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Detail Data SLC22A1


Basic description
Gene Name SLC22A1
Protein Name Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1)
Family SLC22
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550 
MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC QSPGVAELSQ RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL SCVDPLASLA TNRSHLPLGP CQDGWVYDTP GSSIVTEFNL VCADSWKLDL FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL GTVLVNAVSG VLMAFSPNYM SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY QMAFTVGLVA LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL MYLWFTDSVL YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV GRIYPMAMSN LLAGAACLVM IFISPDLHWL NIIIMCVGRM GITIAIQMIC LVNAELYPTF VRNLGVMVCS SLCDIGGIIT PFIVFRLREV WQALPLILFA VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN TIYLKVQTSE PSGT 
CCCHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCCCCC CCCCCCCHHH CCCCCCCCCC CCCCCCCCEE CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCEECCCC CCEEEEEEHH HHHHHHCHHH HHHHHHCCCC CHHHHHHHHH HHCCCCHHHH HHHHHHHHHC HHHHCCHHHH HHHHHHHHHH HHCCCHHHHC HHHHHHHCCC CHHHHHHHHC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCHHHH HCCCHHHHHH HHHHHHHHCC CCCCHHHHHH HHHHHHHHCC CCCHHHHHCC HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHCHHHCCCC CCCHHHHHHH HCCCCCCCCC CCCCCCCCCC CCCC
[Overview] SLC22A1 SLC22A10 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A2 SLC22A20 SLC22A23 SLC22A25 SLC22A3 SLC22A32 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC22A9 SLC22B1 SLC22B2 SLC22B3 SLC22B4 SLC22B5 
SLC22A1   --------------------------------MP--------------------------------------------------------------------------------------------------------------------------------------------------------------------TVDDILEQV---GESGWFQKQAFLILC-LLSAAFAPICVGIVFLGFTPDHH-CQSPGV-AELSQ---------RCGW-----------------SPAEELNYTVPGL-GPAGEA--------------FLGQCRRYEVDWNQ------SALSCVDPLASLATNRS-------------HLPLGP-------------C-QDGW------------VYD-TP--GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSL----------GVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYM---SMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIM-YQMAFTVGLVALTGLAYAL----------------PHWRWLQLAVSLPTFLFLLYYW--CVPESP------RWLLSQKRNTEAIKIMDHIAQKNGKL-------PPA---D--LKML-SLEEDV------TEKLSPSFADLF----------------------------RTPRLRKRTFILMYLWFTDSVLYQGLILHMGATS----------------------------------------------------------------------------------------------------------------------GN----------LYLDFLYSALVEIPGAFIALITIDR--VGRIYPMA---MSNLLAGAACLVMIFISP---------------------------DLHWLNII----IMCVGRMGITIAIQMICLVNAELYPTF-----------VRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTL-LL---P-ETKGVA---LPETMKDAEN-LGRK--------------A-----KPK----ENTIYLKVQTSE---------------PSGT--------
SLC22A10  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FEELLSQV---GGLGRFQMLHLVFIL-PSLMLLIPHILLENFAAAIPGHR-C-----------------------WVHMLDNNTGSGNETGILSEDALLRISIPLD--------------SNL----RPEKCRRFV----------HPQWQLLHLNGTIH-STS-------------EADTEP-------------C-VDGW------------VYD-QSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGI----------IGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFP---VYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVIL-SSGALSIGQIILGGLAYVF----------------RDWQTLHVVASVPFFVFFLLSR--WLVESA------RWLIITNKLDEGLKALRKVARTNGIK-------NAEETLN--IEVVRSTMQEE-LDAAQTKT---TVCDLF----------------------------RNPSMRKRICILVFLRFANTIPFYGTMVNLQHVG----------------------------------------------------------------------------------------------------------------------SN----------IFLLQVLYGAVALIVRCLALLTLNH--MGRRISQI---LFMFLVGLSILANTFVPK---------------------------EMQTLRVA----LACLGIGCSAATFSSVAVHFIELIPTV-----------LRARASGIDLTASRIGAALAPLLMT-LTVFFTTLPWIIYGIFPIIGGLIVF-LL---P-ETKNLP---LPDTIKDVEN-------------------Q-----K-K----NLKEKA---------------------------------
