Detail Data SLC10A1

Basic description

Gene Name	SLC10A1
Protein Name	Sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein) (Na(+)/bile acid cotransporter) (Na(+)/taurocholate transport protein) (Sodium/taurocholate cotransporting polypeptide) (Solute carrier family 10 member 1)
Family	SLC10
Category	-
Reaction name	Co-transport (influx) of bile salts and sodium ions by NTCP
Reaction	1 albumin:bile salt complex [extracellular region] + 2 Na+ [extracellular region] --> 1 bile salts [cytosol] + 2 Na+ [cytosol] + 1 ALB [extracellular region]

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340 
MEAHNASAPF NFTLPPNFGK RPTDLALSVI LVFMLFFIML SLGCTMEFSK IKAHLWKPKG LAIALVAQYG IMPLTAFVLG KVFRLKNIEA LAILVCGCSP GGNLSNVFSL AMKGDMNLSI VMTTCSTFCA LGMMPLLLYI YSRGIYDGDL KDKVPYKGIV ISLVLVLIPC TIGIVLKSKR PQYMRYVIKG GMIIILLCSV AVTVLSAINV GKSIMFAMTP LLIATSSLMP FIGFLLGYVL SALFCLNGRC RRTVSMETGC QNVQLCSTIL NVAFPPEVIG PLFFFPLLYM IFQLGEGLLL IAIFWCYEKF KTPKDKTKMI YTAATTEETI PGALGNGTYK GEDCSPCTA 
CCCCCCCCHH HEECCCCCCC CCHHHHHHHH HHHHHHHHHH HHHHCCCHHH HHHHHCCCHH HHHHHHHHHC HHHHHHHHHH HHCCCCHHHH HHHHHHHCCC CCCHHHHHHH HHCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCHHHHH HHHHHHHHHH HHHHHHHHCC HHHHHHHCCC CHHHHHHHHH HHHHHHHHHH CHHHHHHCHH HHHHHHHHHH HHHHHHHHHH HHHHHCCHHH HHEECCCCCC CCHHHHHHHH HHHCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCC

Family alignment

[Overview]

