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Variant
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Detail Data SLC17A4


Basic description
Gene Name SLC17A4
Protein Name Probable small intestine urate exporter (Solute carrier family 17 member 4)
Family SLC17
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490 
MSTGPDVKAT VGDISSDGNL NVAQEECSRK GFCSVRHGLA LILQLCNFSI YTQQMNLSIA IPAMVNNTAP PSQPNASTER PSTDSQGYWN ETLKEFKAMA PAYDWSPEIQ GIILSSLNYG SFLAPIPSGY VAGIFGAKYV VGAGLFISSF LTLFIPLAAN AGVALLIVLR IVQGIAQVMV LTGQYSIWVK WAPPLERSQL TTIAGSGSML GSFIVLLAGG LLCQTIGWPY VFYIFGGIGC ACCPLWFPLI YDDPVNHPFI SAGEKRYIVC SLAQQDCSPG WSLPIRAMIK SLPLWAILVS YFCEYWLFYT IMAYTPTYIS SVLQANLRDS GILSALPFVV GCICIILGGL LADFLLSRKI LRLITIRKLF TAIGVLFPSV ILVSLPWVRS SHSMTMTFLV LSSAISSFCE SGALVNFLDI APRYTGFLKG LLQVFAHIAG AISPTAAGFF ISQDSEFGWR NVFLLSAAVN ISGLVFYLIF GRADVQDWAK EQTFTHL 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHHHHCC HHHCCCHHHH HHHHHHCHHH HHHHHCHHHH HHHHHCCCHH CCCCHHHHHH HHHHHHHHHH HCHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCH HHHHCCCHHH CHHHHHHHHC CCCCCCCCCC CHHHHHHHHH HHHCCCCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCHHHH HHHCCCCCCC CHHCHHHHHH HHHHHHHHHH HHHHHHHCCC CCHHHHHHHH HHHHHHHHHH HHHHCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCC CCCCCCC
[Overview] SLC17A1 SLC17A2 SLC17A3 SLC17A4 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A9 
SLC17A1   ---------------------------------MQMDNRLPPKKVPGF------------------CSF-----RYGLSFLVHCCNVIITAQRACLNLTMVVMVNSTDPHGLPNTSTKKL-LDN-------------IKNPMYNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGI---GVAWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPCISISEKEYITS--SLVQQVSS----SRQSLPIKAILKSLPVWAISTGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTAA----------GFLLPAIFGVCLPY-LSSTFYSIVIF---LILAGATGSFCLGGVFINGLDIAPRYFGFIKACSTLTGMIGGLIASTLTGLILKQDPESAWFKTFILMAAINVTGLIFYLIVATAEIQDWAKEKQHTR----------L---------------------------------------------------------------------
SLC17A2   -----------------------------------MDGKPATRKGPDF------------------CSL-----RYGLALIMHFSNFTMITQRVSLSIAIIAMVNTTQQQGLSNASTEGPVADAFNNSSISIK-EFDTKASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADF---GVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILS--SLAQQPSS----PGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLRLITVRKLFSSLDMQVSSWESQGDLGSSQ-ESSLPLPLDSSSVRILSLVGGMSFSCLLQSTCLAWSFTSRLD--------------------------------KQNFKTGPKR-------------------GPLPASEDIKLQT-----------------------------------------------------------------------------------
SLC17A3   --------------MATKTELSPTARESKNAQDMQVDETLIPRKVPSL------------------CSA-----RYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPK-SLPAKAPVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDF---GIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIIS--SLKQQVGS----SKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKK-FRLITVRKIATIL----------GSLPSSALIVSLPY-LNSGYITATAL---LTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTR----------L---------------------------------------------------------------------
SLC17A4   --------------MSTGPDVKATVGDISSDGNLNVAQEECSRK--GF------------------CSV-----RHGLALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPSTDSQGYWNETLK-EFKAMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANA---GVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVC--SLAQQDCS----PGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAI----------GVLFPSVILVSLPW-VRSSHSMTMTF---LVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEFGWRNVFLLSAAVNISGLVFYLIFGRADVQDWAKEQTFTH----------L---------------------------------------------------------------------
SLC17A5   ------------MRSPVRDLARN-------------DGEESTDRTPLL-----PGAPRAEAAPVC-CSA-----RYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACP------EHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADL---GVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILS--SLRNQLS-----SQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLI----------GMIGPAVFLVAAGF-IGCDYSLAVAF---LTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWA-----------------L------------------------NDHHGHRH-------------------------------------
SLC17A6   -----MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIK---------------------EKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARV---HYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEE--SIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCG----------GFGMEATLLLVVGY--SHTRGVAISF---LVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDEL----DEETGDITQNYINYGT----TKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYS---
SLC17A7   -----ME-FRQ-------EEFRKLAGRALGKLHRLLEKRQEGAETLELSADGRPVTTQTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVV---------------------QKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARV---HYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIED--AIGESAKLMNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCG----------GFGMEATLLLVVGY--SHSKGVAISF---LVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAE---PPGAPPAPPPSYGAT------------------HSTFQPPRPPPPVRDY----
SLC17A8   MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEI---------------------QTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARV---HYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIET--SIGEGANVV-SLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCG----------GFGMEATLLLVVGF--SHTKGVAISF---LVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDEL----AEEIELNHESFASPKK----KMSYGATSQNCEVQKKEWKGQRGATLDEEELTSYQNEERNFSTIS
SLC17A9   ------------MQPPPDEARRDMAGDT---------------------QWSRPE-----------CQAWTG--------TLLLGTCLLYCARSSMPICTVSMSQD------------------------------------FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGL----TLLWVWYVYR-------YLLSEKDLILALGVLAQSRPVS---RHSRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF--PDAKGWIFNVVPWLVAIPASLFSGFLSDHLINQG-YRAITVRKLMQGM----------GLGLSSVFALCLGH--TSSFCESVVF---ASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLM--ETTGSWTCLFNLVAIISNLGLCTFLVFGQAQRVDLSSTHE------------DL---------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC17A4 13 D/Y 0.000493914 rs143424660
-- SLC17A4 13 D/E 0.000494016 rs150942022
-- SLC17A4 80 R/Q 0.00119457 rs148695938
-- SLC17A4 80 R/W 0.00137368 rs34517537
-- SLC17A4 147 E/D 0.000310935 rs375779309
-- SLC17A4 154 R/H 0.000406734 rs191358923
-- SLC17A4 170 R/W 0.000103475 rs144232109
-- SLC17A4 191 W/R 0.000131376 rs753663996
-- SLC17A4 230 Y/F 0.000115416 rs757167403
-- SLC17A4 270 C/Y 0.000306929 rs192246809
-- SLC17A4 277 C/G 0.00611588 rs80230923
-- SLC17A4 321 S/L 0.00019547 rs145440760
-- SLC17A4 345 I/V 0.00119705 rs150228078
-- SLC17A4 347 L/R 0.000825352 rs112872432
-- SLC17A4 372 A/T 0.36439 rs11754288
-- SLC17A4 472 S/L 0.00122582 rs111601146
-- SLC17A4 485 V/M 0.000318423 rs144164391

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
No data

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data