SLC22A11  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSKLLEQA---GGVGLFQTLQVLTFI-LPCLMIPSQMLLENFSAAIPGHR-C-----------------------WTHMLDNGSAVST---NMTPKALLTISIPPG--------------PNQ----GPHQCRRFR----------QPQWQLLDPNATAT-SWS-------------EADTEP-------------C-VDGW------------VYD-RSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSF----------IWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFV---IYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTV-VGCAFSAGQAALGGLAFAL----------------RDWRTLQLAASVPFFAISLISW--WLPESA------RWLIIKGKPDQALQELRKVARINGHK-------EAKN-LT--IEVLMSSVKEE-VASAKEPR---SVLDLF----------------------------CVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLG----------------------------------------------------------------------------------------------------------------------RD----------IFLLQALFGAVDFLGRATTALLLSF--LGRRTIQA---GSQAMAGLAILANMLVPQ---------------------------DLQTLRVV----FAVLGKGCFGISLTCLTIYKAELFPTP-----------VRMTADGILHTVGRLGAMMGPLILM-SRQALPLLPPLLYGVISIASSLVVLFFL---P-ETQGLP---LPDTIQDLES-------------------Q-----K-S----TAAQGNRQEAVTV-----ESTSL----------------
SLC22A12  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSELLDLV---GGLGRFQVLQTMALM-VSIMWLCTQSMLENFSAAVPSHR-C-----------------------WAPLLDNSTAQASILGSLSPEALLAISIPPG--------------PNQ----RPHQCRRFR----------QPQWQLLDPNATAT-SWS-------------EADTEP-------------C-VDGW------------VYD-RSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAA----------ACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFP---VYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTL-NSLGFSFGHGLTAAVAYGV----------------RDWTLLQLVVSVPFFLCFLYSW--WLAESA------RWLLTTGRLDWGLQELWRVAAINGKG-------AVQDTLT--PEVLLSAMREE-LSMGQPPA---SLGTLL----------------------------RMPGLRFRTCISTLCWFAFGFTFFGLALDLQALG----------------------------------------------------------------------------------------------------------------------SN----------IFLLQMFIGVVDIPAKMGALLLLSH--LGRRPTLA---ASLLLAGLCILANTLVPH---------------------------EMGALRSA----LAVLGLGGVGAAFTCITIYSSELFPTV-----------LRMTAVGLGQMAARGGAILGPLVRL-LGVHGPWLPLLVYGTVPVLSGLAAL-LL---P-ETQSLP---LPDTIQDVQN-------------------Q-----AVK----KATHGTLGNSV-L-----KSTQF----------------
SLC22A13  --------------------------------MA--------------------------------------------------------------------------------------------------------------------------------------------------------------------QFVQVLAEI---GDFGRFQIQLLILLC-VLNFLSPFYFFAHVFMVLDEPHH-CA--------------------VAWV---------KNHTFNLSAAEQLVLSVPLD--------------TAG----HPEPCLMFR----------PPP-----ANASLQ-DIL--SHR--------FNETQP-------------C-DMGW------------EYP-ENRLPS-LKNEFNLVCDRKHLKDTTQSVFMAGLLVGTL----------MFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFE---LYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVL-AQCNFSLGQMVLAGLAYGF----------------RNWRLLQITGTAPGLLLFFYFW--ALPESA------RWLLTRGRMDEAIQLIQKAASVNRRK------------LS--PELMNQLVPEK-TGPSG------NALDLF----------------------------RHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFG----------------------------------------------------------------------------------------------------------------------LD----------VYLTQLIFGAVEVPARCSSIFMMQR--FGRKWSQL---GTLVLGGLMCIIIIFIPA---------------------------DLPVVVTM----LAVVGKMATAAAFTISYVYSAELFPTI-----------LRQTGMGLVGIFSRIGGILTPLVIL-LGEYHAALPMLIYGSLPIVAGLLCT-LL---P-ETHGQG---LKDTLQDLEL---------------GPHPR-----SPK----SVPSEKETEAKGR-----TSSPG-------VAFVSSTYF
SLC22A14  --------------------------------MAGE----------------ENFKEEL--------------------------------------------------RSQDAS----------RNLNQ--------HEVAGHPHSWSL-------------------EMLLRRL-------------RAVHTKQDDKFANLLDAV---GEFGTFQQRLVALTF-IPSIMSAFFMFADHFVFTAQKPY-CN--------------------TSWILAVGP---------HLSKAEQLNLTIPQA--------------PNG----SFLTCFMYL----------PVPWNL----DSII-QFG-------------LNDTDT-------------C-QDGW------------IYP-DAK-KRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSL----------IFRLITDKMGRYPAILLSLLGLIIFGFGTAFMNSFH---LYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIIL-GHCFFAVGAVLLTGIAYSL----------------PHWQLLFLVGGILVIPFISYIW--ILPESP------RWLMMKGKVKEAKQVLCYAASVNKKT-------------------IPSNLLDE-LQLPRKKVTRASVLDFC----------------------------KNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELG----------------------------------------------------------------------------------------------------------------------VS----------VHFRHVVPSIMEVPARLCCIFLLQQ--IGRKWSLA---VTLLQAIIWCLLLLFLPEGEDGLRLKWPRCP------------ATELKSMTIL----VLMLREFSLAATVTVFFLYTAELLPTV-----------LRATGLGLVSLASVAGAILS--LTI-ISQTPSLLPIFLCCVLAIVAFSLSS-LL---P-ETRDQP---LSESLNHSSQ-IR----------------N-----KVK----DMKTKETSSDDV---------------------------
