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Detail Data SLC1A4


Basic description
Gene Name SLC1A4
Protein Name Neutral amino acid transporter A (Alanine/serine/cysteine/threonine transporter 1) (ASCT-1) (SATT) (Solute carrier family 1 member 4)
Family SLC1
Category Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine
SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine
SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine
Reaction 1 Na+ [cytosol] + 1 alanine, serine, threonine, or cysteine [cytosol] + 1 Cys [extracellular region] + 1 Na+ [extracellular region] --> 1 L-Cys [cytosol] + 1 Na+ [cytosol] + 1 alanine, serine, threonine, or cysteine [extracellular region] + 1 Na+ [extracellular region]
1 Na+ [cytosol] + 1 alanine, serine, threonine, or cysteine [cytosol] + 1 L-Ala [extracellular region] + 1 Na+ [extracellular region] --> 1 L-Ala [cytosol] + 1 Na+ [cytosol] + 1 alanine, serine, threonine, or cysteine [extracellular region] + 1 Na+ [extracellular region]
1 L-Ser [extracellular region] + 1 Na+ [cytosol] + 1 alanine, serine, threonine, or cysteine [cytosol] + 1 Na+ [extracellular region] --> 1 Na+ [cytosol] + 1 L-Ser [cytosol] + 1 alanine, serine, threonine, or cysteine [extracellular region] + 1 Na+ [extracellular region]
1 Na+ [cytosol] + 1 alanine, serine, threonine, or cysteine [cytosol] + 1 L-Thr [extracellular region] + 1 Na+ [extracellular region] --> 1 Na+ [cytosol] + 1 L-Thr [cytosol] + 1 alanine, serine, threonine, or cysteine [extracellular region] + 1 Na+ [extracellular region]

