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Detail Data SLC17A1


Basic description
Gene Name SLC17A1
Protein Name Sodium-dependent phosphate transport protein 1 (Na(+)/PI cotransporter 1) (Na/Pi-4) (Renal Na(+)-dependent phosphate cotransporter 1) (Renal sodium-dependent phosphate transport protein 1) (Renal sodium-phosphate transport protein 1) (Sodium/phosphate cotransporter 1) (Solute carrier family 17 member 1)
Family SLC17
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name Type I Na+-coupled phosphate co-transport
Reaction 1 Pi [extracellular region] + 1 Na+ [extracellular region] --> 1 Pi [cytosol] + 1 Na+ [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460 
MQMDNRLPPK KVPGFCSFRY GLSFLVHCCN VIITAQRACL NLTMVVMVNS TDPHGLPNTS TKKLLDNIKN PMYNWSPDIQ GIILSSTSYG VIIIQVPVGY FSGIYSTKKM IGFALCLSSV LSLLIPPAAG IGVAWVVVCR AVQGAAQGIV ATAQFEIYVK WAPPLERGRL TSMSTSGFLL GPFIVLLVTG VICESLGWPM VFYIFGACGC AVCLLWFVLF YDDPKDHPCI SISEKEYITS SLVQQVSSSR QSLPIKAILK SLPVWAISTG SFTFFWSHNI MTLYTPMFIN SMLHVNIKEN GFLSSLPYLF AWICGNLAGQ LSDFFLTRNI LSVIAVRKLF TAAGFLLPAI FGVCLPYLSS TFYSIVIFLI LAGATGSFCL GGVFINGLDI APRYFGFIKA CSTLTGMIGG LIASTLTGLI LKQDPESAWF KTFILMAAIN VTGLIFYLIV ATAEIQDWAK EKQHTRL 
CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCHHHH HHHHHHHHHH HHHHHHHHHH CCHHHHHHHH HHHCCCCHHH HHHHHHHHHH HCCHHHHHCH HHHHHHCCCH HHHHHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCC CHHHHHHHHH HHHHCCCCCC CCCCHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHCCHHHH HHHCCCHHHH CHHCHHHHHH HHHHHHHHHH HHHHHHHCCC CHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CHHCHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCC
[Overview] SLC17A1 SLC17A2 SLC17A3 SLC17A4 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A9 
SLC17A1   ---------------------------------MQMDNRLPPKKVPGF------------------CSF-----RYGLSFLVHCCNVIITAQRACLNLTMVVMVNSTDPHGLPNTSTKKL-LDN-------------IKNPMYNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLIPPAAGI---GVAWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPCISISEKEYITS--SLVQQVSS----SRQSLPIKAILKSLPVWAISTGSFTFFWSHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTAA----------GFLLPAIFGVCLPY-LSSTFYSIVIF---LILAGATGSFCLGGVFINGLDIAPRYFGFIKACSTLTGMIGGLIASTLTGLILKQDPESAWFKTFILMAAINVTGLIFYLIVATAEIQDWAKEKQHTR----------L---------------------------------------------------------------------
SLC17A2   -----------------------------------MDGKPATRKGPDF------------------CSL-----RYGLALIMHFSNFTMITQRVSLSIAIIAMVNTTQQQGLSNASTEGPVADAFNNSSISIK-EFDTKASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADF---GVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILS--SLAQQPSS----PGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLRLITVRKLFSSLDMQVSSWESQGDLGSSQ-ESSLPLPLDSSSVRILSLVGGMSFSCLLQSTCLAWSFTSRLD--------------------------------KQNFKTGPKR-------------------GPLPASEDIKLQT-----------------------------------------------------------------------------------
SLC17A3   --------------MATKTELSPTARESKNAQDMQVDETLIPRKVPSL------------------CSA-----RYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPK-SLPAKAPVYDWSPQIQGIIFGAVGYGGILTMAPSGYLAGRVGTKRVVGISLFATSFLTLCIPLATDF---GIVLLIVTRIVQGLSQSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIIS--SLKQQVGS----SKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKK-FRLITVRKIATIL----------GSLPSSALIVSLPY-LNSGYITATAL---LTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTR----------L---------------------------------------------------------------------