SLC10A1   ----------------------------------------------------MEAHNASA--------------------------------------------------------------------------------PFNFTLPPN-------------------------------------------FGKRPTDLALSV-------ILVFMLFFIML---SLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEAL---AILVCGCSPGGNLSN-VFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIY----SRGIYDGDLKDK-VPYKGIVISL-VLVLIPCTIGIVLK--------SKRPQY----MRYVIK-------------------GGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLN-GRCRRTVSM--ETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEK---------FKTPKDKTKMIYTAATTEETIP------------GALGNGTYKGEDC----------SPCTA-
SLC10A2   --------------MNDPNSC------------------------------VDNATVCSGAS---------------------------------CVVPES---------------------------------------NFNNIL----------------------------------------------------SVVLST-------VLTILLALVMF---SMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAV---VVLIIGCCPGGTASN-ILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIY----TK-MWVDSGSIV-IPYDNIGTSL-VALVVPVSIGMFVN--------HKWPQK----AKIILKIG---------------SIAGAILIVLIAVVGGILY------QSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRC-RTVAF--ETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKK----------CHGKNKAEIPE----SKENGTEPESSFYKAN--GGFQPDEK---------------------
SLC10A3   -----------MVLMQDKGSSQQWPGLGGEGGGTGPLSMLRAALLLISLPWGAQGTASTSLSTAGGHTVPPTGGRYLSIGDGSVMEFEFPEDSEGIIVISSQYPGQANRTAPGPMLRVTSLDTEVLTIKNVSAITWGGGGGFVVSI---------HSGLAGLAPLHIQLVDAHEAPPTLIEERRDFCIKVSPAEDTPATLSADLAHFSENPILYLLLPLIFVNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALAL---GLIITCSSPGGGGSY-LFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIY----SR-LLSIHETLH-VPISKILGTL-LFIAIPIAVGVLIK--------SKLPKF----SQLLLQVV---------------KPFSFVLLL----GGLFLA-YRMGVFILAGIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQR-RTVSI--EVGVQNSLLALAMLQLSLRRLQADYASQAPFIVALSGTSEMLALVIGHFIYSS----LFPVP---------------------------------------------------------------
SLC10A4   MDGNDNVTLLFAPLLRDNY---------------------------------TLAPNASSLGPG----------------------------TDLALAPASSA-------GPGP------------------GLSLGPGPSFGFSPGPTPTPEPTTSGLAGGAA-------SHGPSPF----PRPWAPHALPFWDTPLNHGLNV-------FVGAALCITML---GLGCTVDVNHFGAHVRRPVGALLAALCQFGLLPLLAFLLALAFKLDEVAAV---AVLLCGCCPGGNLSN-LMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIY----SW-AWINTPIVQLLPLGTVTLTL-CSTLIPIGLGVFIR--------YKYSRV----ADYIVK-------------------VSLWSLLVTLVVLFIMTGTMLGPELLASIPAAVYVIAIFMPLAGYASGYGLATLFHLP-PNCKRTVCL--ETGSQNVQLCTAILKLAFPPQFIGSMYMFPLLYALFQSAEAGIFVLIYKMYGS--------EMLHKRDPLDEDEDTDISYKKLKEEEM--------ADTSYGTVKAENI-IMME-----TAQTSL
SLC10A5   -----MIRKLFIVLL----------------------------LLLVTI----EEARMSSLS-------------FLNIEKTEIL---FFTKTEETILVSSSY---ENKRPNSSHLFVKIEDPKILQMVNVAKKISSDATNFTINL---------VTDEEGETNVTIQLWDSEGRQERLIEEIKNVKVKVLKQKD--SLLQAPM-HIDRN-ILMLILPLILLNKCAFGCKIELQLFQTVWKRPLPVILGAVTQFFLMPFCGFLLSQIVALPEAQAF---GVVMTCTCPGGGGGY-LFALLLDGDFTLAILMTCTSTLLALIMMPVNSYIY----SR-ILGLSGTFH-IPVSKIVSTL-LFILVPVSIGIVIK--------HRIPEK----ASFLERII---------------RPLSFILMF----VGIYLT-FTVGLVFLKTDNLEVILLGLLVPALGLLFGYSFAKVCTLPLPVC-KTVAI--ESGMLNSFLALAVIQLSFPQSKANLASVAPFTVAMCSGCEMLLIIL---VYKAKKRCIFFLQDKRKRN---------------------FLI---------------------------------
SLC10A6   ----------------------------------------------------MRANCSSSSA---------------------------------CPANSSEE-------------------------------ELPVGLEVHGNL----------------------------------------------------ELVFTV-------VSTVMMGLLMF---SLGCSVEIRKLWSHIRRPWGIAVGLLCQFGLMPFTAYLLAISFSLKPVQAI---AVLIMGCCPGGTISN-IFTFWVDGDMDLSISMTTCSTVAALGMMPLCIYLY----TW-SWSLQQNLT-IPYQNIGITL-VCLTIPVAFGVYVN--------YRWPKQ----SKIILKIG---------------AVVGGVLLLVVAVAGVVLA------KGSWNSDITLLTISFIFPLIGHVTGFLLALFTHQSWQRC-RTISL--ETGAQNIQMCITMLQLSFTAEHLVQMLSFPLAYGLFQLIDGFLIVAAYQTYKRR------LKNKHGKKNSGCTEVCHTRKSTSSRETNAFLEVNEEGAITPGPPGPMDCHRALEPVGHITSCE--
SLC10A7   -----------MRLLE----------------------RMRKDWFMVGI---VLAIAGAKLEP-----------------------------------------------------------------------------SIGVNGGPL---KPEIT------------------------------------------------------VSYIAVATIFF---NSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWLFLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSS-----------VPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKKPPFGAISSSVLLMIIYTTFCDTFSNPNIDLDKFSLVLIL----------------FIIFSIQLSFMLLTFIFSTRNN-SGFTPA-----------DTVAIIFCSTHKSLTLGIPMLKIVFAGHEHLSLISVPLL--IYHPAQILLGSVLVPTIKSWM----------------------VSRQKGVK---------------------------------LTRPTV-

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC10A1	41	S/L	0.000406459	rs111885789
--	SLC10A1	84	R/W	0.000123373	rs201366799
--	SLC10A1	88	I/T	0.00142054	rs148467625
--	SLC10A1	93	I/V	0.000302442	rs200105842
--	SLC10A1	166	V/F	0.00034992	rs140189034
--	SLC10A1	168	I/T	0.000178935	rs200153803
--	SLC10A1	173	G/R	0.00023858	rs750470666
--	SLC10A1	200	V/M	0.000171252	rs202213974
--	SLC10A1	200	V/E	0.000107526	rs747096695
--	SLC10A1	213	S/R	0.000171197	rs200746820
--	SLC10A1	223	I/T	0.00290316	rs61745930
--	SLC10A1	232	I/T	0.000219179	rs190268737
--	SLC10A1	234	F/L	0.000183431	rs139931299
--	SLC10A1	252	R/C	0.000121041	rs141269120
--	SLC10A1	252	R/H	0.00026168	rs147226818
--	SLC10A1	267	S/F	0.0062943	rs2296651
--	SLC10A1	279	I/T	0.00013528	rs72547507
--	SLC10A1	290	M/I	0.000195005	rs201290531
--	SLC10A1	293	Q/E	0.000238857	rs189313778
--	SLC10A1	319	M/I	0.00018352	rs149272163
--	SLC10A1	332	G/R	0.000139228	rs201537069

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
	SLC10A1	SLC10A1 [plasma membrane]	Recycling of bile acids and salts

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data