Detail Data SLC1A6

Basic description

Gene Name	SLC1A6
Protein Name	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6)
Family	SLC1
Category	Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name	-
Reaction	-

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560 
MSSHGNSLFL RESGQRLGRV GWLQRLQESL QQRALRTRLR LQTMTLEHVL RFLRRNAFIL LTVSAVVIGV SLAFALRPYQ LTYRQIKYFS FPGELLMRML QMLVLPLIVS SLVTGMASLD NKATGRMGMR AAVYYMVTTI IAVFIGILMV TIIHPGKGSK EGLHREGRIE TIPTADAFMD LIRNMFPPNL VEACFKQFKT QYSTRVVTRT MVRTENGSEP GASMPPPFSV ENGTSFLENV TRALGTLQEM LSFEETVPVP GSANGINALG LVVFSVAFGL VIGGMKHKGR VLRDFFDSLN EAIMRLVGII IWYAPVGILF LIAGKILEME DMAVLGGQLG MYTLTVIVGL FLHAGIVLPL IYFLVTHRNP FPFIGGMLQA LITAMGTSSS SATLPITFRC LEEGLGVDRR ITRFVLPVGA TVNMDGTALY EALAAIFIAQ VNNYELNLGQ ITTISITATA ASVGAAGIPQ AGLVTMVIVL TSVGLPTEDI TLIIAVDWFL DRLRTMTNVL GDSIGAAVIE HLSQRELELQ EAELTLPSLG KPYKSLMAQE KGASRGRGGN ESAM 
CCCCCCCEEE CCCCCCCCCC CHHHHHHHHH HHHHHHHHHH HHCCCHHHHH HHHHHCHHHH HHHHHHHHHH HHHHHHCCCC CCHHHHHHCC CHHHHHHHHH HHCHHHHHHC CCCHHHHCCC CCCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCCC CCCCCHHHHH HHHHHCCCCH HHHHHHHHHC CCCCCEECCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCHH HHCCCCHHHH HCCCCCCCCC HHHCCHHHHH HHHHHHHHHH HHHHCCCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHCCC CCHHHHHHHH HHHHHCCCCC CEEEEECCCC CCCCCHHHHH HHHHHHHHHH HCCCCCCHHH HHHHHHHHHH HHHHHCCCCH HHHHHHHHHH HHCCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHCCHHHH HHHHCCCCCC CCCHHHHHHH HHHCCCCCCC CCCC

Family alignment

[Overview]

SLC1A1    ----------------MGKPARKGCEWKR-------------------------------------------FLKNNWVLLSTVAAVVLGITTGVLVREH---SNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQK------VGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKRE-------------------EVKPP-------SDPEMNMTE-----ESFTAVMTTAISKNKTKEYKIVGM--YSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIF-RKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIV-EKLSKKELEQMDVS------SEVNI-------------VNPFALE-----STILDNEDSDTKKSYVNGGFAVDKSDTISFT--------------------------QTSQF----
SLC1A2    ------------MASTEGAN-------------NMPKQVEV--------RMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLA---SPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKL------KKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKV-----------------LVAPP-------PDEEANATS-----AVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIV-YHLSKSELDTIDSQ--HRVHEDIEM-------------TKTQSIY-----DDMKNHRESNSNQCVYAAHNSV-IVDECKVT--------------LAANGKSADCSVEEEPWKREK
SLC1A3    ------------MTKSNGEEPKMGGRMERFQQGVRKRTLLA--------KKKVQNITKED---------VKSYLFRNAFVLLTVTAVIVGTILGFTLRPY----RMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTK------EN-MHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKR-----------------SFKVP-------IQA--NETLVGAVINNVSEAMETLTRIT--EELVPVPG--SVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIV-EHLSRHELKNRDVEMGNSVIEENEM-------------KKPYQ----------LIAQDNETEKPI-DSETKM--------------------------------------------
SLC1A4    --MEKSNETNGYLDSAQAGPAAGPGAP----------GTAAG-------RAR----------------RCAGFLRRQALVLLTVSGVLAGAGLGAALRG----LSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVV-------------------------------TQNSSSGN------------------VTHEKIPIGT--EIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGIL-HHLNQKATKKGEQEL-AEVKVE------AIPNCKSEEETSPLVTH-QNPAGPVASAPELESKESVL--------------------------------------------------
SLC1A5    MVADPPRDSKGL---AAAEPTANGGLALA---SIEDQGAAAGGYCGSRDQVR----------------RC---LRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINAS-VGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYE----------------------------------ERNITG--------------------TRVKVPVGQ--EVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPEL-IQVKSELPLDPLPVPT----EEGNPLLKHYRGPAGDATVASE---KESVM--------------------------------------------------
SLC1A6    ----MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRT--------RLRLQTMTLEH---------VLRFLRRNAFILLTVSAVVIGVSLAFALRPY----QLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSK------EG-LHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPP-------FSVE-NGT---SFLENVTRALGTLQEMLSFEETVPVPG--SANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVI-EHLSQRELELQEAEL-----TLPSL-------------GKPYK---------SLMAQEKGASRGRGGNESAM--------------------------------------------
SLC1A7    ---------------------------------MVPHAILA--------RGR-------------------DVCRRNGLLILSVLSVIVGCLLGFFLRTR----RLSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQ------KETTEQSGK-PIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAP---------EEAPPRRILIYGVQEE-NGSHV----QNFALDLTPPPEVVYKSE----PG--TSDGMNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIM-AHICRKDFA-RDTG------TEKLLP----------CETKPVSLQ-----E-IVAAQQNGCVKSV-AEASEL----TLGPTCPHHVPVQVEQDEELPAASLN-HCTIQISELETNV

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC1A6	2	S/N	0.000560176	rs201428414
--	SLC1A6	15	A/S	0.532025	rs3746295
--	SLC1A6	25	R/W	0.000958839	rs202133222
--	SLC1A6	29	A/V	0.000958839	rs202133222
--	SLC1A6	31	A/T	0.000717281	rs188484412
--	SLC1A6	32	G/R	0.000123648	rs559218629
--	SLC1A6	61	R/C	0.0135565	rs115001292
--	SLC1A6	78	P/S	0.000202877	rs765917635
--	SLC1A6	82	P/L	0.000202877	rs765917635
--	SLC1A6	220	P/L	0.00021491	rs141656938
--	SLC1A6	235	S/G	0.000131235	rs141575919
--	SLC1A6	355	G/S	0.000111484	rs151279780
--	SLC1A6	368	R/Q	0.000312738	rs188504788

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
main	SLC1A6	SLC1A6 [plasma membrane]	Transport of inorganic cations/anions and amino acids/oligopeptides
	SLC1A6	SLC1A6 [plasma membrane]	Glutamate Neurotransmitter Release Cycle

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data