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Detail Data SLC16A7


Basic description
Gene Name SLC16A7
Protein Name Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)
Family SLC16
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470 
MPPMPSAPPV HPPPDGGWGW IVVGAAFISI GFSYAFPKAV TVFFKEIQQI FHTTYSEIAW ISSIMLAVMY AGGPVSSVLV NKYGSRPVVI AGGLLCCLGM VLASFSSSVV QLYLTMGFIT GLGLAFNLQP ALTIIGKYFY RKRPMANGLA MAGSPVFLSS LAPFNQYLFN TFGWKGSFLI LGSLLLNACV AGSLMRPLGP NQTTSKSKNK TGKTEDDSSP KKIKTKKSTW EKVNKYLDFS LFKHRGFLIY LSGNVIMFLG FFAPIIFLAP YAKDQGIDEY SAAFLLSVMA FVDMFARPSV GLIANSKYIR PRIQYFFSFA IMFNGVCHLL CPLAQDYTSL VLYAVFFGLG FGSVSSVLFE TLMDLVGAPR FSSAVGLVTI VECGPVLLGP PLAGKLVDLT GEYKYMYMSC GAIVVAASVW LLIGNAINYR LLAKERKEEN ARQKTRESEP LSKSKHSEDV NVKVSNAQSV TSERETNI 
CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCHHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHCHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC HHHHHHHHHH HHHHHHHHHH CHHCCCHHHH HHHHHHHHHC HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC HHCCCCCCCC CCCCCCCCCC CCCCCCCC
[Overview] SLC16A1 SLC16A10 SLC16A11 SLC16A12 SLC16A13 SLC16A14 SLC16A2 SLC16A3 SLC16A4 SLC16A5 SLC16A6 SLC16A7 SLC16A8 SLC16A9 
SLC16A1   ----------------------------------------------------------MPPAVGGPVGY-------------------------------TPP--DGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATT------SEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPI--------------------GPKPTKAGK---------DKSKAS--LEKAGKSGVKKDL-----------HDANTD------------------------LIGR-HPK--QEKR-------SVFQTINQFL------------------------DLTLFTHR-GFLL-YLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF-LLSILAFVDMVARPSMGLVAN-----TKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLM--DLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFI-------GMGINYRLLAKEQKANEQKKES--------KEEETSIDVAGKPNEVTKAAES--------------------PDQKDTDGGP---------KEE-------ESPV------
SLC16A10  MVLSQEEPDSARG------TSEAQPLG-------------PAPTGAAPP--------PGPGPSDSPEAAVEKVEVELAGPATAEPHEPP-----------EPP--EGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMV-FKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATS-----------------------------------TKDKES------GGSGSSLFSR--------------------------------------------------------------------KKF-------SPPKKIF----------NFAIFKVT-AYAV-WAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEV-VLMCIGVTSGVGRLLFGRIADYVPG-VKKV-----YLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAF--ELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIH-----------SKKQREISKTTGK--------EKME------------------------------------KML----ENQNSLLSSSSGMFKKE-------SDSII-----
SLC16A11  MPA---------------------------------------PQRKHRRGGFSHRCFPTPQTAMTPQPA-------------------------------GPP--DGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSA------QDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPP------------APPRSPLAA------------------------------------------------------------------------------------------------------L------------------------GLSLFTRR-AFSI-FALGTALVGGGYFVPYVHLAPHALDRGLGGYGAAL-VVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLP--GLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSFIYI----------------------------------------------GLPRALPSCGPASPP--------------------ATPPPETGELLPAPQAVLLSPGGPGSTLDTTC------
SLC16A12  MPSGSH--------WT---ANSSKIIT---------WLLE-QPGKEEKRK--------TMAKVNRARST-------------------------------SPP--DGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDY------AQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDHT-------------TPEQNHVCRT--------QKED-----------------------------------------------------------IKRVSPYSSLTKEWAQTCLCCCLQQEYSFL------------------------LMS------DFVV-LAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAF-LMSILGVIDIIGNITFGWLTDRR---CLKNYQYVCYLFAVGM--DGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTT--EIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLG-------------FARLIKRMRKTQLQFIA--------KESD--------------------------------------PKLQLWTNGSVAYSVARELDQK--HGEPVATAVPGYSLT
SLC16A13  ---------------------------------------------MARR-------------------T-------------------------------EPP--DGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQA------ARVSWIASIGIAVQQFGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSALSLHLVACGALLRPPSLAEDPAV-----------GGPRAQLT----------------------------------------------------------------------------------------------------------------------------------SLLHHG-PFLR-YTVALTLINTGYFIPYLHLVAHLQDLDWDPLPAAF-LLSVVAISDLVGRVVSGWLGDAVPGPVTRLLMLWTTLTGVSL---ALFPVAQAPTA----LVALAVAYGFTSGALAPLAFSVLP--ELIGTRRIYCGLGLLQMIESIGGLLGPPLSGYLRDVTGNYTASFVVAGAFLLSGSGILL----------------------------------------------TLPHFFCFSTTTSGPQD-----------------LVTEALDTK--VPLPKEGLEED-----------------
SLC16A14  MYT------------------SHEDIG---------YDFEDGPK-------------------DKKTLK-------------------------------PHPNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSR------GLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLS------PGK----------NPNDPGEK----DVRGLPAHSTES--VKSTGQQGRTEEK------------DGGLGNEET--------------------LCDLQAQEC-PDQAGHRKNMCAL-----RILKTVSWLTMRVRKGFEDWYSGYFG-TASLFTNR-MFVA-FIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCI-------SVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFS--LMPVVTE-DLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIG--ILFL-------LIQPCIRIIEQSRRK----------------YMD-------------------------------------------------------------------GAHV------
SLC16A2   MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE-------PQPEPQPLPDPA-PLPELEFESERVHEPEPTPTVETRGTARGFQPP--EGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEE--EKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPS-----------------------------------SQDTPS-------KRGVRTLHQ--------------------------------------------------------------------RFL-------AQLRKYF----------NMRVFRQR-TYRI-WAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWV-LLVCIGATSGLGRLVSGHISDSIPG-LKKI-----YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAF--ELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQ-------RMFKKEQRDSSK---------------D------------------------------------KMLAPDPDPNGELLPGSP----NP-------EEPI------
