPFIVFGATGLTSGLLSL-LL---P-ETLNSP---LLETFSDLQV-YSYRRLGEEALSLQALDPQQC---VDK----ESSLGSESEEEEEFYDADEETQMIK--------------
SLC22A16  ------------------------------MGSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------HFEGIYDHV---GHFGRFQRVLYFICA-FQNISCGIHYLASVFMGVTPHHV-CRPPG---NVSQVVFH----NHSNW-----------------S----LEDTGAL--LSSGQKDYVTVQLQNGE-IWELSRCSRNKRE-----------------------NTS-------------SLGYEY-----TGSKKEFPC-VDGY------------IYD-QNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSV----------TFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYY---TFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH-LHSFFAVGTLLVALTGYLV----------------RTWWLYQMILSTVTVPFILCCW--VLPETP------FWLLSEGRYEEAQKIVDIMAKWN-----------RASSCK--LSELLSLDLQGPVSNSPTEVQKHNLSYLF----------------------------YNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLG----------------------------------------------------------------------------------------------------------------------GN----------EYLNLFLLGVVEIPAYTFVCIAMDK--VGRRTVLA---YSLFCSALACGVVMVIPQ---------------------------KHYILGVV----TAMVGKFAIGAAFGLIYLYTAELYPTI-----------VRSLAVGSGSMVCRLASILAPFSVD-LSSIWIFIPQLFVGTMALLSGVLTL-KL---P-ETLGKR---LATTWEEAAK-LESE--------------N-----ESK----SSKLLLTTNNSGL-----EKTEA--ITPRDSGLGE----
SLC22A17  --------------------------------MASD----------------PIFTLA-------------------------------------------------------------------PPLH---------CHYGAFP-----------------------------------------------------------PNA---SG-------------W-----------------EQP-----------PNASGVSV----------------------------------ASAALA-ASAASRVATS---TD-------PSCSGFA----------PPD-------------FN-----------H--------------------C-LKDW------------DYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYL----------FLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSST---GVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALA-GELVGVGGHFLFLGLALVS----------------KDWRFLQRMITAPCILFLFYGWPGLFLESA------RWLIVKRQIEEAQSVLRILAERNR---------PHGQMLG---EEAQEALQDLENTCPLPATSSFSFASLL----------------------------NYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGS-------------------------------------------------------------------------------------------------------------------P--SD----------FYLCSLLASGTAALACVFLGVTVDR--FGRRGILL---LSMTLTGIASLVLLGLWD---------CEHPIFPTVWAQQGNPNRDLNEAAIT---TFSVLGLFSSQAAAILSTLLAAEVIPTT-----------VRGRGLGLIMALGALGGLSGPAQRL-HMGHGAFLQHVVLAACALLCILSIM-LL---P-ETKRKL---LPEVLRDGEL-CRRPSLLR------QPPPT-----RCD----HVPLLAT--------------------PNPAL-------
SLC22A18  --------------------------------MQGA---------------------------------------RA-------------------------------------------------------------------PRDQGRSP----------------------------------------------------------GRMSALGRSSVILLT-------------------------------------------------YV----------------------------------------------------------------------------------------------------LAATELT------------C-----------------LFM-QFSIVPYLSRKLGL------------DSIAFGYLQTTF-GVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGR-LGLCFGVGVILGSLLGGTLVSAYGIQCP-------------AILAALATLLGAVLSF-TCIPAST-----------------------KGAKTDAQAPLPG--GPRASVFD--LKAIASLLRLP------------DVPRIF----------LVKVASNCP-----------------TGLFMVMFSIISMDFFQLEAAQAGYL----------------------------------------------------------------------------------------------------------------------MS--------FFGLLQMVTQGLV----------------IGQLSSHF---SEEVLLRASVLVFIVVGL---------------------------AMAWMSSV--FHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTS--------DTGTMLGLCASVQPLLRTLGPTVGG-LLYRSFGVP--VFGHVQVAINTLVLLVLWRKP----------MPQ--------------------------R-----KDKV---R--------------------------------------