SLC22A15  --------------------------------ME---------------------------------------------------------------------------------------------------------------------------------------------------------------------VEEAFQAV---GEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH-------------------------W---------------------DLAELLPNQ--------------SHG--------------------------------------NQSAGEDQ---------------------------A-FGDWLLTANGSEIHKHVHF-SSSFTS-IASEWFLIANRSYKVSAASSFFFSGVFVGVI----------SFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYE---FFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSI-GGLFFAVGIAQYALLGYFI----------------RSWRTLAILVNLQGTVVFLLSL--FIPESP------RWLYSQGRLSEAEEALYLIAKRNRKL-------KCTFSLT--HPANRSCRETG------------SFLDLF----------------------------RYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLG----------------------------------------------------------------------------------------------------------------------GS----------IYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLS---AFLCLGGLACLIVMFLPEKK-------------------------DTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTV-----------IRNVGLGTCSMFSRVGGIIAPFIPS-LKYVQWSLPFIVFGATGLTSGLLSL-LL---P-ETLNSP---LLETFSDLQV-YSYRRLGEEALSLQALDPQQC---VDK----ESSLGSESEEEEEFYDADEETQMIK--------------
SLC22A16  ------------------------------MGSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------HFEGIYDHV---GHFGRFQRVLYFICA-FQNISCGIHYLASVFMGVTPHHV-CRPPG---NVSQVVFH----NHSNW-----------------S----LEDTGAL--LSSGQKDYVTVQLQNGE-IWELSRCSRNKRE-----------------------NTS-------------SLGYEY-----TGSKKEFPC-VDGY------------IYD-QNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSV----------TFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYY---TFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVH-LHSFFAVGTLLVALTGYLV----------------RTWWLYQMILSTVTVPFILCCW--VLPETP------FWLLSEGRYEEAQKIVDIMAKWN-----------RASSCK--LSELLSLDLQGPVSNSPTEVQKHNLSYLF----------------------------YNWSITKRTLTVWLIWFTGSLGFYSFSLNSVNLG----------------------------------------------------------------------------------------------------------------------GN----------EYLNLFLLGVVEIPAYTFVCIAMDK--VGRRTVLA---YSLFCSALACGVVMVIPQ---------------------------KHYILGVV----TAMVGKFAIGAAFGLIYLYTAELYPTI-----------VRSLAVGSGSMVCRLASILAPFSVD-LSSIWIFIPQLFVGTMALLSGVLTL-KL---P-ETLGKR---LATTWEEAAK-LESE--------------N-----ESK----SSKLLLTTNNSGL-----EKTEA--ITPRDSGLGE----
SLC22A17  --------------------------------MASD----------------PIFTLA-------------------------------------------------------------------PPLH---------CHYGAFP-----------------------------------------------------------PNA---SG-------------W-----------------EQP-----------PNASGVSV----------------------------------ASAALA-ASAASRVATS---TD-------PSCSGFA----------PPD-------------FN-----------H--------------------C-LKDW------------DYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYL----------FLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSST---GVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALA-GELVGVGGHFLFLGLALVS----------------KDWRFLQRMITAPCILFLFYGWPGLFLESA------RWLIVKRQIEEAQSVLRILAERNR---------PHGQMLG---EEAQEALQDLENTCPLPATSSFSFASLL----------------------------NYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGS-------------------------------------------------------------------------------------------------------------------P--SD----------FYLCSLLASGTAALACVFLGVTVDR--FGRRGILL---LSMTLTGIASLVLLGLWD---------CEHPIFPTVWAQQGNPNRDLNEAAIT---TFSVLGLFSSQAAAILSTLLAAEVIPTT-----------VRGRGLGLIMALGALGGLSGPAQRL-HMGHGAFLQHVVLAACALLCILSIM-LL---P-ETKRKL---LPEVLRDGEL-CRRPSLLR------QPPPT-----RCD----HVPLLAT--------------------PNPAL-------
SLC22A18  --------------------------------MQGA---------------------------------------RA-------------------------------------------------------------------PRDQGRSP----------------------------------------------------------GRMSALGRSSVILLT-------------------------------------------------YV----------------------------------------------------------------------------------------------------LAATELT------------C-----------------LFM-QFSIVPYLSRKLGL------------DSIAFGYLQTTF-GVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGR-LGLCFGVGVILGSLLGGTLVSAYGIQCP-------------AILAALATLLGAVLSF-TCIPAST-----------------------KGAKTDAQAPLPG--GPRASVFD--LKAIASLLRLP------------DVPRIF----------LVKVASNCP-----------------TGLFMVMFSIISMDFFQLEAAQAGYL----------------------------------------------------------------------------------------------------------------------MS--------FFGLLQMVTQGLV----------------IGQLSSHF---SEEVLLRASVLVFIVVGL---------------------------AMAWMSSV--FHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTS--------DTGTMLGLCASVQPLLRTLGPTVGG-LLYRSFGVP--VFGHVQVAINTLVLLVLWRKP----------MPQ--------------------------R-----KDKV---R--------------------------------------
