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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC16A11


Basic description
Gene Name SLC16A11
Protein Name Monocarboxylate transporter 11 (MCT 11) (Solute carrier family 16 member 11)
Family SLC16
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470 
MPAPQRKHRR GGFSHRCFPT PQTAMTPQPA GPPDGGWGWV VAAAAFAING LSYGLLRSLG LAFPDLAEHF DRSAQDTAWI SALALAVQQA ASPVGSALST RWGARPVVMV GGVLASLGFV FSAFASDLLH LYLGLGLLAG FGWALVFAPA LGTLSRYFSR RRVLAVGLAL TGNGASSLLL APALQLLLDT FGWRGALLLL GAITLHLTPC GALLLPLVLP GDPPAPPRSP LAALGLSLFT RRAFSIFALG TALVGGGYFV PYVHLAPHAL DRGLGGYGAA LVVAVAAMGD AGARLVCGWL ADQGWVPLPR LLAVFGALTG LGLWVVGLVP VVGGEESWGG PLLAAAVAYG LSAGSYAPLV FGVLPGLVGV GGVVQATGLV MMLMSLGGLL GPPLSGFLRD ETGDFTASFL LSGSLILSGS FIYIGLPRAL PSCGPASPPA TPPPETGELL PAPQAVLLSP GGPGSTLDTT C 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCHH HHHHHHHHHH HHHCHHHHHH HHHHHHHHHH HCHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC HHHCCHHHHC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCHH HHHHHHHHHH HHHHHCHHCH HHHHHHHHCH HCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCCEECCC CCCCCCCCCC C
[Overview] SLC16A1 SLC16A10 SLC16A11 SLC16A12 SLC16A13 SLC16A14 SLC16A2 SLC16A3 SLC16A4 SLC16A5 SLC16A6 SLC16A7 SLC16A8 SLC16A9 
SLC16A1   ----------------------------------------------------------MPPAVGGPVGY-------------------------------TPP--DGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATT------SEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPI--------------------GPKPTKAGK---------DKSKAS--LEKAGKSGVKKDL-----------HDANTD------------------------LIGR-HPK--QEKR-------SVFQTINQFL------------------------DLTLFTHR-GFLL-YLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF-LLSILAFVDMVARPSMGLVAN-----TKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLM--DLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFI-------GMGINYRLLAKEQKANEQKKES--------KEEETSIDVAGKPNEVTKAAES--------------------PDQKDTDGGP---------KEE-------ESPV------
SLC16A10  MVLSQEEPDSARG------TSEAQPLG-------------PAPTGAAPP--------PGPGPSDSPEAAVEKVEVELAGPATAEPHEPP-----------EPP--EGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMV-FKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATS-----------------------------------TKDKES------GGSGSSLFSR--------------------------------------------------------------------KKF-------SPPKKIF----------NFAIFKVT-AYAV-WAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEV-VLMCIGVTSGVGRLLFGRIADYVPG-VKKV-----YLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAF--ELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIH-----------SKKQREISKTTGK--------EKME------------------------------------KML----ENQNSLLSSSSGMFKKE-------SDSII-----
SLC16A11  MPA---------------------------------------PQRKHRRGGFSHRCFPTPQTAMTPQPA-------------------------------GPP--DGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSA------QDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPP------------APPRSPLAA------------------------------------------------------------------------------------------------------L------------------------GLSLFTRR-AFSI-FALGTALVGGGYFVPYVHLAPHALDRGLGGYGAAL-VVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLP--GLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSFIYI----------------------------------------------GLPRALPSCGPASPP--------------------ATPPPETGELLPAPQAVLLSPGGPGSTLDTTC------
SLC16A12  MPSGSH--------WT---ANSSKIIT---------WLLE-QPGKEEKRK--------TMAKVNRARST-------------------------------SPP--DGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDY------AQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDHT-------------TPEQNHVCRT--------QKED-----------------------------------------------------------IKRVSPYSSLTKEWAQTCLCCCLQQEYSFL------------------------LMS------DFVV-LAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAF-LMSILGVIDIIGNITFGWLTDRR---CLKNYQYVCYLFAVGM--DGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTT--EIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLG-------------FARLIKRMRKTQLQFIA--------KESD--------------------------------------PKLQLWTNGSVAYSVARELDQK--HGEPVATAVPGYSLT