Network
Structure


[Overview]
Position 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 1 0 0 1 1 0 1 2 0 1 3 0 1 4 0 1 5 0 1 6 0 1 7 0 1 8 0 1 9 0 2 0 0 2 1 0 2 2 0 2 3 0 2 4 0 2 5 0 2 6 0 2 7 0 2 8 0 2 9 0 3 0 0 3 1 0 3 2 0 3 3 0 3 4 0 3 5 0 3 6 0 3 7 0 3 8 0 3 9 0 4 0 0 4 1 0 4 2 0 4 3 0 4 4 0 4 5 0 4 6 0 4 7 0 4 8 0 4 9 0 5 0 0 5 1 0 5 2 0 5 3 0 AA Pred 
        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530 
MEKSNETNGY LDSAQAGPAA GPGAPGTAAG RARRCAGFLR RQALVLLTVS GVLAGAGLGA ALRGLSLSRT QVTYLAFPGE MLLRMLRMII LPLVVCSLVS GAASLDASCL GRLGGIAVAY FGLTTLSASA LAVALAFIIK PGSGAQTLQS SDLGLEDSGP PPVPKETVDS FLDLARNLFP SNLVVAAFRT YATDYKVVTQ NSSSGNVTHE KIPIGTEIEG MNILGLVLFA LVLGVALKKL GSEGEDLIRF FNSLNEATMV LVSWIMWYVP VGIMFLVGSK IVEMKDIIVL VTSLGKYIFA SILGHVIHGG IVLPLIYFVF TRKNPFRFLL GLLAPFATAF ATCSSSATLP SMMKCIEENN GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVE LNAGQIFTIL VTATASSVGA AGVPAGGVLT IAIILEAIGL PTHDLPLILA VDWIVDRTTT VVNVEGDALG AGILHHLNQK ATKKGEQELA EVKVEAIPNC KSEEETSPLV THQNPAGPVA SAPELESKES VL 
CCCCCCCCCC CCCCCCCCCC CCCCCCCHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHCCCCCCHH HHHHCCCCHH HHHHHHHHCH HHHHHHHHCH HHHCCCHHHC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHC CCCCCCHHCC CCCCCCCCCC CCCCCCCCCC HHHHHHHCCC HHHHHHHHHH HCCCCCEEEE CCCCCCCCCC CCCCCCCCCC CCHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHHHHHHHCH HHHHHHHHHH HHHCCCHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHHHH HHCCCCCHHH HHHHHHHHHC CCCCCCCCEE CCCCCCCCCH HHHHHHHHHH HHHHHHCCCC CCHHHHHHHH HHHHHHHHHH CCCCHHHHHH HHHHHHHCCC CHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCHHCHHHHH HHHHHCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CC
[Overview] SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7 
SLC1A1    ----------------MGKPARKGCEWKR-------------------------------------------FLKNNWVLLSTVAAVVLGITTGVLVREH---SNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQK------VGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKRE-------------------EVKPP-------SDPEMNMTE-----ESFTAVMTTAISKNKTKEYKIVGM--YSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIF-RKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIV-EKLSKKELEQMDVS------SEVNI-------------VNPFALE-----STILDNEDSDTKKSYVNGGFAVDKSDTISFT--------------------------QTSQF----
SLC1A2    ------------MASTEGAN-------------NMPKQVEV--------RMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLA---SPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKL------KKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKV-----------------LVAPP-------PDEEANATS-----AVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIV-YHLSKSELDTIDSQ--HRVHEDIEM-------------TKTQSIY-----DDMKNHRESNSNQCVYAAHNSV-IVDECKVT--------------LAANGKSADCSVEEEPWKREK
SLC1A3    ------------MTKSNGEEPKMGGRMERFQQGVRKRTLLA--------KKKVQNITKED---------VKSYLFRNAFVLLTVTAVIVGTILGFTLRPY----RMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTK------EN-MHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKR-----------------SFKVP-------IQA--NETLVGAVINNVSEAMETLTRIT--EELVPVPG--SVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIV-EHLSRHELKNRDVEMGNSVIEENEM-------------KKPYQ----------LIAQDNETEKPI-DSETKM--------------------------------------------
SLC1A4    --MEKSNETNGYLDSAQAGPAAGPGAP----------GTAAG-------RAR----------------RCAGFLRRQALVLLTVSGVLAGAGLGAALRG----LSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVV-------------------------------TQNSSSGN------------------VTHEKIPIGT--EIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGIL-HHLNQKATKKGEQEL-AEVKVE------AIPNCKSEEETSPLVTH-QNPAGPVASAPELESKESVL--------------------------------------------------
SLC1A5    MVADPPRDSKGL---AAAEPTANGGLALA---SIEDQGAAAGGYCGSRDQVR----------------RC---LRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINAS-VGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYE----------------------------------ERNITG--------------------TRVKVPVGQ--EVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPEL-IQVKSELPLDPLPVPT----EEGNPLLKHYRGPAGDATVASE---KESVM--------------------------------------------------
SLC1A6    ----MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRT--------RLRLQTMTLEH---------VLRFLRRNAFILLTVSAVVIGVSLAFALRPY----QLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSK------EG-LHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPP-------FSVE-NGT---SFLENVTRALGTLQEMLSFEETVPVPG--SANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVI-EHLSQRELELQEAEL-----TLPSL-------------GKPYK---------SLMAQEKGASRGRGGNESAM--------------------------------------------
SLC1A7    ---------------------------------MVPHAILA--------RGR-------------------DVCRRNGLLILSVLSVIVGCLLGFFLRTR----RLSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQ------KETTEQSGK-PIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAP---------EEAPPRRILIYGVQEE-NGSHV----QNFALDLTPPPEVVYKSE----PG--TSDGMNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIM-AHICRKDFA-RDTG------TEKLLP----------CETKPVSLQ-----E-IVAAQQNGCVKSV-AEASEL----TLGPTCPHHVPVQVEQDEELPAASLN-HCTIQISELETNV

Variant
check gene name residue number Reference Amino Acid / Variant Amino Acid minor allele frequency rs number
-- SLC1A4 14 A/T 0.00560224 rs149636167
-- SLC1A4 22 P/L 0.00114272 rs201175768
SLC1A4 37 G/R 0.0494654 rs1064512
SLC1A4 219 E/A 0.000112106 rs34259099
SLC1A4 249 R/C 0.000159146 rs183809967
SLC1A4 249 R/H 0.00010347 rs201168258
SLC1A4 256 E/K 0.000234946 rs201278558
SLC1A4 258 T/M 0.00022718 rs148157449
SLC1A4 282 V/M 0.000171005 rs373422737
SLC1A4 289 V/M 0.000811236 rs139319094
SLC1A4 324 N/K 0.000115349 rs751293273
SLC1A4 399 V/I 0.23461 rs759458
SLC1A4 438 I/T 0.00045746 rs141895894
SLC1A4 439 G/E 0.00027845 rs144796570
SLC1A4 457 R/W 0.000123424 rs761533681
-- SLC1A4 484 K/E 0.000974767 rs80013206
-- SLC1A4 486 E/Q 0.000119373 rs113579377

Phylogenetic tree

Pathway
Priority Gene Name Reactome (Gene) Reactome (Pathway)
main SLC1A4 SLC1A4 [plasma membrane] Amino acid transport across the plasma membrane

Disease
Gene Name Reactome (Gene) Reactome (Pathway)
No data