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Disease

Detail Data SLC10A2


Basic description
Gene Name SLC10A2
Protein Name Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)
Family SLC10
Category -
Reaction name -
Reaction -

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340 
MNDPNSCVDN ATVCSGASCV VPESNFNNIL SVVLSTVLTI LLALVMFSMG CNVEIKKFLG HIKRPWGICV GFLCQFGIMP LTGFILSVAF DILPLQAVVV LIIGCCPGGT ASNILAYWVD GDMDLSVSMT TCSTLLALGM MPLCLLIYTK MWVDSGSIVI PYDNIGTSLV ALVVPVSIGM FVNHKWPQKA KIILKIGSIA GAILIVLIAV VGGILYQSAW IIAPKLWIIG TIFPVAGYSL GFLLARIAGL PWYRCRTVAF ETGMQNTQLC STIVQLSFTP EELNVVFTFP LIYSIFQLAF AAIFLGFYVA YKKCHGKNKA EIPESKENGT EPESSFYKAN GGFQPDEK 
CCCCCCCCCC HHCCCCCEEE CCHHHCCHHH HHHHHHHHHH HHHHHHHHHH HCCCHHHHHH HHCCHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHCCCCCC HHHHHHHHHC CCCCHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCHHHCCCHH HHHHHHHHHH HHHCCCCCCC CCCHHHCCHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HCCCCCHHHH HHHHHHHCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHCCCHH CCCHHHCCCC CCCCHHCCCC CCCCCCCC
[Overview] SLC10A1 SLC10A2 SLC10A3 SLC10A4 SLC10A5 SLC10A6 SLC10A7 
SLC10A1   ----------------------------------------------------MEAHNASA--------------------------------------------------------------------------------PFNFTLPPN-------------------------------------------FGKRPTDLALSV-------ILVFMLFFIML---SLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEAL---AILVCGCSPGGNLSN-VFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIY----SRGIYDGDLKDK-VPYKGIVISL-VLVLIPCTIGIVLK--------SKRPQY----MRYVIK-------------------GGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLN-GRCRRTVSM--ETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEK---------FKTPKDKTKMIYTAATTEETIP------------GALGNGTYKGEDC----------SPCTA-
SLC10A2   --------------MNDPNSC------------------------------VDNATVCSGAS---------------------------------CVVPES---------------------------------------NFNNIL----------------------------------------------------SVVLST-------VLTILLALVMF---SMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAV---VVLIIGCCPGGTASN-ILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIY----TK-MWVDSGSIV-IPYDNIGTSL-VALVVPVSIGMFVN--------HKWPQK----AKIILKIG---------------SIAGAILIVLIAVVGGILY------QSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRC-RTVAF--ETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKK----------CHGKNKAEIPE----SKENGTEPESSFYKAN--GGFQPDEK---------------------
SLC10A3   -----------MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSI---------HSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALAL---GLIITCSSPGGGGSY-LFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIY----SR-LLSIHETLH-VPISKILGTL-LFIAIPIAVGVLIK--------SKLPKF----SQLLLQVV---------------KPFSFVLLL----GGLFLA-YRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQR-RTVSI--EVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSS----LFPVP---------------------------------------------------------------
SLC10A4   MDGNDNVTLLFAPLLRDNY---------------------------------TLAPNASSLGPG----------------------------TDLALAPASSA-------GPGP------------------GLSLGPGPSFGFSPGPTPTPEPTTSGLAGGAA-------SHGPSPF----PRPWAPHALPFWDTPLNHGLNV-------FVGAALCITML---GLGCTVDVNHFGAHVRRPVGALLAALCQFGLLPLLAFLLALAFKLDEVAAV---AVLLCGCCPGGNLSN-LMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIY----SW-AWINTPIVQLLPLGTVTLTL-CSTLIPIGLGVFIR--------YKYSRV----ADYIVK-------------------VSLWSLLVTLVVLFIMTGTMLGPELLASIPAAVYVIAIFMPLAGYASGYGLATLFHLP-PNCKRTVCL--ETGSQNVQLCTAILKLAFPPQFIGSMYMFPLLYALFQSAEAGIFVLIYKMYGS--------EMLHKRDPLDEDEDTDISYKKLKEEEM--------ADTSYGTVKAENI-IMME-----TAQTSL
SLC10A5   -----MIRKLFIVLL----------------------------LLLVTI----EEARMSSLS-------------FLNIEKTEIL---FFTKTEETILVSSSY---ENKRPNSSHLFVKIEDPKILQMVNVAKKISSDATNFTINL---------VTDEEGETNVTIQLWDSEGRQERLIEEIKNVKVKVLKQKD--SLLQAPM-HIDRN-ILMLILPLILLNKCAFGCKIELQLFQTVWKRPLPVILGAVTQFFLMPFCGFLLSQIVALPEAQAF---GVVMTCTCPGGGGGY-LFALLLDGDFTLAILMTCTSTLLALIMMPVNSYIY----SR-ILGLSGTFH-IPVSKIVSTL-LFILVPVSIGIVIK--------HRIPEK----ASFLERII---------------RPLSFILMF----VGIYLT-FTVGLVFLKTDNLEVILLGLLVPALGLLFGYSFAKVCTLPLPVC-KTVAI--ESGMLNSFLALAVIQLSFPQSKANLASVAPFTVAMCSGCEMLLIIL---VYKAKKRCIFFLQDKRKRN---------------------FLI---------------------------------
SLC10A6   ----------------------------------------------------MRANCSSSSA---------------------------------CPANSSEE-------------------------------ELPVGLEVHGNL----------------------------------------------------ELVFTV-------VSTVMMGLLMF---SLGCSVEIRKLWSHIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAI---AVLIMGCCPGGTISN-IFTFWVDGDMDLSISMTTCSTVAALGMMPLCIYLY----TW-SWSLQQNLT-IPYQNIGITL-VCLTIPVAFGVYVN--------YRWPKQ----SKIILKIG---------------AVVGGVLLLVVAVAGVVLA------KGSWNSDITLLTISFIFPLIGHVTGFLLALFTHQSWQRC-RTISL--ETGAQNIQMCITMLQLSFTAEHLVQMLSFPLAYGLFQLIDGFLIVAAYQTYKRR------LKNKHGKKNSGCTEVCHTRKSTSSRETNAFLEVNEEGAITPGPPGPMDCHRALEPVGHITSCE--
SLC10A7   -----------MRLLE----------------------RMRKDWFMVGI---VLAIAGAKLEP-----------------------------------------------------------------------------SIGVNGGPL---KPEIT------------------------------------------------------VSYIAVATIFF---NSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSS-----------VPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKKPPFGAISSSVLLMIIYTTFCDTFSNPNIDLDKFSLVLIL----------------FIIFSIQLSFMLLTFIFSTRNN-SGFTPA-----------DTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISVPLL--IYHPAQILLGSVLVPTIKSWM----------------------VSRQKGVK---------------------------------LTRPTV-