SLC22A2   --------------------------------MP-------------------------------------------------------------------------------------------------------------------------------------------------------------------TTVDDVLEHG---GEFHFFQKQMFFLLA-LLSATFAPIYVGIVFLGFTPDHR-CRSPGV-AELSL---------RCGW-----------------SPAEELNYTVPGP-GPAGEA--------------SPRQCRRYEVDWNQ------STFDCVDPLASLDTNRS-------------RLPLGP-------------C-RDGW------------VYE-TP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSM----------SIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYT---WMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF-YQVAYTVGLLVLAGVAYAL----------------PHWRWLQFTVSLPNFFFLLYYW--CIPESP------RWLISQNKNAEAMRIIKHIAKKNGKS-------LPA---S--LQRL-RLEEET------GKKLNPSFLDLV----------------------------RTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAG----------------------------------------------------------------------------------------------------------------------DN----------IYLDFFYSALVEFPAAFMIILTIDR--IGRRYPWA---ASNMVAGAACLASVFIPG---------------------------DLQWLKII----ISCLGRMGITMAYEIVCLVNAELYPTF-----------IRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVL-LL---P-ETKGKA---LPETIEEAEN-MQRP--------------R-----KNK----EKMIYLQVQKLD--------------IPLN---------
SLC22A20  ------------------------------MAMA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FTDLLDAL---GSMGRFQLNHTALLL-LPCGLLACHNFLQNFTAAVPPHH-CRGPANHTEASTNDS-------GAW----------------------LRATIPLD--------------QLG----APEPCRRFT----------KPQWALLSPNSSIP-----------------GAATEG-------------C-KDGW------------VYN-RSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAA----------VFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFS---AYCVFRFLMGMTFSGIILNSVSLVASRV--------------------------IPLAP----------------PAW---QVPVSC--------------TESAEGGCNEREEGGRGKADQGGDELLHPKRV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CK----------CLHLQLNLGPLPNPGHPQGHM-LSH--GDLRGRQ----------------------------------------------------------------------------------------------------RSSGSG------EQGGSCEP------ESRNGRLPA----------------VA---P-AGLGLPFVHLPLSAREKQI-LS----------------S-----KFQ----S--------------------------------------
SLC22A23  MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASA----------------PLGGRAG--------------------------------------------------PGGGAEIQ------PLPPLHPGGGPHPSCCSAAAAPS------------------------LLLL-----------------------DYDGSVLPFL---GGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFW-CRGAGKGTELAGVTTTGRGGDMGNWT----------------SLPTTPFATAPWE-AAGNRSNSSG---ADGGDTPPLPS---------------PPDKGD---------NAS-----------N--------------------CDCRAW------------DYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYL----------ITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVT---MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMV-ASFVAMAGQFLMPGLAALC----------------RDWQVLQALIICPFLLMLLY-W-SIFPESL------RWLMATQQFESAKRLILHFTQKNRMN-------PEGDIKGVIPELEKELSRRPKKVC---------IVKVV----------------------------GTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVK----------------------------------------------------------------------------------------------------------------VPLLEN----------FYADYYTTASIALVSCLAMCVVVRF--LGRRGGLL---LFMILTALASLLQLGLLN----LIGKYSQHP-------DSGMSDSVKDKFSI----AFSIVGMFASHAVGSLSVFFCAEITPTV-----------IRCGGLGLVLASAGFGMLTAPIIEL-HNQKGYFLHHIIFACCTLICIICIL-LL---P-ESRDQN---LPENISNGEH-YTRQPLL----------PH-----KKG----EQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM
SLC22A25  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FQDLLDQV---GGLGRFQILQMVFLI-MFNVIVYHQTQLENFAAFILDHR-C-----------------------WVHILDNDTIPDNDPGTLSQDALLRISIPFD--------------SNL----RPEKCRRFV----------HPQWKLIHLNGTFP-NTS-------------EPDTEP-------------C-VDGW------------VYD-QSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGN----------LYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTIL---VYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTL-TLCAASIGHITLGSLAFVI----------------RDQCILQLVMSAPCFVFFLFSR--WLAESA------RWLIINNKPEEGLKELRKAAHRNGMK-------NAEDILT--MEVLKSTMKQE-LEAAQKKH---SLCELL----------------------------RIPNICKRICFLSFVRFASTIPFWGLTLHLQHLG----------------------------------------------------------------------------------------------------------------------NN----------VFLLQTLFGAVTLLANCVAPWALNH--MSRRLSQM---LLMFLLATCLLAIIFVPQ---------------------------EMQTLRVV----LATLGVGAASLGITCSTAQENELIPSI-----------IRGRATGITGNFANIGGALASLMMI-LSIYSRPLPWIIYGVFAILSGLVVL-LL---P-ETRNQP---LLDSIQDVEN-------------------E-----G-V----NSLAAPQ---R-S-----SVL------------------