SLC16A3   --------------------------------------------------------MGGAVVDEGPTGV-------------------------------KAP--DGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGY------SDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPG------------SGPP----------------------------------------------------------------------------------RPSR-------------------RLL------------------------DLSVFRDR-GFVL-YAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAF-LLTILGFIDIFARPAAGFVAG-----LGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLM--AIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLL-------GNFFCIR---KKPKEPQPEVAA--------AEEE----KLHKP-P----ADSGVDLREVEHF----------LKAEPEKNGE-------VVHTP-------ETSV------
SLC16A4   ---------------------------------------------MLKREG------------KVQPYT-------------------------------KTL--DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTS------EQIGWIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETH--------CHETEESTIKDSTTQKAGLPS-----------KNLTVSQNQSE---------EFYNGPNRNRLLLKSDEESDKVISWSCK----------QLF------------------------DISLFRNP-FFYI-FTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASY-LVSVAGILETVSQIISGWVADQNW--IKKYHYHKSYLI-----LCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLV--DLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFV-----------------------------------------------------------------------------------------------PLAERW------KNSLT-----
SLC16A5   ----------------------------------------------------------------MPQAL-------------------------------ERA--DGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASN------SETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETK--------ECPPPPPETP----------------A--LGCLAACGRTIQ----------------------------------------------------------------------RHL------------------------AFDILRHNTGYCV-YILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAAL-LISIIGFSNIFLRPLAGLMAG-----RPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLM--DIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM----------GGSFYALQKKEQGKQAVAADALER--DLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWG--------CPASSRTSHEWLLWPKAVLQAK-------QTALGWNSPT
SLC16A6   ---------------------------------------------MTQNK--------LKLCSKANVYT-------------------------------EVP--DGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESN------SRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFI-----------------RGPASPKIVIQ--------ENRKEAQYMLENEKTRTSIDS-----------IDSGVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKA--------------PLL------------------------DFSILKEK-SFIC-YALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAF-LLSTMAIAEVFGRIGAGFVLN-----REPIRKIYIELICVILLTVSL--FAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVR---PCKMGLCQHHHSGETKVVSHRGKTLQDIPEDFLEMD---------------------LAKNEHRVH--------VQMEPV---------------------------------
SLC16A7   ----------------------------------------------------------MPPMPSAPPVH-------------------------------PPP--DGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTY------SEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPL--------------------GPNQTTS------------KSK--------NKTGKTED-------------DSS--------------------------------PKKIKTKK-------STWEKVNKYL------------------------DFSLFKHR-GFLI-YLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIAN-----SKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLM--DLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI-------GNAINYRLLAKERKEENARQKT--------RESE--------PLSKSKHSED--------------------VNVKVSNAQS-------VTSER-------ETNI------
SLC16A8   ------------------------------------------------------MGAGGPRRGEGP------------------------------------P--DGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGY------SDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRP-----PPG------------PGPRPRRDSAG--------DRAGDA--PGEAEADGAGLQL-----------REAS----------------------------PRVRPRR-------------------RLL------------------------DLAVCTDR-AFAV-YAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAF-LLSIVGFVDIVARPACGALAG-----LARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLM--AAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAV-------ATNCCLRCAKAAPSGPGTEGGASDT--E-DAEAE----GDSEPLPV--VAEEPGNLEALEVLSARGEPTEPEIEARPRLAAE-------SV--------------------
SLC16A9   -----------------------------------------------------------------MELK-------------------------------KSP--DGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGK------GKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKK---------IAPEDLPDKYSIYNEKG--KNLEEN--INILDKSYSSEEKCRITLANGDWKQDSLLHKNPT--------------------VTHTKEPETYKKKVAEQTYFC-------KQLAKRKW----------QLYKNYCGETVALFKNK-VFSALFIAILLFDIGGF-PPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWI-------NTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNWS--IFPYVTT-KTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL-------AALPSWDTCNKQLPKPA---------PTTFLYKV-------------------------------------------------------------------ASNV------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
SLC16A7 28 I/V 0.000103637 rs181763804
SLC16A7 85 S/R 0.000268727 rs779089980
SLC16A7 86 R/Q 0.000111846 rs148114133
SLC16A7 119 I/V 0.000114536 rs775071557
-- SLC16A7 201 N/S 0.000869628 rs147922874
-- SLC16A7 219 S/I 0.00164671 rs142586562
SLC16A7 292 V/I 0.000167345 rs141650282
SLC16A7 299 S/F 0.0001155 rs140460047
SLC16A7 299 S/T 0.000115485 rs146762077
SLC16A7 346 F/V 0.00282506 rs149587895
SLC16A7 361 T/A 0.00133217 rs143304922
SLC16A7 389 G/D 0.00016107 rs201236531
SLC16A7 445 T/S 0.229175 rs3763980
-- SLC16A7 447 E/V 0.00547922 rs78708164
-- SLC16A7 477 N/K 0.000777789 rs141130331

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC16A7 SLC16A7 [plasma membrane] Proton-coupled monocarboxylate transport

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data