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Detail Data SLC20A2


Basic description
Gene Name SLC20A2
Protein Name Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2)
Family SLC20
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650 
MAMDEYLWMV ILGFIIAFIL AFSVGANDVA NSFGTAVGSG VVTLRQACIL ASIFETTGSV LLGAKVGETI RKGIIDVNLY NETVETLMAG EVSAMVGSAV WQLIASFLRL PISGTHCIVG STIGFSLVAI GTKGVQWMEL VKIVASWFIS PLLSGFMSGL LFVLIRIFIL KKEDPVPNGL RALPVFYAAT IAINVFSIMY TGAPVLGLVL PMWAIALISF GVALLFAFFV WLFVCPWMRR KITGKLQKEG ALSRVSDESL SKVQEAESPV FKELPGAKAN DDSTIPLTGA AGETLGTSEG TSAGSHPRAA YGRALSMTHG SVKSPISNGT FGFDGHTRSD GHVYHTVHKD SGLYKDLLHK IHIDRGPEEK PAQESNYRLL RRNNSYTCYT AAICGLPVHA TFRAADSSAP EDSEKLVGDT VSYSKKRLRY DSYSSYCNAV AEAEIEAEEG GVEMKLASEL ADPDQPREDP AEEEKEEKDA PEVHLLFHFL QVLTACFGSF AHGGNDVSNA IGPLVALWLI YKQGGVTQEA ATPVWLLFYG GVGICTGLWV WGRRVIQTMG KDLTPITPSS GFTIELASAF TVVIASNIGL PVSTTHCKVG SVVAVGWIRS RKAVDWRLFR NIFVAWFVTV PVAGLFSAAV MALLMYGILP YV 
CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCHHHHH HHHHHHHHHC CHHHCCHHHH HHHHHHHHHC HHHHHHHHHH HHHHHHHHHH CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCEEECCCCC CCCHHCCCCC HHCCCCCCCC CCCCCCCCEE CCCCCCCCCC CCCCCCCCHH HCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCEEEEEECC CCCHHHHHHH HCCCCCCCCC CCCHHHHHHH CCCCCCCCHH HHCCCCCCCC CCCCCCCCCC CCHHHHCCCC CCCCCCCCCC CCHHHHHHHH HCCCCCCCCC CCEEEEHHHH CCCCCCCCCC CHHHHHHHCC HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC HHHHHHHHHH HHCCCCCCCC CHHHHHHHHH HHHHHHHHHH HCHHHHHCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHCCC CCCCCHHHHH HEEEHHHCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CC
[Overview] SLC20A1 SLC20A2 
SLC20A1   MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLRALPVFYACTVGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKEDHEETKLSVGDIENKHPVSEVGP-------ATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSID-----------STVNGAVQLP--NGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSG--DKP--------LRRNNSYTSYTMAICGMPLD-SFRAKEGEQKGEEMEKLTWPNAD-SKKRIRMDSYTSYCNAVSDLHSASE---IDMSVKAEMGLGDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM-
SLC20A2   MA---------------MDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGL-VLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGK----------LQKEGALSRVSDESLSKVQEAES--PVFKELPGAKANDDSTIPLTGAAGE--------------------TLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTF-----GFDGHTRSDGHV-YHTVHKDSGLYKDLLHKIHI--------DRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAP-EDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC20A2 178 N/S 0.000164101 rs142888552
-- SLC20A2 254 R/Q 0.000453367 rs138816265
-- SLC20A2 304 G/S 0.0152308 rs73675069
-- SLC20A2 400 A/T 0.000202996 rs116194858
-- SLC20A2 480 A/T 0.0126855 rs79577461
-- SLC20A2 527 T/M 0.000203241 rs145970823
-- SLC20A2 532 T/I 0.000147289 rs138052637
-- SLC20A2 588 I/V 0.000122 rs201815306
-- SLC20A2 609 R/C 0.000107973 rs200340427
-- SLC20A2 645 M/K 0.000477551 rs115580154

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC20A2 SLC20A2 [plasma membrane] Sodium-coupled phosphate cotransporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
SLC20A2 SLC20A2 L170* [plasma membrane] Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
SLC20A2 SLC20A2 S601L [plasma membrane] Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
SLC20A2 SLC20A2 T595M [plasma membrane] Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
SLC20A2 SLC20A2 S610Afs*17 [plasma membrane] Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
SLC20A2 SLC20A2 G498R [plasma membrane] Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)
SLC20A2 SLC20A2 V195L*61 [plasma membrane] Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)