SLC22A3   --------------------------------MP--------------------------------------------------------------------------------------------------------------------------------------------------------------------SFDEALQRV---GEFGRFQRRVFLLLC-LTGVTFAFLFVGVVFLGTQPDHYWCRGPSA-AALAE---------RCGW-----------------SPEEEWNRTAPASRGPEPPE--------------RRGRCQRYLLEAANDSASATSALSCADPLAAFP-NRS--------------APLVP-------------C-RGGW------------RYA-QA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAF----------TLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFP---VFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIV-IQMFFTLGIIILPGIAYFI----------------PNWQGIQLAITLPSFLFLLYYW--VVPESP------RWLITRKKGDKALQILRRIAKCNGKY-------LSS---N--YSEI-TVTDE--------EVSNPSFLDLV----------------------------RTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIG----------------------------------------------------------------------------------------------------------------------GN----------LYIDFFISGVVELPGALLILLTIER--LGRRLPFA---ASNIVAGVACLVTAFLPE---------------------------GIAWLRTT----VATLGRLGITMAFEIVYLVNSELYPTT-----------LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVM-LL---P-ETKGIA---LPETVDDVEK-LGSP--------------HSCKCGRNK----KT-------------------------PVSRSHL-----
SLC22A32  --------------------------------MG--------------------------------------WG-----------------------------------GGGGCTPR--------PPIHQ----QP--------PER---------------------------------------------------------------------RVVTVVFLG-LLLDLLAFTLLLPLLPGLLESHGRAHDP----------------LYGSW--------------------------------------------QGG-------------------------------------------------------------------------V---DWF---------------ATAIGMPVEKRYNSV--------------LFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFA---AFLASRLIGGISKGNVSLST-AIVADLGSPLARSQGMAV-IGVAFSLGFTLGPMLGASL------PLEM------APWFALLFAASDLLFIF------CFLPETL--PLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLS-------------------------SLRRLG-----------------------------------------LVYFLYLFLFSGLEYTLSFLT---------------------------------HQRFQF-------------------------------------------------------------------------------SS----LQQGKMFFLIGLTMATIQGA-------------YARRIHPGGE-----VAAVKRALLLLVPA--FLLIG-----------W-----------------GRSLPVLGLGLLLYSFAAAVVV-----PCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASV--------YWLAGAQACFTTWSGLFLL---P--------FFLLQKLSYPAQ-------------------------TLKA---E--------------------------------------
SLC22A4   --------------------------------MR--------------------------------------------------------------------------------------------------------------------------------------------------------------------DYDEVIAFL---GEWGPFQRLIFFLLS-ASIIPNGFNGMSVVFLAGTPEHR-CRVPDA-ANLS-----------SAW-----------------R-----NNSVPLR-LRDGRE--------------VPHSCSRYR-------------------LATIA-NFS-------------ALGLEPGRDVDLGQLEQESC-LDGW------------EFS-QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSF----------VSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWE---MFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFI----------------RDWRMLLLALTVPGVLCVPLWW--FIPESP------RWLISQRRFREAEDIIQKAAKMNNIA-------VPAVIFD--SVE--ELNPL--------KQQKAFILDLF----------------------------RTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLH----------------------------------------------------------------------------------------------------------------------GD----------AYLNCFLSALIEIPAYITAWLLLRT--LPRRYIIA---AVLFWGGGVLLFIQLVPV---------------------------DYYFLSIG----LVMLGKFGITSAFSMLYVFTAELYPTL-----------VRNMAVGVTSTASRVGSIIAPYFVY-LGAYNRMLPYIVMGSLTVLIGILTL-FF---P-ESLGMT---LPETLEQMQK-VKWF--------------R-----SGK----KTRDSMETEEN----------------PKVL-ITAF---
