Detail Data SLC16A8

Basic description

Gene Name	SLC16A8
Protein Name	Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8)
Family	SLC16
Category	Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name	-
Reaction	-

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500 
MGAGGPRRGE GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRALMRDF DAGYSDTAWV SSIMLAMLYG TGPVSSILVT RFGCRPVMLA GGLLASAGMI LASFATRLLE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA AGSPVFLSAL SPLGQQLLER FGWRGGFLLL GGLLLHCCAC GAVMRPPPGP GPRPRRDSAG DRAGDAPGEA EADGAGLQLR EASPRVRPRR RLLDLAVCTD RAFAVYAVTK FLMALGLFVP AILLVNYAKD AGVPDTDAAF LLSIVGFVDI VARPACGALA GLARLRPHVP YLFSLALLAN GLTDLSSARA RSYGALVAFC VAFGLSYGMV GALQFEVLMA AVGAPRFPSA LGLVLLVEAA AVLIGPPSAG RLVDVLKNYE IIFYLAGSEV ALAGVFMAVA TNCCLRCAKA APSGPGTEGG ASDTEDAEAE GDSEPLPVVA EEPGNLEALE VLSARGEPTE PEIEARPRLA AESV 
CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCH HHHHHHHHHH CHHHHHHHHH HHHHHHHHHH CCHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHHHCC HHHHHHHHHH HHHHHHHCHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCHH HHHHHHHHHH HHHHHHHCCC CCHHHHHHHH HHHHHHCHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHHCHHHHH HHHHHCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCCC CCCCCCHHHC CCCCCCCCCC CCCCCCCHHH HHCCCCCCCC CHHCCCCCCC CCCC

Family alignment

[Overview]

