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Variant
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Disease

Detail Data SLC10A5


Basic description
Gene Name SLC10A5
Protein Name Sodium/bile acid cotransporter 5 (Na(+)/bile acid cotransporter 5) (Solute carrier family 10 member 5)
Family SLC10
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430 
MIRKLFIVLL LLLVTIEEAR MSSLSFLNIE KTEILFFTKT EETILVSSSY ENKRPNSSHL FVKIEDPKIL QMVNVAKKIS SDATNFTINL VTDEEGETNV TIQLWDSEGR QERLIEEIKN VKVKVLKQKD SLLQAPMHID RNILMLILPL ILLNKCAFGC KIELQLFQTV WKRPLPVILG AVTQFFLMPF CGFLLSQIVA LPEAQAFGVV MTCTCPGGGG GYLFALLLDG DFTLAILMTC TSTLLALIMM PVNSYIYSRI LGLSGTFHIP VSKIVSTLLF ILVPVSIGIV IKHRIPEKAS FLERIIRPLS FILMFVGIYL TFTVGLVFLK TDNLEVILLG LLVPALGLLF GYSFAKVCTL PLPVCKTVAI ESGMLNSFLA LAVIQLSFPQ SKANLASVAP FTVAMCSGCE MLLIILVYKA KKRCIFFLQD KRKRNFLI 
CHHHHHHHHH HHHHHHHHHH CCCCEEECCC CCEEEEEECC CCEEEEEEEE CCCCCCCCEE EEEECCCCEE EEEEEEEEEC CCCCEEEEEE EECCCCEEEE EEEEECCCCC CEEEEEEECC EEEEEEECCC CHHCCCCCCC HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHCCHHHHHH HHHHHHHHHH HHHHHHHHCC CCHHHHHHHH HHCCCCCCCC HHHHHHHHCC CCHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC HHHCCEEEEE EECCCCCCCC HHHCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHHHH HHHHHHHCCC CHHCCEEEEE ECCCCHHHHH HHHHHHHCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCC HHHHCCCC
[Overview] SLC10A1 SLC10A2 SLC10A3 SLC10A4 SLC10A5 SLC10A6 SLC10A7 
SLC10A1   ----------------------------------------------------MEAHNASA--------------------------------------------------------------------------------PFNFTLPPN-------------------------------------------FGKRPTDLALSV-------ILVFMLFFIML---SLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEAL---AILVCGCSPGGNLSN-VFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIY----SRGIYDGDLKDK-VPYKGIVISL-VLVLIPCTIGIVLK--------SKRPQY----MRYVIK-------------------GGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLN-GRCRRTVSM--ETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEK---------FKTPKDKTKMIYTAATTEETIP------------GALGNGTYKGEDC----------SPCTA-
SLC10A2   --------------MNDPNSC------------------------------VDNATVCSGAS---------------------------------CVVPES---------------------------------------NFNNIL----------------------------------------------------SVVLST-------VLTILLALVMF---SMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAV---VVLIIGCCPGGTASN-ILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIY----TK-MWVDSGSIV-IPYDNIGTSL-VALVVPVSIGMFVN--------HKWPQK----AKIILKIG---------------SIAGAILIVLIAVVGGILY------QSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRC-RTVAF--ETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKK----------CHGKNKAEIPE----SKENGTEPESSFYKAN--GGFQPDEK---------------------
SLC10A3   -----------MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSI---------HSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALAL---GLIITCSSPGGGGSY-LFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIY----SR-LLSIHETLH-VPISKILGTL-LFIAIPIAVGVLIK--------SKLPKF----SQLLLQVV---------------KPFSFVLLL----GGLFLA-YRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQR-RTVSI--EVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSS----LFPVP---------------------------------------------------------------
