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Detail Data SLC11A1


Basic description
Gene Name SLC11A1
Protein Name Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1)
Family SLC11
Category Transport of bile salts and organic acids, metal ions and amine compounds
Reaction name NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages
Reaction 2 H+ [cytosol] + 1 Divalent metals transported by NRAMP1 [cytosol] --> 1 Divalent metals transported by NRAMP1 [phagocytic vesicle lumen] + 2 H+ [phagocytic vesicle lumen]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 5 4 0 5 5 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550 
MTGDKGPQRL SGSSYGSISS PTSPTSPGPQ QAPPRETYLS EKIPIPDTKP GTFSLRKLWA FTGPGFLMSI AFLDPGNIES DLQAGAVAGF KLLWVLLWAT VLGLLCQRLA ARLGVVTGKD LGEVCHLYYP KVPRTVLWLT IELAIVGSDM QEVIGTAIAF NLLSAGRIPL WGGVLITIVD TFFFLFLDNY GLRKLEAFFG LLITIMALTF GYEYVVARPE QGALLRGLFL PSCPGCGHPE LLQAVGIVGA IIMPHNIYLH SALVKSREID RARRADIREA NMYFLIEATI ALSVSFIINL FVMAVFGQAF YQKTNQAAFN ICANSSLHDY AKIFPMNNAT VAVDIYQGGV ILGCLFGPAA LYIWAIGLLA AGQSSTMTGT YAGQFVMEGF LRLRWSRFAR VLLTRSCAIL PTVLVAVFRD LRDLSGLNDL LNVLQSLLLP FAVLPILTFT SMPTLMQEFA NGLLNKVVTS SIMVLVCAIN LYFVVSYLPS LPHPAYFGLA ALLAAAYLGL STYLVWTCCL AHGATFLAHS SHHHFLYGLL EEDQKGETSG  
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCHHHHHH HHHHHHHHEE HHCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCHHCCC HHHHHHHHCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCCCH HHHHHHHHHH HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHCCCCC HHHHHCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCCC HHCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCHHHHH HHHHCCCCCC HHCCCCCCCH HHHHHHHHHH HHHHHCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH CCHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHHHCCC CCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CCCCCCCCCC HHHHCCCCCC
[Overview] SLC11A1 SLC11A2 
SLC11A1   ------------------------------------------MTGDKGPQRLSGSSYGSI----SSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG---
SLC11A2   MRKKQLKTEAAPHCELKSYSKNSATQVSTMVLGPEQKMSDDSVSGDHG----ESASLGNINPAYSNPSLSQSPGDSEE-YFATYFNEKISIPEEEYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQRLAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRIPLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGMFVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIESCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTS-SPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAIIPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAGGILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDCGHTVSISKGLLTEE---ATRGYVK

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC11A1 11 T/A 0.00259153 rs17235381
-- SLC11A1 11 T/S 0.000638493 rs17235381
-- SLC11A1 70 I/T 0.000120089 rs142874131
-- SLC11A1 87 V/M 0.000141112 rs200995084
-- SLC11A1 88 A/V 0.000137264 rs200307655
-- SLC11A1 134 R/C 0.000271933 rs201910426
-- SLC11A1 149 D/N 0.000123327 rs145071313
-- SLC11A1 158 I/T 0.000441584 rs141932707
-- SLC11A1 180 D/N 0.000314428 rs150015128
-- SLC11A1 269 I/T 0.000108745 rs754247821
-- SLC11A1 292 L/P 0.00105478 rs145536242
-- SLC11A1 294 V/I 0.000115416 rs140981969
-- SLC11A1 343 V/M 0.000131281 rs140098828
-- SLC11A1 350 V/M 0.00216336 rs141861983
-- SLC11A1 359 A/V 0.000104082 rs565399059
-- SLC11A1 385 F/L 0.00034677 rs141050730
-- SLC11A1 394 R/Q 0.000337271 rs145676383
-- SLC11A1 397 R/C 0.000222608 rs74906275
-- SLC11A1 419 R/Q 0.0019052 rs77624405
-- SLC11A1 443 V/A 0.00793329 rs17215556
-- SLC11A1 484 V/L 0.00127332 rs138316650
-- SLC11A1 498 G/S 0.00272793 rs142636978
-- SLC11A1 543 D/N 0.0491389 rs17235409

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC11A1 SLC11A1 [late endosome membrane] Metal ion SLC transporters
SLC11A1 SLC11A1 [late endosome membrane] ROS and RNS production in phagocytes
SLC11A1 SLC11A1 [ficolin-1-rich granule membrane] Neutrophil degranulation
SLC11A1 SLC11A1 [plasma membrane] Neutrophil degranulation
SLC11A1 SLC11A1 [tertiary granule membrane] Neutrophil degranulation
SLC11A1 SLC11A1 [late endosome membrane] Ion influx/efflux at host-pathogen interface

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data