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Detail Data SLC13A4


Basic description
Gene Name SLC13A4
Protein Name Solute carrier family 13 member 4 (Na(+)/sulfate cotransporter SUT-1) (NaS2)
Family SLC13
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name NaS2 co-transports sulphate and two sodium ions
Reaction 1 SO4(2-) [extracellular region] + 2 Na+ [extracellular region] --> 2 Na+ [cytosol] + 1 SO4(2-) [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 6 1 0 6 2 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620 
MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS EAVPLGAAAL VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE KWNLHKRIAL RMVLMAGAKP GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI VEAVLQELVS AEDEQLVAGN SNTEEAEPIS LDVKNSQPSL ELIFVNEESN ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP QVLTPSPRKQ KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK KTKREQLSEK RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG WDSFFEKKGY RTDATVSVFL GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE PIITWKDFQK TMPWEIVILV GGGYALASGS KSSGLSTWIG NQMLSLSSLP PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH INPLYTLIPV TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI NTWGVSLFHL DTYPAWARVS NITDQA 
CCHHHHHHHH HHHHHHHHHH HHHCCCCCCC CHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCHHHHCCCC CCCCCHHCHH CCCCCCCCCH HHHHCCCCCC CCCCCHHCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHH HHHCCCCCHH HCHHHHHHHH HHHHHHHHHH HHHHHCCCCH HHHHHHHHHH CCCCCCCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCH HHHCHHCCCC CCHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCCCCC HHHHHHHHHH HHHHHHCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HCCHHHHHHH HHHHHHHHHH HHHCCCHHHH HCCHHCCCCC HHHHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHC CCCCCCCEEE ECCCCCCHHH HHHHCHHHHH HHHHHHHHHH HHHHHHHCCC CCCCHHHHHC CCCCCC
[Overview] SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 
SLC13A1   ----MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSK-------------------------------------------------KVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI---------INAEAEVEATQMTY--FNGSTNHGLEIDESVNGHE-------INERKEK-----------------TKPVPGYNNDTGKISSKVELE--------KNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDC-RCLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQ-----KACAEV-IKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPG------FATDSTVALLIGLLFFLIPAKTL---------TKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWA------------PAMSNETMP--
SLC13A2   ---MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL----------------HSSQASSNVEEGSNNPTFELQEPSPQKE----VTKLDNGQA-------------------LPV-TSASSEGRA---HLSQ--------------------KHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQ------QQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLA--FPNAKGES-MVSDGTVAIFIGIIMFIIPSKFPGLTQ-----DPENPGKLKAPL---GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQ---SNTTAQCLPSLANTTTPSP
SLC13A3   MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSN-------------------------------------------------KVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESE-ENTAAVR--RNGLHTVPTEMQF-------------LASTEAK-----------------DHPGETEVPLDLPADSRKEDE--------------------YRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQC-DVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFR-----GWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLF--NPG------FLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETE--------PLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTA-LPPTLANDTFRTL
SLC13A4   ----MGLLQGLLRVRKLLLVVCVPLLLLPLPVLHPSSEASCAYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSN-------------------------------------------------EVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQEL---------VSAEDE----QLVA--GNSNTEEAEPISLDVKNSQPSLELIFVNEESNADLTTLMHNENLNGVPSITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNRKYRSHHDQMICKCLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYPAA-EVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGCNFKETCSLSKKKKTKR-----EQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPGWDSFF-EKKG------YRTDATVSVFLGFLLFLIPAKKPCFG------KKNDGENQEHSLGTEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLFHLDTYPAWA-------------RVSNITDQA-
SLC13A5   ---MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSR-------------------------------------------------QVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQM----------------EATSAAT--EAG-----LEL---------------VDKGKAK-----------------ELPG-SQVIFEGPTLGQQEDQ--------------------ERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKN------EKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVA--W--VEGETKYVSDATVAIFVATLLFIVPSQKPKFNF-----RSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWA-------------NVTHIET---

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC13A4 95 V/M 0.00169879 rs34547425
-- SLC13A4 287 T/P 0.000108673 rs753226439
-- SLC13A4 367 E/D 0.000202906 rs552109489
-- SLC13A4 451 P/S 0.0274029 rs36004833
-- SLC13A4 485 L/F 0.000777134 rs535102941
-- SLC13A4 538 T/M 0.00014647 rs141643096
-- SLC13A4 590 V/I 0.00056157 rs137894236
-- SLC13A4 624 D/G 0.000199164 rs374471422

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC13A4 SLC13A4 [plasma membrane] Sodium-coupled sulphate, di- and tri-carboxylate transporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data