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Detail Data SLC15A2


Basic description
Gene Name SLC15A2
Protein Name Solute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)
Family SLC15
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720 
MNPFQKNESK ETLFSPVSIE EVPPRPPSPP KKPSPTICGS NYPLSIAFIV VNEFCERFSY YGMKAVLILY FLYFLHWNED TSTSIYHAFS SLCYFTPILG AAIADSWLGK FKTIIYLSLV YVLGHVIKSL GALPILGGQV VHTVLSLIGL SLIALGTGGI KPCVAAFGGD QFEEKHAEER TRYFSVFYLS INAGSLISTF ITPMLRGDVQ CFGEDCYALA FGVPGLLMVI ALVVFAMGSK IYNKPPPEGN IVAQVFKCIW FAISNRFKNR SGDIPKRQHW LDWAAEKYPK QLIMDVKALT RVLFLYIPLP MFWALLDQQG SRWTLQAIRM NRNLGFFVLQ PDQMQVLNPL LVLIFIPLFD FVIYRLVSKC GINFSSLRKM AVGMILACLA FAVAAAVEIK INEMAPAQPG PQEVFLQVLN LADDEVKVTV VGNENNSLLI ESIKSFQKTP HYSKLHLKTK SQDFHFHLKY HNLSLYTEHS VQEKNWYSLV IREDGNSISS MMVKDTESRT TNGMTTVRFV NTLHKDVNIS LSTDTSLNVG EDYGVSAYRT VQRGEYPAVH CRTEDKNFSL NLGLLDFGAA YLFVITNNTN QGLQAWKIED IPANKMSIAW QLPQYALVTA GEVMFSVTGL EFSYSQAPSS MKSVLQAAWL LTIAVGNIIV LVVAQFSGLV QWAEFILFSC LLLVICLIFS IMGYYYVPVK TEDMRGPADK HIPHIQGNMI KLETKKTKL 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCH HHHHHHHHHH HHHHHHHHHH CCCCCCCCHH HHHHHHHHHH HHHHHCCCCC HHCHHHHHHH HCCCCCHHHH HHHHCHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCHHHHH HHHHHHHHHH HHHHHHCCCC CCCCCCCCCC HHHHHHHHHH HHHHCCCCCC CCCCCCHHHH CCCHHHHCCC HHHHHHHHHH HHHHHHCCCH HHHHHHHCCC HHHHHHHHHC CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCHH CHHHHHHHHH HHHHHHHHHH HHCCCCCCCC HHHHHHHHHH HHCCCCEEEE CCCCCCHHHH HHHHHHCCCC CCCCCCCCCC CCCHHHCHHH CCCCCCCCCC CCCCCCEEEE ECCCCCCCCE EEECCCCCCC CCCCEEEEEH HCCCCCCEEE CCCCCCCCCC CCCCCCHHEE ECCCCCCEEE ECCCCCCCCC CHHHHHHHHH HHHHHHHCCC CCCEEEEECC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHCCCCC HHHCCCCCHH CCCCCCCCCC CCCCCCCCC
[Overview] SLC15A1 SLC15A2 SLC15A3 SLC15A4 
SLC15A1   ----MGMSKSHSFFG--------------------------YPL-----------------------SIFFIVVNEFCERFSYYGMRAILILYF--TNFISWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLP----------------------------------VHVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMLR--VQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPK------------REHWLDWAK----EKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMS---------GKIGA--------LEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQ-------------------VVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANI-SSYNASTYQFFPSGIKGFTISSTEIPP-QCQ---PNF--NTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNII---VLIVAGAGQFSK--QWAE----------------YILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDE------------DEKKNRLEKSNPYFMSGANSQKQM
SLC15A2   MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPL-----------------------SIAFIVVNEFCERFSYYGMKAVLILYF--LYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLG---------------ALPI----LGGQ------------------------VVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFG----EDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPK------------RQHWLDWAA----EKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMN---------RNLGF--------FVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVG--------NENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKD-TESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYR---------TVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNII---VLVVA---QFSGLVQWAE----------------FILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL-----------------
SLC15A3   -------------------------MPAPRAREQPRVPGERQPLLPRGAR---------GPRRWRRAAGAAVLLVEMLERAAFFGVTANLVLYLNSTNF-NWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYRAVALSLLLYLAASGLLPAT---------------AFPDGRSSFCGE---MPASPLGPACPSAGCPRSSPSPYCAPVLYAGLLLLGLAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQ----------QNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHSARDRQCARVLADERSPQP-----------GASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPANISVALRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEME---------------------------------------------------------------------------------------------------R----------------------------LHYIHHNETVS----------QQIGEVLYN--------------------------------------------------------------AAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALL---SLPG--GWLHCPKDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERASQ----GPASH----------------SRFSRDR-----G-------
SLC15A4   ------------------------------MEGSGGGAGERAPLL--GARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVLFLNGAPF-CWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLL---------------AAPATRAALCGSARLLNCTAPGPD-AAARC--------CSPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQ----------QNVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQ--KRSGERQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEI-----SNITT------TPHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESK---------------------------------------------------------------------------------------------------R----------------------------LNLV-KEKTIN----------QTIGNVVYH--------------------------------------------------------------AADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLALV---SIKA-IGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHR--------DH----------------QR-SRAN-----GVPTSRRA

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
SLC15A2 247 P/L 0.000712585 rs540091469
SLC15A2 350 L/F 0.419542 rs2257212
SLC15A2 409 P/S 0.419591 rs1143671
SLC15A2 465 H/R 0.000111409 rs748018463
SLC15A2 473 L/F 0.000119353 rs540111577
SLC15A2 492 R/H 0.000290899 rs139931241
SLC15A2 509 R/K 0.419371 rs1143672
SLC15A2 590 N/S 0.00305857 rs116307792
SLC15A2 609 A/V 0.00036124 rs1143668
SLC15A2 674 E/K 0.000233728 rs368822521
-- SLC15A2 705 R/W 0.00107396 rs138745887

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC15A2 SLC15A2 [plasma membrane] Proton/oligopeptide cotransporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data