SLC16A13  ---------------------------------------------MARR-------------------T-------------------------------EPP--DGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQA------ARVSWIASIGIAVQQFGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSALSLHLVACGALLRPPSLAEDPAV-----------GGPRAQLT----------------------------------------------------------------------------------------------------------------------------------SLLHHG-PFLR-YTVALTLINTGYFIPYLHLVAHLQDLDWDPLPAAF-LLSVVAISDLVGRVVSGWLGDAVPGPVTRLLMLWTTLTGVSL---ALFPVAQAPTA----LVALAVAYGFTSGALAPLAFSVLP--ELIGTRRIYCGLGLLQMIESIGGLLGPPLSGYLRDVTGNYTASFVVAGAFLLSGSGILL----------------------------------------------TLPHFFCFSTTTSGPQD-----------------LVTEALDTK--VPLPKEGLEED-----------------
SLC16A14  MYT------------------SHEDIG---------YDFEDGPK-------------------DKKTLK-------------------------------PHPNIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSR------GLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLS------PGK----------NPNDPGEK----DVRGLPAHSTES--VKSTGQQGRTEEK------------DGGLGNEET--------------------LCDLQAQEC-PDQAGHRKNMCAL-----RILKTVSWLTMRVRKGFEDWYSGYFG-TASLFTNR-MFVA-FIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCI-------SVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFS--LMPVVTE-DLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIG--ILFL-------LIQPCIRIIEQSRRK----------------YMD-------------------------------------------------------------------GAHV------
SLC16A2   MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE-------PQPEPQPLPDPA-PLPELEFESERVHEPEPTPTVETRGTARGFQPP--EGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEE--EKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPS-----------------------------------SQDTPS-------KRGVRTLHQ--------------------------------------------------------------------RFL-------AQLRKYF----------NMRVFRQR-TYRI-WAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWV-LLVCIGATSGLGRLVSGHISDSIPG-LKKI-----YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAF--ELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQ-------RMFKKEQRDSSK---------------D------------------------------------KMLAPDPDPNGELLPGSP----NP-------EEPI------
SLC16A3   --------------------------------------------------------MGGAVVDEGPTGV-------------------------------KAP--DGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGY------SDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPG------------SGPP----------------------------------------------------------------------------------RPSR-------------------RLL------------------------DLSVFRDR-GFVL-YAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAF-LLTILGFIDIFARPAAGFVAG-----LGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLM--AIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLL-------GNFFCIR---KKPKEPQPEVAA--------AEEE----KLHKP-P----ADSGVDLREVEHF----------LKAEPEKNGE-------VVHTP-------ETSV------
SLC16A4   ---------------------------------------------MLKREG------------KVQPYT-------------------------------KTL--DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTS------EQIGWIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGL-TFLLAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETH--------CHETEESTIKDSTTQKAGLPS-----------KNLTVSQNQSE---------EFYNGPNRNRLLLKSDEESDKVISWSCK----------QLF------------------------DISLFRNP-FFYI-FTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASY-LVSVAGILETVSQIISGWVADQNW--IKKYHYHKSYLI-----LCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLV--DLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFV-----------------------------------------------------------------------------------------------PLAERW------KNSLT-----
SLC16A5   ----------------------------------------------------------------MPQAL-------------------------------ERA--DGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASN------SETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETK--------ECPPPPPETP----------------A--LGCLAACGRTIQ----------------------------------------------------------------------RHL------------------------AFDILRHNTGYCV-YILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAAL-LISIIGFSNIFLRPLAGLMAG-----RPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLM--DIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM----------GGSFYALQKKEQGKQAVAADALER--DLFLEAKDGPGKQRSPEIMCQSSRQPRPAGVNKHLWG--------CPASSRTSHEWLLWPKAVLQAK-------QTALGWNSPT
