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Structure
Seq./Align.
Variant
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Pathway
Disease

Detail Data SLC15A3


Basic description
Gene Name SLC15A3
Protein Name Solute carrier family 15 member 3 (Osteoclast transporter) (Peptide transporter 3) (Peptide/histidine transporter 2)
Family SLC15
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580 
MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF GVTANLVLYL NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR YRAVALSLLL YLAASGLLPA TAFPDGRSSF CGEMPASPLG PACPSAGCPR SSPSPYCAPV LYAGLLLLGL AASSVRSNLT SFGADQVMDL GRDATRRFFN WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA FFIFLFATPV FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF PANPANISVA LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR CKLLPSALQK MALGMFFGFT SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL YNAAPLSIWW QIPQYLLIGI SEIFASIPGL EFAYSEAPRS MQGAIMGIFF CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL YFFLLAGIQA VTALLFVWIA GRYERASQGP ASHSRFSRDR G 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHEEEEC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHCCCHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCHHHHC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCHHHHHH HHHHHHHHHH HHHHHHCCHH HCCCCCCCCC CCEEEEEHHH CCCHHHHHCC CCCHHHHHHH HHCCCCCCCC CCCHHHHHHH HHHHHHHCHH CCCCCHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCHHHH HHCCCCCCCC CHHHHHHHHH HHHHHHHHHH CEEEHHHHHC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCHHH HCCHHHHHHH HHHCCCCCHH HHHHHHCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC C
[Overview] SLC15A1 SLC15A2 SLC15A3 SLC15A4 
SLC15A1   ----MGMSKSHSFFG--------------------------YPL-----------------------SIFFIVVNEFCERFSYYGMRAILILYF--TNFISWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLP----------------------------------VHVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMLR--VQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPK------------REHWLDWAK----EKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMS---------GKIGA--------LEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQ-------------------VVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANI-SSYNASTYQFFPSGIKGFTISSTEIPP-QCQ---PNF--NTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNII---VLIVAGAGQFSK--QWAE----------------YILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDE------------DEKKNRLEKSNPYFMSGANSQKQM
SLC15A2   MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPL-----------------------SIAFIVVNEFCERFSYYGMKAVLILYF--LYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLG---------------ALPI----LGGQ------------------------VVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFG----EDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPK------------RQHWLDWAA----EKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMN---------RNLGF--------FVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVG--------NENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKD-TESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYR---------TVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNII---VLVVA---QFSGLVQWAE----------------FILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL-----------------
SLC15A3   -------------------------MPAPRAREQPRVPGERQPLLPRGAR---------GPRRWRRAAGAAVLLVEMLERAAFFGVTANLVLYLNSTNF-NWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYRAVALSLLLYLAASGLLPAT---------------AFPDGRSSFCGE---MPASPLGPACPSAGCPRSSPSPYCAPVLYAGLLLLGLAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQ----------QNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHSARDRQCARVLADERSPQP-----------GASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPANISVALRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEME---------------------------------------------------------------------------------------------------R----------------------------LHYIHHNETVS----------QQIGEVLYN--------------------------------------------------------------AAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALL---SLPG--GWLHCPKDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERASQ----GPASH----------------SRFSRDR-----G-------
SLC15A4   ------------------------------MEGSGGGAGERAPLL--GARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVLFLNGAPF-CWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLL---------------AAPATRAALCGSARLLNCTAPGPD-AAARC--------CSPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQ----------QNVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQ--KRSGERQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEI-----SNITT------TPHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESK---------------------------------------------------------------------------------------------------R----------------------------LNLV-KEKTIN----------QTIGNVVYH--------------------------------------------------------------AADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLALV---SIKA-IGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHR--------DH----------------QR-SRAN-----GVPTSRRA

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC15A3 41 E/D 0.000355671 rs188161059
-- SLC15A3 73 T/P 0.000304031 rs568354419
-- SLC15A3 78 V/I 0.0515271 rs150370599
-- SLC15A3 90 G/V 0.00148188 rs200982819
-- SLC15A3 93 L/P 0.00043393 rs199743083
-- SLC15A3 191 G/S 0.000138723 rs140918009
-- SLC15A3 197 R/C 0.000588527 rs528183979
-- SLC15A3 269 L/P 0.000222535 rs149694525
-- SLC15A3 285 R/H 0.00254091 rs570961645
-- SLC15A3 303 P/Q 0.0106598 rs77943698
-- SLC15A3 303 P/R 0.00208589 rs77943698
-- SLC15A3 353 N/K 0.000210774 rs200292846
-- SLC15A3 365 G/V 0.0135352 rs78193365
-- SLC15A3 379 N/S 0.000554271 rs144904455
-- SLC15A3 392 R/C 0.000183214 rs140596697
-- SLC15A3 395 D/N 0.000250878 rs201995321
-- SLC15A3 400 R/W 0.000932122 rs140945002
-- SLC15A3 400 R/Q 0.000521767 rs182999629
-- SLC15A3 581 G/S 0.000103627 rs774963789

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC15A3 SLC15A3 [lysosomal membrane] Proton/oligopeptide cotransporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data