SLC17A4   --------------MSTGPDVKATVGDISSDGNLNVAQEECSRK--GF------------------CSV-----RHGLALILQLCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPSTDSQGYWNETLK-EFKAMAPAYDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAANA---GVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLAGGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVC--SLAQQDCS----PGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILSALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAI----------GVLFPSVILVSLPW-VRSSHSMTMTF---LVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFFISQDSEFGWRNVFLLSAAVNISGLVFYLIFGRADVQDWAKEQTFTH----------L---------------------------------------------------------------------
SLC17A5   ------------MRSPVRDLARN-------------DGEESTDRTPLL-----PGAPRAEAAPVC-CSA-----RYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACP------EHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADL---GVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILS--SLRNQLS-----SQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLI----------GMIGPAVFLVAAGF-IGCDYSLAVAF---LTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWA-----------------L------------------------NDHHGHRH-------------------------------------
SLC17A6   -----MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELTEDGKPLEVPERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIK---------------------EKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARV---HYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEE--SIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCG----------GFGMEATLLLVVGY--SHTRGVAISF---LVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADPEETSEEKCGFIHEDEL----DEETGDITQNYINYGT----TKSYGATTQANGGWPSGWEKKEEFVQGEVQDSHSYKDRVDYS---
SLC17A7   -----ME-FRQ-------EEFRKLAGRALGKLHRLLEKRQEGAETLELSADGRPVTTQTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVV---------------------QKAQFSWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARV---HYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIED--AIGESAKLMNPLTKFSTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRRIMSTTNVRKLMNCG----------GFGMEATLLLVVGY--SHSKGVAISF---LVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDDSEMEDEAE---PPGAPPAPPPSYGAT------------------HSTFQPPRPPPPVRDY----
SLC17A8   MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEI---------------------QTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARV---HYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIET--SIGEGANVV-SLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCG----------GFGMEATLLLVVGF--SHTKGVAISF---LVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDEL----AEEIELNHESFASPKK----KMSYGATSQNCEVQKKEWKGQRGATLDEEELTSYQNEERNFSTIS
SLC17A9   ------------MQPPPDEARRDMAGDT---------------------QWSRPE-----------CQAWTG--------TLLLGTCLLYCARSSMPICTVSMSQD------------------------------------FGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGL----TLLWVWYVYR-------YLLSEKDLILALGVLAQSRPVS---RHSRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETF--PDAKGWIFNVVPWLVAIPASLFSGFLSDHLINQG-YRAITVRKLMQGM----------GLGLSSVFALCLGH--TSSFCESVVF---ASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLM--ETTGSWTCLFNLVAIISNLGLCTFLVFGQAQRVDLSSTHE------------DL---------------------------------------------------------------------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC17A1 38 A/V 0.000295938 rs147069707
-- SLC17A1 44 M/I 0.000211732 rs148954451
-- SLC17A1 75 W/C 0.001238 rs149708935
-- SLC17A1 76 S/N 0.00860425 rs6933573
-- SLC17A1 140 R/G 0.000163191 rs191415930
-- SLC17A1 167 R/Q 0.00021893 rs146175657
-- SLC17A1 169 R/Q 0.000262701 rs148635037
-- SLC17A1 269 T/I 0.61792 rs1165196
-- SLC17A1 288 F/C 0.00023218 rs79078661
-- SLC17A1 322 S/P 0.000115511 rs199533219
-- SLC17A1 337 R/Q 0.000207066 rs200727863
-- SLC17A1 466 R/C 0.000163338 rs112164493

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC17A1 SLC17A1 [plasma membrane] Organic anion transporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data