SLC22A5   --------------------------------MR--------------------------------------------------------------------------------------------------------------------------------------------------------------------DYDEVTAFL---GEWGPFQRLIFFLLS-ASIIPNGFTGLSSVFLIATPEHR-CRVPDA-ANLS-----------SAW-----------------R-----NHTVPLR-LRDGRE--------------VPHSCRRYR-------------------LATIA-NFS-------------ALGLEPGRDVDLGQLEQESC-LDGW------------EFS-QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSF----------ISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFE---MFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFI----------------RDWRMLLVALTMPGVLCVALWW--FIPESP------RWLISQGRFEEAEVIIRKAAKANGIV-------VPSTIFD--PSELQDLSSK--------KQQSHNILDLL----------------------------RTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLH----------------------------------------------------------------------------------------------------------------------GD----------IFVNCFLSAMVEVPAYVLAWLLLQY--LPRRYSMA---TALFLGGSVLLFMQLVPP---------------------------DLYYLATV----LVMVGKFGVTAAFSMVYVYTAELYPTV-----------VRNMGVGVSSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTL-FL---P-ESFGTP---LPDTIDQMLR-VKGM--------------K-----HRKT-PSHTRMLKDGQER----------------PTILKSTAF---
SLC22A6   --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FNDLLQQV---GGVGRFQQIQVTLVV-LPLLLMASHNTLQNFTAAIPTHH-CR-PPADANLSKNGG------LEVW--------------------------LPRD--------------RQG----QPESCLRFT----------SPQWGLPFLNGTEA-NGT--------------GATEP-------------C-TDGW------------IYD-NSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAM----------VFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFP---IYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSLGQFLLAGVAYAV----------------PHWRHLQLLVSAPFFAFFIYSW--FFIESA------RWHSSSGRLDLTLRALQRVARINGKR-------EEGAKLS--MEVLRASLQKE-LTMGKGQA---SAMELL----------------------------RCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFG----------------------------------------------------------------------------------------------------------------------VS----------IYLIQVIFGAVDLPAKLVGFLVINS--LGRRPAQM---AALLLAGICILLNGVIPQ---------------------------DQSIVRTS----LAVLGKGCLAASFNCIFLYTGELYPTM-----------IRQTGMGMGSTMARVGSIVSPLVSM-TAELYPSMPLFIYGAVPVAASAVTV-LL---P-ETLGQP---LPDTVQDLESRWAPTQ------KEAGIYPR-----KGK----QTRQQQEHQK--------YMVPLQASAQEKNGL------
SLC22A7   --------------------------------MG---------------------------------------------------------------------------------------------------------------------------------------------------------------------FEELLEQV---GGFGPFQLRNVALLA-LPRVLLPLHFLLPIFLAAVPAHR-CALPGAPANFSHQ---------DVW----------------------LEAHLPRE--------------PDG----TLSSCLRFA----------YPQ--------ALP-NTTLGEERQSRGELEDEPATVP-------------C-SQGW------------EYD-HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAV----------AFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYV---MFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVL-SSTFWTGGVMLLALVGYLI----------------RDWRWLLLAVTLPCAPGILSLW--WVPESA------RWLLTQGHVKEAHRYLLHCARLNGRP-------VCEDSFS--QEAVSKVAAGE-RVVRRP-----SYLDLF----------------------------RTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLG----------------------------------------------------------------------------------------------------------------------LN----------VYQTQLLFGAVELPSKLLVYLSVRY--AGRRLTQA---GTLLGTALAFGTRLLVSS---------------------------DMKSWSTV----LAVMGKAFSEAAFTTAYLFTSELYPTV-----------LRQTGMGLTALVGRLGGSLAPLAAL-LDGVWLSLPKLTYGGIALLAAGTAL-LL---P-ETRQAQ---LPETIQDVER---------------------------K----SAPTSLQEEEMPM-----KQVQN----------------
SLC22A8   --------------------------------MT---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSEILDRV---GSMGHFQFLHVAILG-LPILNMANHNLLQIFTAATPVHH-CR-PPHNASTGP------------WV-------------------------LPMG--------------PNG----KPERCLRFV----------HPP------NASLP-NDT-------------QRAMEP-------------C-LDGW------------VY--NST-KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGL----------VLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP---IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA-LGYCYTFGQFILPGLAYAI----------------PQWRWLQLTVSIPFFVFFLSSW--WTPESI------RWLVLSGKSSKALKILRRVAVFNGKK-------EEGERLS--LEELKLNLQKE-ISLAKAKY---TASDLF----------------------------RIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFG----------------------------------------------------------------------------------------------------------------------VN----------LYILQIIFGGVDVPAKFITILSLSY--LGRHTTQA---AALLLAGGAILALTFVPL---------------------------DLQTVRTV----LAVFGKGCLSSSFSCLFLYTSELYPTV-----------IRQTGMGVSNLWTRVGSMVSPLVKI-TGEVQPFIPNIIYGITALLGGSAAL-FL---P-ETLNQP---LPETIEDLEN-WS----------------L-----RAK----KPKQEPEVEKA-S-----QRIPLQPHGP---GLGSS---