SLC22A2   --------------------------------MP-------------------------------------------------------------------------------------------------------------------------------------------------------------------TTVDDVLEHG---GEFHFFQKQMFFLLA-LLSATFAPIYVGIVFLGFTPDHR-CRSPGV-AELSL---------RCGW-----------------SPAEELNYTVPGP-GPAGEA--------------SPRQCRRYEVDWNQ------STFDCVDPLASLDTNRS-------------RLPLGP-------------C-RDGW------------VYE-TP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSM----------SIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYT---WMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF-YQVAYTVGLLVLAGVAYAL----------------PHWRWLQFTVSLPNFFFLLYYW--CIPESP------RWLISQNKNAEAMRIIKHIAKKNGKS-------LPA---S--LQRL-RLEEET------GKKLNPSFLDLV----------------------------RTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAG----------------------------------------------------------------------------------------------------------------------DN----------IYLDFFYSALVEFPAAFMIILTIDR--IGRRYPWA---ASNMVAGAACLASVFIPG---------------------------DLQWLKII----ISCLGRMGITMAYEIVCLVNAELYPTF-----------IRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVL-LL---P-ETKGKA---LPETIEEAEN-MQRP--------------R-----KNK----EKMIYLQVQKLD--------------IPLN---------
SLC22A20  ------------------------------MAMA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FTDLLDAL---GSMGRFQLNHTALLL-LPCGLLACHNFLQNFTAAVPPHH-CRGPANHTEASTNDS-------GAW----------------------LRATIPLD--------------QLG----APEPCRRFT----------KPQWALLSPNSSIP-----------------GAATEG-------------C-KDGW------------VYN-RSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAA----------VFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFS---AYCVFRFLMGMTFSGIILNSVSLVASRV--------------------------IPLAP----------------PAW---QVPVSC--------------TESAEGGCNEREEGGRGKADQGGDELLHPKRV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CK----------CLHLQLNLGPLPNPGHPQGHM-LSH--GDLRGRQ----------------------------------------------------------------------------------------------------RSSGSG------EQGGSCEP------ESRNGRLPA----------------VA---P-AGLGLPFVHLPLSAREKQI-LS----------------S-----KFQ----S--------------------------------------
SLC22A23  MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASA----------------PLGGRAG--------------------------------------------------PGGGAEIQ------PLPPLHPGGGPHPSCCSAAAAPS------------------------LLLL-----------------------DYDGSVLPFL---GGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFW-CRGAGKGTELAGVTTTGRGGDMGNWT----------------SLPTTPFATAPWE-AAGNRSNSSG---ADGGDTPPLPS---------------PPDKGD---------NAS-----------N--------------------CDCRAW------------DYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYL----------ITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVT---MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMV-ASFVAMAGQFLMPGLAALC----------------RDWQVLQALIICPFLLMLLY-W-SIFPESL------RWLMATQQFESAKRLILHFTQKNRMN-------PEGDIKGVIPELEKELSRRPKKVC---------IVKVV----------------------------GTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVK----------------------------------------------------------------------------------------------------------------VPLLEN----------FYADYYTTASIALVSCLAMCVVVRF--LGRRGGLL---LFMILTALASLLQLGLLN----LIGKYSQHP-------DSGMSDSVKDKFSI----AFSIVGMFASHAVGSLSVFFCAEITPTV-----------IRCGGLGLVLASAGFGMLTAPIIEL-HNQKGYFLHHIIFACCTLICIICIL-LL---P-ESRDQN---LPENISNGEH-YTRQPLL----------PH-----KKG----EQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM
SLC22A25  --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FQDLLDQV---GGLGRFQILQMVFLI-MFNVIVYHQTQLENFAAFILDHR-C-----------------------WVHILDNDTIPDNDPGTLSQDALLRISIPFD--------------SNL----RPEKCRRFV----------HPQWKLIHLNGTFP-NTS-------------EPDTEP-------------C-VDGW------------VYD-QSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGN----------LYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTIL---VYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTL-TLCAASIGHITLGSLAFVI----------------RDQCILQLVMSAPCFVFFLFSR--WLAESA------RWLIINNKPEEGLKELRKAAHRNGMK-------NAEDILT--MEVLKSTMKQE-LEAAQKKH---SLCELL----------------------------RIPNICKRICFLSFVRFASTIPFWGLTLHLQHLG----------------------------------------------------------------------------------------------------------------------NN----------VFLLQTLFGAVTLLANCVAPWALNH--MSRRLSQM---LLMFLLATCLLAIIFVPQ---------------------------EMQTLRVV----LATLGVGAASLGITCSTAQENELIPSI-----------IRGRATGITGNFANIGGALASLMMI-LSIYSRPLPWIIYGVFAILSGLVVL-LL---P-ETRNQP---LLDSIQDVEN-------------------E-----G-V----NSLAAPQ---R-S-----SVL------------------
