Detail Data SLC13A2

Basic description

Gene Name	SLC13A2
Protein Name	Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter)
Family	SLC13
Category	Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name	NaDC1 co-transports dicarboxylic acids and a sodium ion
Reaction	1 Dicarboxylates transported by NaDC1 [extracellular region] + 1 Na+ [extracellular region] --> 1 Na+ [cytosol] + 1 Dicarboxylates transported by NaDC1 [cytosol]

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590        600        610        620        630        640 
MATCWQALWA YRSYLIVFFV PILLLPLPIL VPSKEAYCAY AIILMALFWC TEALPLAVTA LFPLILFPMM GIVDASEIIQ RPFPSSFESP GECQSVGMSV TASHNLGGTV GDSRVFPPLS HVSTCQVAVE YLKDSNLLFF GGLLVAIAVE HWNLHKRIAL RVLLIVGVRP APLILGFMLV TAFLSMWISN TATSAMMVPI AHAVLDQLHS SQASSNVEEG SNNPTFELQE PSPQKEVTKL DNGQALPVTS ASSEGRAHLS QKHLHLTQCM SLCVCYSASI GGIATLTGTA PNLVLQGQIN SLFPQNGNVV NFASWFSFAF PTMVILLLLA WLWLQILFLG FNFRKNFGIG EKMQEQQQAA YCVIQTEHRL LGPMTFAEKA ISILFVILVL LWFTREPGFF LGWGNLAFPN AKGESMVSDG TVAIFIGIIM FIIPSKFPGL TQDPENPGKL KAPLGLLDWK TVNQKMPWNI VLLLGGGYAL AKGSERSGLS EWLGNKLTPL QSVPAPAIAI ILSLLVATFT ECTSNVATTT IFLPILASMA QAICLHPLYV MLPCTLATSL AFMLPVATPP NAIVFSFGDL KVLDMARAGF LLNIIGVLII ALAINSWGIP LFSLHSFPSW AQSNTTAQCL PSLANTTTPS P 
CHHHHHHHHH HHHHHHHHHH HHHHCCHHCC CCHHHHHHHH HHHHHHHHHH HCHHHHHHHH HHHHHHHHHH CCCCHHHHCC CCCCCCCCCC CCCCCCCEEE EHHCCCCCCC CCCCCCCCCC CCCHHHHHHH HCCHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHCCCC CHHHHHHHHH HHHHHHHHHH HHHHHCCCCH HHHHHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCHHHCC CCCHHHHHHH HHHHHHHCCC CCCCCCCCCH HHHHHHHHHH HHCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCHHHCCCCC HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHHHHHHH HHHHCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCHH HHHHHCCCCC EEEEHHHHHH HHHHHHCCHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHC HHCCHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHHH CCCCCCCCCC CEEEECCCCC CHHHHHHCCH HHHHHHHHHH HHHHHHHHHH HHCCCCCCHH HHCCCCCCCC CCCCCCCCCC C

Family alignment

[Overview]

SLC13A1   ----MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSK-------------------------------------------------KVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI---------INAEAEVEATQMTY--FNGSTNHGLEIDESVNGHE-------INERKEK-----------------TKPVPGYNNDTGKISSKVELE--------KNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDC-RCLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQ-----KACAEV-IKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPG------FATDSTVALLIGLLFFLIPAKTL---------TKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWA------------PAMSNETMP--
SLC13A2   ---MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL----------------HSSQASSNVEEGSNNPTFELQEPSPQKE----VTKLDNGQA-------------------LPV-TSASSEGRA---HLSQ--------------------KHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQ------QQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLA--FPNAKGES-MVSDGTVAIFIGIIMFIIPSKFPGLTQ-----DPENPGKLKAPL---GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQ---SNTTAQCLPSLANTTTPSP
SLC13A3   MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSN-------------------------------------------------KVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESE-ENTAAVR--RNGLHTVPTEMQF-------------LASTEAK-----------------DHPGETEVPLDLPADSRKEDE--------------------YRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQC-DVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFR-----GWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLF--NPG------FLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETE--------PLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTA-LPPTLANDTFRTL
SLC13A4   ----MGLLQGLLRVRKLLLVVCVPLLLLPLPVLHPSSEASCAYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSN-------------------------------------------------EVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQEL---------VSAEDE----QLVA--GNSNTEEAEPISLDVKNSQPSLELIFVNEESNADLTTLMHNENLNGVPSITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNRKYRSHHDQMICKCLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYPAA-EVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGCNFKETCSLSKKKKTKR-----EQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPGWDSFF-EKKG------YRTDATVSVFLGFLLFLIPAKKPCFG------KKNDGENQEHSLGTEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLFHLDTYPAWA-------------RVSNITDQA-
SLC13A5   ---MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSR-------------------------------------------------QVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQM----------------EATSAAT--EAG-----LEL---------------VDKGKAK-----------------ELPG-SQVIFEGPTLGQQEDQ--------------------ERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKN------EKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVA--W--VEGETKYVSDATVAIFVATLLFIVPSQKPKFNF-----RSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWA-------------NVTHIET---

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC13A2	31	V/I	0.00011549	rs200486942
--	SLC13A2	44	L/F	0.00163548	rs45443898
--	SLC13A2	46	A/V	0.000115405	rs148941136
--	SLC13A2	85	S/T	0.00034012	rs551438310
--	SLC13A2	117	P/L	0.000210803	rs200253633
--	SLC13A2	129	V/I	0.000111348	rs111227982
--	SLC13A2	129	V/L	0.000536856	rs111227982
--	SLC13A2	187	W/C	0.000202887	rs199634594
--	SLC13A2	249	T/M	0.000119604	rs200761343
--	SLC13A2	274	V/M	0.000179271	rs199777182
--	SLC13A2	359	A/P	0.000147487	rs11568441
--	SLC13A2	434	P/S	0.000182939	rs45546232
--	SLC13A2	446	N/S	0.000520891	rs142200484
--	SLC13A2	526	V/M	0.00178657	rs11568476
--	SLC13A2	530	T/M	0.000462634	rs146166923
--	SLC13A2	550	V/I	0.000348245	rs149423247
--	SLC13A2	599	I/V	0.404738	rs11567842
--	SLC13A2	635	N/T	0.000514851	rs142292882

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
main	SLC13A2	SLC13A2 [plasma membrane]	Sodium-coupled sulphate, di- and tri-carboxylate transporters

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data