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Detail Data SLC13A5


Basic description
Gene Name SLC13A5
Protein Name Solute carrier family 13 member 5 (Na(+)/citrate cotransporter) (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter)
Family SLC13
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name NACT co-transports trivalent citrate and a sodium ion
Reaction 1 CIT [extracellular region] + 1 Na+ [extracellular region] --> 1 CIT [cytosol] + 1 Na+ [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560 
MASALSYVSK FKSFVILFVT PLLLLPLVIL MPAKFVRCAY VIILMAIYWC TEVIPLAVTS LMPVLLFPLF QILDSRQVCV QYMKDTNMLF LGGLIVAVAV ERWNLHKRIA LRTLLWVGAK PARLMLGFMG VTALLSMWIS NTATTAMMVP IVEAILQQME ATSAATEAGL ELVDKGKAKE LPGSQVIFEG PTLGQQEDQE RKRLCKAMTL CICYAASIGG TATLTGTGPN VVLLGQMNEL FPDSKDLVNF ASWFAFAFPN MLVMLLFAWL WLQFVYMRFN FKKSWGCGLE SKKNEKAALK VLQEEYRKLG PLSFAEINVL ICFFLLVILW FSRDPGFMPG WLTVAWVEGE TKYVSDATVA IFVATLLFIV PSQKPKFNFR SQTEEERKTP FYPPPLLDWK VTQEKVPWGI VLLLGGGFAL AKGSEASGLS VWMGKQMEPL HAVPPAAITL ILSLLVAVFT ECTSNVATTT LFLPIFASMS RSIGLNPLYI MLPCTLSASF AFMLPVATPP NAIVFTYGHL KVADMVKTGV IMNIIGVFCV FLAVNTWGRA IFDLDHFPDW ANVTHIET 
CHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHH CCCCHHHHHH HCCCCCCCCH HHHHHHHHHH HHCCHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHCC HHHHHHHHHH HHHHHHHHHH HCCCCCHHHH HHHHHCCCCC CCCCCEEECC CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHCCCCHH HHHHHHHHHH CCCCCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCCH HHHCHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HCCCCCCCCC CHHHHHCCCC CCCCCHHHHH HHHHHHHHHC CCCCCCCCCC CCCCHHCCCC CCCCCCCCHH HHHHHCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HCCCHHHHHH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHCCCCCCC CEEEECCCCC CHHHHHHHCH HHHHHHHHHH HHHHHHHHHH HCCCCCCCHH HHCCCCCC
[Overview] SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 
SLC13A1   ----MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSK-------------------------------------------------KVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI---------INAEAEVEATQMTY--FNGSTNHGLEIDESVNGHE-------INERKEK-----------------TKPVPGYNNDTGKISSKVELE--------KNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDC-RCLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQ-----KACAEV-IKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPG------FATDSTVALLIGLLFFLIPAKTL---------TKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWA------------PAMSNETMP--
SLC13A2   ---MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL----------------HSSQASSNVEEGSNNPTFELQEPSPQKE----VTKLDNGQA-------------------LPV-TSASSEGRA---HLSQ--------------------KHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQ------QQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLA--FPNAKGES-MVSDGTVAIFIGIIMFIIPSKFPGLTQ-----DPENPGKLKAPL---GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQ---SNTTAQCLPSLANTTTPSP
SLC13A3   MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSN-------------------------------------------------KVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESE-ENTAAVR--RNGLHTVPTEMQF-------------LASTEAK-----------------DHPGETEVPLDLPADSRKEDE--------------------YRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQC-DVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFR-----GWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLF--NPG------FLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETE--------PLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTA-LPPTLANDTFRTL
SLC13A4   ----MGLLQGLLRVRKLLLVVCVPLLLLPLPVLHPSSEASCAYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSN-------------------------------------------------EVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQEL---------VSAEDE----QLVA--GNSNTEEAEPISLDVKNSQPSLELIFVNEESNADLTTLMHNENLNGVPSITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNRKYRSHHDQMICKCLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYPAA-EVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGCNFKETCSLSKKKKTKR-----EQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPGWDSFF-EKKG------YRTDATVSVFLGFLLFLIPAKKPCFG------KKNDGENQEHSLGTEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLFHLDTYPAWA-------------RVSNITDQA-
SLC13A5   ---MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSR-------------------------------------------------QVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQM----------------EATSAAT--EAG-----LEL---------------VDKGKAK-----------------ELPG-SQVIFEGPTLGQQEDQ--------------------ERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKN------EKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVA--W--VEGETKYVSDATVAIFVATLLFIVPSQKPKFNF-----RSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWA-------------NVTHIET---

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC13A5 92 V/I 0.0124661 rs139509544
SLC13A5 147 M/I 0.000107665 rs764711084
SLC13A5 201 R/Q 0.000131266 rs200275193
SLC13A5 219 G/R 0.00015516 rs144332569
SLC13A5 315 A/T 0.000143197 rs201857984
-- SLC13A5 346 W/L 0.000251006 rs746999375
SLC13A5 431 V/M 0.000266589 rs201036096
SLC13A5 456 V/I 0.000202812 rs146047560
SLC13A5 458 V/M 0.000143163 rs372801738

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC13A5 SLC13A5 [plasma membrane] Sodium-coupled sulphate, di- and tri-carboxylate transporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data