SLC22A3   --------------------------------MP--------------------------------------------------------------------------------------------------------------------------------------------------------------------SFDEALQRV---GEFGRFQRRVFLLLC-LTGVTFAFLFVGVVFLGTQPDHYWCRGPSA-AALAE---------RCGW-----------------SPEEEWNRTAPASRGPEPPE--------------RRGRCQRYLLEAANDSASATSALSCADPLAAFP-NRS--------------APLVP-------------C-RGGW------------RYA-QA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAF----------TLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFP---VFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIV-IQMFFTLGIIILPGIAYFI----------------PNWQGIQLAITLPSFLFLLYYW--VVPESP------RWLITRKKGDKALQILRRIAKCNGKY-------LSS---N--YSEI-TVTDE--------EVSNPSFLDLV----------------------------RTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIG----------------------------------------------------------------------------------------------------------------------GN----------LYIDFFISGVVELPGALLILLTIER--LGRRLPFA---ASNIVAGVACLVTAFLPE---------------------------GIAWLRTT----VATLGRLGITMAFEIVYLVNSELYPTT-----------LRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVM-LL---P-ETKGIA---LPETVDDVEK-LGSP--------------HSCKCGRNK----KT-------------------------PVSRSHL-----
SLC22A32  --------------------------------MG--------------------------------------WG-----------------------------------GGGGCTPR--------PPIHQ----QP--------PER---------------------------------------------------------------------RVVTVVFLG-LLLDLLAFTLLLPLLPGLLESHGRAHDP----------------LYGSW--------------------------------------------QGG-------------------------------------------------------------------------V---DWF---------------ATAIGMPVEKRYNSV--------------LFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFA---AFLASRLIGGISKGNVSLST-AIVADLGSPLARSQGMAV-IGVAFSLGFTLGPMLGASL------PLEM------APWFALLFAASDLLFIF------CFLPETL--PLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLS-------------------------SLRRLG-----------------------------------------LVYFLYLFLFSGLEYTLSFLT---------------------------------HQRFQF-------------------------------------------------------------------------------SS----LQQGKMFFLIGLTMATIQGA-------------YARRIHPGGE-----VAAVKRALLLLVPA--FLLIG-----------W-----------------GRSLPVLGLGLLLYSFAAAVVV-----PCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASV--------YWLAGAQACFTTWSGLFLL---P--------FFLLQKLSYPAQ-------------------------TLKA---E--------------------------------------
SLC22A4   --------------------------------MR--------------------------------------------------------------------------------------------------------------------------------------------------------------------DYDEVIAFL---GEWGPFQRLIFFLLS-ASIIPNGFNGMSVVFLAGTPEHR-CRVPDA-ANLS-----------SAW-----------------R-----NNSVPLR-LRDGRE--------------VPHSCSRYR-------------------LATIA-NFS-------------ALGLEPGRDVDLGQLEQESC-LDGW------------EFS-QDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSF----------VSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWE---MFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFI----------------RDWRMLLLALTVPGVLCVPLWW--FIPESP------RWLISQRRFREAEDIIQKAAKMNNIA-------VPAVIFD--SVE--ELNPL--------KQQKAFILDLF----------------------------RTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLH----------------------------------------------------------------------------------------------------------------------GD----------AYLNCFLSALIEIPAYITAWLLLRT--LPRRYIIA---AVLFWGGGVLLFIQLVPV---------------------------DYYFLSIG----LVMLGKFGITSAFSMLYVFTAELYPTL-----------VRNMAVGVTSTASRVGSIIAPYFVY-LGAYNRMLPYIVMGSLTVLIGILTL-FF---P-ESLGMT---LPETLEQMQK-VKWF--------------R-----SGK----KTRDSMETEEN----------------PKVL-ITAF---
