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Detail Data SLC14A2


Basic description
Gene Name SLC14A2
Protein Name Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)
Family SLC14
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 6 3 0 6 4 0 6 5 0 6 6 0 6 7 0 6 8 0 6 9 0 7 0 0 7 1 0 7 2 0 7 3 0 7 4 0 7 5 0 7 6 0 7 7 0 7 8 0 7 9 0 8 0 0 8 1 0 8 2 0 8 3 0 8 4 0 8 5 0 8 6 0 8 7 0 8 8 0 8 9 0 9 0 0 9 1 0 9 2 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640        650        660        670        680        690        700        710        720        730        740        750        760        770        780        790        800        810        820        830        840        850        860        870        880        890        900        910        920 
MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK DLRSSNEDSH IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG DMKEYRIWLK DKHLALQFID WVLRGTAQVM FINNPLSGLI IFIGLLIQNP WWTITGGLGT VVSTLTALAL GQDRSAIASG LHGYNGMLVG LLMAVFSEKL DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF NIAVTLYLAA TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC VLSCIAIGGM FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW AFCLATIIFL LLTTNNPAIF RLPLSKVTYP EANRIYYLTV KSGEEEKAPS GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH IEWSSIRRRS KVFGKGEHQE RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS WIRSSMAASG KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL VGLLMAVFSD KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL PFNITVTLYL AATGHYNLFF PTTLLQPASA MPNITWSEVQ VPLLLRAIPV GIGQVYGCDN PWTGGIFLIA LFISSPLICL HAAIGSTMGM LAALTIATPF DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF AAYLGAALAN MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL SQERNRRASI ITKYQAYDVS  
CCCCCCCCCC CCCCCCCCCC HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCEECCCC CCCCCCCCCC CCCCCCCHHC HHHHHHHHHC CHHHHHHHHH CCCHHHHHHH HHHHHHCHHH CCCCHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HHHHHHCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCH HHHHHHCCCH HHHHCCCCHH HHHHHHHHHH HCCHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCHHHH HHHHHHHHHH HHHCCCCHHC CCCCCCCCCC HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCEEEECCCC CCCCCHHCCC CCHHHHCCHH CCCCCCCCCC CCCCCCCCCC CCCCCCEEEE CCCCCCCCCC CHHCCCCCCC CHHHHHHHCC CCHHHHHHHH CCCCHHCCCC CCCCCHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHCC CHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HCCCCHHHHH HHHHHHHHCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCCCH HHHHHHHHHH HHHHCCCCCC CHHCCCCCCC CCCCCCCCCC CCHHHHHCCC CCCCEECCCC HHHHHHHHHH HHHCCHHHHH HHHHHHHHHH HHHHHCCCCH HHHHCCCHHH HHHHHHHHHH HCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCCH HHHHHHHHHH HHHHHCCCCH HHCCCCCCCC CCHHHHHHHH HHHHHHHHHH CCCCHHHCCC
[Overview] SLC14A1 SLC14A2 
SLC14A1   ------------------------------------------------------------------MNGRS----------------------------------------------------------------------------------LIGGAG-------------------DARHG--------------------------------------------------PVWKDPF----------------------------------------------------------------------------------GTKAGDAARRGIA-------------------------------------------------------------------------------------RLSLA--------------LADGSQEQEP------------------------------------------------EEEIAMED-------SPTMVRVDSPTM-----VRGENQVS---------PCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL---------
SLC14A2   MSDPHSSPLLPEPLSSRYKLYEAEFTSPSWPSTSPDTHPALPLLEMPEEKDLRSSNEDSHIVKIEKLNERSKRKDDGVAHRDSAGQRCICLSKAVGYLTGDMKEYRIWLKDKHLALQFIDWVLRGTAQVMFINNPLSGLIIFIGLLIQNPWWTITGGLGTVVSTLTALALGQDRSAIASGLHGYNGMLVGLLMAVFSEKLDYYWWLLFPVTFTAMSCPVLSSALNSIFSKWDLPVFTLPFNIAVTLYLAATGHYNLFFPTTLVEPVSSVPNITWTEMEMPLLLQAIPVGVGQVYGCDNPWTGGVFLVALFISSPLICLHAAIGSIVGLLAALSVATPFETIYTGLWSYNCVLSCIAIGGMFYALTWQTHLLALICALFCAYMEAAISNIMSVVGVPPGTWAFCLATIIFLLLTTNNPAIFRLPLSKVTYPEANRIYYLTVKSGEEEKAPSGGGGEHPPTAGPKVEEGSEAVLSKHRSVFHIEWSSIRRRSKVFGKGEHQERQNKDPFPYRYRKPTVELLDLDTMEESSEIKVETNISKTSWIRSSMAASGKR-VSKALSYITGEMKECGEGLKDKSPVFQFFDWVLRGTSQVMFVNNPLSGILIILGLFIQNPWWAISGCLGTIMSTLTALILSQDKSAIAAGFHGYNGVLVGLLMAVFSDKGDYYWWLLLPVIIMSMSCPILSSALGTIFSKWDLPVFTLPFNITVTLYLAATGHYNLFFPTTLLQPASAMPNITWSEVQVPLLLRAIPVGIGQVYGCDNPWTGGIFLIALFISSPLICLHAAIGSTMGMLAALTIATPFDSIYFGLCGFNSTLACIAIGGMFYVITWQTHLLAIACALFAAYLGAALANMLSVFGLPPCTWPFCLSALTFLLLTTNNPAIYKLPLSKVTYPEANRIYYLSQERNRRASIITKYQAYDVS