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC10A2 9 D/H 0.000207943 rs200018808
-- SLC10A2 27 N/S 0.000632554 rs147075283
-- SLC10A2 44 L/F 0.000564716 rs199553519
-- SLC10A2 64 R/W 0.000978692 rs142620512
-- SLC10A2 65 P/L 0.00154359 rs112657170
-- SLC10A2 77 G/E 0.000155229 rs143297386
-- SLC10A2 90 F/S 0.000314465 rs199894506
-- SLC10A2 98 V/I 0.027146 rs55971546
-- SLC10A2 100 V/A 0.000155212 rs138949597
-- SLC10A2 105 C/R 0.000123355 rs201206937
-- SLC10A2 139 G/R 0.000445881 rs200749358
-- SLC10A2 142 P/L 0.0009397 rs117447044
-- SLC10A2 144 C/Y 0.000203046 rs143238545
-- SLC10A2 154 D/N 0.000127428 rs149100459
-- SLC10A2 154 D/E 0.000418123 rs199645187
-- SLC10A2 159 V/I 0.0177839 rs60380298
-- SLC10A2 167 T/I 0.000242941 rs202168953
-- SLC10A2 171 S/A 0.854486 rs188096
-- SLC10A2 172 L/P 0.000143344 rs764173717
-- SLC10A2 187 P/L 0.000151322 rs201929731
-- SLC10A2 219 A/T 0.000103464 rs147515410
-- SLC10A2 257 T/M 0.000119381 rs145541774
-- SLC10A2 262 T/M 0.00052913 rs72547505
-- SLC10A2 290 P/S 0.00998185 rs56398830
-- SLC10A2 296 F/L 0.00463863 rs71640248
-- SLC10A2 304 F/L 0.00238981 rs61966074

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
SLC10A2 SLC10A2 [plasma membrane] Recycling of bile acids and salts

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data