SLC22A5   --------------------------------MR--------------------------------------------------------------------------------------------------------------------------------------------------------------------DYDEVTAFL---GEWGPFQRLIFFLLS-ASIIPNGFTGLSSVFLIATPEHR-CRVPDA-ANLS-----------SAW-----------------R-----NHTVPLR-LRDGRE--------------VPHSCRRYR-------------------LATIA-NFS-------------ALGLEPGRDVDLGQLEQESC-LDGW------------EFS-QDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSF----------ISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFE---MFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFI----------------RDWRMLLVALTMPGVLCVALWW--FIPESP------RWLISQGRFEEAEVIIRKAAKANGIV-------VPSTIFD--PSELQDLSSK--------KQQSHNILDLL----------------------------RTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLH----------------------------------------------------------------------------------------------------------------------GD----------IFVNCFLSAMVEVPAYVLAWLLLQY--LPRRYSMA---TALFLGGSVLLFMQLVPP---------------------------DLYYLATV----LVMVGKFGVTAAFSMVYVYTAELYPTV-----------VRNMGVGVSSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTL-FL---P-ESFGTP---LPDTIDQMLR-VKGM--------------K-----HRKT-PSHTRMLKDGQER----------------PTILKSTAF---
SLC22A6   --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FNDLLQQV---GGVGRFQQIQVTLVV-LPLLLMASHNTLQNFTAAIPTHH-CR-PPADANLSKNGG------LEVW--------------------------LPRD--------------RQG----QPESCLRFT----------SPQWGLPFLNGTEA-NGT--------------GATEP-------------C-TDGW------------IYD-NSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAM----------VFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFP---IYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTL-IGYVYSLGQFLLAGVAYAV----------------PHWRHLQLLVSAPFFAFFIYSW--FFIESA------RWHSSSGRLDLTLRALQRVARINGKR-------EEGAKLS--MEVLRASLQKE-LTMGKGQA---SAMELL----------------------------RCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFG----------------------------------------------------------------------------------------------------------------------VS----------IYLIQVIFGAVDLPAKLVGFLVINS--LGRRPAQM---AALLLAGICILLNGVIPQ---------------------------DQSIVRTS----LAVLGKGCLAASFNCIFLYTGELYPTM-----------IRQTGMGMGSTMARVGSIVSPLVSM-TAELYPSMPLFIYGAVPVAASAVTV-LL---P-ETLGQP---LPDTVQDLESRWAPTQ------KEAGIYPR-----KGK----QTRQQQEHQK--------YMVPLQASAQEKNGL------
SLC22A7   --------------------------------MG---------------------------------------------------------------------------------------------------------------------------------------------------------------------FEELLEQV---GGFGPFQLRNVALLA-LPRVLLPLHFLLPIFLAAVPAHR-CALPGAPANFSHQ---------DVW----------------------LEAHLPRE--------------PDG----TLSSCLRFA----------YPQ--------ALP-NTTLGEERQSRGELEDEPATVP-------------C-SQGW------------EYD-HSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAV----------AFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYV---MFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVL-SSTFWTGGVMLLALVGYLI----------------RDWRWLLLAVTLPCAPGILSLW--WVPESA------RWLLTQGHVKEAHRYLLHCARLNGRP-------VCEDSFS--QEAVSKVAAGE-RVVRRP-----SYLDLF----------------------------RTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLG----------------------------------------------------------------------------------------------------------------------LN----------VYQTQLLFGAVELPSKLLVYLSVRY--AGRRLTQA---GTLLGTALAFGTRLLVSS---------------------------DMKSWSTV----LAVMGKAFSEAAFTTAYLFTSELYPTV-----------LRQTGMGLTALVGRLGGSLAPLAAL-LDGVWLSLPKLTYGGIALLAAGTAL-LL---P-ETRQAQ---LPETIQDVER---------------------------K----SAPTSLQEEEMPM-----KQVQN----------------
SLC22A8   --------------------------------MT---------------------------------------------------------------------------------------------------------------------------------------------------------------------FSEILDRV---GSMGHFQFLHVAILG-LPILNMANHNLLQIFTAATPVHH-CR-PPHNASTGP------------WV-------------------------LPMG--------------PNG----KPERCLRFV----------HPP------NASLP-NDT-------------QRAMEP-------------C-LDGW------------VY--NST-KDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGL----------VLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP---IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTA-LGYCYTFGQFILPGLAYAI----------------PQWRWLQLTVSIPFFVFFLSSW--WTPESI------RWLVLSGKSSKALKILRRVAVFNGKK-------EEGERLS--LEELKLNLQKE-ISLAKAKY---TASDLF----------------------------RIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFG----------------------------------------------------------------------------------------------------------------------VN----------LYILQIIFGGVDVPAKFITILSLSY--LGRHTTQA---AALLLAGGAILALTFVPL---------------------------DLQTVRTV----LAVFGKGCLSSSFSCLFLYTSELYPTV-----------IRQTGMGVSNLWTRVGSMVSPLVKI-TGEVQPFIPNIIYGITALLGGSAAL-FL---P-ETLNQP---LPETIEDLEN-WS----------------L-----RAK----KPKQEPEVEKA-S-----QRIPLQPHGP---GLGSS---
