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Detail Data SLC18A1


Basic description
Gene Name SLC18A1
Protein Name Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)
Family SLC18
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520 
MLRTILDAPQ RLLKEGRASR QLVLVVVFVA LLLDNMLFTV VVPIVPTFLY DMEFKEVNSS LHLGHAGSSP HALASPAFST IFSFFNNNTV AVEESVPSGI AWMNDTASTI PPPATEAISA HKNNCLQGTG FLEEEITRVG VLFASKAVMQ LLVNPFVGPL TNRIGYHIPM FAGFVIMFLS TVMFAFSGTY TLLFVARTLQ GIGSSFSSVA GLGMLASVYT DDHERGRAMG TALGGLALGL LVGAPFGSVM YEFVGKSAPF LILAFLALLD GALQLCILQP SKVSPESAKG TPLFMLLKDP YILVAAGSIC FANMGVAILE PTLPIWMMQT MCSPKWQLGL AFLPASVSYL IGTNLFGVLA NKMGRWLCSL IGMLVVGTSL LCVPLAHNIF GLIGPNAGLG LAIGMVDSSM MPIMGHLVDL RHTSVYGSVY AIADVAFCMG FAIGPSTGGA IVKAIGFPWL MVITGVINIV YAPLCYYLRS PPAKEEKLAI LSQDCPMETR MYATQKPTKE FPLGEDSDEE PDHEE 
CHHHHHHHHH HHHHHHHHCC HHHHHHHHHH HHHHHHHHHC CCCCCHHHHH HCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCHHHHHCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCHHHHHH HHHHHHHHHH HHCHHHCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCHH HHHHHHHHHH HHHHHHHHCC CCCHHHHHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCC
[Overview] SLC18A1 SLC18A2 SLC18A3 SLC18B1 
SLC18A1   -----------------------MLRTIL-DAPQRLLKEGRASRQLVLVVVFVAL--LLDNMLFTVVVPIVPTFLYDMEFKEVNSSLHLG---HAGSSPHALASPAFSTIFSFFNNNTVAVEESV------PSGIAWMNDTASTIPPPATEAISAHKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLS---TVMFAFSGT-------YTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGLLVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQP----SKVSPESAKGT-PLFMLLKDPYILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLANKMG---RWLCSLIGMLVVGTSLLC--VPLAH---NIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDLRH-------TSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIV--YAPLCYYLRS----PPAK--------EEKLAIL-SQDCPMETRMYATQKPTKEFPL-GEDSDE----------EPDHEE-----
SLC18A2   -----------------------MALSEL--ALVRWLQESRRSRKLILFIVFLAL--LLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTAS-----ISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVP-----------SDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVS---TIMFAFSSS-------YAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQP----SRVQPESQKGT-PLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMG---RWLCALLGMIIVGVSILC--IPFAK---NIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRH-------VSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIL--FAPLCFFLRS----PPAK--------EEKMAILMDHNCPIKTKMY-TQNNIQSYPI-GEDEES----------ESD--------
SLC18A3   MESA------------EPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVAL--LLDNMLYMVIVPIVPDYIAHMR--------------GGGEGP----------------TRTPEVWEPTLPLPT-PANASAYTANTSASPTAAWPAGSALRPRYPTES-----EDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFAS---TVLFAFAED-------YATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGT-PIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPH-LQWLYGALGLAVIGASSCI--VPACR---SFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRH-------VSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLL--YAPVLLLLRNVGLLTRSR--------SERDVLL---DEPPQG-LY-DAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
SLC18B1   MEALGDLEGPRAPGGDDPAGSAGETPGWL-------------SREQVFVLISAASVNLGSMMCYSILGPFFP---------------------KEAEKKGA--------------------------------------------------------------------SNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAG---MFVSGGVTILFGVLDRVPDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNN--VATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNY--------ESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGM---SIIPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRKRSKSQNILSTEEERTTLL-----PNET------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC18A1 4 T/P 0.319689 rs2270641
-- SLC18A1 10 Q/R 0.000322744 rs150204882
-- SLC18A1 11 R/W 0.00201403 rs117666725
-- SLC18A1 29 V/I 0.000127494 rs199716982
-- SLC18A1 74 A/V 0.00377181 rs17215815
-- SLC18A1 84 F/S 0.00374444 rs17215801
-- SLC18A1 87 N/H 0.000827505 rs566187173
-- SLC18A1 98 S/T 0.195402 rs2270637
-- SLC18A1 101 A/P 0.00541291 rs17222218
-- SLC18A1 117 A/T 0.00114137 rs140491634
-- SLC18A1 133 E/D 0.000107384 rs113046456
-- SLC18A1 135 E/D 0.000155108 rs199821433
-- SLC18A1 136 I/T 0.71403 rs1390938
-- SLC18A1 138 R/L 0.000377845 rs148468662
-- SLC18A1 140 G/R 0.000711973 rs17215808
-- SLC18A1 164 I/M 0.000447676 rs17222092
-- SLC18A1 168 I/T 0.000969436 rs61731076
-- SLC18A1 216 A/V 0.00040426 rs199809287
-- SLC18A1 223 H/R 0.000189177 rs141355658
-- SLC18A1 248 S/G 0.000127658 rs199840153
-- SLC18A1 249 V/I 0.00253684 rs17215759
-- SLC18A1 270 D/V 0.000553265 rs201615820
-- SLC18A1 283 V/I 0.000604749 rs200353170
-- SLC18A1 308 S/F 0.000135583 rs781589769
-- SLC18A1 350 L/F 0.000103383 rs745919058
-- SLC18A1 385 L/P 0.00158024 rs138289026
-- SLC18A1 392 L/V 0.0692627 rs17092104
-- SLC18A1 396 N/S 0.000119376 rs138654774
-- SLC18A1 424 S/P 0.000203299 rs147579147
-- SLC18A1 446 S/F 0.000208377 rs374331698
-- SLC18A1 450 A/V 0.000145162 rs149742774
-- SLC18A1 453 G/E 0.000301517 rs527363991
-- SLC18A1 454 D/E 0.000638329 rs116409427
-- SLC18A1 461 E/D 0.00012414 rs752429311
-- SLC18A1 470 V/I 0.000215179 rs201904218
-- SLC18A1 479 R/W 0.000190961 rs147512321
-- SLC18A1 498 E/K 0.000301517 rs527363991
-- SLC18A1 499 T/I 0.000160586 rs116409427
-- SLC18A1 499 T/S 0.000638329 rs116409427
-- SLC18A1 506 K/M 0.00012414 rs752429311
-- SLC18A1 524 E/K 0.000301534 rs200741431

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC18A1 SLC18A1 [clathrin-sculpted monoamine transport vesicle membrane] Na+/Cl- dependent neurotransmitter transporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data