SLC10A4   MDGNDNVTLLFAPLLRDNY---------------------------------TLAPNASSLGPG----------------------------TDLALAPASSA-------GPGP------------------GLSLGPGPSFGFSPGPTPTPEPTTSGLAGGAA-------SHGPSPF----PRPWAPHALPFWDTPLNHGLNV-------FVGAALCITML---GLGCTVDVNHFGAHVRRPVGALLAALCQFGLLPLLAFLLALAFKLDEVAAV---AVLLCGCCPGGNLSN-LMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIY----SW-AWINTPIVQLLPLGTVTLTL-CSTLIPIGLGVFIR--------YKYSRV----ADYIVK-------------------VSLWSLLVTLVVLFIMTGTMLGPELLASIPAAVYVIAIFMPLAGYASGYGLATLFHLP-PNCKRTVCL--ETGSQNVQLCTAILKLAFPPQFIGSMYMFPLLYALFQSAEAGIFVLIYKMYGS--------EMLHKRDPLDEDEDTDISYKKLKEEEM--------ADTSYGTVKAENI-IMME-----TAQTSL
SLC10A5   -----MIRKLFIVLL----------------------------LLLVTI----EEARMSSLS-------------FLNIEKTEIL---FFTKTEETILVSSSY---ENKRPNSSHLFVKIEDPKILQMVNVAKKISSDATNFTINL---------VTDEEGETNVTIQLWDSEGRQERLIEEIKNVKVKVLKQKD--SLLQAPM-HIDRN-ILMLILPLILLNKCAFGCKIELQLFQTVWKRPLPVILGAVTQFFLMPFCGFLLSQIVALPEAQAF---GVVMTCTCPGGGGGY-LFALLLDGDFTLAILMTCTSTLLALIMMPVNSYIY----SR-ILGLSGTFH-IPVSKIVSTL-LFILVPVSIGIVIK--------HRIPEK----ASFLERII---------------RPLSFILMF----VGIYLT-FTVGLVFLKTDNLEVILLGLLVPALGLLFGYSFAKVCTLPLPVC-KTVAI--ESGMLNSFLALAVIQLSFPQSKANLASVAPFTVAMCSGCEMLLIIL---VYKAKKRCIFFLQDKRKRN---------------------FLI---------------------------------
SLC10A6   ----------------------------------------------------MRANCSSSSA---------------------------------CPANSSEE-------------------------------ELPVGLEVHGNL----------------------------------------------------ELVFTV-------VSTVMMGLLMF---SLGCSVEIRKLWSHIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAI---AVLIMGCCPGGTISN-IFTFWVDGDMDLSISMTTCSTVAALGMMPLCIYLY----TW-SWSLQQNLT-IPYQNIGITL-VCLTIPVAFGVYVN--------YRWPKQ----SKIILKIG---------------AVVGGVLLLVVAVAGVVLA------KGSWNSDITLLTISFIFPLIGHVTGFLLALFTHQSWQRC-RTISL--ETGAQNIQMCITMLQLSFTAEHLVQMLSFPLAYGLFQLIDGFLIVAAYQTYKRR------LKNKHGKKNSGCTEVCHTRKSTSSRETNAFLEVNEEGAITPGPPGPMDCHRALEPVGHITSCE--
SLC10A7   -----------MRLLE----------------------RMRKDWFMVGI---VLAIAGAKLEP-----------------------------------------------------------------------------SIGVNGGPL---KPEIT------------------------------------------------------VSYIAVATIFF---NSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSS-----------VPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKKPPFGAISSSVLLMIIYTTFCDTFSNPNIDLDKFSLVLIL----------------FIIFSIQLSFMLLTFIFSTRNN-SGFTPA-----------DTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISVPLL--IYHPAQILLGSVLVPTIKSWM----------------------VSRQKGVK---------------------------------LTRPTV-

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC10A5 14 V/M 0.000392525 rs747119566
-- SLC10A5 26 F/L 0.000114295 rs200277995
-- SLC10A5 47 S/T 0.0421777 rs78323957
-- SLC10A5 61 F/L 0.0103698 rs79849182
-- SLC10A5 85 N/S 0.000111495 rs753640170
-- SLC10A5 88 I/V 0.000545617 rs138969745
-- SLC10A5 104 L/F 0.000167268 rs150315173
-- SLC10A5 143 I/N 0.0068672 rs78567257
-- SLC10A5 144 L/I 0.000115461 rs190331215
-- SLC10A5 247 L/P 0.000350355 rs149116678
-- SLC10A5 287 I/T 0.00491466 rs7012758
-- SLC10A5 292 K/R 0.00025921 rs147682409
-- SLC10A5 296 P/A 0.000646242 rs145450315
-- SLC10A5 322 F/L 0.00134146 rs142422017
-- SLC10A5 378 F/L 0.000143453 rs754034601
-- SLC10A5 423 R/S 0.000417262 rs551595553

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
No data

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data