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Detail Data SLC16A12


Basic description
Gene Name SLC16A12
Protein Name Monocarboxylate transporter 12 (MCT 12) (Creatine transporter 2) (CRT2) (Solute carrier family 16 member 12)
Family SLC16
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510 
MPSGSHWTAN SSKIITWLLE QPGKEEKRKT MAKVNRARST SPPDGGWGWM IVAGCFLVTI CTRAVTRCIS IFFVEFQTYF TQDYAQTAWI HSIVDCVTML CAPLGSVVSN HLSCQVGIML GGLLASTGLI LSSFATSLKH LYLTLGVLTG LGFALCYSPA IAMVGKYFSR RKALAYGIAM SGSGIGTFIL APVVQLLIEQ FSWRGALLIL GGFVLNLCVC GALMRPITLK EDHTTPEQNH VCRTQKEDIK RVSPYSSLTK EWAQTCLCCC LQQEYSFLLM SDFVVLAVSV LFMAYGCSPL FVYLVPYALS VGVSHQQAAF LMSILGVIDI IGNITFGWLT DRRCLKNYQY VCYLFAVGMD GLCYLCLPML QSLPLLVPFS CTFGYFDGAY VTLIPVVTTE IVGTTSLSSA LGVVYFLHAV PYLVSPPIAG RLVDTTGSYT AAFLLCGFSM IFSSVLLGFA RLIKRMRKTQ LQFIAKESDP KLQLWTNGSV AYSVARELDQ KHGEPVATAV PGYSLT 
CCCCCCCCCC CCCCCHHHHC CCCCHHHHHH HHHHCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHHHHHHHHC CCHHHHHHHH HHHHHHHHHH HCCHHHHHHH HHCCCCHHHH HHHHHHHCHH HHHHHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCHHCCCCC CCCCCCCCCC CCCCCC
[Overview] SLC16A1 SLC16A10 SLC16A11 SLC16A12 SLC16A13 SLC16A14 SLC16A2 SLC16A3 SLC16A4 SLC16A5 SLC16A6 SLC16A7 SLC16A8 SLC16A9 
SLC16A1   ----------------------------------------------------------MPPAVGGPVGY-------------------------------TPP--DGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATT------SEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPI--------------------GPKPTKAGK---------DKSKAS--LEKAGKSGVKKDL-----------HDANTD------------------------LIGR-HPK--QEKR-------SVFQTINQFL------------------------DLTLFTHR-GFLL-YLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF-LLSILAFVDMVARPSMGLVAN-----TKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLM--DLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFI-------GMGINYRLLAKEQKANEQKKES--------KEEETSIDVAGKPNEVTKAAES--------------------PDQKDTDGGP---------KEE-------ESPV------
SLC16A10  MVLSQEEPDSARG------TSEAQPLG-------------PAPTGAAPP--------PGPGPSDSPEAAVEKVEVELAGPATAEPHEPP-----------EPP--EGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMV-FKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATS-----------------------------------TKDKES------GGSGSSLFSR--------------------------------------------------------------------KKF-------SPPKKIF----------NFAIFKVT-AYAV-WAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEV-VLMCIGVTSGVGRLLFGRIADYVPG-VKKV-----YLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAF--ELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIH-----------SKKQREISKTTGK--------EKME------------------------------------KML----ENQNSLLSSSSGMFKKE-------SDSII-----
SLC16A11  MPA---------------------------------------PQRKHRRGGFSHRCFPTPQTAMTPQPA-------------------------------GPP--DGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSA------QDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPP------------APPRSPLAA------------------------------------------------------------------------------------------------------L------------------------GLSLFTRR-AFSI-FALGTALVGGGYFVPYVHLAPHALDRGLGGYGAAL-VVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLP--GLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSFIYI----------------------------------------------GLPRALPSCGPASPP--------------------ATPPPETGELLPAPQAVLLSPGGPGSTLDTTC------
SLC16A12  MPSGSH--------WT---ANSSKIIT---------WLLE-QPGKEEKRK--------TMAKVNRARST-------------------------------SPP--DGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDY------AQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDHT-------------TPEQNHVCRT--------QKED-----------------------------------------------------------IKRVSPYSSLTKEWAQTCLCCCLQQEYSFL------------------------LMS------DFVV-LAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAF-LMSILGVIDIIGNITFGWLTDRR---CLKNYQYVCYLFAVGM--DGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTT--EIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLG-------------FARLIKRMRKTQLQFIA--------KESD--------------------------------------PKLQLWTNGSVAYSVARELDQK--HGEPVATAVPGYSLT
SLC16A13  ---------------------------------------------MARR-------------------T-------------------------------EPP--DGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQA------ARVSWIASIGIAVQQFGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSALSLHLVACGALLRPPSLAEDPAV-----------GGPRAQLT----------------------------------------------------------------------------------------------------------------------------------SLLHHG-PFLR-YTVALTLINTGYFIPYLHLVAHLQDLDWDPLPAAF-LLSVVAISDLVGRVVSGWLGDAVPGPVTRLLMLWTTLTGVSL---ALFPVAQAPTA----LVALAVAYGFTSGALAPLAFSVLP--ELIGTRRIYCGLGLLQMIESIGGLLGPPLSGYLRDVTGNYTASFVVAGAFLLSGSGILL----------------------------------------------TLPHFFCFSTTTSGPQD-----------------LVTEALDTK--VPLPKEGLEED-----------------
SLC16A14  MYT------------------SHEDIG---------YDFEDGPK-------------------DKKTLK-------------------------------PHPNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSR------GLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLS------PGK----------NPNDPGEK----DVRGLPAHSTES--VKSTGQQGRTEEK------------DGGLGNEET--------------------LCDLQAQEC-PDQAGHRKNMCAL-----RILKTVSWLTMRVRKGFEDWYSGYFG-TASLFTNR-MFVA-FIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCI-------SVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFS--LMPVVTE-DLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIG--ILFL-------LIQPCIRIIEQSRRK----------------YMD-------------------------------------------------------------------GAHV------
SLC16A2   MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE-------PQPEPQPLPDPA-PLPELEFESERVHEPEPTPTVETRGTARGFQPP--EGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEE--EKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPS-----------------------------------SQDTPS-------KRGVRTLHQ--------------------------------------------------------------------RFL-------AQLRKYF----------NMRVFRQR-TYRI-WAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWV-LLVCIGATSGLGRLVSGHISDSIPG-LKKI-----YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAF--ELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQ-------RMFKKEQRDSSK---------------D------------------------------------KMLAPDPDPNGELLPGSP----NP-------EEPI------
