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Detail Data SLC19A3
Basic description
| Gene Name | SLC19A3 |
|---|---|
| Protein Name | Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3) |
| Family | SLC19 |
| Category | - |
| Reaction name | - |
| Reaction | - |
[Overview]
10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 MDCYRTSLSS SWIYPTVILC LFGFFSMMRP SEPFLIPYLS GPDKNLTSAE ITNEIFPVWT YSYLVLLLPV FVLTDYVRYK PVIILQGISF IITWLLLLFG QGVKTMQVVE FFYGMVTAAE VAYYAYIYSV VSPEHYQRVS GYCRSVTLAA YTAGSVLAQL LVSLANMSYF YLNVISLASV SVAFLFSLFL PMPKKSMFFH AKPSREIKKS SSVNPVLEET HEGEAPGCEE QKPTSEILST SGKLNKGQLN SLKPSNVTVD VFVQWFQDLK ECYSSKRLFY WSLWWAFATA GFNQVLNYVQ ILWDYKAPSQ DSSIYNGAVE AIATFGGAVA AFAVGYVKVN WDLLGELALV VFSVVNAGSL FLMHYTANIW ACYAGYLIFK SSYMLLITIA VFQIAVNLNV ERYALVFGIN TFIALVIQTI MTVIVVDQRG LNLPVSIQFL VYGSYFAVIA GIFLMRSMYI TYSTKSQKDV QSPAPSENPD VSHPEEESNI IMSTKL CCCCCCCCCC CCHHHHHHHH HHHHHHHCCC CCCCCHHHHC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHHHC CHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHH HHHHHHHHHC CCCCHHHCCC CCCCHHHCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHHHHHH CCHHHHHHHH EEEEECCCCC CCCEECCCHH HHHHHHHHHH HHHHHHHHCC HHHHHHHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCHHHCCC EEEEEC
[Overview]
SLC19A1 MVPSSPAVEKQVPVEPGPDPELRS-------WRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRG--RC--------------------------------ETSASELERMNP-----GPGGKLGHA-LRVACGDSVLARML----RELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFL-GAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLS-PEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ SLC19A2 MDVPGPVSRRAAAAAAT--VLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEP-------------------KPDRLLV-LKVLW-NDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAA-IYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTV---GNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLA-SGAVSVMKKCRK-----------------------------------------LEDPQSS------------------------------SQVTTS------------------------------------------------ SLC19A3 MD-----CYRTSLSSS---------------WIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSR-------EIKKSSSVNPVLEETH-------------EGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSS-IYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYT---ANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKD---VQSPA--------------------------PSENPDVSHPEEE------------------------------SNIIMST------------------------------KL---------------
Variant
| check | gene name | residue number | Reference Amino Acid / Variant Amino Acid | minor allele frequency | rs number |
|---|---|---|---|---|---|
| -- | SLC19A3 | 9 | R/G | 0.0010097 | rs768902061 |
| -- | SLC19A3 | 44 | G/D | 0.000817987 | rs151020575 |
| -- | SLC19A3 | 63 | Y/H | 0.000123533 | rs144817990 |
| -- | SLC19A3 | 92 | A/V | 0.0001208 | rs756911054 |
| -- | SLC19A3 | 112 | F/S | 0.000190869 | rs200971390 |
| -- | SLC19A3 | 128 | Y/C | 0.00012727 | rs770685804 |
| -- | SLC19A3 | 141 | G/S | 0.00423432 | rs148144444 |
| -- | SLC19A3 | 146 | V/I | 0.000123403 | rs147502239 |
| -- | SLC19A3 | 174 | V/I | 0.00770326 | rs59736804 |
| -- | SLC19A3 | 204 | S/N | 0.000115346 | rs773705000 |
| -- | SLC19A3 | 205 | R/G | 0.000330138 | rs199558186 |
| -- | SLC19A3 | 207 | I/M | 0.00127281 | rs145804755 |
| -- | SLC19A3 | 260 | D/V | 0.000425681 | rs371155923 |
| -- | SLC19A3 | 295 | V/I | 0.000119315 | rs754406086 |
| -- | SLC19A3 | 301 | I/V | 0.000242593 | rs199513368 |
| -- | SLC19A3 | 350 | V/A | 0.029576 | rs34507036 |
| -- | SLC19A3 | 352 | F/L | 0.00018691 | rs149806390 |
| -- | SLC19A3 | 371 | A/V | 0.000449358 | rs142166552 |
| -- | SLC19A3 | 378 | I/V | 0.00198032 | rs117864472 |
| -- | SLC19A3 | 382 | S/N | 0.000246542 | rs145288025 |
| -- | SLC19A3 | 402 | R/C | 0.000143453 | rs150523975 |
| -- | SLC19A3 | 418 | Q/E | 0.00058936 | rs368364131 |
| -- | SLC19A3 | 447 | A/T | 0.000111576 | rs754794859 |
| -- | SLC19A3 | 448 | V/A | 0.000227014 | rs201544540 |
| -- | SLC19A3 | 457 | S/N | 0.00042186 | rs138839321 |
Phylogenetic tree
Pathway
| Priority | Gene Name | Reactome (Gene) | Reactome (Pathway) |
|---|---|---|---|
| SLC19A3 | SLC19A3 [plasma membrane] | Vitamin B1 (thiamin) metabolism |
Disease
| Gene Name | Reactome (Gene) | Reactome (Pathway) |
|---|---|---|
| No data | ||