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Detail Data SLC15A1


Basic description
Gene Name SLC15A1
Protein Name Solute carrier family 15 member 1 (Intestinal H(+)/peptide cotransporter) (Oligopeptide transporter, small intestine isoform) (Peptide transporter 1)
Family SLC15
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700 
MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV SSINDLTDHN HDGTPDSLPV HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ FEEGQEKQRN RFFSIFYLAI NAGSLLSTII TPMLRVQQCG IHSKQACYPL AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI GFAIKNRFRH RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK CGFNFTSLKK MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL NIGNNTMNIS LPGEMVTLGP MSQTNAFMTF DVNKLTRINI SSPGSPVTAV TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK PEKGENGIRF VNTFNELITI TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ PNFNTFYLEF GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI LFAALLLVVC VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS GANSQKQM 
CCCCCCCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC CCCCCCCCHH HHHHHHHHHH HHHHCCCCCC CCHHHHHCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCCCCHHH HHHHCHHHHH HHHHHHHHCC CHHHCCCCCC CHHHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCHHHHHCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH CCCCCCCCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCC HHHHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCEEEEEEE ECCCCEEEEE ECCCHHCCCC HHHHCCHHHC CCCCCEEEEE CCCCCCCEEC CCCCHHCCCC EEEECCCCCC EEEECCCCCC CCCCCCCCEE EECHHHHHHH HHCCCEEEEC CCCCCCCCCC CCCCCCCEEE ECCCCCCCCC CEECEEECCC CCEEEEEEEC CCCCCCCCEE ECCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCHHHHHH CCCHHHHHHH HHCCCCCCCC CCCCCCCC
[Overview] SLC15A1 SLC15A2 SLC15A3 SLC15A4 
SLC15A1   ----MGMSKSHSFFG--------------------------YPL-----------------------SIFFIVVNEFCERFSYYGMRAILILYF--TNFISWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLP----------------------------------VHVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMLR--VQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPK------------REHWLDWAK----EKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMS---------GKIGA--------LEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQ-------------------VVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANI-SSYNASTYQFFPSGIKGFTISSTEIPP-QCQ---PNF--NTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNII---VLIVAGAGQFSK--QWAE----------------YILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDE------------DEKKNRLEKSNPYFMSGANSQKQM
SLC15A2   MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPL-----------------------SIAFIVVNEFCERFSYYGMKAVLILYF--LYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLG---------------ALPI----LGGQ------------------------VVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFG----EDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPK------------RQHWLDWAA----EKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMN---------RNLGF--------FVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVG--------NENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKD-TESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYR---------TVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNII---VLVVA---QFSGLVQWAE----------------FILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL-----------------
SLC15A3   -------------------------MPAPRAREQPRVPGERQPLLPRGAR---------GPRRWRRAAGAAVLLVEMLERAAFFGVTANLVLYLNSTNF-NWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYRAVALSLLLYLAASGLLPAT---------------AFPDGRSSFCGE---MPASPLGPACPSAGCPRSSPSPYCAPVLYAGLLLLGLAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQ----------QNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHSARDRQCARVLADERSPQP-----------GASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPANISVALRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEME---------------------------------------------------------------------------------------------------R----------------------------LHYIHHNETVS----------QQIGEVLYN--------------------------------------------------------------AAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALL---SLPG--GWLHCPKDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERASQ----GPASH----------------SRFSRDR-----G-------
SLC15A4   ------------------------------MEGSGGGAGERAPLL--GARRAAAAAAAAGAFAGRRAACGAVLLTELLERAAFYGITSNLVLFLNGAPF-CWEGAQASEALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLL---------------AAPATRAALCGSARLLNCTAPGPD-AAARC--------CSPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQ----------QNVSFVTGYAIPTVCVGLAFVVFLCGQSVFITKPPDGSAFTDMFKILTYSCCSQ--KRSGERQSNGEGIGVFQQSSKQSLFDSCKMSHGGPFTEEKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLRIPEI-----SNITT------TPHTLPAAWLTMFDAVLILLLIPLKDKLVDPILRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESK---------------------------------------------------------------------------------------------------R----------------------------LNLV-KEKTIN----------QTIGNVVYH--------------------------------------------------------------AADLSLWWQVPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGVGSFVGSGLLALV---SIKA-IGWMSSHTDFGNINGCYLNYYFFLLAAIQGATLLLFLIISVKYDHHR--------DH----------------QR-SRAN-----GVPTSRRA

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
SLC15A1 12 Y/C 0.000744367 rs144970844
SLC15A1 21 V/I 0.000425583 rs8187818
SLC15A1 66 T/M 0.000107382 rs374943370
-- SLC15A1 115 P/A 0.000103413 rs149558491
SLC15A1 117 S/N 0.217319 rs2297322
SLC15A1 117 S/R 0.00021479 rs8187821
-- SLC15A1 192 H/L 0.000258538 rs202183689
SLC15A1 283 V/L 0.000767603 rs375733107
SLC15A1 303 R/K 0.000258517 rs138374185
SLC15A1 370 M/V 0.000128023 rs759378438
SLC15A1 416 V/L 0.000220894 rs146304164
SLC15A1 419 G/A 0.0376531 rs4646227
SLC15A1 450 V/I 0.0111623 rs2274828
SLC15A1 451 T/N 0.0263739 rs8187838
SLC15A1 459 R/C 0.00259987 rs2274827
SLC15A1 548 L/H 0.000421911 rs145351711
SLC15A1 564 S/R 0.000208469 rs200602769
SLC15A1 605 F/I 0.000242794 rs764880757
SLC15A1 631 I/T 0.00112813 rs150580715
SLC15A1 659 V/I 0.000112627 rs367765684
SLC15A1 665 I/V 0.00453578 rs144553892
SLC15A1 667 A/G 0.000108462 rs769397773
SLC15A1 676 A/V 0.000116413 rs552772082
SLC15A1 677 E/G 0.000357206 rs527441718
-- SLC15A1 689 N/S 0.000351572 rs189869941

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC15A1 SLC15A1 [plasma membrane] Proton/oligopeptide cotransporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data