Detail Data SLC18A2

Basic description

Gene Name	SLC18A2
Protein Name	Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)
Family	SLC18
Category	Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name	loading of Serotonin in synaptic vesicles Loading of dopamine into synaptic veiscles
Reaction	1 5HT [cytosol] --> 1 5HT [clathrin-sculpted monoamine transport vesicle lumen] 1 DA [cytosol] --> 1 DA [clathrin-sculpted monoamine transport vesicle lumen]

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510 
MALSELALVR WLQESRRSRK LILFIVFLAL LLDNMLLTVV VPIIPSYLYS IKHEKNATEI QTARPVHTAS ISDSFQSIFS YYDNSTMVTG NATRDLTLHQ TATQHMVTNA SAVPSDCPSE DKDLLNENVQ VGLLFASKAT VQLITNPFIG LLTNRIGYPI PIFAGFCIMF VSTIMFAFSS SYAFLLIARS LQGIGSSCSS VAGMGMLASV YTDDEERGNV MGIALGGLAM GVLVGPPFGS VLYEFVGKTA PFLVLAALVL LDGAIQLFVL QPSRVQPESQ KGTPLTTLLK DPYILIAAGS ICFANMGIAM LEPALPIWMM ETMCSRKWQL GVAFLPASIS YLIGTNIFGI LAHKMGRWLC ALLGMIIVGV SILCIPFAKN IYGLIAPNFG VGFAIGMVDS SMMPIMGYLV DLRHVSVYGS VYAIADVAFC MGYAIGPSAG GAIAKAIGFP WLMTIIGIID ILFAPLCFFL RSPPAKEEKM AILMDHNCPI KTKMYTQNNI QSYPIGEDEE SESD 
CCHHHHHHHH HHHHHHHCCH HHHHHHHHHH HHHHHHHHCC CCCCHHHHHH HCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCC CCCCHHHHCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCHHHH HHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCHH HHHHHHHHHH HHHHHCHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHH CCCCCHHHHH HHHCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCC

Family alignment

[Overview]

SLC18A1   -----------------------MLRTIL-DAPQRLLKEGRASRQLVLVVVFVAL--LLDNMLFTVVVPIVPTFLYDMEFKEVNSSLHLG---HAGSSPHALASPAFSTIFSFFNNNTVAVEESV------PSGIAWMNDTASTIPPPATEAISAHKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLS---TVMFAFSGT-------YTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQP----SKVSPESAKGT-PLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMG---RWLCSLIGMLVVGTSLLC--VPLAH---NIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRH-------TSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIV--YAPLCYYLRS----PPAK--------EEKLAIL-SQDCPMETRMYATQKPTKEFPL-GEDSDE----------EPDHEE-----
SLC18A2   -----------------------MALSEL--ALVRWLQESRRSRKLILFIVFLAL--LLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTAS-----ISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVP-----------SDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVS---TIMFAFSSS-------YAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQP----SRVQPESQKGT-PLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMG---RWLCALLGMIIVGVSILC--IPFAK---NIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRH-------VSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIL--FAPLCFFLRS----PPAK--------EEKMAILMDHNCPIKTKMY-TQNNIQSYPI-GEDEES----------ESD--------
SLC18A3   MESA------------EPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVAL--LLDNMLYMVIVPIVPDYIAHMR--------------GGGEGP----------------TRTPEVWEPTLPLPT-PANASAYTANTSASPTAAWPAGSALRPRYPTES-----EDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFAS---TVLFAFAED-------YATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGT-PIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPH-LQWLYGALGLAVIGASSCI--VPACR---SFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRH-------VSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLL--YAPVLLLLRNVGLLTRSR--------SERDVLL---DEPPQG-LY-DAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
SLC18B1   MEALGDLEGPRAPGGDDPAGSAGETPGWL-------------SREQVFVLISAASVNLGSMMCYSILGPFFP---------------------KEAEKKGA--------------------------------------------------------------------SNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAG---MFVSGGVTILFGVLDRVPDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNN--VATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNY--------ESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGM---SIIPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRKRSKSQNILSTEEERTTLL-----PNET------------------------------------------

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC18A2	17	R/C	0.000265816	rs148348449
--	SLC18A2	62	T/M	0.000179066	rs140529367
--	SLC18A2	68	T/I	0.00114143	rs137920074
--	SLC18A2	149	I/T	0.00013187	rs200653019
--	SLC18A2	164	A/V	0.000182955	rs184073241
--	SLC18A2	230	M/L	0.000338798	rs200460457

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
main	SLC18A2	SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]	Na+/Cl- dependent neurotransmitter transporters
	SLC18A2	SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]	Serotonin Neurotransmitter Release Cycle
	SLC18A2	SLC18A2 [plasma membrane]	Serotonin Neurotransmitter Release Cycle
	SLC18A2	SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]	Norepinephrine Neurotransmitter Release Cycle
	SLC18A2	SLC18A2 [plasma membrane]	Norepinephrine Neurotransmitter Release Cycle
	SLC18A2	SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]	Dopamine Neurotransmitter Release Cycle
	SLC18A2	SLC18A2 [plasma membrane]	Dopamine Neurotransmitter Release Cycle

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data