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Detail Data SLC10A4


Basic description
Gene Name SLC10A4
Protein Name Sodium/bile acid cotransporter 4 (Na(+)/bile acid cotransporter 4) (Solute carrier family 10 member 4)
Family SLC10
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430 
MDGNDNVTLL FAPLLRDNYT LAPNASSLGP GTDLALAPAS SAGPGPGLSL GPGPSFGFSP GPTPTPEPTT SGLAGGAASH GPSPFPRPWA PHALPFWDTP LNHGLNVFVG AALCITMLGL GCTVDVNHFG AHVRRPVGAL LAALCQFGLL PLLAFLLALA FKLDEVAAVA VLLCGCCPGG NLSNLMSLLV DGDMNLSIIM TISSTLLALV LMPLCLWIYS WAWINTPIVQ LLPLGTVTLT LCSTLIPIGL GVFIRYKYSR VADYIVKVSL WSLLVTLVVL FIMTGTMLGP ELLASIPAAV YVIAIFMPLA GYASGYGLAT LFHLPPNCKR TVCLETGSQN VQLCTAILKL AFPPQFIGSM YMFPLLYALF QSAEAGIFVL IYKMYGSEML HKRDPLDEDE DTDISYKKLK EEEMADTSYG TVKAENIIMM ETAQTSL 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCHHHC CCCCCCCCCC CCHHHHCCCH HHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHCCHHHHH HHHHHHHHHH HHHHHHHHHH HCCHHHHHHH HHHHCCCCCC CCHHHHHHHC CCCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHCCH HHHHHCCHHH HHHHHHHHHH HHHHHHHHHH HCCCCHHHCE EEEECCCCCC HHHHHHHHHH HCCHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCCCC CCCCCCHHHH HHHCCCCCCC CEECCCCEEC CCCCCCC
[Overview] SLC10A1 SLC10A2 SLC10A3 SLC10A4 SLC10A5 SLC10A6 SLC10A7 
SLC10A1   ----------------------------------------------------MEAHNASA--------------------------------------------------------------------------------PFNFTLPPN-------------------------------------------FGKRPTDLALSV-------ILVFMLFFIML---SLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEAL---AILVCGCSPGGNLSN-VFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIY----SRGIYDGDLKDK-VPYKGIVISL-VLVLIPCTIGIVLK--------SKRPQY----MRYVIK-------------------GGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLN-GRCRRTVSM--ETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEK---------FKTPKDKTKMIYTAATTEETIP------------GALGNGTYKGEDC----------SPCTA-
SLC10A2   --------------MNDPNSC------------------------------VDNATVCSGAS---------------------------------CVVPES---------------------------------------NFNNIL----------------------------------------------------SVVLST-------VLTILLALVMF---SMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAV---VVLIIGCCPGGTASN-ILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIY----TK-MWVDSGSIV-IPYDNIGTSL-VALVVPVSIGMFVN--------HKWPQK----AKIILKIG---------------SIAGAILIVLIAVVGGILY------QSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRC-RTVAF--ETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKK----------CHGKNKAEIPE----SKENGTEPESSFYKAN--GGFQPDEK---------------------
SLC10A3   -----------MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSI---------HSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALAL---GLIITCSSPGGGGSY-LFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIY----SR-LLSIHETLH-VPISKILGTL-LFIAIPIAVGVLIK--------SKLPKF----SQLLLQVV---------------KPFSFVLLL----GGLFLA-YRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQR-RTVSI--EVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSS----LFPVP---------------------------------------------------------------