SLC16A3   --------------------------------------------------------MGGAVVDEGPTGV-------------------------------KAP--DGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGY------SDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPG------------SGPP----------------------------------------------------------------------------------RPSR-------------------RLL------------------------DLSVFRDR-GFVL-YAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAF-LLTILGFIDIFARPAAGFVAG-----LGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLM--AIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLL-------GNFFCIR---KKPKEPQPEVAA--------AEEE----KLHKP-P----ADSGVDLREVEHF----------LKAEPEKNGE-------VVHTP-------ETSV------
SLC16A4   ---------------------------------------------MLKREG------------KVQPYT-------------------------------KTL--DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTS------EQIGWIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETH--------CHETEESTIKDSTTQKAGLPS-----------KNLTVSQNQSE---------EFYNGPNRNRLLLKSDEESDKVISWSCK----------QLF------------------------DISLFRNP-FFYI-FTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASY-LVSVAGILETVSQIISGWVADQNW--IKKYHYHKSYLI-----LCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLV--DLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFV-----------------------------------------------------------------------------------------------PLAERW------KNSLT-----
SLC16A5   ----------------------------------------------------------------MPQAL-------------------------------ERA--DGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASN------SETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETK--------ECPPPPPETP----------------A--LGCLAACGRTIQ----------------------------------------------------------------------RHL------------------------AFDILRHNTGYCV-YILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAAL-LISIIGFSNIFLRPLAGLMAG-----RPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLM--DIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM----------GGSFYALQKKEQGKQAVAADALER--DLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWG--------CPASSRTSHEWLLWPKAVLQAK-------QTALGWNSPT
SLC16A6   ---------------------------------------------MTQNK--------LKLCSKANVYT-------------------------------EVP--DGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESN------SRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFI-----------------RGPASPKIVIQ--------ENRKEAQYMLENEKTRTSIDS-----------IDSGVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKA--------------PLL------------------------DFSILKEK-SFIC-YALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAF-LLSTMAIAEVFGRIGAGFVLN-----REPIRKIYIELICVILLTVSL--FAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVR---PCKMGLCQHHHSGETKVVSHRGKTLQDIPEDFLEMD---------------------LAKNEHRVH--------VQMEPV---------------------------------
SLC16A7   ----------------------------------------------------------MPPMPSAPPVH-------------------------------PPP--DGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTY------SEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPL--------------------GPNQTTS------------KSK--------NKTGKTED-------------DSS--------------------------------PKKIKTKK-------STWEKVNKYL------------------------DFSLFKHR-GFLI-YLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIAN-----SKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLM--DLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI-------GNAINYRLLAKERKEENARQKT--------RESE--------PLSKSKHSED--------------------VNVKVSNAQS-------VTSER-------ETNI------
SLC16A8   ------------------------------------------------------MGAGGPRRGEGP------------------------------------P--DGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGY------SDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRP-----PPG------------PGPRPRRDSAG--------DRAGDA--PGEAEADGAGLQL-----------REAS----------------------------PRVRPRR-------------------RLL------------------------DLAVCTDR-AFAV-YAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAF-LLSIVGFVDIVARPACGALAG-----LARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLM--AAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAV-------ATNCCLRCAKAAPSGPGTEGGASDT--E-DAEAE----GDSEPLPV--VAEEPGNLEALEVLSARGEPTEPEIEARPRLAAE-------SV--------------------
SLC16A9   -----------------------------------------------------------------MELK-------------------------------KSP--DGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGK------GKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKK---------IAPEDLPDKYSIYNEKG--KNLEEN--INILDKSYSSEEKCRITLANGDWKQDSLLHKNPT--------------------VTHTKEPETYKKKVAEQTYFC-------KQLAKRKW----------QLYKNYCGETVALFKNK-VFSALFIAILLFDIGGF-PPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWI-------NTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNWS--IFPYVTT-KTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL-------AALPSWDTCNKQLPKPA---------PTTFLYKV-------------------------------------------------------------------ASNV------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC16A12 17 W/G 0.0795583 rs3740030
-- SLC16A12 33 K/E 0.000282729 rs144003754
-- SLC16A12 87 T/M 0.000262676 rs375833021
-- SLC16A12 158 S/P 0.000586996 rs150800688
-- SLC16A12 290 V/I 0.000211292 rs578168671
-- SLC16A12 298 S/N 0.000705674 rs201390928
-- SLC16A12 327 V/A 0.000714577 rs190510733
-- SLC16A12 406 S/C 0.000545765 rs145362501
-- SLC16A12 440 T/P 0.000175338 rs201915707
-- SLC16A12 496 R/G 0.000111402 rs775480404
-- SLC16A12 514 S/R 0.000103497 rs151275788

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
No data

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data