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Detail Data SLC13A3


Basic description
Gene Name SLC13A3
Protein Name Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (hNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2)
Family SLC13
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion
Reaction 1 SUCCA [extracellular region] + 3 Na+ [extracellular region] --> 1 SUCCA [cytosol] + 3 Na+ [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 6 0 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600 
MAALAAAAKK VWSARRLLVL LFTPLALLPV VFALPPKEGR CLFVILLMAV YWCTEALPLS VTALLPIVLF PFMGILPSNK VCPQYFLDTN FLFLSGLIMA SAIEEWNLHR RIALKILMLV GVQPARLILG MMVTTSFLSM WLSNTASTAM MLPIANAILK SLFGQKEVRK DPSQESEENT AAVRRNGLHT VPTEMQFLAS TEAKDHPGET EVPLDLPADS RKEDEYRRNI WKGFLISIPY SASIGGTATL TGTAPNLILL GQLKSFFPQC DVVNFGSWFI FAFPLMLLFL LAGWLWISFL YGGLSFRGWR KNKSEIRTNA EDRARAVIRE EYQNLGPIKF AEQAVFILFC MFAILLFTRD PKFIPGWASL FNPGFLSDAV TGVAIVTILF FFPSQRPSLK WWFDFKAPNT ETEPLLTWKK AQETVPWNII LLLGGGFAMA KGCEESGLSV WIGGQLHPLE NVPPALAVLL ITVVIAFFTE FASNTATIII FLPVLAELAI RLRVHPLYLM IPGTVGCSFA FMLPVSTPPN SIAFASGHLL VKDMVRTGLL MNLMGVLLLS LAMNTWAQTI FQLGTFPDWA DMYSVNVTAL PPTLANDTFR TL 
CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHHHHHH HHHHCCCCCC HHHCHHHHHH CCCCCCCCCC CCHHHCCCCC HHHHHHHHHH HHHHHCCHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHHHHH HHHCCCCCCC CCCCCCHHHH HHHHHCCCCC CCCHHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCHHHCCH HHHHHHHHHH HHCCCCCCCC CCCCCCHHHH HHHHHHCCCC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCCCCH HHHHHHHHHH HHHHHCCCCH HHHHHHHHHH HHHHHHHHCC CCCCCCCHHH CCCCCCHHHH HHHHHHHHHH CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH HHHCCCHHHH HHHHHHHHHH HHHHHCCCHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHCH HCCCHHHHHH HHHHHHHHHH HCCCCCHHHH HHHHHHHHHH HHCCCCCCCC HHHHCCCCCC HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCCCCHHH HCCCCCCCCC CCCCCCCCCC CC
[Overview] SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 
SLC13A1   ----MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSK-------------------------------------------------KVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI---------INAEAEVEATQMTY--FNGSTNHGLEIDESVNGHE-------INERKEK-----------------TKPVPGYNNDTGKISSKVELE--------KNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDC-RCLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQ-----KACAEV-IKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPG------FATDSTVALLIGLLFFLIPAKTL---------TKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWA------------PAMSNETMP--
SLC13A2   ---MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL----------------HSSQASSNVEEGSNNPTFELQEPSPQKE----VTKLDNGQA-------------------LPV-TSASSEGRA---HLSQ--------------------KHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQ------QQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLA--FPNAKGES-MVSDGTVAIFIGIIMFIIPSKFPGLTQ-----DPENPGKLKAPL---GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQ---SNTTAQCLPSLANTTTPSP
SLC13A3   MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSN-------------------------------------------------KVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESE-ENTAAVR--RNGLHTVPTEMQF-------------LASTEAK-----------------DHPGETEVPLDLPADSRKEDE--------------------YRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQC-DVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFR-----GWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLF--NPG------FLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETE--------PLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTA-LPPTLANDTFRTL
SLC13A4   ----MGLLQGLLRVRKLLLVVCVPLLLLPLPVLHPSSEASCAYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSN-------------------------------------------------EVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQEL---------VSAEDE----QLVA--GNSNTEEAEPISLDVKNSQPSLELIFVNEESNADLTTLMHNENLNGVPSITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNRKYRSHHDQMICKCLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYPAA-EVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGCNFKETCSLSKKKKTKR-----EQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPGWDSFF-EKKG------YRTDATVSVFLGFLLFLIPAKKPCFG------KKNDGENQEHSLGTEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLFHLDTYPAWA-------------RVSNITDQA-
SLC13A5   ---MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSR-------------------------------------------------QVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQM----------------EATSAAT--EAG-----LEL---------------VDKGKAK-----------------ELPG-SQVIFEGPTLGQQEDQ--------------------ERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKN------EKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVA--W--VEGETKYVSDATVAIFVATLLFIVPSQKPKFNF-----RSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWA-------------NVTHIET---

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC13A3 4 P/L 0.000143191 rs140812730
-- SLC13A3 40 R/G 0.000107096 rs77731467
-- SLC13A3 40 R/C 0.00491355 rs77731467
-- SLC13A3 41 C/G 0.00014901 rs144600005
-- SLC13A3 48 M/I 0.000181557 rs559408530
-- SLC13A3 98 I/F 0.000529471 rs201443231
-- SLC13A3 110 R/W 0.000116217 rs145550194
-- SLC13A3 184 R/Q 0.000119748 rs201164820
-- SLC13A3 186 G/R 0.000147322 rs147255591
-- SLC13A3 187 F/S 0.000154071 rs527638420
-- SLC13A3 208 G/E 0.000147322 rs147255591
-- SLC13A3 286 M/T 0.000107381 rs181492581
-- SLC13A3 303 G/A 0.0173069 rs141554970
-- SLC13A3 325 R/Q 0.000365846 rs143334841
-- SLC13A3 383 V/M 0.000143179 rs146413120
-- SLC13A3 421 A/S 0.000306406 rs200172953
-- SLC13A3 454 G/R 0.000127926 rs745537970
-- SLC13A3 462 V/M 0.000151611 rs149282922
-- SLC13A3 473 V/M 0.000143418 rs138354653
-- SLC13A3 546 R/Q 0.000157141 rs188700676

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC13A3 SLC13A3 [plasma membrane] Sodium-coupled sulphate, di- and tri-carboxylate transporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data