SLC16A1   ----------------------------------------------------------MPPAVGGPVGY-------------------------------TPP--DGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATT------SEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPI--------------------GPKPTKAGK---------DKSKAS--LEKAGKSGVKKDL-----------HDANTD------------------------LIGR-HPK--QEKR-------SVFQTINQFL------------------------DLTLFTHR-GFLL-YLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF-LLSILAFVDMVARPSMGLVAN-----TKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLM--DLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFI-------GMGINYRLLAKEQKANEQKKES--------KEEETSIDVAGKPNEVTKAAES--------------------PDQKDTDGGP---------KEE-------ESPV------
SLC16A10  MVLSQEEPDSARG------TSEAQPLG-------------PAPTGAAPP--------PGPGPSDSPEAAVEKVEVELAGPATAEPHEPP-----------EPP--EGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMV-FKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATS-----------------------------------TKDKES------GGSGSSLFSR--------------------------------------------------------------------KKF-------SPPKKIF----------NFAIFKVT-AYAV-WAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEV-VLMCIGVTSGVGRLLFGRIADYVPG-VKKV-----YLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAF--ELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIH-----------SKKQREISKTTGK--------EKME------------------------------------KML----ENQNSLLSSSSGMFKKE-------SDSII-----
SLC16A11  MPA---------------------------------------PQRKHRRGGFSHRCFPTPQTAMTPQPA-------------------------------GPP--DGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSA------QDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPP------------APPRSPLAA------------------------------------------------------------------------------------------------------L------------------------GLSLFTRR-AFSI-FALGTALVGGGYFVPYVHLAPHALDRGLGGYGAAL-VVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLP--GLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSFIYI----------------------------------------------GLPRALPSCGPASPP--------------------ATPPPETGELLPAPQAVLLSPGGPGSTLDTTC------
SLC16A12  MPSGSH--------WT---ANSSKIIT---------WLLE-QPGKEEKRK--------TMAKVNRARST-------------------------------SPP--DGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDY------AQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDHT-------------TPEQNHVCRT--------QKED-----------------------------------------------------------IKRVSPYSSLTKEWAQTCLCCCLQQEYSFL------------------------LMS------DFVV-LAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAF-LMSILGVIDIIGNITFGWLTDRR---CLKNYQYVCYLFAVGM--DGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTT--EIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLG-------------FARLIKRMRKTQLQFIA--------KESD--------------------------------------PKLQLWTNGSVAYSVARELDQK--HGEPVATAVPGYSLT
SLC16A13  ---------------------------------------------MARR-------------------T-------------------------------EPP--DGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQA------ARVSWIASIGIAVQQFGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSALSLHLVACGALLRPPSLAEDPAV-----------GGPRAQLT----------------------------------------------------------------------------------------------------------------------------------SLLHHG-PFLR-YTVALTLINTGYFIPYLHLVAHLQDLDWDPLPAAF-LLSVVAISDLVGRVVSGWLGDAVPGPVTRLLMLWTTLTGVSL---ALFPVAQAPTA----LVALAVAYGFTSGALAPLAFSVLP--ELIGTRRIYCGLGLLQMIESIGGLLGPPLSGYLRDVTGNYTASFVVAGAFLLSGSGILL----------------------------------------------TLPHFFCFSTTTSGPQD-----------------LVTEALDTK--VPLPKEGLEED-----------------
SLC16A14  MYT------------------SHEDIG---------YDFEDGPK-------------------DKKTLK-------------------------------PHPNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSR------GLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLS------PGK----------NPNDPGEK----DVRGLPAHSTES--VKSTGQQGRTEEK------------DGGLGNEET--------------------LCDLQAQEC-PDQAGHRKNMCAL-----RILKTVSWLTMRVRKGFEDWYSGYFG-TASLFTNR-MFVA-FIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCI-------SVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFS--LMPVVTE-DLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIG--ILFL-------LIQPCIRIIEQSRRK----------------YMD-------------------------------------------------------------------GAHV------
SLC16A2   MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE-------PQPEPQPLPDPA-PLPELEFESERVHEPEPTPTVETRGTARGFQPP--EGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEE--EKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPS-----------------------------------SQDTPS-------KRGVRTLHQ--------------------------------------------------------------------RFL-------AQLRKYF----------NMRVFRQR-TYRI-WAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWV-LLVCIGATSGLGRLVSGHISDSIPG-LKKI-----YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAF--ELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQ-------RMFKKEQRDSSK---------------D------------------------------------KMLAPDPDPNGELLPGSP----NP-------EEPI------
SLC16A3   --------------------------------------------------------MGGAVVDEGPTGV-------------------------------KAP--DGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGY------SDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPG------------SGPP----------------------------------------------------------------------------------RPSR-------------------RLL------------------------DLSVFRDR-GFVL-YAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAF-LLTILGFIDIFARPAAGFVAG-----LGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLM--AIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLL-------GNFFCIR---KKPKEPQPEVAA--------AEEE----KLHKP-P----ADSGVDLREVEHF----------LKAEPEKNGE-------VVHTP-------ETSV------
SLC16A4   ---------------------------------------------MLKREG------------KVQPYT-------------------------------KTL--DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTS------EQIGWIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETH--------CHETEESTIKDSTTQKAGLPS-----------KNLTVSQNQSE---------EFYNGPNRNRLLLKSDEESDKVISWSCK----------QLF------------------------DISLFRNP-FFYI-FTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASY-LVSVAGILETVSQIISGWVADQNW--IKKYHYHKSYLI-----LCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLV--DLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFV-----------------------------------------------------------------------------------------------PLAERW------KNSLT-----
SLC16A5   ----------------------------------------------------------------MPQAL-------------------------------ERA--DGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASN------SETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETK--------ECPPPPPETP----------------A--LGCLAACGRTIQ----------------------------------------------------------------------RHL------------------------AFDILRHNTGYCV-YILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAAL-LISIIGFSNIFLRPLAGLMAG-----RPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLM--DIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM----------GGSFYALQKKEQGKQAVAADALER--DLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWG--------CPASSRTSHEWLLWPKAVLQAK-------QTALGWNSPT
SLC16A6   ---------------------------------------------MTQNK--------LKLCSKANVYT-------------------------------EVP--DGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESN------SRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFI-----------------RGPASPKIVIQ--------ENRKEAQYMLENEKTRTSIDS-----------IDSGVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKA--------------PLL------------------------DFSILKEK-SFIC-YALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAF-LLSTMAIAEVFGRIGAGFVLN-----REPIRKIYIELICVILLTVSL--FAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVR---PCKMGLCQHHHSGETKVVSHRGKTLQDIPEDFLEMD---------------------LAKNEHRVH--------VQMEPV---------------------------------
SLC16A7   ----------------------------------------------------------MPPMPSAPPVH-------------------------------PPP--DGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTY------SEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPL--------------------GPNQTTS------------KSK--------NKTGKTED-------------DSS--------------------------------PKKIKTKK-------STWEKVNKYL------------------------DFSLFKHR-GFLI-YLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIAN-----SKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLM--DLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI-------GNAINYRLLAKERKEENARQKT--------RESE--------PLSKSKHSED--------------------VNVKVSNAQS-------VTSER-------ETNI------
SLC16A8   ------------------------------------------------------MGAGGPRRGEGP------------------------------------P--DGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGY------SDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRP-----PPG------------PGPRPRRDSAG--------DRAGDA--PGEAEADGAGLQL-----------REAS----------------------------PRVRPRR-------------------RLL------------------------DLAVCTDR-AFAV-YAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAF-LLSIVGFVDIVARPACGALAG-----LARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLM--AAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAV-------ATNCCLRCAKAAPSGPGTEGGASDT--E-DAEAE----GDSEPLPV--VAEEPGNLEALEVLSARGEPTEPEIEARPRLAAE-------SV--------------------
SLC16A9   -----------------------------------------------------------------MELK-------------------------------KSP--DGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGK------GKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKK---------IAPEDLPDKYSIYNEKG--KNLEEN--INILDKSYSSEEKCRITLANGDWKQDSLLHKNPT--------------------VTHTKEPETYKKKVAEQTYFC-------KQLAKRKW----------QLYKNYCGETVALFKNK-VFSALFIAILLFDIGGF-PPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWI-------NTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNWS--IFPYVTT-KTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL-------AALPSWDTCNKQLPKPA---------PTTFLYKV-------------------------------------------------------------------ASNV------