SLC22A9   --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FQDLLGHA---GDLWRFQILQTVFLS-IFAVATYLHFMLENFTAFIPGHR-C-----------------------WVHILDNDTVSDNDTGALSQDALLRISIPLD--------------SNM----RPEKCRRFV----------HPQWQLLHLNGTFP-NTS-------------DADMEP-------------C-VDGW------------VYD-RISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGI----------LGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFL---IYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITL-GMCPSGIAFMTLAGLAFAI----------------RDWHILQLVVSVPYFVIFLTSS--WLLESA------RWLIINNKPEEGLKELRKAAHRSGMK-------NARDTLT--LEILKSTMKKE-LEAAQKKK--PSLCEML----------------------------HMPNICKRISLLSFTRFANFMAYFGLNLHVQHLG----------------------------------------------------------------------------------------------------------------------NN----------VFLLQTLFGAVILLANCVAPWALKY--MNRRASQM---LLMFLLAICLLAIIFVPQ---------------------------EMQTLREV----LATLGLGASALANTLAFAHGNEVIPTI-----------IRARAMGINATFANIAGALAPLMMI-LSVYSPPLPWIIYGVFPFISGFAFL-LL---P-ETRNKP---LFDTIQDEKN-------------------E-----R-K----DPREPKQEDPR-V-----EVTQF----------------
SLC22B1   --------------------------------MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPSDGYYRGEGTQDEEE---GGASSDATEGHDEDDEIYE--------GEYQGIPRAESGG---------KGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLG-LALMADGVEVFVVGFV--LPSAE-KD----------------------M------------------------------------------------------------------------------------------------------------------------C-LSDS----------------NKGMLGLIV--------------------YLGMMVGAF----------LWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYG---TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSW-LCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALT--TQPESP------RFFLENGKHDEAWMVLKQVHDTNMRAK-----GHPERVFS--VTHIKTIHQED------------ELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPL------DVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDK--IGRLRMLA---GSSVMSCVSCFFLSFGNS-ESAMIA--------------------------------LLCLFGGVSIASWNALDVLTVELYPSD-----------KRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL-KL---P-ETRGQV---LQ-------------------------------------------------------------------------------
SLC22B2   --------------------------------MDDY-------------------------------KYQDNYG--------------GY-APSDGYYRGNESNPEED-----AQSDVTEGHDEEDEIYE--------GEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDL------------------MAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLG-LALMADGVEVFVVSFA--LPSAE-KD----------------------M------------------------------------------------------------------------------------------------------------------------C-LSSS----------------KKGMLGMIV--------------------YLGMMAGAF----------ILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG---AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSW-LGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALK--FMPESP------RFLLEMGKHDEAWMILKQVHDTNMRAK-----GTPEKVFT--VSNIKTPKQMD------------EFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLE--QDND------FLIYLVSFLGSLSVLPGNIISALLMDR--IGRLKMIG---GSMLISAVCCFFLFFGNS-ESAMIG--------------------------------WQCLFCGTSIAAWNALDVITVELYPTN-----------QRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIAL-RL---P-ETREQV---LM-------------------------------------------------------------------------------
SLC22B3   --------------------------------MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDY-YPAGETYNGEANDDE-------GSSEATEGHDEDDEIYE--------GEYQGIPSMNQAKDSIVSVGQPKGDEYKDRREL------------------ESERRADEEELAQQYELIIQECGHGRFQWALFFVLG-MALMADGVEVFVVGFV--LPSAE-TD----------------------L------------------------------------------------------------------------------------------------------------------------C-IPNS----------------GSGWLGSIV--------------------YLGMMVGAF----------FWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYG---FFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSW-LCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALT--FMPESP------RFLLEVGKHDEAWMILKLIHDTNMRAR-----GQPEKVFT--VNKIKTPKQID------------ELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFD--DDYS-----AYWIYFVNFLGTLAVLPGNIVSALLMDR--IGRLTMLG---GSMVLSGISCFFLWFGTS-ESMMIG--------------------------------MLCLYNGLTISAWNSLDVVTVELYPTD-----------RRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGL-CL---P-DTRTQV---LM-------------------------------------------------------------------------------
