Detail Data SLC1A2

Basic description

Gene Name	SLC1A2
Protein Name	Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
Family	SLC1
Category	Transport of inorganic cations/anions and amino acids/oligopeptides
Reaction name	-
Reaction	-

Network

Structure

Sequence

[Overview]

        10         20         30         40         50         60         70         80         90        100        110        120        130        140        150        160        170        180        190        200        210        220        230        240        250        260        270        280        290        300        310        320        330        340        350        360        370        380        390        400        410        420        430        440        450        460        470        480        490        500        510        520        530        540        550        560        570 
MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT VFGVILGAVC GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS LITGLSGLDA KASGRLGTRA MVYYMSTTII AAVLGVILVL AIHPGNPKLK KQLGPGKKND EVSSLDAFLD LIRNLFPENL VQACFQQIQT VTKKVLVAPP PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM NVLGLIGFFI AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG IFQAWITALG TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG TALYEAVAAI FIAQMNGVVL DGGQIVTVSL TATLASVGAA SIPSAGLVTM LLILTAVGLP TEDISLLVAV DWLLDRMRTS VNVVGDSFGA GIVYHLSKSE LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA AHNSVIVDEC KVTLAANGKS ADCSVEEEPW KREK 
CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCHHHHHHHH HHHCHHHHHH HHHHHHHHHH HHHHHHCCCC CHHHHHHHHC CHHHHHHHHH HCHHHHHHHH HHHHHHCCCH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH HCCCCCCHHH HCCCCCCCCC CCCHHHHHHH HHHHHCHHHH HHHHHHHHHH HHCCCCCCCC CCCCCCCCHH HHHHHHHHCC CCCCCCCCHH CCCCCCCCCC CHHHHHHHHH HHHHHHHHCC HHHHHHHHHH HHHHHHHHHH HHHHHHCCCC HHHHHHHHHH HHCCCHHHHH HHHHHHHHHH HHHHHHHHHH HHHHHHHHHH CCCHHHHHHH HHHHHHHHHH HCCHHCHHHH HHHHHHHHHC CCCCCEEEEE CCCCHHCCCH HHHHHHHHHH HHHHHCCCCC CHHHHHHHHH HHHHHHHHHC CCCHHHHHHH HHHHHHHCCC HHHHHHHHHH HHHHHHHCHH CHHHHHHHHH HHHHHHHHHH HCCCCCCCCC HHHCCCCCCC CCCCCHHHCC CCCCCCCCCC CCCCEEECCC CCCCCCCCCC CCCCCCCCCC CCCC

Family alignment

[Overview]

SLC1A1    ----------------MGKPARKGCEWKR-------------------------------------------FLKNNWVLLSTVAAVVLGITTGVLVREH---SNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQK------VGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKRE-------------------EVKPP-------SDPEMNMTE-----ESFTAVMTTAISKNKTKEYKIVGM--YSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIF-RKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIV-EKLSKKELEQMDVS------SEVNI-------------VNPFALE-----STILDNEDSDTKKSYVNGGFAVDKSDTISFT--------------------------QTSQF----
SLC1A2    ------------MASTEGAN-------------NMPKQVEV--------RMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLA---SPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKL------KKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKV-----------------LVAPP-------PDEEANATS-----AVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIV-YHLSKSELDTIDSQ--HRVHEDIEM-------------TKTQSIY-----DDMKNHRESNSNQCVYAAHNSV-IVDECKVT--------------LAANGKSADCSVEEEPWKREK
SLC1A3    ------------MTKSNGEEPKMGGRMERFQQGVRKRTLLA--------KKKVQNITKED---------VKSYLFRNAFVLLTVTAVIVGTILGFTLRPY----RMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTK------EN-MHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKR-----------------SFKVP-------IQA--NETLVGAVINNVSEAMETLTRIT--EELVPVPG--SVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIV-EHLSRHELKNRDVEMGNSVIEENEM-------------KKPYQ----------LIAQDNETEKPI-DSETKM--------------------------------------------
SLC1A4    --MEKSNETNGYLDSAQAGPAAGPGAP----------GTAAG-------RAR----------------RCAGFLRRQALVLLTVSGVLAGAGLGAALRG----LSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVV-------------------------------TQNSSSGN------------------VTHEKIPIGT--EIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGIL-HHLNQKATKKGEQEL-AEVKVE------AIPNCKSEEETSPLVTH-QNPAGPVASAPELESKESVL--------------------------------------------------
SLC1A5    MVADPPRDSKGL---AAAEPTANGGLALA---SIEDQGAAAGGYCGSRDQVR----------------RC---LRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINAS-VGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYE----------------------------------ERNITG--------------------TRVKVPVGQ--EVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPEL-IQVKSELPLDPLPVPT----EEGNPLLKHYRGPAGDATVASE---KESVM--------------------------------------------------
SLC1A6    ----MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRT--------RLRLQTMTLEH---------VLRFLRRNAFILLTVSAVVIGVSLAFALRPY----QLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSK------EG-LHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPP-------FSVE-NGT---SFLENVTRALGTLQEMLSFEETVPVPG--SANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVI-EHLSQRELELQEAEL-----TLPSL-------------GKPYK---------SLMAQEKGASRGRGGNESAM--------------------------------------------
SLC1A7    ---------------------------------MVPHAILA--------RGR-------------------DVCRRNGLLILSVLSVIVGCLLGFFLRTR----RLSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQ------KETTEQSGK-PIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAP---------EEAPPRRILIYGVQEE-NGSHV----QNFALDLTPPPEVVYKSE----PG--TSDGMNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIM-AHICRKDFA-RDTG------TEKLLP----------CETKPVSLQ-----E-IVAAQQNGCVKSV-AEASEL----TLGPTCPHHVPVQVEQDEELPAASLN-HCTIQISELETNV

Variant

check	gene name	residue number	Reference Amino Acid / Variant Amino Acid	minor allele frequency	rs number
--	SLC1A2	31	R/Q	0.000254966	rs199599866
--	SLC1A2	79	A/G	0.0002189	rs377633002
--	SLC1A2	79	R/G	0.0002145	rs531126908
--	SLC1A2	80	I/T	0.00154621	rs117044959
--	SLC1A2	194	K/E	0.000613717	rs150854080
--	SLC1A2	195	V/D	0.00170916	rs180817412
--	SLC1A2	221	E/K	0.000195085	rs766112847
--	SLC1A2	223	P/Q	0.000258816	rs142741081
--	SLC1A2	437	V/I	0.00109679	rs374090482

Phylogenetic tree

Pathway

Priority	Gene Name	Reactome (Gene)	Reactome (Pathway)
main	SLC1A2	SLC1A2 [plasma membrane]	Transport of inorganic cations/anions and amino acids/oligopeptides
	SLC1A2	SLC1A2 [plasma membrane]	Astrocytic Glutamate-Glutamine Uptake And Metabolism
	SLC1A2	SLC1A2 [plasma membrane]	Glutamate Neurotransmitter Release Cycle

Disease

Gene Name	Reactome (Gene)	Reactome (Pathway)
No data