SLC16A6   ---------------------------------------------MTQNK--------LKLCSKANVYT-------------------------------EVP--DGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESN------SRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFI-----------------RGPASPKIVIQ--------ENRKEAQYMLENEKTRTSIDS-----------IDSGVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRPSEKKA--------------PLL------------------------DFSILKEK-SFIC-YALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAF-LLSTMAIAEVFGRIGAGFVLN-----REPIRKIYIELICVILLTVSL--FAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVR---PCKMGLCQHHHSGETKVVSHRGKTLQDIPEDFLEMD---------------------LAKNEHRVH--------VQMEPV---------------------------------
SLC16A7   ----------------------------------------------------------MPPMPSAPPVH-------------------------------PPP--DGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTY------SEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPL--------------------GPNQTTS------------KSK--------NKTGKTED-------------DSS--------------------------------PKKIKTKK-------STWEKVNKYL------------------------DFSLFKHR-GFLI-YLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIAN-----SKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLM--DLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI-------GNAINYRLLAKERKEENARQKT--------RESE--------PLSKSKHSED--------------------VNVKVSNAQS-------VTSER-------ETNI------
SLC16A8   ------------------------------------------------------MGAGGPRRGEGP------------------------------------P--DGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGY------SDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRP-----PPG------------PGPRPRRDSAG--------DRAGDA--PGEAEADGAGLQL-----------REAS----------------------------PRVRPRR-------------------RLL------------------------DLAVCTDR-AFAV-YAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAF-LLSIVGFVDIVARPACGALAG-----LARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLM--AAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAV-------ATNCCLRCAKAAPSGPGTEGGASDT--E-DAEAE----GDSEPLPV--VAEEPGNLEALEVLSARGEPTEPEIEARPRLAAE-------SV--------------------
SLC16A9   -----------------------------------------------------------------MELK-------------------------------KSP--DGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGK------GKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKK---------IAPEDLPDKYSIYNEKG--KNLEEN--INILDKSYSSEEKCRITLANGDWKQDSLLHKNPT--------------------VTHTKEPETYKKKVAEQTYFC-------KQLAKRKW----------QLYKNYCGETVALFKNK-VFSALFIAILLFDIGGF-PPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWI-------NTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNWS--IFPYVTT-KTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL-------AALPSWDTCNKQLPKPA---------PTTFLYKV-------------------------------------------------------------------ASNV------

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC16A11 56 L/P 0.000111893 rs763119915
-- SLC16A11 81 S/R 0.000189701 rs199869009
-- SLC16A11 103 G/V 0.000252943 rs543004946
-- SLC16A11 104 A/S 0.0466023 rs75636181
-- SLC16A11 107 V/M 0.000101445 rs373049645
-- SLC16A11 113 V/I 0.0575922 rs117767867
-- SLC16A11 127 D/G 0.0819366 rs13342692
-- SLC16A11 146 V/A 0.000120764 rs781270721
-- SLC16A11 189 D/H 0.000200731 rs199684329
-- SLC16A11 220 P/T 0.000104705 rs759252457
-- SLC16A11 228 R/H 0.000331606 rs34269551
-- SLC16A11 235 G/D 0.000904656 rs200366816
-- SLC16A11 266 A/P 0.000329046 rs201095648
-- SLC16A11 278 G/R 0.000395352 rs200478682
-- SLC16A11 282 V/A 0.000367359 rs199720953
-- SLC16A11 304 G/D 0.000108072 rs773641427
-- SLC16A11 340 G/S 0.0609176 rs75418188
-- SLC16A11 405 F/L 0.000884379 rs35712788
-- SLC16A11 443 P/T 0.0543424 rs75493593
-- SLC16A11 445 E/A 0.000647293 rs201074878

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
No data

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data