SLC22B4   --------------------------------MEED------LF--------QLRQLPVVKFRRT----------------------------------GESARSEDDTASGEHEVQIEGVHVGLEAVEL--------DDGAAVPKE------------------------------------------FANPTDDTFMVEDAVEAI----GFGKFQWKLSVLTG-LAWMADAMEMMILSIL--APQLH-CE----------------------W------------------------------------------------------------------------------------------------------------------------R-LPSW----------------QVALLTSVV--------------------FVGMMSSST----------LWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYS---WILVLRGLVGFGIGG-VPQSVTLYAEFLPMKARAKCILL-IEVFWAIGTVFEVVLAVFVMPSLG-------------WRWLLILSAVPLLLFAVLCF--WLPESA------RYDVLSGNQEKAIATLKRIATENGAP-------MPLGKLI--ISRQEDRGKMR------------DL--------------------------------FTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAV----------------------------------------------------------EAKCSLA------------------------------CEYLSE--ED-----------YMDLLWTTLSEFPGVLVTLWIIDR--LGRKKTMAL---CFVIFSFCSLLLFICVG-RNVLTL--------------------------------LLFIARAFISGGFQAAYVYTPEVYPTA-----------TRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASC-FL---PIETKGRG---LQESSHREWG-------------------QEM-VGRGMHGAGVTRSNSGSQE-----------------------------
SLC22B5   --------------------------------MATKPTEPVTIL--------SLRKLSL----------------------------------------------------GTAEPQVKE------------------------PK--------------------------------------------------TFTVEDAVETI----GFGRFHIALFLIMG-STGVVEAMEIMLIAVV--SPVIR-CE----------------------W------------------------------------------------------------------------------------------------------------------------Q-LENW----------------QVALVTTMV--------------------FFGYMVFSI----------LFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYI---WFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGYMLPL-SQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFK--FIPESA------RFNVSTGNTRAALATLERVAKMNRSV-------MPEGKLV--EPVLEKRGRFA------------DL--------------------------------LDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVV---------------------------------------------------VTGGDSGESQSPCY------------------------------CHMFAP--SD-----------YRTMIISTIGEIALNPLNILGINF--LGRRLSLSITMGCTALF---FLLLNICTS-SAGLIG--------------------------------FLFMLRALVAANFNTVYIYTAEVYPTT-----------MRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAF-TL---PIETKGRA---LQQIK----------------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC22A12 75 I/T 0.000148256 rs141570522
-- SLC22A12 90 R/H 0.000178366 rs121907896
-- SLC22A12 92 R/C 0.000197684 rs144328876
-- SLC22A12 92 R/P 0.000102774 rs758636962
-- SLC22A12 131 I/V 0.000161538 rs150428327
-- SLC22A12 227 A/T 0.000151339 rs201136391
-- SLC22A12 325 R/W 0.000393919 rs150255373
-- SLC22A12 342 R/H 0.000160451 rs140376651
-- SLC22A12 342 R/C 0.000393025 rs548145636
-- SLC22A12 359 A/T 0.00022073 rs201322494
-- SLC22A12 382 Q/L 0.000115774 rs765990518
-- SLC22A12 388 V/M 0.000151739 rs146388519
-- SLC22A12 395 G/S 0.00013988 rs781358659
-- SLC22A12 408 T/M 0.000168871 rs146048999
-- SLC22A12 434 R/C 0.000136212 rs145200251
-- SLC22A12 434 R/H 0.00156629 rs147647315
-- SLC22A12 447 A/V 0.000112752 rs572933684
-- SLC22A12 450 T/I 0.000137479 rs201423508
-- SLC22A12 467 T/M 0.00118128 rs200104135
-- SLC22A12 487 R/Q 0.000171427 rs151308640
-- SLC22A12 512 A/T 0.000100881 rs759924740
-- SLC22A12 538 A/T 0.00028004 rs199535450

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC22A12 SLC22A12 [plasma membrane] Organic anion transport

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC22A12 SLC22A12 G361V [plasma membrane] Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
SLC22A12 SLC22A12 L418R [plasma membrane] Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
SLC22A12 SLC22A12 R90H [plasma membrane] Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
SLC22A12 SLC22A12 E298D [plasma membrane] Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)
SLC22A12 SLC22A12 W258* [plasma membrane] Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)