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC16A8	26	F/S	0.00303166	rs76230437
--	SLC16A8	30	G/S	0.000403079	rs113748161
--	SLC16A8	36	P/A	0.000144708	rs751666464
--	SLC16A8	38	A/T	0.000513453	rs200624792
--	SLC16A8	55	S/G	0.000127734	rs780287223
--	SLC16A8	56	D/N	0.000103994	rs747603470
--	SLC16A8	68	L/F	0.000296764	rs188395735
--	SLC16A8	94	L/P	0.000397518	rs766167270
--	SLC16A8	106	T/K	0.000582128	rs61737837
--	SLC16A8	147	G/A	0.000160356	rs543643447
--	SLC16A8	163	L/F	0.00591956	rs189345550
--	SLC16A8	225	A/G	0.00029249	rs374567790
--	SLC16A8	235	R/W	0.499667	rs4289289
--	SLC16A8	238	P/S	0.000241962	rs541520159
--	SLC16A8	257	A/V	0.0683728	rs75640043
--	SLC16A8	286	T/S	0.000272967	rs201896042
--	SLC16A8	303	R/L	0.000758736	rs201193689
--	SLC16A8	344	G/D	0.000197632	rs140235485
--	SLC16A8	401	R/H	0.000181918	rs777819488
--	SLC16A8	405	V/A	0.753159	rs2076371
--	SLC16A8	474	G/S	0.000147375	rs149941944
--	SLC16A8	478	A/T	0.000139523	rs201036628
--	SLC16A8	485	R/W	0.000400157	rs200126325
--	SLC16A8	487	E/K	0.000292843	rs768630769
--	SLC16A8	500	A/P	0.000127725	rs546955144
--	SLC16A8	502	E/K	0.000737903	rs187455529

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
main	SLC16A8	SLC16A8 [plasma membrane]	Proton-coupled monocarboxylate transport
	SLC16A8	SLC16A8 [plasma membrane]	Basigin interactions
	SLC16A8	SLC16A8 [plasma membrane]	Pyruvate metabolism

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data