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Detail Data SLC13A1


Basic description
Gene Name SLC13A1
Protein Name Solute carrier family 13 member 1 (Renal sodium/sulfate cotransporter) (Na(+)/sulfate cotransporter) (hNaSi-1)
Family SLC13
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name NaS1 co-transports sulphate and a sodium ion
Reaction 1 SO4(2-) [extracellular region] + 1 Na+ [extracellular region] --> 1 Na+ [cytosol] + 1 SO4(2-) [cytosol]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 5 6 0 5 7 0 5 8 0 5 9 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570        580        590 
MKFFSYILVY RRFLFVVFTV LVLLPLPIVL HTKEAECAYT LFVVATFWLT EALPLSVTAL LPSLMLPMFG IMPSKKVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL KMVMMVGVNP AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI AEAVVQQIIN AEAEVEATQM TYFNGSTNHG LEIDESVNGH EINERKEKTK PVPGYNNDTG KISSKVELEK NSGMRTKYRT KKGHVTRKLT CLCIAYSSTI GGLTTITGTS TNLIFAEYFN TRYPDCRCLN FGSWFTFSFP AALIILLLSW IWLQWLFLGF NFKEMFKCGK TKTVQQKACA EVIKQEYQKL GPIRYQEIVT LVLFIIMALL WFSRDPGFVP GWSALFSEYP GFATDSTVAL LIGLLFFLIP AKTLTKTTPT GEIVAFDYSP LITWKEFQSF MPWDIAILVG GGFALADGCE ESGLSKWIGN KLSPLGSLPA WLIILISSLM VTSLTEVASN PATITLFLPI LSPLAEAIHV NPLYILIPST LCTSFAFLLP VANPPNAIVF SYGHLKVIDM VKAGLGVNIV GVAVVMLGIC TWIVPMFDLY TYPSWAPAMS NETMP 
CCHHHHHHHH HHHHHHHHHH HHHCCCCCCC CHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHC CCCHHHHHHH CCCHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHCC CCCCCHHHHH CCCCCCHHHH HHHHHHHCCC CCCHHCCCCC CHHHHHHHHH HCCCCCCCCC HHHHHHHHHC HHHHHHHHHH HHHHHHHHCC CHHHHHHCCC CCHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHCCCCCCCC CHHHCCCCCC CCCHHHHHHH HHHHHHHHCC CCCCCCCCCC CCCCCCCCCC CCCHHHHHHH CCHHHHHHHH HHHHHHHHHH HHCCHHHHHH HHHHCCCCCH HHHHHHHHHH HHHHHHHCCC HHHHHHHHCC CCHHHHHCCC CCHHHHHHHH HHHCCCCCCC CCCCCCEEEE CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCCHHHCCC CCCCC
[Overview] SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5 
SLC13A1   ----MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSK-------------------------------------------------KVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI---------INAEAEVEATQMTY--FNGSTNHGLEIDESVNGHE-------INERKEK-----------------TKPVPGYNNDTGKISSKVELE--------KNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDC-RCLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQ-----KACAEV-IKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPG------FATDSTVALLIGLLFFLIPAKTL---------TKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWA------------PAMSNETMP--
SLC13A2   ---MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL----------------HSSQASSNVEEGSNNPTFELQEPSPQKE----VTKLDNGQA-------------------LPV-TSASSEGRA---HLSQ--------------------KHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQ------QQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLA--FPNAKGES-MVSDGTVAIFIGIIMFIIPSKFPGLTQ-----DPENPGKLKAPL---GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQ---SNTTAQCLPSLANTTTPSP
SLC13A3   MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSN-------------------------------------------------KVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESE-ENTAAVR--RNGLHTVPTEMQF-------------LASTEAK-----------------DHPGETEVPLDLPADSRKEDE--------------------YRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQC-DVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFR-----GWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLF--NPG------FLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETE--------PLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTA-LPPTLANDTFRTL
SLC13A4   ----MGLLQGLLRVRKLLLVVCVPLLLLPLPVLHPSSEASCAYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSN-------------------------------------------------EVAAEYFKNTTLLLVGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMPIVEAVLQEL---------VSAEDE----QLVA--GNSNTEEAEPISLDVKNSQPSLELIFVNEESNADLTTLMHNENLNGVPSITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNRKYRSHHDQMICKCLSLSISYSATIGGLTTIIGTSTSLIFLEHFNNQYPAA-EVVNFGTWFLFSFPISLIMLVVSWFWMHWLFLGCNFKETCSLSKKKKTKR-----EQLSEKRIQEEYEKLGDISYPEMVTGFFFILMTVLWFTREPGFVPGWDSFF-EKKG------YRTDATVSVFLGFLLFLIPAKKPCFG------KKNDGENQEHSLGTEPIITWKDFQKTMPWEIVILVGGGYALASGSKSSGLSTWIGNQMLSLSSLPPWAVTLLACILVSIVTEFVSNPATITIFLPILCSLSETLHINPLYTLIPVTMCISFAVMLPVGNPPNAIVFSYGHCQIKDMVKAGLGVNVIGLVIVMVAINTWGVSLFHLDTYPAWA-------------RVSNITDQA-
SLC13A5   ---MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSR-------------------------------------------------QVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQM----------------EATSAAT--EAG-----LEL---------------VDKGKAK-----------------ELPG-SQVIFEGPTLGQQEDQ--------------------ERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKN------EKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVA--W--VEGETKYVSDATVAIFVATLLFIVPSQKPKFNF-----RSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWA-------------NVTHIET---

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC13A1 11 R/H 0.000199294 rs143242073
-- SLC13A1 45 A/T 0.000518527 rs199650403
-- SLC13A1 54 P/S 0.000103679 rs777702216
-- SLC13A1 151 A/V 0.00014339 rs148839931
-- SLC13A1 157 Q/E 0.000195104 rs28364196
-- SLC13A1 174 N/S 0.304646 rs2140516
-- SLC13A1 199 T/I 0.000136277 rs774990981
-- SLC13A1 237 R/C 0.00147285 rs139376972
-- SLC13A1 240 T/M 0.00162024 rs10231144
-- SLC13A1 332 V/A 0.000679894 rs28364201
-- SLC13A1 342 P/Q 0.000103704 rs201161356
-- SLC13A1 364 R/Q 0.00210615 rs138989506
-- SLC13A1 401 A/T 0.000172484 rs200909313
-- SLC13A1 466 G/R 0.000132033 rs750656344
-- SLC13A1 584 S/L 0.000111746 rs139324379

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC13A1 SLC13A1 [plasma membrane] Sodium-coupled sulphate, di- and tri-carboxylate transporters

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data