Menu
Basic
Network
Structure
Seq./Align.
Variant
Phylogenetic Tree
Pathway
Disease

Detail Data SLC19A1


Basic description
Gene Name SLC19A1
Protein Name Folate transporter 1 (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (Solute carrier family 19 member 1)
Family SLC19
Category -
Reaction name Extracellular 5-methyltetrahydrofolate import across the plasma membrane
Reaction 1 5-methyl-THF [extracellular region] --> 1 5-methyl-THF [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590 
MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP YLLGPDKNFT REQVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG LSFVSVWLLL LLGHSVAHMQ LMELFYSVTM AARIAYSSYI FSLVRPARYQ RVAGYSRAAV LLGVFTSSVL GQLLVTVGRV SFSTLNYISL AFLTFSVVLA LFLKRPKRSL FFNRDDRGRC ETSASELERM NPGPGGKLGH ALRVACGDSV LARMLRELGD SLRRPQLRLW SLWWVFNSAG YYLVVYYVHI LWNEVDPTTN SARVYNGAAD AASTLLGAIT SFAAGFVKIR WARWSKLLIA GVTATQAGLV FLLAHTRHPS SIWLCYAAFV LFRGSYQFLV PIATFQIASS LSKELCALVF GVNTFFATIV KTIITFIVSD VRGLGLPVRK QFQLYSVYFL ILSIIYFLGA MLDGLRHCQR GHHPRQPPAQ GLRSAAEEKA AQALSVQDKG LGGLQPAQSP PLSPEDSLGA VGPASLEQRQ SDPYLAQAPA PQAAEFLSPV TTPSPCTLCS AQASGPEAAD ETCPQLAVHP PGVSKLGLQC LPSDGVQNVN Q 
CCCCCCCCCC CCCCCCCCCH HHCCHHHHHH HHHHHHHHHH CCCCCCCCHH HHCCCCCCCC HHHHCCCCCC CHHHHHHHHH HHHHHHCHHC CCCHHHHHHH HHHHHHHHHH HHHCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCHHHHH HHHHHHHHCH HHHHHHHHHH HHHHHHCCCC CHHHHHHHHH HHHHHHHHHH HHHHCCCCHH HCCCCCCCCC CCCHHHHHHH CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HEEECCCCCC CCCHHHHHHH HHHHHHHHHH HHHCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CHHHHHHHHH HHHCHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCCC CCCCHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC C
[Overview] SLC19A1 SLC19A2 SLC19A3 
SLC19A1   MVPSSPAVEKQVPVEPGPDPELRS-------WRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRG--RC--------------------------------ETSASELERMNP-----GPGGKLGHA-LRVACGDSVLARML----RELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFL-GAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLS-PEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
SLC19A2   MDVPGPVSRRAAAAAAT--VLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEP-------------------KPDRLLV-LKVLW-NDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAA-IYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTV---GNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLA-SGAVSVMKKCRK-----------------------------------------LEDPQSS------------------------------SQVTTS------------------------------------------------
SLC19A3   MD-----CYRTSLSSS---------------WIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSR-------EIKKSSSVNPVLEETH-------------EGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSS-IYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYT---ANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKD---VQSPA--------------------------PSENPDVSHPEEE------------------------------SNIIMST------------------------------KL---------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC19A1 10 P/S 0.000490654 rs556372489
-- SLC19A1 27 H/R 0.550284 rs1051266
-- SLC19A1 56 D/H 0.000540881 rs146321452
-- SLC19A1 132 A/V 0.000246858 rs758374344
-- SLC19A1 178 G/S 0.000476045 rs760930392
-- SLC19A1 195 F/Y 0.000107154 rs756426597
-- SLC19A1 206 E/K 0.000733417 rs186761177
-- SLC19A1 211 R/W 0.000408864 rs557888995
-- SLC19A1 212 R/Q 0.000423139 rs182482191
-- SLC19A1 216 V/L 0.000255004 rs532482611
-- SLC19A1 218 A/V 0.000124081 rs565070756
-- SLC19A1 219 R/S 0.000234586 rs768105790
-- SLC19A1 222 P/R 0.000184754 rs748961133
-- SLC19A1 224 G/S 0.000437324 rs774934710
-- SLC19A1 225 E/K 0.000229546 rs769582552
-- SLC19A1 229 R/H 0.000177459 rs201955040
-- SLC19A1 235 L/V 0.000106025 rs1430472138
-- SLC19A1 236 A/V 0.000529833 rs560781871
-- SLC19A1 237 A/V 0.000453669 rs758940524
-- SLC19A1 239 G/E 0.000275197 rs368917550
-- SLC19A1 244 E/K 0.00220321 rs143407489
-- SLC19A1 249 W/R 0.000773697 rs578206452
-- SLC19A1 262 W/C 0.000180247 rs765500690
-- SLC19A1 309 A/V 0.000209178 rs373685390
-- SLC19A1 324 A/V 0.000425487 rs200647386
-- SLC19A1 338 L/F 0.00123855 rs59638403
-- SLC19A1 342 V/F 0.000491869 rs142899279
-- SLC19A1 389 S/T 0.000346799 rs139437559
-- SLC19A1 417 I/T 0.00235086 rs138047632
-- SLC19A1 422 R/Q 0.000235322 rs374164733
-- SLC19A1 437 V/M 0.000142742 rs745527688
-- SLC19A1 458 C/G 0.000404402 rs58227024
-- SLC19A1 460 R/Q 0.000100184 rs546839730
-- SLC19A1 469 A/S 0.000113304 rs560827689
-- SLC19A1 469 A/V 0.00445723 rs7278825
-- SLC19A1 485 E/K 0.000317259 rs529475108
-- SLC19A1 511 V/L 0.000177177 rs201529810
-- SLC19A1 521 V/A 0.00132844 rs567854723
-- SLC19A1 522 D/N 0.000442775 rs58836581
-- SLC19A1 527 G/S 0.00208153 rs145373876
-- SLC19A1 528 E/K 0.000100982 rs370098385
-- SLC19A1 531 P/L 0.00030058 rs202244244
-- SLC19A1 533 R/Q 0.000145233 rs749282880
-- SLC19A1 533 R/W 0.000123541 rs571491004
-- SLC19A1 536 G/A 0.000102291 rs944085346
-- SLC19A1 551 A/T 0.000100055 rs376071998

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
SLC19A1 SLC19A1 [plasma membrane] Metabolism of folate and pterines

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data