SLC10A4   MDGNDNVTLLFAPLLRDNY---------------------------------TLAPNASSLGPG----------------------------TDLALAPASSA-------GPGP------------------GLSLGPGPSFGFSPGPTPTPEPTTSGLAGGAA-------SHGPSPF----PRPWAPHALPFWDTPLNHGLNV-------FVGAALCITML---GLGCTVDVNHFGAHVRRPVGALLAALCQFGLLPLLAFLLALAFKLDEVAAV---AVLLCGCCPGGNLSN-LMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIY----SW-AWINTPIVQLLPLGTVTLTL-CSTLIPIGLGVFIR--------YKYSRV----ADYIVK-------------------VSLWSLLVTLVVLFIMTGTMLGPELLASIPAAVYVIAIFMPLAGYASGYGLATLFHLP-PNCKRTVCL--ETGSQNVQLCTAILKLAFPPQFIGSMYMFPLLYALFQSAEAGIFVLIYKMYGS--------EMLHKRDPLDEDEDTDISYKKLKEEEM--------ADTSYGTVKAENI-IMME-----TAQTSL
SLC10A5   -----MIRKLFIVLL----------------------------LLLVTI----EEARMSSLS-------------FLNIEKTEIL---FFTKTEETILVSSSY---ENKRPNSSHLFVKIEDPKILQMVNVAKKISSDATNFTINL---------VTDEEGETNVTIQLWDSEGRQERLIEEIKNVKVKVLKQKD--SLLQAPM-HIDRN-ILMLILPLILLNKCAFGCKIELQLFQTVWKRPLPVILGAVTQFFLMPFCGFLLSQIVALPEAQAF---GVVMTCTCPGGGGGY-LFALLLDGDFTLAILMTCTSTLLALIMMPVNSYIY----SR-ILGLSGTFH-IPVSKIVSTL-LFILVPVSIGIVIK--------HRIPEK----ASFLERII---------------RPLSFILMF----VGIYLT-FTVGLVFLKTDNLEVILLGLLVPALGLLFGYSFAKVCTLPLPVC-KTVAI--ESGMLNSFLALAVIQLSFPQSKANLASVAPFTVAMCSGCEMLLIIL---VYKAKKRCIFFLQDKRKRN---------------------FLI---------------------------------
SLC10A6   ----------------------------------------------------MRANCSSSSA---------------------------------CPANSSEE-------------------------------ELPVGLEVHGNL----------------------------------------------------ELVFTV-------VSTVMMGLLMF---SLGCSVEIRKLWSHIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAI---AVLIMGCCPGGTISN-IFTFWVDGDMDLSISMTTCSTVAALGMMPLCIYLY----TW-SWSLQQNLT-IPYQNIGITL-VCLTIPVAFGVYVN--------YRWPKQ----SKIILKIG---------------AVVGGVLLLVVAVAGVVLA------KGSWNSDITLLTISFIFPLIGHVTGFLLALFTHQSWQRC-RTISL--ETGAQNIQMCITMLQLSFTAEHLVQMLSFPLAYGLFQLIDGFLIVAAYQTYKRR------LKNKHGKKNSGCTEVCHTRKSTSSRETNAFLEVNEEGAITPGPPGPMDCHRALEPVGHITSCE--
SLC10A7   -----------MRLLE----------------------RMRKDWFMVGI---VLAIAGAKLEP-----------------------------------------------------------------------------SIGVNGGPL---KPEIT------------------------------------------------------VSYIAVATIFF---NSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSS-----------VPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKKPPFGAISSSVLLMIIYTTFCDTFSNPNIDLDKFSLVLIL----------------FIIFSIQLSFMLLTFIFSTRNN-SGFTPA-----------DTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISVPLL--IYHPAQILLGSVLVPTIKSWM----------------------VSRQKGVK---------------------------------LTRPTV-

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC10A4 23 P/S 0.000188873 rs191494036
-- SLC10A4 24 N/S 0.000160359 rs571460795
-- SLC10A4 42 A/V 0.000127518 rs777912060
-- SLC10A4 69 T/M 0.00292767 rs374329024
-- SLC10A4 91 P/R 0.000879822 rs752991725
-- SLC10A4 257 K/T 0.000115314 rs540600785
-- SLC10A4 314 S/T 0.000115323 rs372151754
-- SLC10A4 375 A/V 0.00011183 rs201020849
-- SLC10A4 430 M/V 0.000103522 rs142691812

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
No data

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data