SLC22A9   --------------------------------MA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FQDLLGHA---GDLWRFQILQTVFLS-IFAVATYLHFMLENFTAFIPGHR-C-----------------------WVHILDNDTVSDNDTGALSQDALLRISIPLD--------------SNM----RPEKCRRFV----------HPQWQLLHLNGTFP-NTS-------------DADMEP-------------C-VDGW------------VYD-RISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGI----------LGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFL---IYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITL-GMCPSGIAFMTLAGLAFAI----------------RDWHILQLVVSVPYFVIFLTSS--WLLESA------RWLIINNKPEEGLKELRKAAHRSGMK-------NARDTLT--LEILKSTMKKE-LEAAQKKK--PSLCEML----------------------------HMPNICKRISLLSFTRFANFMAYFGLNLHVQHLG----------------------------------------------------------------------------------------------------------------------NN----------VFLLQTLFGAVILLANCVAPWALKY--MNRRASQM---LLMFLLAICLLAIIFVPQ---------------------------EMQTLREV----LATLGLGASALANTLAFAHGNEVIPTI-----------IRARAMGINATFANIAGALAPLMMI-LSVYSPPLPWIIYGVFPFISGFAFL-LL---P-ETRNKP---LFDTIQDEKN-------------------E-----R-K----DPREPKQEDPR-V-----EVTQF----------------
SLC22B1   --------------------------------MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPSDGYYRGEGTQDEEE---GGASSDATEGHDEDDEIYE--------GEYQGIPRAESGG---------KGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLG-LALMADGVEVFVVGFV--LPSAE-KD----------------------M------------------------------------------------------------------------------------------------------------------------C-LSDS----------------NKGMLGLIV--------------------YLGMMVGAF----------LWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYG---TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSW-LCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALT--TQPESP------RFFLENGKHDEAWMVLKQVHDTNMRAK-----GHPERVFS--VTHIKTIHQED------------ELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPL------DVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDK--IGRLRMLA---GSSVMSCVSCFFLSFGNS-ESAMIA--------------------------------LLCLFGGVSIASWNALDVLTVELYPSD-----------KRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLAL-KL---P-ETRGQV---LQ-------------------------------------------------------------------------------
SLC22B2   --------------------------------MDDY-------------------------------KYQDNYG--------------GY-APSDGYYRGNESNPEED-----AQSDVTEGHDEEDEIYE--------GEYQGIPHPDDVKAKQAKMAPSRMDSLRGQTDL------------------MAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLG-LALMADGVEVFVVSFA--LPSAE-KD----------------------M------------------------------------------------------------------------------------------------------------------------C-LSSS----------------KKGMLGMIV--------------------YLGMMAGAF----------ILGGLADKLGRKRVLSMSLAVNASFASLSSFVQGYG---AFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSW-LGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALK--FMPESP------RFLLEMGKHDEAWMILKQVHDTNMRAK-----GTPEKVFT--VSNIKTPKQMD------------EFIEIQSSTGTWYQRWLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLE--QDND------FLIYLVSFLGSLSVLPGNIISALLMDR--IGRLKMIG---GSMLISAVCCFFLFFGNS-ESAMIG--------------------------------WQCLFCGTSIAAWNALDVITVELYPTN-----------QRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIAL-RL---P-ETREQV---LM-------------------------------------------------------------------------------
SLC22B3   --------------------------------MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDY-YPAGETYNGEANDDE-------GSSEATEGHDEDDEIYE--------GEYQGIPSMNQAKDSIVSVGQPKGDEYKDRREL------------------ESERRADEEELAQQYELIIQECGHGRFQWALFFVLG-MALMADGVEVFVVGFV--LPSAE-TD----------------------L------------------------------------------------------------------------------------------------------------------------C-IPNS----------------GSGWLGSIV--------------------YLGMMVGAF----------FWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYG---FFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSW-LCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALT--FMPESP------RFLLEVGKHDEAWMILKLIHDTNMRAR-----GQPEKVFT--VNKIKTPKQID------------ELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFD--DDYS-----AYWIYFVNFLGTLAVLPGNIVSALLMDR--IGRLTMLG---GSMVLSGISCFFLWFGTS-ESMMIG--------------------------------MLCLYNGLTISAWNSLDVVTVELYPTD-----------RRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGL-CL---P-DTRTQV---LM-------------------------------------------------------------------------------
