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Detail Data SLC15A4


Basic description
Gene Name SLC15A4
Protein Name Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)
Family SLC15
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570 
MEGSGGGAGE RAPLLGARRA AAAAAAAGAF AGRRAACGAV LLTELLERAA FYGITSNLVL FLNGAPFCWE GAQASEALLL FMGLTYLGSP FGGWLADARL GRARAILLSL ALYLLGMLAF PLLAAPATRA ALCGSARLLN CTAPGPDAAA RCCSPATFAG LVLVGLGVAT VKANITPFGA DQVKDRGPEA TRRFFNWFYW SINLGAILSL GGIAYIQQNV SFVTGYAIPT VCVGLAFVVF LCGQSVFITK PPDGSAFTDM FKILTYSCCS QKRSGERQSN GEGIGVFQQS SKQSLFDSCK MSHGGPFTEE KVEDVKALVK IVPVFLALIP YWTVYFQMQT TYVLQSLHLR IPEISNITTT PHTLPAAWLT MFDAVLILLL IPLKDKLVDP ILRRHGLLPS SLKRIAVGMF FVMCSAFAAG ILESKRLNLV KEKTINQTIG NVVYHAADLS LWWQVPQYLL IGISEIFASI AGLEFAYSAA PKSMQSAIMG LFFFFSGVGS FVGSGLLALV SIKAIGWMSS HTDFGNINGC YLNYYFFLLA AIQGATLLLF LIISVKYDHH RDHQRSRANG VPTSRRA 
CCCCCCCCCC CCCCCCCCCC HHHHHCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHCCEEE ECCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHHHCCC CCCEECCCCC HHHCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCHHHH HHHHHHHHHH HHCCEECCCC CCCCCCHHHH HHHHHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC HHHHHHHHCC CCCCCCCCCC CCCCCHHHHC CHHHHHHHHH HHHHHHCCCC HHHHCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CHHHCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHCC CCCCCCC
[Overview] SLC15A1 SLC15A2 SLC15A3 SLC15A4 
SLC15A1   ----MGMSKSHSFFG--------------------------YPL-----------------------SIFFIVVNEFCERFSYYGMRAILILYF--TNFISWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLP----------------------------------VHVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMLR--VQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPK------------REHWLDWAK----EKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMS---------GKIGA--------LEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQ-------------------VVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANI-SSYNASTYQFFPSGIKGFTISSTEIPP-QCQ---PNF--NTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNII---VLIVAGAGQFSK--QWAE----------------YILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDE------------DEKKNRLEKSNPYFMSGANSQKQM
SLC15A2   MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPL-----------------------SIAFIVVNEFCERFSYYGMKAVLILYF--LYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLG---------------ALPI----LGGQ------------------------VVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFG----EDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPK------------RQHWLDWAA----EKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMN---------RNLGF--------FVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVG--------NENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKD-TESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYR---------TVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNII---VLVVA---QFSGLVQWAE----------------FILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL-----------------
SLC15A3   -------------------------MPAPRAREQPRVPGERQPLLPRGAR---------GPRRWRRAAGAAVLLVEMLERAAFFGVTANLVLYLNSTNF-NWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYRAVALSLLLYLAASGLLPAT---------------AFPDGRSSFCGE---MPASPLGPACPSAGCPRSSPSPYCAPVLYAGLLLLGLAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQ----------QNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHSARDRQCARVLADERSPQP-----------GASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPANISVALRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEME---------------------------------------------------------------------------------------------------R----------------------------LHYIHHNETVS----------QQIGEVLYN--------------------------------------------------------------AAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALL---SLPG--GWLHCPKDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERASQ----GPASH----------------SRFSRDR-----G-------
SLC15A4   ------------------------------MEGSGGGAGERAPLL--GARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVLFLNGAPF-CWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLL---------------AAPATRAALCGSARLLNCTAPGPD-AAARC--------CSPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQ----------QNVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQ--KRSGERQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEI-----SNITT------TPHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESK---------------------------------------------------------------------------------------------------R----------------------------LNLV-KEKTIN----------QTIGNVVYH--------------------------------------------------------------AADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLALV---SIKA-IGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHR--------DH----------------QR-SRAN-----GVPTSRRA

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC15A4 75 S/T 0.00417812 rs201649968
-- SLC15A4 102 R/W 0.000100328 rs746374738
-- SLC15A4 148 A/T 0.000104871 rs753741475
-- SLC15A4 157 T/S 0.000419805 rs767011396
-- SLC15A4 188 P/L 0.00180381 rs144816528
-- SLC15A4 239 V/A 0.0844547 rs33990080
-- SLC15A4 243 G/S 0.00262844 rs35580712
-- SLC15A4 263 I/V 0.000198912 rs756449348
-- SLC15A4 279 S/I 0.000649868 rs35439692
-- SLC15A4 361 P/R 0.000767354 rs143468681
-- SLC15A4 443 V/I 0.000374019 rs188218535
-- SLC15A4 550 F/S 0.000330133 rs552468714
-- SLC15A4 577 A/V 0.00199913 rs113773617

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC15A4 SLC15A4 [lysosomal membrane] Proton/oligopeptide cotransporters
SLC15A4 SLC15A4 [specific granule membrane] Neutrophil degranulation
SLC15A4 SLC15A4 [plasma membrane] Neutrophil degranulation

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data