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC14A2 33 T/S 0.000195701 rs760635115
-- SLC14A2 37 T/I 0.0311957 rs34461862
-- SLC14A2 39 P/A 0.000702648 rs149251757
-- SLC14A2 53 R/W 0.000183303 rs200534486
-- SLC14A2 77 G/R 0.000196977 rs142465327
-- SLC14A2 85 G/D 0.000211202 rs145955125
-- SLC14A2 109 L/Q 0.000155858 rs747173661
-- SLC14A2 132 I/V 0.91016 rs1484873
-- SLC14A2 181 L/I 0.000355219 rs139829385
-- SLC14A2 303 G/S 0.000119351 rs767386635
-- SLC14A2 304 V/M 0.000564972 rs113938461
-- SLC14A2 322 I/T 0.00076879 rs147437273
-- SLC14A2 379 C/R 0.000509052 rs139048592
-- SLC14A2 395 V/M 0.000143548 rs781119545
-- SLC14A2 443 G/S 0.00192188 rs35245152
-- SLC14A2 447 K/N 0.000127392 rs758164198
-- SLC14A2 478 V/I 0.00137242 rs150313115
-- SLC14A2 510 R/Q 0.446576 rs9960464
-- SLC14A2 564 M/I 0.000179163 rs148706000
-- SLC14A2 586 R/Q 0.000457467 rs139711773
-- SLC14A2 624 M/T 0.000163093 rs144385284
-- SLC14A2 640 A/T 0.00014726 rs758687472
-- SLC14A2 647 N/S 0.000111393 rs148811905
-- SLC14A2 662 G/D 0.000437473 rs148964498
-- SLC14A2 663 D/N 0.000115334 rs142205866
-- SLC14A2 671 P/L 0.000147145 rs561656468
-- SLC14A2 718 L/I 0.000143189 rs149341098
-- SLC14A2 734 I/V 0.000155417 rs79960135
-- SLC14A2 750 V/I 0.165583 rs1123617
-- SLC14A2 757 G/S 0.00303293 rs142459777
-- SLC14A2 770 A/D 0.000226696 rs780338834
-- SLC14A2 775 S/L 0.000135231 rs552561427
-- SLC14A2 880 A/T 0.436289 rs3745009
-- SLC14A2 896 R/H 0.00822196 rs41301139

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC14A2 SLC14A2 [plasma membrane] Transport of bile salts and organic acids, metal ions and amine compounds

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data