SLC22B4   --------------------------------MEED------LF--------QLRQLPVVKFRRT----------------------------------GESARSEDDTASGEHEVQIEGVHVGLEAVEL--------DDGAAVPKE------------------------------------------FANPTDDTFMVEDAVEAI----GFGKFQWKLSVLTG-LAWMADAMEMMILSIL--APQLH-CE----------------------W------------------------------------------------------------------------------------------------------------------------R-LPSW----------------QVALLTSVV--------------------FVGMMSSST----------LWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYS---WILVLRGLVGFGIGG-VPQSVTLYAEFLPMKARAKCILL-IEVFWAIGTVFEVVLAVFVMPSLG-------------WRWLLILSAVPLLLFAVLCF--WLPESA------RYDVLSGNQEKAIATLKRIATENGAP-------MPLGKLI--ISRQEDRGKMR------------DL--------------------------------FTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGDVCGISSRKKAV----------------------------------------------------------EAKCSLA------------------------------CEYLSE--ED-----------YMDLLWTTLSEFPGVLVTLWIIDR--LGRKKTMAL---CFVIFSFCSLLLFICVG-RNVLTL--------------------------------LLFIARAFISGGFQAAYVYTPEVYPTA-----------TRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASC-FL---PIETKGRG---LQESSHREWG-------------------QEM-VGRGMHGAGVTRSNSGSQE-----------------------------
SLC22B5   --------------------------------MATKPTEPVTIL--------SLRKLSL----------------------------------------------------GTAEPQVKE------------------------PK--------------------------------------------------TFTVEDAVETI----GFGRFHIALFLIMG-STGVVEAMEIMLIAVV--SPVIR-CE----------------------W------------------------------------------------------------------------------------------------------------------------Q-LENW----------------QVALVTTMV--------------------FFGYMVFSI----------LFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYI---WFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGYMLPL-SQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFK--FIPESA------RFNVSTGNTRAALATLERVAKMNRSV-------MPEGKLV--EPVLEKRGRFA------------DL--------------------------------LDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVV---------------------------------------------------VTGGDSGESQSPCY------------------------------CHMFAP--SD-----------YRTMIISTIGEIALNPLNILGINF--LGRRLSLSITMGCTALF---FLLLNICTS-SAGLIG--------------------------------FLFMLRALVAANFNTVYIYTAEVYPTT-----------MRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAF-TL---PIETKGRA---LQQIK----------------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC22A1 11 V/A 0.000103672 rs749926302
-- SLC22A1 14 S/F 0.00189196 rs34447885
-- SLC22A1 23 L/V 0.000147177 rs34570655
-- SLC22A1 38 G/D 0.00384851 rs35888596
-- SLC22A1 61 R/C 0.0517482 rs12208357
-- SLC22A1 71 N/S 0.000239529 rs149135239
-- SLC22A1 85 L/F 0.000244172 rs35546288
-- SLC22A1 88 C/R 0.00191254 rs55918055
-- SLC22A1 99 A/S 0.000100377 rs535669545
-- SLC22A1 115 H/P 0.00148161 rs201731508
-- SLC22A1 117 P/L 0.000439174 rs200684404
-- SLC22A1 160 L/F 0.830854 rs683369
-- SLC22A1 165 G/C 0.00286401 rs201942835
-- SLC22A1 168 Y/H 0.000123323 rs775723458
-- SLC22A1 174 G/S 0.000119566 rs751044707
-- SLC22A1 175 R/H 0.000163004 rs144273196
-- SLC22A1 189 S/L 0.0012593 rs34104736
-- SLC22A1 198 N/S 0.00012912 rs200245693
-- SLC22A1 220 G/V 0.000185036 rs36103319
-- SLC22A1 237 A/E 0.000163858 rs201454956
-- SLC22A1 273 F/L 0.000402849 rs537937675
-- SLC22A1 283 P/L 0.000505063 rs4646277
-- SLC22A1 287 R/W 0.00105775 rs4646278
-- SLC22A1 291 S/P 0.000966249 rs138369190
-- SLC22A1 340 T/M 0.00106568 rs372021398
-- SLC22A1 341 P/L 0.0376329 rs2282143
-- SLC22A1 342 R/H 0.00174165 rs34205214
-- SLC22A1 400 V/L 0.000108031 rs143522800
-- SLC22A1 400 V/M 0.000108031 rs143522800
-- SLC22A1 401 G/S 0.0160975 rs34130495
-- SLC22A1 403 I/V 0.00260147 rs188898744
-- SLC22A1 408 M/V 0.632577 rs628031
-- SLC22A1 414 G/A 0.000486594 rs72552762
-- SLC22A1 419 V/I 0.000349084 rs200915918
-- SLC22A1 440 M/I 0.00699078 rs35956182
-- SLC22A1 461 V/I 0.000747842 rs34295611
-- SLC22A1 464 V/I 0.0291864 rs41267797
-- SLC22A1 465 G/R 0.0131288 rs34059508
-- SLC22A1 481 G/D 0.000509052 rs78899680
-- SLC22A1 481 G/V 0.00160272 rs78899680
-- SLC22A1 488 R/M 0.00277298 rs35270274
-- SLC22A1 519 V/F 0.00160272 rs78899680
-- SLC22A1 519 V/I 0.000509052 rs78899680

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC22A1 SLC22A1 [plasma membrane] Na+/Cl- dependent neurotransmitter transporters
main SLC22A1 SLC22A1 [plasma membrane] Organic cation transport
SLC22A1 SLC22A1 [plasma membrane] Neurotransmitter clearance
SLC22A1 SLC22A1 [plasma membrane] Norepinephrine Neurotransmitter Release Cycle
SLC22A1 SLC22A1 [plasma membrane] Abacavir transmembrane transport

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data